Clinical trials: Smoking Reduction
Smoking Cessation
Smoking Reduction: Testing a Novel Approach to Cessation in Primary Care Practice Settings
Traditional models of smoking cessation focus on delivering advice and counseling to quit and providing assistance to patients ready to quit smoking, but do not actively intervene with patients who are not ready to quit (NRTQ).
- Trial name
- NCT03128554
- Testing
- Intervention with Training and Materials
- Where
- Canada
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Healthy Smokers, Smoking Cessation
Efficacy and Safety of an Electronic Nicotine Delivery Device (E-Cigarette) Without Nicotine Cartridges
The study's major aim is to investigate the ability of a commercial Electronic Nicotine Delivery Device (E-Cigarette) to induce long-term smoking reduction/abstinence in smokers unwilling to quit.
- Trial name
- NCT01194583
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Catania
Smoking
Reduced Exposure Study in Smokers Using the Tobacco Heating System 2.2 (THS 2.2) for 5 Days in a Confinement Setting
The overall goal of the study is to evaluate if the ad libitum use of the Tobacco Heating System 2.2 (THS 2.2) for 5 consecutive days by adult Japanese healthy smokers affects the levels of biomarkers of exposure for selected…
- Trial name
- NCT01970982
- Testing
- Tobacco Heating System (THS 2.2), Smoking abstinence (SA), Conventional cigarette (CC)
- Where
- Japan
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Smoking
Combined Treatment for Tobacco and Alcohol Use in Puerto Rico
Objectives: 1. Assess MAPS and MAPS+ effects on alcohol at-risk behaviors and smoking cessation. 2. Assess MAPS and MAPS+ effects on treatment mechanisms (increased self-efficacy, decreased temptations/craving, decreased stress…
- Trial name
- NCT00570804
- Testing
- Telephone Counseling, Telephone Assessments
- Where
- United States
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Alcohol Drinking, Cigarette Smoking Toxicity
Reduced Nicotine Cigarettes in Smokers With and Without Alcohol Use Disorder
The proposed research will investigate whether smokers with vs. without current at-risk alcohol drinking (ARD) respond to reduced nicotine cigarettes by increasing their alcohol consumption or smoke exposure, thereby diminishing…
- Trial name
- RedNic (NCT02990455)
- Testing
- Reduced nicotine cigarettes
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Battelle Memorial Institute
Non-Alcoholic Fatty Liver Disease
Cigarette Smoking in Non-alcoholic Steatohepatitis
This non-randomized clinical trial was performed to clarify the effect of cigarette smoking reduction on liver function and some anthropocentric indices in smoker patients with non-alcoholic steatohepatitis.
- Trial name
- NCT04688307
- Testing
- Motivational interviewing
- Where
- 2 sites in Iran
- Volunteers
- 104 people
- Sponsor
- Tehran University of Medical Sciences
Sedentary Lifestyle, Cigarette Smoking
Step-up to Quit: Using Low-to-moderate Intensity Exercise for Reducing Smoking Cue Reactivity Among Low-income Smokers
The study's primary aim is to test the hypothesis that an intervention that integrates low to moderate physical activity (walking) with evidence-based smoking cessation counseling (LMPA) will result is greater reductions in…
- Trial name
- NCT02220465
- Testing
- PA+ Smoking Cessation (LMPA), Standard Care Smoking Counseling (SCC)
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Temple University
Smoking Cessation
A Study To Evaluate The Efficacy And Safety Of Varenicline Compared To Placebo For Smoking Cessation Through Reduction
This study will determine whether varenicline is safe and helps people to quit smoking through reduction when they are not willing/able to make an abrupt quit attempt.
- Trial name
- NCT01370356
- Testing
- Varenicline Tartrate
- Where
- 65 sites in United States, Australia and 8 more
- Volunteers
- 1,510 people
- Sponsor
- Pfizer
Cigarette Smoking
Serbian Smoking Reduction/Cessation Trial (2SRT)
The study aims to establish if a low-nitrosamine, smokeless tobacco product (Swedish snus) can help adult smokers to reduce and eventually completely quit smoking.
- Trial name
- 2SRT (NCT00601042)
- Testing
- Swedish snus (smokeless tobacco), Onico
- Where
- 2 sites in Serbia
- Volunteers
- 319 people, healthy volunteers welcome
- Sponsor
- Swedish Match AB
Breast Cancer, Smoking Cessation
Brief Intervention for Tobacco and Alcohol Risk Reduction for Couple During Breast Cancer Treatment.
This study will examine the benefits of involving partner in a Screening, Brief Intervention and Referral to Treatment (SBIRT) program for tobacco and alcohol for women treated for breast cancer.
- Conditions
- Breast Cancer, Smoking Cessation, Alcohol Use, Unspecified
- Trial name
- IBMC (NCT04007549)
- Testing
- Brief motivational interview on tobacco/alcohol risk reduction
- Where
- France
- Sponsor
- Institut Bergonié
Nicotine Use Disorder, Nicotine Dependence
Accelerated rTMS for the Reduction of Nicotine Craving
The purpose if this study is to determine if five treatments of repetitive transcranial magnetic stimulation (rTMS) can reduce craving for cigarettes in smokers.
- Trial name
- NCT03352609
- Testing
- Active rTMS with MagVenture MagPro double blind rTMS system
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Medical University of South Carolina
Anger, Smoking Cessation
Computerized Anger-Reduction Treatment for Smoking Cessation
Problematic anger is a strong predictor of failed attempts at smoking cessation. The investigators proposed study seeks to evaluate whether a novel 8-session computerized anger-reduction treatment improves quit rates among…
- Trial name
- NCT02413814
- Testing
- Anger Reduction Treatment, Control Condition
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Florida State University
Tobacco Use Disorder
Low Nicotine Content Cigarettes in Vulnerable Populations: Women of Reproductive Age
Despite marked reductions in cigarette smoking in the general population, smoking among economically disadvantaged women has increased.
- Trial name
- NCT04092387
- Testing
- Varying the nicotine content of cigarettes, E-Cigarettes
- Where
- 2 sites in United States
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Smoking, Cigarette
Switching to a Vaping Device: Evaluating Risk Reduction Among Quitline Treatment Failures
The overall aim of the study is to evaluate the provision of e-cigarette (EC) versus NRT on smoking behavior, product use patterns and continued use, and iCO, a biomarker of toxicant exposure, among a sample of recent QL…
- Trial name
- NCT03502200
- Testing
- JUUL, Treatment As Usual
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Tobacco Use Disorder
Efficacy of Oral Tobacco Products Compared to a Medicinal Nicotine
For the primary goals, we hypothesize that 1) the oral tobacco product will be more efficacious than the medicinal nicotine product in substituting for smoking cigarettes; 2) among non-abstainers, the oral tobacco product will…
- Trial name
- NCT00710034
- Testing
- Oral tobacco, Nicotine Gum
- Where
- 2 sites in United States
- Volunteers
- 391 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Tobacco-Related Carcinoma
Episodic Future Thinking and Future Thinking Priming for Smoking Cessation
This trial studies the main and interactive effects of episodic future thinking and future thinking priming tasks on helping participants to quit smoking.
- Trial name
- NCT04297332
- Testing
- Behavioral Intervention, Informational Intervention, Nicotine Replacement
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
Schizophrenia, Schizoaffective
Safety and Tolerability of Varenicline in Schizophrenia (SATOVA)
This is a 15 week trial to determine (1) the safety and tolerability of varenicline when used for smoking cessation/reduction in individuals with schizophrenia; (2) if treatment with varenicline affects the symptoms of…
- Conditions
- Schizophrenia, Schizoaffective, Psychosis
- Trial name
- NCT00702793
- Testing
- Varenicline
- Sponsor
- University of British Columbia
Nicotine Dependence, Smoking, Cigarette
Isradipine Enhancement of Virtual Reality Cue Exposure for Smoking Cessation
The proposed study represents a crucial and important stage in translating basic research to strategies for treating nicotine dependence.
- Conditions
- Nicotine Dependence, Smoking, Cigarette, Smoking Cessation, Smoking Behaviors
- Trial name
- NCT03083353
- Testing
- Isradipine, Cue Exposure
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Jasper A. Smits
Tobacco Smoking, Oxidative Stress
N-acetylcysteine for Tobacco Smoking
The purpose of this study is to investigate the efficacy of N-acetylcysteine (NAC) for smoking cessation in a double blind, randomized, placebo-controlled trial.
- Conditions
- Tobacco Smoking, Oxidative Stress, Inflammation
- Trial name
- NACNOS (NCT02124525)
- Testing
- N-acetylcysteine
- Where
- Brazil
- Volunteers
- 32 people
- Sponsor
- Universidade Estadual de Londrina
Electronic Cigarette Use
Assessing the Effect of Nicotine Reduction on ENDS User's Addiction and Exposures
The rapid increase of electronic nicotine delivery systems (ENDS) use by young people in the US and their potential to harm health, cause addiction, and serve as a risk for cigarette smoking or dual-use is alarming.
- Trial name
- NCT05205382
- Testing
- 5% nicotine (Partial Nicotine Reduction), 3% or 2.4% nicotine (Partial Nicotine Reduction), 5% nicotine (Total Nicotine Reduction)
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Florida International University