Clinical trials: Smell Loss
Anosmia, Head Trauma
NAC for Head Trauma-induced Anosmia
This study will compare administration of N-Acetyl Cysteine (NAC) versus placebo for the treatment of olfactory loss due to head injury.
- Trial name
- NCT03680911
- Testing
- N Acetyl Cysteine
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Miami
Olfaction
A Clinical Trial to Study the Effects on the Olfaction Capacity of an Individual Undergoing Skull Base Surgeries Using Cautery vs Scalpel .
Olfaction is a prominent entity that determines a person's quality of life. During human evolution, olfaction has played an essential role in determining safe food, assessing threats, and developing social relationships.
- Trial name
- NCT07385911
- Testing
- Scalpel, Cautery
- Where
- India
- Volunteers
- 80 people
- Sponsor
- All India Institute of Medical Sciences, Jodhpur
Anosmia, Inflammatory Anosmia
Intranasal Platelet-Rich Plasma With or Without Topical Insulin for Post-Inflammatory Anosmia
This study evaluates whether adding topical insulin to intranasal platelet-rich plasma (PRP) improves smell recovery in adults with post-inflammatory anosmia.
- Trial name
- PRP-I RCT (NCT07383415)
- Testing
- Intranasal PRP Plus Topical Insulin
- Volunteers
- 20 people
- Sponsor
- Amin Javer
Alcohol Use Disorder
Effects of Olfactory Stimuli in Virtual Reality Cue Exposure on Craving and Attentional Bias in Alcohol Use Disorder
Alcohol use disorder (AUD) is a prevalent and burdensome clinical condition with high relapse rates. A central risk factor for relapse is craving for alcohol-often accompanied by an attentional bias toward alcohol-related…
- Trial name
- OLFA-VR (NCT07667790)
- Testing
- VR-CE
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Charite University, Berlin, Germany
Smell Dysfunction, Olfactory Disorder
Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT for Long COVID)
Persistent smell loss that can include diminished or distorted smell function is a common symptom of long COVID syndrome. There are limited treatment options for long COVID-related smell loss.
- Conditions
- Smell Dysfunction, Olfactory Disorder, Long COVID
- Trial name
- NCT05855369
- Testing
- Trigeminal Nerve Stimulation (TNS), Active Smell Training (ST)
- Where
- United States
- Volunteers
- 145 people
- Sponsor
- Medical University of South Carolina
Alcohol Dependence
Feasibility of Integrating Olfactory Stimuli Into Virtual Reality Cue Exposure for Patients With Alcohol Dependence
Alcohol dependence (AD) is a prevalent and burdensome clinical condition with high relapse rates. A central risk factor for relapse is craving for alcohol, which can be evoked by both real-world and virtual cues in immersive…
- Trial name
- NCT07388693
- Testing
- VR Cue-Exposure Including Olfactory Stimuli
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Charite University, Berlin, Germany
End Stage Renal Disease, Olfactory Disorders
Helping Olfaction and Nutrition On Renal Replacement
This clinical trial examines whether nasal theophylline administration can improve olfaction and nutrition in hemodialysis patients.
- Trial name
- HONORR (NCT02479451)
- Testing
- Theophylline
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Massachusetts General Hospital
Olfactory Disorder
cAMP (Cyclic Adenosine Monophosphate) Levels in the Nose
The purpose of this study is to determine the normal distribution of nasal tissue cathelicidin antimicrobial peptides (cAMP) levels in subjects with normal smell and subjects with smell dysfunction.
- Trial name
- NCT01332825
- Testing
- saline nasal irrigation
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Washington
Cognitive Function
Sensory Enrichment for Older Adults
This study evaluates the efficacy of multi-odorant enrichment on cognitive skills, olfactory function, and quality of life.
- Trial name
- NCT03914989
- Testing
- olfactory enrichment (essential oils)
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Anosmia
Investigating the Efficacy of OMT to Recover Olfactory Perception After COVID-19
One of the most widespread symptoms of COVID-19 is loss of the sense of smell. There are very few treatments for helping individuals recover their sense of smell.
- Trial name
- NCT06766279
- Testing
- Osteopathic Manipulative Treatment
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Burrell College of Health Sciences
Olfactory Dysfunction, Post-traumatic Olfactory Dysfunction
PANDORA: Evaluation of Platelet-rich Plasma in Non-tumoural Odour Disorders: a Descriptive Pilot Study.
This is a prospective, single-center, single-arm, non-comparative descriptive pilot study evaluating autologous platelet-rich plasma (PRP) injections in adults with persistent (>6 months) non-tumoural olfactory dysfunction…
- Conditions
- Olfactory Dysfunction, Post-traumatic Olfactory Dysfunction, Age-related Degenerative Olfactory Dysfunction
- Trial name
- PANDORA (NCT07473830)
- Testing
- Autologous Platelet-Rich Plasma (PRP) Injection
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Olfactory and Taste Dysfunction in SARS-CoV2 Infection
EFFECT OF COVID-19 DISEASE IN SMELL AND TASTE OF PATIENTS WITH MILD, MODERATE OR SEVERE SYMPTOMATOLOGY
This is an observational data and recording study. The aim of our study is to investigate the effect of SARS-COV2 infection on patients' sense of smell and taste, through quality control measurements using optic analogue scale…
- Trial name
- NCT04657445
- Testing
- visual analogue scale
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- University Hospital, Ioannina
Cancer
Sensory Approach of Food Modifications Led by Chemotherapy
The aim of the present study was to evaluate the impact of chemotherapy on sensorial perception in lung cancer patients in comparison to a control group (individuals without lung cancer and chemotherapy treatment).
- Trial name
- ARC-1 (NCT02368509)
- Testing
- Perform sensory tests
- Where
- 3 sites in France
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Olfaction Disorders, COVID-19
Morphological Abnormalities of the Olfactory Bulb on MRI and Olfactometry in Anosmic Versus Normosmic COVID-19 Patients
Olfactory and gustatory disorders are prevalent symptoms in European COVID-19 patients. This study aimed to detect these disturbances among positive COVID-19 patients (symptom not initially highlighted by the patient and not…
- Trial name
- NCT04526054
- Testing
- ENT exam, Olfactometry, Brain MRI
- Where
- 2 sites in France
- Volunteers
- 13 people
- Sponsor
- Hopital Foch
COVID-19, Anosmia
Finding Out if COVID-19 Infection Can be pREdicted by ChAnges in Smell and/or Taste
The FORECAST Study is an observational cohort study looking at two cohorts of patients presenting with COVID-19: a general public cohort, aiming to investigate if new loss or reduced sense of smell and/or taste are early signs of…
- Trial name
- FORECAST (NCT04377815)
- Testing
- General Public cohort
- Where
- 2 sites in United Kingdom
- Volunteers
- 569 people, healthy volunteers welcome
- Sponsor
- University College, London
Smell Dysfunction, Taste Dysfunction
Post-Covid-19 Patients Follow-up Study
Taste, smell, trigeminal and salivary function is impacted in post-COVID-19 patients
- Conditions
- Smell Dysfunction, Taste Dysfunction, Trigeminal Dysfunction, Salivary Dysfunction
- Trial name
- COVID-19 (NCT07571382)
- Testing
- Smell training
- Where
- Norway
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Olfactory Disorder
Anosmia Rehabilitation in Patients Post Coronavirus Disease (COVID 19)
The study will be a randomized controlled trial, involving patients with hyposmia/anosmia of onset immediately after an upper respiratory viral illness, assigned to three distinct study arms.
- Trial name
- NCT04374474
- Testing
- Olfactory retraining, corticosteroid nasal irrigation, smell household Items
- Where
- Canada
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Olfactory Disorder, COVID19
Assessment of Olfactory Dysfunction in SARS CoV-2 (COVID-19) Infection
This study is designed to investigate the acuity of olfactory dysfunction in COVID-19 positive patients in the United Kingdom. In particular defining severity with objective testing and determining if this has any predictive…
- Conditions
- Olfactory Disorder, COVID19, SARS-CoV-2, Anosmia
- Trial name
- ODYSSI (NCT04466982)
- Where
- 3 sites in United Kingdom
- Volunteers
- 81 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Post COVID-19 Anosmia (Loss of Smell)
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell.
Investigating the potential role of Aerosolized retinoic acid, a potent Vitamin A metabolite for treating COVID-19 Anosmia and retinoic acid insufficiency .A novel approach for regaining Sense of Smell.
- Trial name
- NCT05002530
- Testing
- Aerosolized 13 cis retinoic acid plus Vitamin D, Aerosolized All trans retinoic acid plus Vitamin D, Standard therapy
- Where
- 3 sites in China, Egypt and 1 more
- Volunteers
- 10,000 people
- Sponsor
- Kafrelsheikh University
Olfaction Disorders, Smell Disorders
Olfactory Training on Smell Dysfunction Patients in HK
Causes of olfactory dysfunction can be classified into conductive and sensorineural causes. Conductive causes are mainly due to structural nasal problem, which can be treated by nasal surgery Sensorineural causes included…
- Conditions
- Olfaction Disorders, Smell Disorders, Anosmia, Hyposmia
- Trial name
- NCT05364125
- Testing
- Olfactory Training, Control
- Where
- Hong Kong
- Volunteers
- 80 people
- Sponsor
- Pamela Youde Nethersole Eastern Hospital