Clinical trials: Small Intestinal Bacterial Overgrowth
Chronic Abdominal Pain, Small Intestinal Bacterial Overgrowth
Is Chronic Abdominal Pain in Pediatric Patients Due to Small Intestinal Bacterial Overgrowth?
Chronic abdominal pain (CAP) is an extremely pervasive childhood condition and, like IBS in adults, it is one of the functional bowel disorders without a clear framework of understanding or an effective treatment.
- Trial name
- CAP&SIBO (NCT00619970)
- Testing
- Lactulose Breath Test, xifaxan
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Small Intestinal Bacterial Overgrowth
Evaluating the Effect Of Rifaximin on the Gut Microbiota and Metabolome in SIBO Using CapScan®
We will sample intestinal microbiota using a microbiome sampling capsule in patients with Small Intestinal Bacterial Overgrowth (SIBO)
- Trial name
- NCT06298409
- Testing
- CapScan collection capsule
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Envivo Bio Inc
Irritable Bowel Syndrome, Small Intestinal Bacterial Overgrowth
Effect of a Probiotic Formula on Reducing SIBO in IBS Patients
This randomized study evaluates the effectiveness of the a probiotic formula, compared with the antibiotic rifaximin, in the treatment of Small Intestinal Bacterial Overgrowth (SIBO) in Irritable Bowel Syndrome (IBS) patients.
- Trial name
- NCT04316806
- Testing
- Probiotic, Rifaximin
- Where
- Spain
- Volunteers
- 8 people
- Sponsor
- AB Biotics, SA
Small Intestinal Bacterial Overgrowth
Methane and Hydrogen Breath Test for the Diagnosis of Small Intestinal Bacterial Overgrowth
To investigate whether the positive rates of methane and hydrogen breath test were different between the experimental group and the control group.
- Trial name
- NCT06483360
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Small Intestinal Bacterial Overgrowth, Critical Illness
Small Intestinal Bacterial Overgrowth in Critically Ill Patients
Small intestinal bacterial overgrowth (SIBO) syndrome, though associated with potentially serious complications, has not been adequately studied to date in critically ill patients hospitalized in intensive care units (ICU).
- Conditions
- Small Intestinal Bacterial Overgrowth, Critical Illness, Intensive Care Unit
- Trial name
- NCT05765994
- Testing
- Modified hydrogen breath test
- Where
- Greece
- Volunteers
- 52 people
- Sponsor
- University of Ioannina
Small Intestinal Bacterial Overgrowth, Liver Cirrhosis
Effycacy of Rifaximin on Reverse Minimal Hepatic Encephalopathy and Elimation Small Intestinal Bacterial
A total of 46 patients diagnosed with liver cirrhosis will be recruited. All patients will be evaluated with five psychometric tests and critical flicker frequency to diagnosis minimal hepatic encephalopathy (MHE).
- Trial name
- NCT02439307
- Testing
- Rifaximin
- Where
- Mexico
- Volunteers
- 11 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
SIBO, Pancreatic Insufficiency
Breath Test-Based Assessment of SIBO in Chronic Pancreatitis and Partial Pancreatectomy
Pancreatic exocrine insufficiency (PEI) results from reduced pancreatic enzyme secretion, leading to malabsorption, malnutrition, and impaired quality of life.
- Conditions
- SIBO, Pancreatic Insufficiency, Chronic Pancreatitis, Pancreatic Surgey
- Trial name
- DCP-PCT-EPI (NCT07479238)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
SIBO, Small Intestinal Bacterial Overgrowth
The Low FODMAP Diet in Individuals With Small Intestinal Bacterial Overgrowth (SIBO)
This study aims to assess the impact of a low FODMAP diet (LFD) on gastrointestinal symptoms and nutritional status in individuals diagnosed with small intestinal bacterial overgrowth (SIBO).
- Conditions
- SIBO, Small Intestinal Bacterial Overgrowth, Small Intestinal Bacterial Overgrowth Syndrome (SIBO)
- Trial name
- NCT07424313
- Testing
- Low FODMAP Diet, Healthy Eating Diet
- Where
- Poland
- Volunteers
- 51 people
- Sponsor
- Warsaw University of Life Sciences
Decompensated Cirrhosis, Small Bowel Bacterial Overgrowth Syndrome
Primary Prophylaxis for Spontaneous Bacterial Peritonitis
Patient with liver cirrhosis commonly have co-existing small bowel bacterial overgrowth (SIBO) yet may be asymptomatic. It is unclear as to the value of treating SIBO in asymptomatic individuals.
- Trial name
- SIBOC (NCT04775329)
- Testing
- Rifaximin
- Where
- Singapore
- Volunteers
- 2 people
- Sponsor
- Changi General Hospital
Irritable Bowel Syndrome
A Longitudinal Study to Identify IBS Phenotypes Using Fecal Microbiota and Hydrogen Breath Testing
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a highly prevalent but poorly understood condition with limited treatment options.
- Trial name
- NCT03219528
- Testing
- Rifaximin 550 MG, Low FODMAP Diet
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of Michigan
Systemic Sclerosis, Small Intestinal Bacterial Overgrowth
The Small Intestine Bacterial Overgrowth Study Pilot
This is a pragmatic study in which will compare a detailed treat-to-target (T2T) treatment algorithm to standard care for SSc SIBO at multiple sites around the world.
- Trial name
- SIBO (NCT03588845)
- Testing
- Treatment Protocol, Standard of Care
- Where
- 2 sites in United States, Australia
- Volunteers
- 500 people
- Sponsor
- Canadian Scleroderma Research Group
Microbial Colonization, Small Intestinal Bacterial Overgrowth
High-fat Diet (HFD) and Small Intestinal Microbiome
The investigators aim to characterize the upper small intestinal microbiome in healthy conditions in dependency on feeding condition (starved vs.
- Trial name
- FATBOM (NCT07019142)
- Testing
- HFD
- Where
- Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Small Bowel Bacterial Overgrowth, Gastrointestinal Diseases
Transit Time and Bacterial Overgrowth Using SmartPill Capsule
The primary purpose of this exploratory study is to measure orocecal transit time using the SmartPill ambulant capsule technology and to compare this with the lactulose hydrogen breath test.
- Conditions
- Small Bowel Bacterial Overgrowth, Gastrointestinal Diseases, Stomach Diseases, Digestive System Diseases
- Trial name
- NCT00577772
- Testing
- Xifaxan, SmartPill, Lactulose hydrogen breath test (H_2BT)
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Small Intestinal Bacterial Overgrowth, Irritable Bowel Syndrome
SIBO, Immune Activation, and FGIDs in Children
PURPOSE: This study will evaluate the relationships between small intestinal bacterial overgrowth (SIBO), immune activation, inflammation, and symptoms in pediatric abdominal pain-related functional gastrointestinal disorders…
- Conditions
- Small Intestinal Bacterial Overgrowth, Irritable Bowel Syndrome, Functional Dyspepsia, Functional Abdominal Pain
- Trial name
- SIBO (NCT02872961)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- The University of Texas Health Science Center, Houston
Small Intestinal Bacterial Overgrowth
Novel Supplement-based Therapy for the Treatment of Small Intestinal Bacterial Overgrowth
Study Synopsis This pilot study will determine the efficacy of a novel supplement protocol and low FODMAP diet for the treatment of small intestinal bacterial overgrowth (SIBO).
- Trial name
- NCT03420976
- Testing
- Novel Supplement Based Therapy
- Where
- United States
- Sponsor
- Atrium Innovations
Functional Dyspepsia, Small Intestinal Bacterial Overgrowth
Does Small Intestinal Bacterial Overgrowth Contribute to Functional Dyspepsia
The prevalence of functional dyspepsia (FD) is estimated to be 15% of the adult population. FD is commonly described as a condition of chronic abdominal discomfort localized to the upper abdomen.
- Conditions
- Functional Dyspepsia, Small Intestinal Bacterial Overgrowth, Chronic Abdominal Discomfort
- Trial name
- NCT00956397
- Testing
- Rifaximin, Lactulose Breath Test
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Henry C. Lin, MD
Pancreatic Adenocarcinoma, Weight Loss
Small Intestinal Bacterial Overgrowth (SIBO) in Pancreatic Adenocarcinoma (PDAC)
The purpose of this study is to prospectively analyze the prevalence of SIBO in patients with Pancreatic adenocarcinoma (PDAC) and understand its association with weight loss and pancreatic resection status.
- Trial name
- SIBO in PDAC (NCT06988150)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Cedars-Sinai Medical Center
Small Intestinal Bacterial Overgrowth, Gastrointestinal Disorder, Functional
Therapeutic Effect of Olive Leaf Tea on SIBO
The goal of this study is to learn about the effect of olive leaf tea (OLT) in patients with small intestinal bacterial overgrowth aging from 18 to 60 years old.
- Trial name
- SIBO (NCT05915767)
- Testing
- Olive leaf tea
- Where
- Pakistan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Veterinary and Animal Sciences, Lahore - Pakistan
Small Intestinal Bacterial Overgrowth, Gastrointestinal Disease
Efficacy of AEMCOLO (Rifamycin SV MMX) in the Treatment of Small Intestinal Bacterial Overgrowth (SIBO)
Open label interventional randomized pilot study utilizing two dosing regimens of AEMCOLO. The goal of this study is to evaluate effectiveness of a novel antibiotic, AEMCOLO (Rifamycin SV MMX) in the treatment of Small intestinal…
- Conditions
- Small Intestinal Bacterial Overgrowth, Gastrointestinal Disease, Gastrointestinal Infection
- Trial name
- NCT04501380
- Testing
- AEMCOLO (Rifamycin SV MMX)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bradley Connor
Small Intestine Bacterial Overgrowth
Nutrition, Overgrowth, and Vaccine Efficacy in Low-income Settings
The purpose of this study is to assess the impact of small intestine bacterial overgrowth (SIBO) on childhood nutritional status, growth, and oral vaccine efficacy.
- Trial name
- NOVEL (NCT02745327)
- Where
- Bangladesh
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- University of Virginia