Clinical trials: Smoking Behavior
Smoking, Tobacco
Nicotine Pharmacokinetics of THS Single Use of a Regular or a Menthol Stick Compared to CIG
The purpose of this study was to describe the nicotine pharmacokinetic (PK) profile during and after single use of THS (Induction heating technology, with either a regular or menthol stick) compared to singular CIG smoking in…
- Trial name
- NCT05789420
- Testing
- P1R stick, P1M stick, CIG
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Smoking
Nicotine Pharmacokinetic Profile and Safety of the Tobacco Heating System 2.2 (THS 2.2)
The primary objective of this clinical study is to evaluate the pharmacokinetic (PK) profile (rate and amount of nicotine absorbed) following a single use of the THS 2.2 compared to the PK profiles from a single use of a…
- Trial name
- NCT01967732
- Testing
- THS 2.2, CC, NNS
- Where
- United Kingdom
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Smoking Cessation, Smoking
NicVAX/Placebo as an Aid for Smoking Cessation
The purpose of this study is to evaluate NicVAX as an aid to smoking cessation for long term abstinence.
- Conditions
- Smoking Cessation, Smoking, Tobacco Cessation
- Trial name
- NCT00836199
- Testing
- NicVAX vaccine
- Where
- 22 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Nabi Biopharmaceuticals
Smoking Cessation
Efficacy and Safety Following Use of a Novel Nicotine Replacement Therapy
A comparison of a novel nicotine replacement therapy and placebo treatment in smokers motivated to quit smoking.
- Trial name
- NCT00882375
- Testing
- Nicotine
- Where
- 3 sites in Denmark, Germany
- Volunteers
- 479 people
- Sponsor
- McNeil AB
Smoking
A Comparability Study of the Phase 3 Lot and a Single Commercial Lot of NicVAX in Healthy Adult Smokers
The purpose of this study is to assess the comparability of the phase 3 lot and a single commercial lot of NicVAX in healthy smokers.
- Trial name
- NCT01375933
- Testing
- NicVAX Vaccine
- Where
- 6 sites in United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Nabi Biopharmaceuticals
Smoking
Reduced Exposure Study Using THS 2.2 Menthol With 5 Days in a Confinement Setting and 85 Days in an Ambulatory Setting
The main goal of the study is to evaluate if the ad libitum use of the THS 2.2 Menthol (mTHS 2.2) for 5 days in confinement and after 85 days of product use in an ambulatory setting, by Japanese adult healthy smokers results in a…
- Trial name
- NCT01970995
- Testing
- THS 2.2 Menthol (mTHS 2.2), Smoking Abstinence (SA), Menthol Conventional Cigarette (mCC)
- Where
- Japan
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Lung Cancer
Airway Epithelium Gene Expression in the Diagnosis of Lung Cancer: AEGIS CLIA
The primary objective of this study is to substantiate prediction accuracy(with a tighter 95% confidence interval compared to current diagnostic modalities), of a lung cancer biomarker for risk stratification of patients into…
- Trial name
- AEGIS (NCT01309087)
- Where
- 14 sites in United States, Canada and 1 more
- Volunteers
- 756 people
- Sponsor
- Allegro Diagnostics, Corp.
Smoking, Tobacco Use
CSD190301: A Study to Assess Elements of Abuse Liability for Two Dissolvable Nicotine Lozenge Tobacco Products
This is a two-arm, single use, single-center, randomized, 10-sequence per arm, open-label, crossover pharmacokinetic/pharmacodynamic (PK/PD) study, designed to evaluate elements of abuse liability (AL) including subjective…
- Conditions
- Smoking, Tobacco Use, Tobacco Smoking
- Trial name
- NCT04167384
- Testing
- Product A, Product B, Product C
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Smoking, Tobacco Use
CSD210904: Study to Assess Actual Use of a Heated Tobacco Product With Four Non-Combusted Cigarette Variants in Current Adult Smokers
This is a multi-site, open-label, 8-week, prospective observational study, conducted at multiple sites geographically dispersed within the U.S. The purpose of this Actual Use Study (AUS) is to investigate how U.S.
- Conditions
- Smoking, Tobacco Use, Tobacco Smoking
- Trial name
- NCT05102786
- Testing
- 40007388, 40007385, 40007387
- Where
- 10 sites in United States
- Volunteers
- 1,180 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Tobacco Dependence
Comparative Pharmacokinetic Study of New Oral Nicotine Replacement Therapy Products.
Comparative pharmacokinetic study of new oral nicotine replacement therapy products.
- Trial name
- NCT01227720
- Testing
- Experimental Nicotine Replacement Therapy (NRT) 2 mg, Experimental Nicotine Replacement Therapy (NRT), Marketed Nicotine Lozenge
- Where
- 2 sites in Sweden
- Volunteers
- 104 people
- Sponsor
- McNeil AB
Smoking Cessation
Cumulative Skin Irritation Potential of a New 25 mg Nicotine Patch
An investigation on the cumulative skin irritation potential of a newly developed 25 mg nicotine patch. Evaluation of skin irritation of a newly developed 25 mg nicotine transdermal patch
- Trial name
- NCT00967174
- Testing
- Nicotine Patch, SLS Comparator Patch
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- McNeil AB
Electronic Cigarette Use, Cigarette Use, Electronic
Changes in Biomarkers of Cigarette Smoke Exposure After Switching Either Exclusively or Partly to JUUL ENDS
A Randomized, Open Label, Parallel Group Study in Adult Smokers to Evaluate Changes in Biomarkers of Cigarette Smoke Exposure After Switching Either Exclusively or Partly to using JUUL Electronic Nicotine Delivery Systems With…
- Conditions
- Electronic Cigarette Use, Cigarette Use, Electronic, Tobacco Use, Tobacco Smoking
- Trial name
- NCT04107779
- Testing
- Switch from UB of Combustible Cigarette to JUUL 5% Virginia Tobacco ENDS, Switch from UB of Combustible Cigarette to JUUL 3% Virginia Tobacco ENDS, Switch from UB of Combustible Cigarette to JUUL 5% Mint ENDS
- Where
- 5 sites in United States
- Volunteers
- 279 people, healthy volunteers welcome
- Sponsor
- Juul Labs, Inc.
Smoking Cessation
Study of a Smartphone-Based Switch Program
Prospective, open label, single center clinical study enrolling up to 120 participants to evaluate the Pivot cigarette smoking cessation program in adult smokers, previously unable to quit, who also use other smoke-free nicotine…
- Trial name
- NCT06544772
- Testing
- Pivot cigarette smoking cessation program
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Pivot Health Technologies Inc.
Tobacco Use, Smoking
CSD200902: Assessment of Indoor Air Quality for a Heated Tobacco Product With Four Non-Combusted Cigarette Variants in an Environmental Testing Chamber
This is a single-center, open-label, parallel-cohort study to measure and compare the levels of selected secondhand smoke (SHS) constituents of a heated tobacco product (HTP) against combustible cigarettes (CC) after ad libitum…
- Conditions
- Tobacco Use, Smoking, Tobacco Smoking
- Trial name
- NCT05363254
- Testing
- Marlboro Gold Box, Newport Box, Non-combusted cigarette variant 42001401
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Electronic Cigarette Use, Retina; Change
Nicotine Influence on the Retina Following the Use of Electronic Cigarette
The marketing of electronic cigarettes (e-cigarettes) in 2003 was initially intended to present a healthier alternative to smokers.
- Trial name
- NCT05801419
- Testing
- RETI-port/scan 21, Zilia Ocular, OCT-A
- Where
- Canada
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Christian Casanova
Smoking
Exploratory THS 2.1 Nicotine Pharmacokinetics and Safety Study
The main goal of this exploratory study is to evaluate the pharmacokinetic profile of nicotine for the candidate modified risk tobacco product THS 2.1 and for conventional cigarettes (CC).
- Trial name
- NCT01780688
- Testing
- Conventional cigarettes (CC), THS 2.1
- Where
- United Kingdom
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Chronic Obstructive Pulmonary Disease - COPD
Formoterol Dose Ranging Study (ACHIEVE Duaklir USA Phase IIb)
To assess the bronchodilation of three doses of formoterol fumarate (6 μg, 12 μg and 24 μg) twice daily (BID) administered via Pressair® compared to placebo and to open-label nebulized formoterol fumarate (20 μg and 40 μg).
- Trial name
- NCT02796651
- Testing
- Formoterol fumarate (6 μg), Formoterol furmarate (20 μg), Formoterol fumarate (12 μg)
- Where
- 20 sites in United States
- Volunteers
- 132 people
- Sponsor
- AstraZeneca
Smoking Cessation, Harm Reduction
In-vivo Extraction of Lead, Cadmium and Tobacco Specific Nitrosamines From Swedish 'Snus' in Regular Snus Users
In an open label, randomized, two-way cross-over study, 32 male healthy regular snus users will be given repeated doses of four different types of portion snus: "General", "Catch", "Catch Mini" and "Catch Dry Mini".
- Trial name
- SMWS03 (NCT01838473)
- Testing
- Buccal Administration of nicotine
- Where
- Sweden
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Contract Research Organization el AB
Tobacco Dependence
Bioequivalence Between Two Oral Nicotine Sublingual Tablets, 2 mg and 4 mg
The purpose of this study is to assess the bioequivalence between two oral nicotine sublingual tablets, 2 mg and 4 mg.
- Trial name
- NCT01238627
- Testing
- Nicotine Sublingual Tablet Mint (NSTM), Marketed Nicotine Tablet
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- McNeil AB
Nicotine Dependence, Other Tobacco Product, Tobacco Use
Identify Biomarkers of Tobacco Exposure and Nicotine Uptake From JUUL 5% in Adult Smokers
The JUUL 5% Electronic Nicotine Delivery System (ENDS) is being studied as an alternative to combustible cigarette use. This study aims to find out how much nicotine is in the blood and urine of healthy adult subjects after using…
- Conditions
- Nicotine Dependence, Other Tobacco Product, Tobacco Use, Smoking, Tobacco
- Trial name
- Diamond (NCT03463837)
- Testing
- Treatment with JUUL 5%, Virginia Tobacco, Treatment with JUUL 5%, Cool Mint, ENDS, Treatment with JUUL 5%, Mango, ENDS
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Juul Labs, Inc.