Clinical trials: Small Airway Disease
COPD Bronchitis, Pollution Related Respiratory Disorder
Effect of the Inhaled Triple Therapies Over the Small Airway in Biomass Exposure
This phase IV randomized controlled clinical trial intend to compare the effect of three close standard inhaled triple therapies and one close standard inhaled double therapy on the small airway in patients with Chronic…
- Trial name
- NCT06571942
- Testing
- Vilanterol / Umeclidinium (25/62.5 mcg), Fluthicasone / Vilanterol / Umeclidinium (100/25/62.5 mcg), Beclomethasone / Formoterol / Glycopyrronyum 100/6/12.5 mcg
- Where
- Mexico
- Volunteers
- 128 people
- Sponsor
- National Institute of Respiratory Diseases, Mexico
Tobacco Cessation, Asthma COPD
The Effect of Immediate Smoking Cessation Interventions for Smokers With Chronic Airway Diseases
Smoking cessation support is provided by smoking cessation outpatient clinics in our country. Smokers with chronic airway diseases can also apply to these services by making an appointment from quit lines.
- Conditions
- Tobacco Cessation, Asthma COPD, Bronchiectasis Adult
- Trial name
- NCT05764343
- Testing
- Immediate smoking cessation support
- Where
- Turkey (Türkiye)
- Volunteers
- 397 people
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Asthma, Reactive Airway Disease
Comparison of Asthma Programs for Schools
The purpose was to evaluate effectiveness and impact of an academic and counseling asthma health education program (SHARP) for fourth- and fifth-grade students diagnosed with asthma.
- Trial name
- CAPS (NCT01625364)
- Testing
- SHARP program, Open Airways for Schools
- Where
- United States
- Volunteers
- 432 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Chronic Obstructive Pulmonary Disease (COPD), Asthma
Chronic Airway Disease and Multimorbidity Cohort
Background: Chronic airway diseases (CAD), including chronic obstructive pulmonary disease (COPD), asthma and bronchiectasis, are highly prevalent and cause serious disease burden.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Asthma, Bronchiectasis
- Trial name
- CAM Cohort (NCT06798077)
- Where
- 9 sites in China
- Volunteers
- 2,000 people
- Sponsor
- China-Japan Friendship Hospital
Chronic Obstructive Pulmonary Disease
Effect of Tiotropium Bromide Combined With Odaterol on Small Airway Remodeling in Patients With Mild to Moderate Chronic Obstructive Pulmonary Disease
72 patients with mild to moderate chronic obstructive pulmonary disease were planned to be enrolled in this study and then treated with olodaterol combined with thiotropium bromide, and thiotropium bromide, respectively, for 52…
- Trial name
- NCT05295355
- Testing
- Tiotropium Bromide Combined With Odaterol
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Intubation;Difficult, Videolaryngoscopy
GlideScope Videolaryngoscopy in Patients With Reduced Mouth Opening
This study aims to evaluate the clinical performance, quality of larynx visualization and difficulty of videolaryngoscopic intubation in patients with a reduced mouth opening (1.0 to 3.0 cm) utilizing the latest generation of…
- Conditions
- Intubation;Difficult, Videolaryngoscopy, Small Mouth
- Trial name
- NCT04174833
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Smoking, COPD
Canadian Cohort on the Origin and Progression of Airway Disease: Physiology Platform
The Canadian Respiratory Research Network (CRRN) has recently been established to study the origins and evolution of airways disease in the population.
- Trial name
- NCT02153684
- Where
- 3 sites in Canada
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Dr. Denis O'Donnell
COPD, Asthma
Imaging Lung Function Using Oxygen Enhanced MRI
The goal of this study is to perform a pilot study to evaluate the utilization of oxygen as an inhaled contrast agent to image the airway spaces in normal and diseased human lungs to allow an effect size estimate to power future…
- Conditions
- COPD, Asthma, Cystic Fibrosis, Emphysema
- Trial name
- NCT01731015
- Testing
- Medical Grade Oxygen
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Hal C Charles
Small Airway Disorders, COPD
Impact of Airways Function After HFNC Evaluated by IOS
In addition to pharmacological treatment, nonpharmacological treatment with high-flow nasal cannula (HFNC) may play a vital role in the treatment of patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT05130112
- Testing
- high flow nasal cannula and nasal cannula
- Where
- Taiwan
- Volunteers
- 26 people
- Sponsor
- Fu Jen Catholic University Hospital
Pneumonia, Bronchiolitis
Diagnosing Respiratory Disease in Children Using Cough Sounds 2
The purpose of this prospective study is to evaluate the efficacy of the ResAppDx software application in the diagnosis of childhood acute respiratory disease, including pneumonia, bronchiolitis, asthma/reactive airways disease…
- Conditions
- Pneumonia, Bronchiolitis, Asthma Exacerbation, Croup
- Trial name
- SMARTCOUGH-C-2 (NCT03392363)
- Testing
- Recordings of Infants and Children's Cough Sounds
- Where
- 3 sites in United States
- Volunteers
- 1,470 people
- Sponsor
- ResApp Health Limited
Chronic Obstructive Pulmonary Disease
The Effect of Beclomethasone/Formoterol in Extra-fine Formulation on Quality of Life and SAD in COPD Patients.
In patients with chronic obstructive pulmonary disease (COPD), small-airway dysfunction (SAD) is considered a key element and a functional consequence of the pathology.
- Trial name
- NCT04421742
- Testing
- Beclomethasone Dipropionate/Formoterol Fumarate
- Where
- Italy
- Volunteers
- 43 people
- Sponsor
- Alfredo Antonio Chetta
Pulmonary Disease, Chronic Obstructive, Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome
Differences of Small Airways Function Between Chronic Obstructive Pulmonary Disease(COPD) and Asthma-copd Overlap(ACO)
The purpose of this study is to research the differences of small airways function between subjects with diagnosis of chronic obstructive pulmonary disease(COPD) and asthma-COPD overlap(ACO).The assessment of quality of life is…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome, Small Airway Disease, Quality of Life
- Trial name
- NCT03563001
- Testing
- Budesonide(160ug) and Formoterol(4.5ug) bid
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Zhujiang Hospital
Thoracic Cancer
Bronchial Mapping (GCC 1635)
In order to better understand radiation-induced lung toxicity, the investigator proposes a novel functional avoidance approach that incorporates central as well as peripheral BSS segments in the treatment planning process in…
- Trial name
- NCT02745548
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Maryland, Baltimore
COPD
The Effect on Small Airways of Addition of Theophylline as Inducer of Histone Deacilase Activity for Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD), Treated With Inhaled Steroids and Long Acting Beta Agonists
Chronic obstructive pulmonary disease (COPD) is a chronic progressive respiratory disorder causing disability with an increasing burden to the patient, his family and to the health services.
- Trial name
- COPD (NCT00893009)
- Testing
- Theophylline
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Assaf-Harofeh Medical Center
Pulmonary Disease, Chronic Obstructive, Emphysema
Evaluating the Clinical Effectiveness of 3D Printing for a Patient-specific Silicone Stent Airway Implant
The goal of the small feasibility trial is to establish a method, material, and patient-specific design that is superior to what is in use today.
- Trial name
- NCT03111888
- Testing
- Silicone Stent Airway Implant
- Where
- United States
- Sponsor
- The Cleveland Clinic
Asthma
Efficacy of Ciclesonide on Small Airways in Patients With Stable Asthma (18 to 60 y) (BY9010/M1-131)
The aim of this study is to evaluate the involvement of small airways in asthma, as determined by bronchial challenges, CT-scanning, and cellular markers of inflammation. Ciclesonide will be inhaled at one dose level once daily.
- Trial name
- NCT00163345
- Testing
- Ciclesonide
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- AstraZeneca
Chronic Obstructive Airway Disease
Effect of Prolonged Decubitus on Nitric Oxide Concentration in Chronic Obstructive Pulmonary Disease
Bronchial obstruction in Chronic Obstructive Pulmonary Disease (COPD) is caused by inflammation of peripheral airways walls. Neutrophils and other inflammatory mediators Interleukin-6 (IL6), Interleukin-8 (IL8), Interleukin-1…
- Trial name
- NCT01555593
- Testing
- Cardioline Exp'air by Medi-soft - Sorinnes (B)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Milan
Non-small Cell Lung Cancer, Lung Function Decreased
Effects of Nonintubated Thoracoscopic Lobectomy on Lung Protection
A novel nonintubated thoracoscopic technique is promising to enhance recovery after thoracic surgery. However, the effects of nonintubated technique on specific organ protection in not clear yet.
- Conditions
- Non-small Cell Lung Cancer, Lung Function Decreased, Tracheal Intubation Morbidity
- Trial name
- NCT03471884
- Testing
- Nonintubated thoracoscopic lobectomy, Intubated thoracoscopic lobectomy
- Where
- Taiwan
- Volunteers
- 82 people
- Sponsor
- National Taiwan University Hospital
COPD, COPD, Early-Onset
Change in Airway Peripheral Tone in COPD
Small airways disease is a pathological feature in mild to moderate COPD, which might be causally involved in disease progression.
- Trial name
- CAPTO-COPD (NCT04166812)
- Testing
- oscillometry, multiple breath washout testing, spirometry
- Where
- 2 sites in Germany
- Volunteers
- 150 people
- Sponsor
- Heidelberg University
Reactive Airway Disease, Wheezing
Nasal Findings in Reactive Airway Diseases
Reactive airway diseases is a common respiratory diseases affecting 1-18% of the population in different countries. It carries a significant burden to children, their families, the healthcare system and the overall community.The…
- Trial name
- nasalfinding (NCT03131323)
- Testing
- • Flexible fiberopticnasopharyngoscope
- Volunteers
- 50 people
- Sponsor
- Assiut University