Clinical trials: Snake Bites
Snake Bite
Phase 3 Multicenter Comparative Study to Confirm Safety and Effectiveness of the F(ab)2 Antivenom Anavip.
The purpose of this study is to establish if F(ab)2 antivenom (Anavip) is safe for crotalinae envenomation. Confirm its effectiveness in preventing the occurrence of delayed coagulopathies and compare the safety and efficacy with…
- Trial name
- NCT00636116
- Testing
- Crotalinae (pit viper) equine immune F(ab)2, Crotalidae Polyvalent Immune Fab, ovine
- Where
- 18 sites in United States
- Volunteers
- 121 people
- Sponsor
- Instituto Bioclon S.A. de C.V.
Snake Bite
Study to Evaluate the Efficacy of Two Treatment Schemes With Antivipmyn ® for the Treatment of Snake Bite Envenomation
The purpose of this study is to compare whether a same total dose given up front as a single dose is more effective and as safe as the same dose given as a fractioned dose.
- Trial name
- NCT00639951
- Testing
- A, Antivipmyn ®
- Where
- 5 sites in Mexico
- Volunteers
- 10 people
- Sponsor
- Instituto Bioclon S.A. de C.V.
Snake Bites
Routine Antibiotic vs. Directed Antibiotic Treatment in Snake Bite
Clinicians tend to overuse antibiotics in snake bite despite evidence from three previous clinical trials that failed to show a benefit. But, none of these trials was done in India.
- Trial name
- RADIANS (NCT02570347)
- Testing
- Co-amoxiclav, Tetanus toxoid
- Where
- India
- Volunteers
- 66 people
- Sponsor
- Jawaharlal Institute of Postgraduate Medical Education & Research
Snake Bites, Antivenins
Evaluation of Anti-venoms Serum in Africa
There is little or no assessment under real-use conditions of the efficacy and the tolerance in the short, medium and long term of the antivenoms currently on the market and used in the treatment of snake bites.
- Conditions
- Snake Bites, Antivenins, Snake Venoms
- Trial name
- ESAA (NCT03326492)
- Testing
- Antivenom serum Inoserp Pan-Africa® injection
- Where
- 13 sites in Cameroon
- Volunteers
- 474 people
- Sponsor
- Institut Pasteur
Snakebite Cases Evaluation Clinical and Laboratory
Evaluation of Snakebite Cases in Assiut Governorate, Egypt (Prospective Study)
1. Study the sociodemographic profile of snakebite victims in Assiut Governorate. 2. Portray the clinical profile of snakebite victims admitted to Assiut University , El Eman General Hospital and Assiut General Hospital. 3.
- Trial name
- NCT06703645
- Volunteers
- 49 people
- Sponsor
- Assiut University
Rattlesnake Bite (Diagnosis)
Point-of-care Ultrasound in the Assessment of Snake Bite
Early identification of tissue injury from a rattlesnake bite is critical to prevent complications and reduce health care costs.
- Trial name
- NCT04188899
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Arizona
Snake Bite, Blood Coagulation Disorders
A Comparison of Crotalinae Equine Immune F(ab)2 Antivenom (Anavip) and Crotalidae Polyvalent Immune Fab,
This phase II study was a prospective, randomized, open-label, multi-center study in the United States, involving patients from 18 to 70 years of age, comparing Anavip (Antivenin Crotalinae [pit viper] equine immune F(ab)2…
- Trial name
- NCT00868309
- Testing
- Anavip, CroFab
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Instituto Bioclon S.A. de C.V.
Snake Bite
Multicenter Application Verification and Effect Evaluation of Artificial Intelligence-Based Snake Species Identification System in the Diagnosis and Treatment of Snakebites
This multicenter prospective observational study aims to develop and validate a deep learning-based artificial intelligence snake species identification system, and evaluate its clinical application efficacy in real-world…
- Trial name
- NCT07658885
- Testing
- SSRS system-assisted snake species identification
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Snakebite, Snake Envenomation
Mapping Snakebite Risk in Ghana and Rwanda
Snakebite causes approximately 138,000 deaths each year and non-fatal bites lead to considerable health burden, particularly in low-income tropical countries. Data on snakebite burden are lacking.
- Trial name
- NCT06808789
- Where
- Ghana
- Volunteers
- 32,000 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
Snake Envenomation
The Efficacy of Crotaline Fab Antivenom for Copperhead Snake Envenomations
Most patients bitten by copperhead snakes do not currently receive antivenom. Some snakebite victims have long term problems with the function of the limb that was bitten.
- Trial name
- NCT00303303
- Testing
- Crotaline Polyvalent Immune Fab (ovine) (active initial and maintenance therapy)
- Where
- 4 sites in United States
- Volunteers
- 13 people
- Sponsor
- Wake Forest University Health Sciences
Snake Bites
Cryotherapy as a Coadjuvant in Crotaline Snakebite Management With Antivenom.
The study aimed to determine the effect of local cryotherapy as a coadjuvant in patients with snakebite treated with F(ab')2 therapy venom at the Hospital Juárez de Mexico.
- Trial name
- NCT04470791
- Testing
- F(ab)2 antivenom therapy (antivipmyn®)., Local cryotherapy.
- Volunteers
- 38 people
- Sponsor
- Hospital Juarez de Mexico
Snake Bites
Improving Safety of Antivenom in People Bitten by Snakes
A study to increase the safety of polyvalent antivenom involving 1000 patients in three centres: low dose adrenaline, promethazine, \& hydrocortisone (alone and in combination) to prevent acute adverse reactions to antivenom in…
- Trial name
- NCT00270777
- Testing
- adrenaline, promethazine, hydrocortisone
- Where
- Sri Lanka
- Volunteers
- 1,000 people
- Sponsor
- University of Kelaniya
Snakebite, Epidemiology
Mapping Snakebite Risk in Kenya and Eswatini
The goal of this observational study is to learn about how snakebite risk varies in different environments in Kenya and understand how this information can be used to support decision makers.
- Trial name
- NCT06124872
- Testing
- Survey questionnaire, Key informant interview
- Where
- Kenya
- Volunteers
- 70,000 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
Snakebites, Envenoming
Broad-spectrum Rapid Antidote: Varespladib Oral for Snakebite
This is a multicenter, randomized, double-blind, placebo-controlled, phase 2 study designed to evaluate the safety, tolerability and efficacy of varespladib-methyl, concurrently with standard of care (SOC), in subjects bitten by…
- Conditions
- Snakebites, Envenoming, Envenoming, Snake, Envenomation, Snake
- Trial name
- BRAVO (NCT04996264)
- Testing
- Varespladib Methyl, Standard of care (SOC)
- Where
- 16 sites in United States, India
- Volunteers
- 95 people
- Sponsor
- Ophirex, Inc.
SNAKEBITE, THROMBOTIC MICROANGIOPATHY
Incidence of Snakebite Associated Thrombotic Microangiopathy & Role of Peripheral Blood Smear as a Predictor of Clinical Outcome
The aim of this study is to find the overall incidence of thrombotic microangiopathy in snakebite victims. As we know snakebite is a common in tropical regions.
- Conditions
- SNAKEBITE, THROMBOTIC MICROANGIOPATHY, SCHISTOCYTES
- Trial name
- NCT04845022
- Where
- India
- Volunteers
- 81 people
- Sponsor
- Jubilee Mission Medical College and Research Institute
Snakebite, Envenoming, Snake
Broad-spectrum Rapid Antidote: Varespladib IV to Oral Trial for Snakebite (BRAVIO)
This is a multicenter,randomized,double-blind, placebo-controlled, phase 2 study designed to evaluate the safety, tolerability and efficacy of a continuous rate infusion (CRI) of IV varespladib followed by transition to the oral…
- Trial name
- BRAVIO (NCT05717062)
- Testing
- Varespladib intravenous form, varespladib-methyl- oral form
- Where
- 10 sites in United States
- Volunteers
- 140 people
- Sponsor
- Ophirex, Inc.
Snakebite
Trial of Oral Community SVMP INhibitors for Snakebite
Bites by venomous snakes can cause disability and can be life-threatening. We are doing research in adult patients to try and find medications that can be administered orally and can help to reduce disability and death due to…
- Trial name
- TOCSINS (NCT07500233)
- Testing
- 2,3-dimercapto-1-propanesulfonic acid, marimastat, Antivenom Snakes
- Volunteers
- 504 people
- Sponsor
- Liverpool School of Tropical Medicine
Copperhead Snake Envenomation
Copperhead Envenomation Observational Study
The primary objective of the study is to evaluate the responsiveness and utility of several clinical outcome assessments in the setting of copperhead snakebite.
- Trial name
- NCT01651299
- Where
- 11 sites in United States
- Volunteers
- 20 people
- Sponsor
- BTG International Inc.
Snake Envenomation, Thrombi
Effects of Bothrops Spp. Snake Envenomation on Willebrand Factor Activity in Martinique and French Guiana
In 2017, the World Health Organization placed snakebites at the top of its list of neglected tropical diseases in an effort to facilitate funding for prevention programs, improve access to anti-venom, and stimulate new research…
- Conditions
- Snake Envenomation, Thrombi, Coagulopathy, Hemorrhage
- Trial name
- WBOTHROPS (NCT06304714)
- Testing
- Patients suffering from envenomation by Bothrops
- Where
- Martinique
- Volunteers
- 30 people
- Sponsor
- University Hospital Center of Martinique
Snake Bites
Safety and Effectiveness of PANAF-Premium TM Snake Venom Antiserum As Standard Treatment for Snakebites
Snakebite envenomation (SBE) is a major public health problem in many developing countries. Standard snake antivenom (SA) remains the primary treatment and has been shown to reduce mortality in observational studies conducted in…
- Trial name
- PMS (NCT06615960)
- Where
- Cameroon
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Premium Serums & Vaccines Pvt.Ltd.