Clinical trials: Sodium-sensitivity
Dentin Sensitivity
Effectiveness of Arginin and Potassium Nitrate Dentifrices in Dentin Hypersensitivity Therapy
Introduction: Dentin hypersensitivity (DH) could be defined as a brief and sharp pain in response to thermical, chemical, tactile and osmotic stimuli, which cannot be attributed to any dental condition or pathology.
- Trial name
- NCT02829879
- Testing
- 8% arginine/1450ppm sodium monofluorophosphate dentifrice, 5% potassium nitrate/2500ppm sodium fluoride dentifrice
- Where
- Chile
- Volunteers
- 50 people
- Sponsor
- University of Chile
Hypertension, Diabetes
The Effect of Calcium Supplementation on Insulin Resistance and 24h Blood Pressure
Increased levels of intracellular calcium are thought to diminish maximal cellular response to insulin and induce insulin resistance.
- Conditions
- Hypertension, Diabetes, Insulin Resistance
- Trial name
- NCT00549536
- Testing
- tablets each containing of 1000mg elemental calcium (Mega-Calcium Sandoz)
- Where
- Greece
- Volunteers
- 31 people
- Sponsor
- Aristotle University Of Thessaloniki
Sensitivity, Tooth
Reduction of Dentine Hypersensitivity After Use of Different Dentifrices
To assess the impact of the use of 5% Calcium Sodium Phosphosilicate or 8% Arginine dentifrices on dentinal hypersensitivity following non-surgical periodontal therapy in patients with periodontitis.
- Trial name
- Dentrifices (NCT06273930)
- Testing
- 5% CALCIUM SODIUM PHOSPHOSILICATE, 8% Arginine
- Where
- Pakistan
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Armed Forces Institute of Dentistry, Pakistan
Eczema, Atopic Dermatitis
Sodium in the Skin and Atopic Dermatitis
The goal of this observational study is to understand factors associated with skin sodium storage in healthy adults and people with atopic dermatitis ages 50 and above.
- Trial name
- SIS-AD (NCT06998446)
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Dentinal Hypersensitivity, Plaque, Dental
Evaluation of Dental and Periodontal Health After IPR in Patients in Orthodontic Treatment With Clear Aligners
This study aimed to evaluate dental and periodontal health after interproximal enamel reduction and to compare Laser diode (a device used in the Orthodontic Program) and sodium fluoride (often used in the Orthodontic Program and…
- Conditions
- Dentinal Hypersensitivity, Plaque, Dental, Bleeding Gum
- Trial name
- NCT06685016
- Testing
- Evaluation of Dentin hypersensitivity with VAS scale
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Campania Luigi Vanvitelli
Allergic Conjunctivitis
Evaluation of the Efficacy of Topical Ophthalmic Steroids in a Modified Conjunctival Allergen Challenge (CAC) Model
The purpose of this study is to evaluate the effectiveness of the modified Conjunctival Allergen Challenge (CAC) and observe how the produced allergic inflammation reacts to treatment with a proven ocular anti-inflammatory…
- Trial name
- NCT01534195
- Testing
- Prednisolone Sodium Phosphate Ophthalmic Solution 1%, Tears Naturale II Ophthalmic Solution
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- ORA, Inc.
Asthma, Allergic Rhinitis
A Study to Compare Effectiveness of Montelukast Sodium With Comparator in Mild to Moderate Persistent Asthmatics (0476-329)
Subjects have 8-week with montelukast sodium or comparator drug administration period, 2-week wash-out period and 8-week comparator drug or the drug administration period (with cross-over design) for assessment of the drug…
- Trial name
- NCT00157937
- Testing
- MK0476; montelukast sodium/Duration of Treatment: 16 weeks, Comparator: theophylline ER/Duration of Treatment: 16 weeks
- Volunteers
- 31 people
- Sponsor
- Organon and Co
Hypertension
The Role of COX-2 Inhibition in Salt Sensitivity of Blood Pressure
The purpose of this study is to determine if the drug Celebrex changes the way the kidney gets rid of salt and maintains blood pressure.
- Trial name
- NCT00624559
- Testing
- celecoxib (Celebrex)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Asthma
A Study to Assess the Effect of Montelukast Sodium With Concomitant Administration of Inhaled Budesonide in Asthmatic Patients (0476-075)
A study to assess the clinical effect of montelukast sodium with concomitant administration of inhaled budesonide in asthmatic patients.
- Trial name
- NCT00140946
- Testing
- MK0476; montelukast sodium/Duration of Treatment: 16 weeks
- Volunteers
- 546 people
- Sponsor
- Organon and Co
Moderate Asthma
Safety and Efficacy Study of the Use of Sodium Pyruvate Bronchodilation in Asthmatics
Sodium pyruvate in sodium chloride solution will be delivered by nebulization to the lungs. It is believed that this administration will produce bronchodilation in asthmatics as determined by improvement in FEV1.
- Trial name
- NCT00262652
- Testing
- sodium pyruvate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Emphycorp
Dentin Sensitivity
A Study to Assess the Efficacy of a Calcium Sodium Phosphosilicate Toothpaste for the Relief of Dentine Hypersensitivity
The aim of this study is to demonstrate the clinical efficacy of the Test Toothpaste containing Calcium Sodium Phosphosilicate (CSPS) in reducing Dentin Hypersensitivity (DH) to an evaporative (air) stimulus, compared to a sodium…
- Trial name
- NCT07894796
- Testing
- Test Toothpaste, Regular Fluoride Toothpaste
- Where
- Canada
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- HALEON
Hypertension
Nebivolol Versus Metoprolol: Sodium Sensitivity
Research objectives The objective of this randomized, placebo-controlled, 2 period crossover clinical trial is to determine the effects of nebivolol versus metoprolol on ambulatory blood pressure, the blood pressure response to…
- Trial name
- NCT00992056
- Testing
- nebivolol, Metoprolol
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Miami
Dentin Hypersensitivity
The Effect of Using Desensitizers Containing S-PRG In Treatment Of Dentin Hypersensitivity Over 6 Months: A Randomized Clinical Trial
The goal of this clinical trial is to compare the effect of desensitizer containing S-PRG have similar effect as sodium fluoride with functionalized tri-calcium phosphate containing desensitizer in relieving dentinal…
- Trial name
- S-PRG (NCT06276777)
- Testing
- Tooth varnish (PRG Barrier Coat from Shofu), Tooth varnish (Clinpro white varnish 3M)
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Eman Omar Elfarouk
Seasonal Allergic Rhinitis
Effectiveness of Sodium Hyaluronate In Relieving Nasal Symptoms Of Children With Seasonal Allergic Rhinitis
Nasal irrigation (NI) is recommended as an add-on therapy in patients with allergic rhinitis (AR). The primary purpose of this study was to evaluate the clinical effectiveness of adding hyaluronic acid (HA) solution and normal…
- Trial name
- EHA (NCT04752956)
- Testing
- "Total nasal symptom score" (TNSS), Paediatric Rhinoconjunctivitis Quality of Life Questionnaire" (PRQLQ), Nasal cytology
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Dentin Hypersensitivity
Effectiveness of Calcium Silicate and Sodium Fluoride Nanoparticles in The Management of Dentin Hypersensitivity
This study will be performed to assess the effect of inert prepared tooth paste loaded with Calcium Silicate Nanoparticles (CSNPs) and compare it to another one containing Sodium Fluoride Nanoparticles in the management of…
- Trial name
- NCT06557980
- Testing
- toothpaste
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Minia University
Sodium, Renal Function
The Effect of Sodium on Erythrocyte Salt Sensitivity, Syndecan-1 and Heparin Sulfate in Healthy Subjects.
The study was a double-blinded, randomized, placebo-controlled cross-over study. 27 healthy subjects received a four days standardized, sodium reduced diet (100 mmol sodium) and treatment with sodium chloride (200 mmol sodium) or…
- Conditions
- Sodium, Renal Function, Blood Pressure
- Trial name
- EGNA (NCT06968182)
- Testing
- Sodium Chloride
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Frank Mose
Cough
GSK2339345 Hypertussive Challenge Study
This study is designed to evaluate the effect of GSK2339345 relative to placebo on the number of coughs in patients with Chronic Idiopathic Cough (CIC) administered by an Aqueous Droplet Inhaler (ADI).
- Trial name
- NCT01899768
- Testing
- GSK2339345
- Where
- 2 sites in United Kingdom
- Volunteers
- 16 people
- Sponsor
- GlaxoSmithKline
Tooth Sensitivity
Effect of CPP-ACP Associated With NaF or SnF₂ on Post-Bleaching Tooth Sensitivity
This randomized, triple-blind, placebo-controlled clinical trial aims to evaluate the efficacy of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) associated with sodium fluoride (NaF) or stannous fluoride (SnF₂) in…
- Trial name
- NCT07506850
- Testing
- CPP-ACPF, CPP-ACP+SnF2
- Where
- Brazil
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Para
Allergic Rhinitis
Application of Ectoine Nasal Spray in Comparison With Cromolyn Sodium Containing Nasal Spray in Patients With Allergic Rhinitis
This is a comparative, open label, parallel group, non interventional study to further demonstrate the effectiveness and tolerability of Ectoin Allergy Nasal Spray.
- Trial name
- NCT02131038
- Testing
- Medica device, drug-like
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Bitop AG
Cardiovascular Diseases, Heart Diseases
Sodium Sensitivity in African Americans
To compare the effects of two levels of dietary sodium on blood pressure in Black men and women, and to determine what factors predict the degree of response.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension, Vascular Diseases
- Trial name
- NCT00000536
- Testing
- sodium, dietary
- Sponsor
- University of Minnesota