Clinical trials: Sleep Restriction
Sleep Deprivation
Physiologic Effects of Sleep Restriction
Evidence suggests a relationship between sleep deprivation and cardiovascular disease. The investigators wish to determine whether 9 nights of modest sleep restriction results in activation of cardiovascular disease mechanisms…
- Trial name
- NCT01433315
- Testing
- sleep restriction
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Cardiometabolic Syndrome, Type 2 Diabetes
Circadian Intervention to Improve Cardiometabolic Health
The overall goal is to examine the efficacy of a circadian intervention in people with overweight and obesity and habitual short sleep duration (HSSD).
- Conditions
- Cardiometabolic Syndrome, Type 2 Diabetes, Sleep, Time Restricted Feeding
- Trial name
- TOCS (NCT05943626)
- Testing
- Circadian Intervention
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Utah
Inflammatory Response, Inflammation
Sleep and Inflammatory Resolution Pathway
Goal of this project is to investigate whether increases in inflammation that result from common patterns of restricting sleep on week nights and catching up on sleep over the weekend are caused by disruption in the newly…
- Conditions
- Inflammatory Response, Inflammation, Sleep, Sleep Restriction
- Trial name
- NCT03377543
- Testing
- Aspirin
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Obesity
The Impact of Sleep Restriction on Gastric Emptying, Appetite and Energy Intake
This study aims to examine if partial sleep deprivation results in alterations blood markers and subjective markers of homeostatic, and hedonic appetite, as well as provide initial data as to the impact of sleep restriction on…
- Trial name
- NCT05953285
- Testing
- Sleep restriction
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Obesity, Obesity & Overweight
Interaction of Sleep, Diurnal Eating Pattern, Gut Microbiota, and Obesity
The goals of the proposed study are 1) to provide scientific basis for the relationship between subjective sleep quality, diurnal eating pattern, gut microbiome, and obesity, 2) to develop and test a pragmatic, cost-effective new…
- Trial name
- ObeApp (NCT04850391)
- Testing
- Mobile app
- Where
- Finland
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Acute and Partial Sleep Deprivation
Cortical Excitability and Decision Making After Total Sleep Deprivation and Sleep Restriction
The investigators examine changes in decision making, vigilance and cortical excitability in healthy male subjects undergoing total acute sleep deprivation (40 hours) on the one hand, and chronic partial sleep restriction (7…
- Trial name
- NCT02305225
- Testing
- Sleep Deprivation
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Christian Baumann
Sleep Deprivation, Cognitive Impairment
Delta Waves and Cognitive Recovery
In a laboratory protocol in healthy adults, exposed to a prolonged period of wakefulness with a restricted opportunity for sleep (40h of wakefulness / 3h of sleep / 21h of wakefulness), we hypothesize that the relative increase…
- Trial name
- RECOPS (NCT05924737)
- Testing
- Sleep deprivatin, Sleep recovery
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche Biomedicale des Armees
Obesity, Diet Modification
Metabolic Impact of Time Restricted Feeding
The investigators are interested in how time-restricted feeding will impact weight, sleep duration and efficacy, and activity levels in obese adults.
- Trial name
- NCT03129581
- Testing
- Dietary Counseling
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Sleep Deprivation
Strategies to Augment Ketosis: Ketone Conferred Resiliency Against Sleep Restriction
Sleep deprivation is a major problem in military populations. Some major consequences of sleep loss are inability to concentrate, poor work efficiency, and increase in errors during daily tasks.
- Trial name
- STAK-Sleep (NCT05519644)
- Testing
- Sleep Deprivation, Heart Rate, Sleep Monitoring
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Sleep Deprivation, Nutritional Intervention
Ketone Conferred Resiliency Against Sleep Restriction With Nutritional Intervention.
Sleep deprivation is a major problem in military populations. Some major consequences of sleep loss are inability to concentrate, poor work efficiency, and increase in errors during daily tasks.
- Trial name
- NCT06075914
- Testing
- Ketogenic Intervention, Mediterranean Intervention, Ketone Ester
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Sleep, Pregnancy
Ghana PrenaBelt Trial: A Positional Therapy Device to Reduce Still-Birth
Every day in Ghana, 47 babies are stillborn (SB) and 232 babies are born with low birth-weight (LBW) - many of whom will die in infancy or suffer lifelong consequences.
- Conditions
- Sleep, Pregnancy, Stillbirth, Infant, Low Birth Weight
- Trial name
- NCT02379728
- Testing
- PrenaBelt, Body Position Sensor
- Where
- Ghana
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Allan Kember
Caffeine, Insufficient Sleep
Consequences of Caffeine Intake in Sleep Restricted Teenagers
The goal of this clinical trial is to systematically investigate two prominent factors in teenagers' daily life: Caffeine and sleep restriction (SR) and their combined influence on sleep, cognition, and behavior in healthy…
- Trial name
- NCT05790161
- Testing
- Caffeine
- Where
- Switzerland
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Psychiatric Hospital of the University of Basel
Sleep Deprivation, Obesity
Sleep and Metabolism
The goal of this study is to uncover sleep and circadian mechanisms contributing to adverse metabolic health. The protocol is a 21 day (7 outpatient days, 14 inpatient days) mechanistic randomized-crossover study designed to…
- Conditions
- Sleep Deprivation, Obesity, Glucose Intolerance, Weight Gain
- Trial name
- SAM (NCT05775627)
- Testing
- Sleep Restriction
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Energy Restriction, Sleep Deprivation
Brain Energy and Cognition
This proposed laboratory study will extend previous findings on relationships between cognitive function and nutritional status to conditions that more closely resemble military operations where aerobic exercise, inadequate…
- Trial name
- NCT01603550
- Testing
- Sleep Deprivation, Energy Restriction
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Caloric Restriction, Exercise
Trial of Testosterone Undecanoate for Optimizing Performance During Military Operations
The objective of this study is to determine the effects of a single dose of testosterone undecanoate during and in recovery from simulated operational stress.
- Conditions
- Caloric Restriction, Exercise, Sleep
- Trial name
- OPS II (NCT04120363)
- Testing
- Testosterone Undecanoate, Sesame Oil
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Glucose Intolerance, Sleep Deprivation
Influence of Nocturnal Light Exposure on the Impairment of Glucose Tolerance Induced by Chronic Sleep Restriction
This project is designed to test for the first time whether glucose metabolism is differentially impaired by sleep restriction with and without additional exposure to artificial light at night (ALAN).
- Conditions
- Glucose Intolerance, Sleep Deprivation, Sleep
- Trial name
- NCT04868539
- Testing
- Sleep Restriction with ALAN first, then Sleep Restriction without ALAN, Sleep Restriction without ALAN first, then sleep restriction with ALAN
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Alzheimer Disease, Late Onset, Mild Cognitive Impairment
Time-in-bed Restriction in Older Adults With Sleep Difficulties With and Without Risk for Alzheimer's Disease
Dementia caused by Alzheimer's disease affects approximately 5.6 million adults over age 65, with costs expected to rise from $307 billion to $1.5 trillion over the next 30 years.
- Conditions
- Alzheimer Disease, Late Onset, Mild Cognitive Impairment, Sleep, Cognitive Change
- Trial name
- ALPS (NCT05138848)
- Testing
- Time in Bed Restriction, Sleep Schedule
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Obesity
Sleep Restriction and Obesity
Insufficient sleep may be one of the most common, and most preventable, obesity risk factors. The investigators wish to determine whether 14 nights of modest sleep restriction results in increased energy balance, thus potentially…
- Trial name
- NCT01580761
- Testing
- Sleep restriction
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Sleep Deprivation, Obesity
Effects of Sleep Restriction on BAT Activation in Humans
The goal of this proposed research is to test the hypothesis that long-term mild sleep restriction (SR), as occurs frequently in adults and adolescents, leads to a positive energy balance and weight gain. Aim 1.
- Trial name
- BAT (NCT02770118)
- Testing
- Partial Sleep Restriction, Total Sleep Deprivation, Habitual Sleep
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Columbia University
Sleep Restriction
CNS Correlates of Extended Sleep Restriction
Chronic sleep restriction is ubiquitous in both the general population and the military. The deleterious effects of sleep loss on human alertness and cognitive performance have been documented in numerous studies dating back to…
- Trial name
- NCT05547880
- Testing
- [11C]ER176
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Institute of Research (WRAIR)