Clinical trials: Smell Dysfunction, open to volunteers
Olfactory Dysfunction, Post Viral Olfactory Dysfunction (PVOD)
The Efficacy of Modified Olfactory Training Method for Patients With Post-viral Olfactory Dysfunction
The goal of this clinical trial is to validate the effectiveness of the modified olfactory training device, the main questions it aims to answer are: Is the modified olfactory training device effective in treating patients with…
- Trial name
- NCT06829706
- Testing
- Conventional olfactory training device, Modified olfactory training device
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Peking University Third Hospital
Smell Dysfunction
The Effectiveness of Steroid Nasal Drops in the Olfactory Cleft Combined With Olfactory Training for Patients With PIOD
This study aims to evaluate the effectiveness of hormone nasal drops in the olfactory cleft combined with olfactory training for treating postinfectious olfactory dysfunction (PIOD).
- Trial name
- PIOD (NCT07386860)
- Testing
- Steroid nasal drops combined with olfactory training
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University Third Hospital
Subjective Cognitive Concerns, Mild Cognitive Impairment
Digital Accessible Remote Olfactory Mediated Health Assessments for Preclinical AD
The goal of this study is to objectively test one's sense of smell, called olfaction, in participants with Subjective Cognitive Concerns (SCC), Mild Cognitive Impairment, Mild Behavioral Impairment (MBI), and age-matched…
- Conditions
- Subjective Cognitive Concerns, Mild Cognitive Impairment, Mild Behavioral Impairment, Healthy Aging
- Trial name
- NCT05881239
- Testing
- AROMHA Brain Health Test
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Olfactory Dysfunction, Chronic Rhinosinusitis
The Effect of Modified Olfactory Training on Postoperative Olfactory Dysfunction in Patients With CRS
The goal of this clinical trial is to validate the effectiveness of the modified olfactory training device, the main questions it aims to answer are: Is it possible that the device can treat postoperative olfactory dysfunction in…
- Trial name
- NCT06837051
- Testing
- Conventional olfactory training device, Modified olfactory training device, Budesonide irrigation
- Where
- China
- Volunteers
- 213 people
- Sponsor
- Peking University Third Hospital
Alzheimer s Disease, Mild Cognitive Impairment (MCI)
Crownlands Observing Progression With Neurons Study
The CROWN-I Study is an observational study to learn about molecular features of Alzheimer's disease (AD) and mild cognitive impairment (MCI).
- Trial name
- CROWN-I (NCT07611396)
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Crownlands
Mild Cognitive Impairment
Observation of Inhalation of CXMCI-01 Essential Oil on Patients With Mild Cognitive Impairment
Memory declined and cognitive impairment are common complaints in neurology clinics. Before diagnosing as dementia, individuals will undergo a transition period, including mild cognitive impairment (MCI).
- Trial name
- CXMCI-01-MCI (NCT06902181)
- Testing
- Experimental Group - 100% CXMCI-01 Essential Oil
- Where
- 2 sites in Taiwan
- Volunteers
- 100 people
- Sponsor
- China Medical University Hospital
Olfactory Dysfunction, Anosmia
Topical Versus Injection PRP for Olfactory Dysfunction
The goal of this clinical trial is to determine whether two different delivery methods of autologous platelet-rich plasma (PRP) can improve olfactory function in adults with persistent olfactory dysfunction lasting more than…
- Conditions
- Olfactory Dysfunction, Anosmia, Hyposmia
- Trial name
- TOP-IN (NCT07151703)
- Testing
- Intranasal Injection of Autologous PRP, Carrier-Assisted Topical Application of Autologous PRP, platelet-rich plasma
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Down Syndrome, Cognitive Decline
GnRH Therapy on Cognition in Down Syndrome
Down syndrome (DS) is the most common chromosomal disorder; with the increasing life expectancy, about 80% of DS adults reach age 65 years old.
- Conditions
- Down Syndrome, Cognitive Decline, Alzheimer Disease, Early Onset, Olfaction Disorders
- Trial name
- NCT04390646
- Testing
- GnRH, gonadorelin acetate, 0.9% NaCl
- Where
- Switzerland
- Volunteers
- 56 people
- Sponsor
- Nelly Pitteloud
Meningioma, Pituitary Disease
The Impact of Endoscopic Endonasal Skull Base Surgery on Olfaction
In this study, the research team will investigate the incidence and etiology of olfactory dysfunction following endoscopic endonasal skull base surgery, by combining clinical assessments with histomolecular analysis.
- Conditions
- Meningioma, Pituitary Disease, Pituitary Adenoma, Craniopharyngioma
- Trial name
- Endo-Olfact (NCT06874426)
- Testing
- Endoscopic endonasal skull base surgery
- Where
- 3 sites in Belgium, Germany and 1 more
- Volunteers
- 154 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Idiopathic Anosmia, Idiopathic Hyposmia
Alpha-synuclein Rt-quic and Neurologic Symptoms in Persons With idiOpathic anosMiA
Test of early warning signs and RT-QuIC in patients with idiopathic olfactory dysfunction
- Conditions
- Idiopathic Anosmia, Idiopathic Hyposmia, Idiopathic Olfactory Dysfunction
- Trial name
- AROMA (NCT05740683)
- Testing
- RT-QuiC
- Where
- 2 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Danish Dementia Research Centre
Hyposmia, COVID-19
Olfactory Training as a Treatment for Olfactory Dysfunction Post COVID-19
Olfactory dysfunction is a defining symptom of COVID-19 infection. Studies have demonstrated improved olfaction in patients with post infectious olfactory dysfunction after an olfactory training (OT).
- Conditions
- Hyposmia, COVID-19, Parosmia, Anosmia
- Trial name
- OTTODC19 (NCT05384561)
- Testing
- Smell training
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Université du Québec à Trois-Rivières
Endonasal Surgery, Endoscopic Sinus Surgery
In Vivo Imaging of the Olfactory Epithelium Using Confocal Laser Endomicroscopy
This research is being done to better characterize the part of the nose that helps people smell. Currently, the only ways to study smell loss mostly rely on how people report it, rather than being able to see the underlying…
- Conditions
- Endonasal Surgery, Endoscopic Sinus Surgery, Olfactory Dysfunction
- Trial name
- NCT07546617
- Testing
- CONVIVO system, Fluorescein injection, USP 10%
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Covid19, Olfactory Dysfunction
Dysfunction of Olfaction After COVID-19 Infection: Morphological and Histomolecular Investigation
Investigation of the mechanisms of persistent SARS-CoV-2 associated olfactory dysfunction (OD) in patients with well-documented olfactory function.
- Trial name
- DysOSMIC (NCT06482138)
- Testing
- Biopsy and Cytobrush
- Where
- 7 sites in Belgium, Germany and 1 more
- Volunteers
- 240 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Alzheimer Disease, Smell Loss
Olfactory Biopsies
This research study aims to investigate the function of the olfactory lining in the nasal cavity and its potential alterations in both healthy and diseased conditions. The olfactory lining is involved in the sense of smell.
- Conditions
- Alzheimer Disease, Smell Loss, Smell Dysfunction
- Trial name
- NCT07021040
- Testing
- olfactory testing, Odor stimulation, Olfactory biopsy
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Duke University
Subjective Cognitive Decline (SCD), Olfactory Dysfunction
The Efficacy of Modified Olfactory Training for MCI High-Risk Individuals
The goal of this clinical trial is to validate the effectiveness of the modified olfactory training device, the main questions it aims to answer are: Is it possible that the device can delay the progression of MCI in older…
- Conditions
- Subjective Cognitive Decline (SCD), Olfactory Dysfunction, Mild Cognitive Impairment (MCI), ELDERLY PEOPLE
- Trial name
- NCT06821828
- Testing
- Modified olfactory training device, Conventional olfactory training device
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Peking University Third Hospital
Olfactory Impairment
Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT): Open Label
Smell dysfunction significantly impacts quality of life and safety, with limited effective treatments. This open-label study evaluates the preliminary efficacy of combining non-invasive trigeminal nerve stimulation (TNS) with…
- Trial name
- SCENT-OL (NCT07689773)
- Testing
- Trigeminal Nerve Stimulation-enhanced Smell Training
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Medical University of South Carolina
Olfactory Dysfunction
Olfactory Dysfunction in Aging Adults
This prospective longitudinal cohort study will enroll adults aged 50 years and older to characterize olfactory dysfunction in aging.
- Trial name
- NCT07660887
- Testing
- Clinical and Biomarker Assessments
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Chronic Rhinosinusitis (CRS), Olfactory Dysfunction
Position-Directed Budesonide Nasal Drops for CRS-associated Olfactory Dysfunction
This single-center randomized controlled trial evaluates whether budesonide nasal drops delivered in the Wu's position (Wu's 45° Head-Hanging Reclination Position) improve olfactory function more effectively than conventional…
- Trial name
- NCT07386873
- Testing
- Nasal Drops, Nasal Spray
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Peking University Third Hospital
Olfactory Dysfunction, Wellbeing
Impact of Smell Testing on Health Outcomes
Smell dysfunction is frequent yet neglected. The sense of smell plays a crucial role in signaling disease, safety, and overall quality of life.
- Trial name
- NCT07222891
- Testing
- Patient-centered information and education
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Monell Chemical Senses Center
Post-traumatic Olfactory Dysfunction, Traumatic Brain Injury
Acupuncture for Post-traumatic Olfactory Dysfunction: A Randomized Controlled Trial
The goal of this clinical trial is to learn if acupuncture based on the "Form-Qi-Spirit" theory works to treat post-traumatic olfactory dysfunction in adults. It will also learn about the safety of this acupuncture treatment.
- Conditions
- Post-traumatic Olfactory Dysfunction, Traumatic Brain Injury, Olfactory Dysfunction
- Trial name
- NCT07834047
- Testing
- Acupuncture, Corticosteroid therapy
- Where
- 2 sites in China
- Volunteers
- 84 people
- Sponsor
- Beijing Tiantan Hospital