Clinical trials: Smoking Cessation, open to volunteers
Tobacco, Tobacco Abstinence
Quitting Matters Human Immunodeficiency Virus Hybrid Trial
The purpose of this study is to compare the advantages and disadvantages of two approaches for quitting smoking among people living with HIV (PWH).
- Conditions
- Tobacco, Tobacco Abstinence, Smoking Cessation, Smoking Cessation; Tobacco Dependence
- Trial name
- QMH (NCT06883097)
- Testing
- Learn to Quit-HIV (LTQ-H) App, QuitStart
- Where
- United States
- Volunteers
- 314 people
- Sponsor
- Wake Forest University Health Sciences
Smoking Cessation
A Study Of Vagal Nerve Stimulation In Conjunction With NRT For Smoking Cessation
The purpose of this study is to provide preliminary evidence for the efficacy of 12 weeks of vagal nerve stimulation (VNS) and nicotine replacement therapy (NRT) for increasing smoking abstinence rates.
- Trial name
- NCT07487818
- Testing
- Non-invasive vagus nerve stimulator plus nicotine replacement patches, nicotine replacement patches
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Mayo Clinic
Tobacco Use Disorder, Substance Use Disorder
Smoking Cessation CM for Veterans With or at Risk for Cancer
Tobacco use among US Veterans poses significant health problems and challenges to their overall well-being. The aim of this project is to evaluate the effectiveness of a program called Contingency Management (CM) in helping…
- Trial name
- CM_TUD_Cancer (NCT06432985)
- Testing
- Focus Group, Contingency Management (CM), TUD Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Smoking Cessation, Smoking, Cigarette
Leveraging Community Pharmacists to Optimize Smoking Cessation Services for Rural Smokers in Appalachia
The goal of this clinical trial is to evaluate the effectiveness and implementation of a pharmacist-delivered MTM (medication therapy management) approach, called QuitAid, to quitting cigarette smoking in rural Appalachia.
- Conditions
- Smoking Cessation, Smoking, Cigarette, Smoking Reduction, Smoking
- Trial name
- NCT05660525
- Testing
- 4 weeks of Nicotine lozenge, 8 weeks of Nicotine Replacement Therapy Patch, QuitAid
- Where
- United States
- Volunteers
- 768 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Smoking, Tibia Fracture
Effect of Tobacco Heating System (THS) on Closed Lower Limb Fracture Healing
The goal of this clinical trial is to investigate the role of switching from cigarette smoking (CS) to tobacco heat system (THS) on the clinical outcome of closed lower limb (tibia and femur) fractures from smokers' orthopedic…
- Trial name
- NCT05859451
- Testing
- Tobacco Heating System (THS), Smoking abstinence
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- University Hospital Tuebingen
Smoking Cessation
ChatGPT-Supported Text Messaging Program for Smoking Cessation
The current research proposal aims to explore how a purpose driven LLM ChatGPT chatbot, BeFreeBot, might enhance an evidence-based text messaging smoking cessation program, BeFree.
- Trial name
- NCT07079306
- Testing
- BeFree+Bot, BeFree
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- George Washington University
Lung Cancer
Implementing Low-dose ct Lung Cancer Screening in France.
The main objective is to estimate the detection rate of lung cancer in the population screened by low-dose chest CT scans.
- Trial name
- IMPULSION (NCT07513818)
- Testing
- Low-dose computed tomography of the chest
- Where
- 2 sites in France
- Volunteers
- 20,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obesity, Smoking Cessation
A Multiple Health Behavior Change (MHBC) Intervention for Weight Loss and Smoking Cessation for Pre-Bariatric Surgery Patients
The purpose of this research study is to evaluate a multiple health behavior change intervention for weight loss and smoking cessation using medication (Naltrexone + Bupropion) and behavior therapy in adults seeking bariatric…
- Conditions
- Obesity, Smoking Cessation, Bariatric Surgery Patients
- Trial name
- NCT07398404
- Testing
- Naltrexone hydrochloride, Bupropion Hydrochloride Extended-release, Cognitive-Behavioral Therapy
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Medical University of South Carolina
Dual Use of Cigarettes and E-cigarettes, Gestational Weight Gain
Cessation of Dual Use of Cigarettes and E-cigarettes During Pregnancy
We propose a randomized controlled trial to develop and evaluate a cessation program with two different strategies for dual users during pregnancy.
- Conditions
- Dual Use of Cigarettes and E-cigarettes, Gestational Weight Gain, Birth-weight-for-gestational-age z Score
- Trial name
- NCT07124702
- Testing
- Simultaneous cessation intervention, Stepwise cessation intervention, Behavior counseling only
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- State University of New York at Buffalo
Smoking Cessation
Rural COPD E-Visit Study
The purpose of this study is to evaluate an electronic visit (e-visit) for COPD screening and for quitting smoking. Participants will be randomly assigned to receive either the smoking cessation e-visit or not.
- Trial name
- NCT06236347
- Testing
- Smoking cessation e-visit, Treatment as usual
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Smoking Cessation
Studying NMDA and Sigma-1 in Smoking Cessation Treatment (SUMMIT)
This study is a Phase 3, multicenter, randomized, double-blind, placebo- and active-controlled, parallel-group trial to evaluate the efficacy and safety of AXS-05 compared to placebo and bupropion for smoking cessation in adults.
- Trial name
- SUMMIT (NCT07766655)
- Testing
- AXS-05 (dextromethorphan-bupropion), Bupropion
- Where
- 28 sites in United States
- Volunteers
- 705 people
- Sponsor
- Axsome Therapeutics, Inc.
Former Smoker, Non-Smoker
Vaped Phenanthrene
Some people who used to smoke cigarettes continue to be at higher risk of developing lung cancer, even years after quitting. This study will look to see if a specific chemical, phenanthrene, is broken down in the lungs of former…
- Trial name
- NCT07134426
- Testing
- D10-phenanthrene
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Tobacco Use Disorder
5-HT2A Agonist Psilocybin in the Treatment of Tobacco Use Disorder
This is a multi-site, double-blind, randomized clinical trial of the 5-HT2A receptor agonist psilocybin for smoking cessation. Four sites with experience in conducting psilocybin research will be involved in this trial: Johns…
- Trial name
- NCT05452772
- Testing
- Psilocybin, Niacin
- Where
- 3 sites in United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Smoking
Implementation of Transcranial Magnetic Stimulation for Smoking Cessation
Repetitive transcranial magnetic stimulation (rTMS) is an alternative non-invasive treatment to help people quit smoking. rTMS uses a magnetic field to stimulate regions of the brain that are involved in addiction.
- Trial name
- NCT06346028
- Testing
- Brainsway H4 deep rTMS coil and Brainsway stimulator system
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Smoking Cessation
The Effects of Cigarette Addiction on Lower Extremity Movement Speed and Coordination
This observational study will aim to investigate the effects of cigarette addiction on lower extremity motor coordination and movement speed in young adults.
- Trial name
- NCT07075068
- Testing
- Behavioral and Functional Performance Assessment Battery
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Saglik Bilimleri Universitesi
Psychiatric Disorders
TORCH - Transdiagnostic Observation of Risk Factors, Craving and Health Behaviours in Psychiatric Patients
Mental disorders are often accompanied by health-risk behaviours, psychiatric comorbidity, and reduced functioning. TORCH investigates transdiagnostic mechanisms underlying multiple health behaviour change in adult psychiatric…
- Trial name
- TORCH (NCT07844798)
- Testing
- person-centred interventions
- Where
- Germany
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Jacobs University Bremen gGmbH
Smoking Cessation
3A-OR Very Brief Tobacco Cessation Intervention in Primary Care
Introduction: Türkiye is far from the World Health Organization (WHO)'s target of reducing tobacco use prevalence by 30% by 2025. Most tobacco users consider quitting, and most have attempted to quit at least once.
- Trial name
- NCT07609199
- Testing
- 3A-OR very brief smoking cessation intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 2,400 people
- Sponsor
- Aydin Adnan Menderes University
Smoking (Tobacco) Addiction, Young Adult
Designing a Smoking Intervention for Youth Smokers
This study aims to develop a typology-based intervention delivered by smoking cessation (SC) counsellors to prevent smoking relapse in ex-smokers who recently quit.
- Conditions
- Smoking (Tobacco) Addiction, Young Adult, RCT
- Trial name
- NCT07178899
- Testing
- typology-based intervention, Routine Treatment
- Where
- Hong Kong
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Smoking Cessation
American Indian Smokefree Native RCT
The aim of this clinical trial is to test the efficacy of a culturally aligned digital smoking cessation resource for American Indian persons who smoke, via a remotely conducted randomized controlled trial.
- Trial name
- NCT06544811
- Testing
- Smoking Cessation Program, Cultural Smoking Cessation Program
- Where
- United States
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Smoking Cessation
Phone Enabled Implementation of Cessation Support
The tobacco use burden in Lebanon is exceptionally high: 35% of adults are current cigarette smokers and 39% are current waterpipe smokers.
- Trial name
- PHOENICS (NCT05628389)
- Testing
- Educational materials, Phone counseling, Nicotine Replacement Therapy
- Where
- Lebanon
- Volunteers
- 1,500 people
- Sponsor
- University of Florida