Clinical trials: Smell Dysfunction, open to volunteers
Olfactory Dysfunction, Smell Loss
Scents of Progress: Leveraging a Novel Device for Olfactory Training in Older Adults
The goal of this clinical trial is to learn if ScentCare, a novel olfactory training device and accompanying companion web-based application, will lead to improved olfactory and well-being outcomes in elderly patients with…
- Conditions
- Olfactory Dysfunction, Smell Loss, Anosmia, Hyposmia
- Trial name
- SPLENDOR-OA (NCT06733636)
- Testing
- Sudoku Puzzles, ScentCare (Olfactory Training Device)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Johns Hopkins University
Chronic Rhinosinusitis (CRS)
Impact of Structural and Microenvironmental Abnormalities in Olfactory Cleft on Olfaction in CRS
The purpose of this research is to investigate the impact of structural abnormalities and microenvironmental changes in the olfactory cleft on olfactory function in patients with chronic rhinosinusitis (CRS).
- Trial name
- NCT06834477
- Testing
- Computed Tomography
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Olfactory Disorder, Taste Disorders
Prospective Registery of Smell/Taste Clinic Ear/Nose/Throat
Smell/taste disorders are common conditions with a significant impact on quality of life. In September 2021, a specific consultation for patients with smell and taste disorders was initiated at the ENT-HNS (ear, nose, and throat…
- Conditions
- Olfactory Disorder, Taste Disorders, Smell Dysfunction, Smell Disorder
- Trial name
- ProspeRo'Scent (NCT06456008)
- Testing
- Standard of care
- Where
- Belgium
- Volunteers
- 500 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cystic Fibrosis in Children, Cystic Fibrosis
Sinus Disease in Young Children With Cystic Fibrosis
This is a prospective, observational study examining the impact of highly effective cystic fibrosis transmembrane conductance regulator (CFTR) modulators on chronic rhinosinusitis (CRS) and olfactory dysfunction (OD) in young…
- Conditions
- Cystic Fibrosis in Children, Cystic Fibrosis, Chronic Rhinosinusitis (Diagnosis), Olfactory Disorder
- Trial name
- NCT06191640
- Testing
- Ivacaftor or elexacaftor/tezacaftor/ivacaftor
- Where
- 6 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of California, Los Angeles
Glioblastoma Multiforme, Adult, Glioblastoma or Gliosarcoma
Prognostic Potential of Olfactory Function in Glioblastoma: a Prospective Observational Study
The study aims to investigate the prognostic significance of olfactory function in patients with glioblastoma. We are examining olfactory function at various points during therapy and correlating the results with survival data.
- Conditions
- Glioblastoma Multiforme, Adult, Glioblastoma or Gliosarcoma, Glioblastoma, Adult
- Trial name
- OLFGBM (NCT06954636)
- Testing
- olfactory testing (threshold and identification test)
- Where
- 2 sites in Germany
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Sied Kebir
Olfactory Dysfunction, Post-traumatic Olfactory Dysfunction
PANDORA: Evaluation of Platelet-rich Plasma in Non-tumoural Odour Disorders: a Descriptive Pilot Study.
This is a prospective, single-center, single-arm, non-comparative descriptive pilot study evaluating autologous platelet-rich plasma (PRP) injections in adults with persistent (>6 months) non-tumoural olfactory dysfunction…
- Conditions
- Olfactory Dysfunction, Post-traumatic Olfactory Dysfunction, Age-related Degenerative Olfactory Dysfunction
- Trial name
- PANDORA (NCT07473830)
- Testing
- Autologous Platelet-Rich Plasma (PRP) Injection
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Alzheimer Disease, Late Onset, Mild Cognitive Impairment
Establish Diagnostic and Prognostic Models for Preclinical AD Patients Based on Multimodal MRI, Behavioral, Genetic, and Plasma Biomarkers
To establish the diagnostic and prognostic models that could help the preclinical identification of subjects at higher risk of clinical progression to mild cognitive impairment and dementia based on combined features of baseline…
- Conditions
- Alzheimer Disease, Late Onset, Mild Cognitive Impairment, Subjective Cognitive Decline
- Trial name
- NCT06561906
- Testing
- Multimodal magnetic resonance imaging scanning, behavioral, genetic and plasma biomarker testing
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Olfactory Dysfunction, Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Neural Dissimilarity in Patients With Chronic Rhinosinusitis With Nasal Polyps Treated With Biologics
This project will focus on rehabilitation of olfactory dysfunction in patients with chronic rhinosinusitis with polyps given biological treatment based on functional magnetic resonance imaging.
- Conditions
- Olfactory Dysfunction, Chronic Rhinosinusitis With Nasal Polyps (CRSwNP), Functional Magnetic Resonance Imaging (fMRI)
- Trial name
- NCT07819162
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Olfaction Disorders, Smell Disorders
Olfactory Training on Smell Dysfunction Patients in HK
Causes of olfactory dysfunction can be classified into conductive and sensorineural causes. Conductive causes are mainly due to structural nasal problem, which can be treated by nasal surgery Sensorineural causes included…
- Conditions
- Olfaction Disorders, Smell Disorders, Anosmia, Hyposmia
- Trial name
- NCT05364125
- Testing
- Olfactory Training, Control
- Where
- Hong Kong
- Volunteers
- 80 people
- Sponsor
- Pamela Youde Nethersole Eastern Hospital
Smell Loss, Chronic Rhinosinusitis (CRS)
Cognitive and Immunologic Profiles of Patients With Olfactory Dysfunction After Smell Training
A research study to assess the baseline olfactory function, mental health status, clinical severity, and immunological profile in patients with smell loss.
- Trial name
- CIPOD (NCT07681973)
- Testing
- Smell Training
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Outcome
Factors Influencing the Prognosis of Olfactory Dysfunction After Upper Sensation
Objective: This study aimed to analyze the outcomes of post-infectious olfactory dysfunction treated with different doses of corticosteroids and specify factors related to the curative effect.
- Trial name
- NCT04918953
- Testing
- methylprednisolone, budesonide atomization suspension
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Smell Dysfunction, Olfactory Disorder
Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT for Long COVID)
Persistent smell loss that can include diminished or distorted smell function is a common symptom of long COVID syndrome. There are limited treatment options for long COVID-related smell loss.
- Conditions
- Smell Dysfunction, Olfactory Disorder, Long COVID
- Trial name
- NCT05855369
- Testing
- Trigeminal Nerve Stimulation (TNS), Active Smell Training (ST)
- Where
- United States
- Volunteers
- 145 people
- Sponsor
- Medical University of South Carolina
Mild Cognitive Impairment
Olfactory Training in Mild Cognitive Impairment
Sense of smell tends to decline in individuals with early Alzheimer's disease, typically earlier than when other senses and thinking abilities begin to decline.
- Trial name
- OTMCI (NCT06825403)
- Testing
- Olfactory Memory Training, Visual Memory Training
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Jeffrey Motter
Hyposmia, Olfactory Dysfunction
Slow-SPEED UK: A Double-Blind Randomised Feasibility Trial
Slow-SPEED UK is an 18-month randomised, double-blind feasibility trial evaluating the delivery, adherence, and acceptability of a digitally supported physical activity programme in community-dwelling adults aged 40 and over with…
- Conditions
- Hyposmia, Olfactory Dysfunction, Anosmia
- Trial name
- Slow-SPEED (NCT06600438)
- Testing
- Slow-SPEED app
- Where
- United Kingdom
- Volunteers
- 110 people
- Sponsor
- Queen Mary University of London