Clinical trials: Sleep Fragmentation
Sleep Disorder, Healthy
Effects of Experimental Sleep Disturbances on Receptor Function of Study Drug
The overall goal of this project is to determine whether common sleep disturbance patterns, sleep continuity disturbance (SCD) and Sleep Fragmentation (SF), alter cerebral study drug receptor availability, drug-based analgesia…
- Trial name
- Sleep-MOR (NCT04299490)
- Testing
- Sleep Fragmentation, Sleep Continuity Disruption, Undisturbed Sleep
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Sleep Fragmentation, Poor Quality Sleep
Impact of Behavioral Treatment of Insomnia on Nighttime Urine Production
Nocturia is prevalent in older adults and it vastly reduces quality of life. Yet its treatment remains inadequate because its causes are not well understood, especially nocturnal polyuria or increased urine production at night.
- Conditions
- Sleep Fragmentation, Poor Quality Sleep, Nocturia, Nocturnal Enuresis
- Trial name
- NCT03883724
- Testing
- Brief behavioral treatment of insomnia (BBTI), Information-only control (IC)
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Histamine, Cowhage
Investigation of the Effects of Sleep Fragmentation on Itch and Pain Sensitivity
In This experiment, the investigators would like to test following hypotheses regarding the influence of sleep fragmentation on itch: To investigate similarity and differences between itch and pain by comparing the effect of…
- Conditions
- Histamine, Cowhage, Sleep Fragmentation
- Trial name
- NCT06081946
- Testing
- Histamine, Cowhage
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Pain, Healthy
Fragmented Sleep, Pain, and Biomechanics
This interventional study aims to test the effects of sleep disruption on pain sensitivity and biomechanics in healthy individuals during experimental knee and shoulder pain.
- Conditions
- Pain, Healthy, Sleep Disturbance
- Trial name
- NCT06336109
- Testing
- Hypertonic saline knee and shoulder injection
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University
The Role of the LC-NA System in Sleep Regulation
The Role of the LC-NA System in Experimental Sleep Fragmentation
Sleep-wake regulation affects every person's life, yet the molecular mechanisms underlying these processes remain poorly understood.
- Trial name
- DMTN_FragSleep (NCT07167316)
- Testing
- DMTN, Auditory Stimulation, Placbo
- Where
- Switzerland
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hans-Peter Landolt
Apnea, Restless Legs Syndrome
Validation Study for an Unobtrusive Online Sleep Measurement System
The purpose of the study is to determine the precision of an unobtrusive sleep measurement system. The system measures a force sensor signal under the mattress and analyzes sleep quality.
- Conditions
- Apnea, Restless Legs Syndrome, Sleep Fragmentation
- Trial name
- NCT01633151
- Where
- Finland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Beddit.com Ltd
Sleep Fragmentation
Sleep Disruption in Post-operative Patients in the Neurocritical Care Unit
The role of sleep in patients admitted to the intensive care unit is an emerging field of research. There have been studies that show patients in the ICU have poor sleep including sleep fragmentation, multiple arousals, decreased…
- Trial name
- SDPPNCU (NCT02997839)
- Testing
- sleep disruption
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Sleep, Mild Cognitive Impairment
Light and Sleep Fragmentation
This trial will examine scheduled exposure to bright light in the morning and afternoon as a countermeasure to sleep fragmentation in older individuals with mild cognitive impairment.
- Conditions
- Sleep, Mild Cognitive Impairment, Mood Disorders
- Trial name
- NCT06009289
- Testing
- Light therapy
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Stanford University
Menopause
Menopausal Sleep Fragmentation and Body Fat Gain
This study aims to investigate the impact of menopause-related sleep fragmentation on metabolic biomarkers of body fat gain. The investigators hypothesize that experimental sleep fragmentation will result in an adverse leptin…
- Trial name
- NCT03047330
- Testing
- Estradiol withdrawal, Fragmented sleep
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Obstructive Sleep Apnea, Metabolic Syndrome X
Obstructive Sleep Apnea (OSA) and Metabolic Syndrome: Role of Oxidative Stress
The purpose of this study is to define the mechanism(s) through which Obstructive Sleep Apnea/Hypopnea (OSAH) promotes abnormal metabolic processes which characterize the metabolic syndrome.
- Trial name
- NCT00177892
- Testing
- sleep disruption, sleep with and without positive pressure
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Snoring, Sleep Fragmentation
Improving Sleep Quality During Pregnancy Using an Oral Appliance
Many pregnant women suffer from poor sleep quality and snoring. Evidence shows an increasing association between (1) sleep disordered breathing and (2) maternal cardiovascular disease and in-hospital death.
- Trial name
- PREGNCCT (NCT03646214)
- Testing
- Midline traction oral appliance
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Texas A&M University