Clinical trials: Smoking
Electronic Cigarettes
Effects of Electronic Cigarette Settings and Liquid Concentrations in Cigarette Smokers and Electronic Cigarette Users
The purpose of this research study is to find out how different types of electronic cigarettes (ECIG) settings, combined with e-liquids of differing nicotine concentrations, affect blood nicotine levels, use behavior (how users…
- Trial name
- NCT03710590
- Testing
- ECIG Lab Session 15 watts, 10 mg nicotine, ECIG Lab Session 15 watts, 15 mg nicotine, ECIG Lab Session 15 watts, 30 mg nicotine
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Smoking, Cigarette, Breastfeeding
Lung and Breast Cancer Prevention by an Integrated Intervention of Maternal Smoking Cessation and Breastfeeding
This pilot clinical trial aims to integrate maternal smoking cessation and breastfeeding interventions to enhance both cancer prevention behaviors.
- Trial name
- NCT05123118
- Testing
- Integrated intervention of smoking cessation and breastfeeding
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Xiaozhong Wen
Tobacco Use Disorder, Medication Adherence
Varenicline Smoking Cessation Treatment for Methadone Maintenance Patients
This randomized trial will evaluate whether varenicline directly observed therapy provided at a methadone clinic is more efficacious than self-administered varenicline for promoting smoking cessation and enhancing adherence.
- Trial name
- NCT01378858
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Albert Einstein College of Medicine
Environmental Exposure
Real-Life Passive Exposure Assessment of IQOS
This study is a non-interventional observational study designed to assess the impact of passive exposure to IQOS environmental tobacco aerosol in Non-Smokers in a real-life restaurant setting.
- Trial name
- NCT03550989
- Testing
- Non-Exposure Event, Exposure Event
- Where
- Japan
- Volunteers
- 401 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Smoking Cessation
Disease Management for Smoking Cessation
The primary aim of this study is to assess the effectiveness of both high and low intensity, disease management programs for smoking.
- Trial name
- NCT00440115
- Testing
- High intensity disease management, Low intensity disease management, Comparison group
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Basaloid Squamous Cell Carcinoma, Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
De-intensified Radiation Therapy With Chemotherapy (Cisplatin) or Immunotherapy (Nivolumab) in Treating Patients With Early-Stage, HPV-Positive, Non-Smoking Associated Oropharyngeal Cancer
This phase II/III trial studies how well a reduced dose of radiation therapy works with nivolumab compared to cisplatin in treating patients with human papillomavirus (HPV)-positive oropharyngeal cancer that is early in its…
- Conditions
- Basaloid Squamous Cell Carcinoma, Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Oropharyngeal Squamous Cell Carcinoma
- Trial name
- NCT03952585
- Testing
- Biopsy Procedure, Biospecimen Collection, Cisplatin
- Where
- 494 sites in United States, Canada
- Volunteers
- 384 people
- Sponsor
- National Cancer Institute (NCI)
Smoking
TeleQuit Smoking Cessation Program
TeleQuit is a group randomized trial testing whether a telephone care coordination program increases the rate of smoking cessation treatment for VA patients at study sites.
- Trial name
- NCT00123682
- Testing
- Proactive outreach to counseling, Reactive outreach to counseling, Intensive counseling
- Where
- 3 sites in United States
- Volunteers
- 3,120 people
- Sponsor
- US Department of Veterans Affairs
Behavior, Health Risk, Implementation Science
Incentive-based and Media Literacy Informed Approaches to Improve Vaping Cessation
This study aims to evaluate the feasibility and compare the preliminary effect of vaping cessation program consisting of media literacy education and real-time text messaging support and leverage insights from behavioral…
- Conditions
- Behavior, Health Risk, Implementation Science, E Cigarette Use, Cessation, Smoking
- Trial name
- NCT05586308
- Testing
- Text-massaging suport, Financial incentive, Media literacy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Nebraska
Tobacco Cigarette Smoking
Testing the Impact of Smartphone-based Messaging to Support Young Adult Smoking Cessation - Pilot
Clinical practice guidelines for smoking cessation emphasize cognitive behavioral therapy (CBT) to help patients develop coping strategies for urges.
- Trial name
- NCT05991934
- Testing
- Smartphone-based intervention messages
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Nicotine Dependence
Study Two on the Effectiveness of Mindfulness Training for Smokers
The MTS2 study enrollment goal is N=240 adult smokers randomized to study treatments. The study design includes two randomized arms to compare matched intensive interventions and a third non-randomized option for participants who…
- Trial name
- MTS2 (NCT01299909)
- Testing
- Integrated Training for Smokers, Mindfulness Training for Smokers, Quitline
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- University of Wisconsin, Madison
Smoking, Stress Disorders, Post-Traumatic
CPT-SMART for Treatment of PTSD and Cigarette Smoking
Smoking is the leading cause of preventable illness, disability, and death in the United States. The rate of smoking is disproportionately higher among Veterans with posttraumatic stress disorder (PTSD).
- Trial name
- CPT-SMART (NCT03978442)
- Testing
- Smoking Cessation Cognitive Behavioral Therapy (CBT), Bupropion, Cognitive Processing Therapy
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- VA Office of Research and Development
Cigarette Smoker, Current Smoker
18F-FSPG PET/CT in Diagnosing Early Lung Cancer in Patients With Lung Nodules
This phase II trial studies how well 18F-FSPG positron emission tomography (PET)/computed tomography (CT) work in diagnosing early lung cancer in patients with indeterminate lung nodules.
- Conditions
- Cigarette Smoker, Current Smoker, Former Smoker, Multiple Pulmonary Nodules
- Trial name
- NCT03824535
- Testing
- Computed Tomography, Fludeoxyglucose F-18, Fluorine F 18 L-glutamate Derivative BAY94-9392
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Andrei Iagaru
Smoking Cessation
Gemfibrozil for Nicotine Smoking Cessation
This project will test whether gemfibrozil, a well-studied medication for high cholesterol, will help people stop smoking nicotine cigarette smoking.
- Trial name
- GEMNIC (NCT02638597)
- Testing
- Gemfibrozil, smoking cessation counseling
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Texas Southwestern Medical Center
Tobacco Use Cessation
Mobile Media-Rich Interactive Guideline System (MMRIGS) Pilot Study
The goal of this research study is to learn about 2 different interactive methods that are designed to help people with HIV/AIDS stop smoking.
- Trial name
- NCT02302859
- Testing
- Nicotine Patch, Questionnaires, Pamphlet
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Nicotine Addiction
Nicotine Reinforcement and Aversion in Young Adult Light Smokers
The proposed study will examine the threshold for nicotine self-administration (NSA) using five different nicotine doses in young adult male and female non-dependent smokers (light and intermittent smokers or LITS).
- Trial name
- NCT01495819
- Testing
- Saline, Nicotine
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Yale University
Smoking
Behaviorally Enhanced Counseling on Nicotine Dependence (BEACON) Trial.
The major purpose of this exploratory developmental study will be to develop a patient-centered and feasible protocol for communicating genetic data as it relates to drug efficacy for smoking cessation inpatients receiving…
- Trial name
- NCT00991081
- Testing
- Counseling, Self-help guide, Pharmacotherapy
- Where
- 3 sites in United States
- Volunteers
- 36 people
- Sponsor
- Stanford University
Tobacco Smoking
E-cigarettes to Promote Smoking Reduction Among Individuals With Schizophrenia
The purpose of this study is to assess if access to an electronic nicotine delivery device, or e-cigarette, in addition to nicotine patch (21 mg) can help reduce cigarette smoking among individuals diagnosed with schizophrenia…
- Trial name
- NCT02918630
- Testing
- Nicotine Patch, E-cigarette
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cigarette Smoking
Strengthening Instrumental Extinction to Prevent Smoking Relapse (VLNCCue)
The central objective of the project is to evaluate the effect of incorporating smoking related contexts into very low nicotine content (VLNC) cigarette extinction trials on clinically relevant, smoking-related outcomes.
- Trial name
- VLNCCue (NCT02538042)
- Testing
- Nicotine Patch, SPECTRUM Nicotine Research Cigarettes (0.07 mg), MCE+
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Francis McClernon, Ph.D.
Self-regulation, Binge Eating
Using Mobile Technology to Improve Self-Regulation
This study will evaluate the degree to which engaging targets produces a desired change in medical regimen adherence (across 4-week interventions) and health behavior among smokers (n=50) and overweight/obese persons with binge…
- Conditions
- Self-regulation, Binge Eating, Smoking
- Trial name
- NCT03774433
- Testing
- Laddr
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Smoking Cessation
Tech and Telephone Smoking Cessation Treatment for Young Veterans With PTSD
This project aims to enhance the scalability of an office-based smoking cessation treatment protocol for veterans with PTSD, integrated care (IC), by adapting it to be delivered over the telephone and to incorporate mobile…
- Trial name
- NCT03552978
- Testing
- Tech-Facilitated IC Intervention, VA Quitline
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of California, San Francisco