Clinical trials: Sleep Disorders, Circadian Rhythm
Eveningness, Insomnia
Digital Insomnia and Circadian Therapy for Reducing Depression Symptoms in College Students
Depression is a leading cause of global disease burden, poor quality of life, disability and suicide, and commonly occurs in adolescence and early adulthood.
- Conditions
- Eveningness, Insomnia, Circadian Rhythm, Depressed Mood
- Trial name
- NCT07677930
- Testing
- digital cognitive behavioral therapy for insomnia and digital circadian intervention, digital cognitive behavioral therapy for insomnia, digital health education
- Volunteers
- 195 people
- Sponsor
- Chinese University of Hong Kong
Stroke, Sleep
Personalised Sleep and Circadian Intervention After Stroke
This is a two-arm, parallel-group randomized controlled feasibility trial involving 40 community-dwelling adults with chronic stroke and ongoing sleep or circadian difficulties.
- Trial name
- NCT07731516
- Testing
- ISleepFAST, Stroke and Sleep Health Education
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- The Hong Kong Polytechnic University
Shift Work Type Circadian Rhythm Sleep Disorder, Diabetes Mellitus, Type 2
Shift Work, Heredity, Insulin, and Food Timing Study
The purpose of this study is to determine whether night time eating that coincides with elevated endogenous melatonin impairs glucose tolerance, particularly in carriers of the MTNR1B risk allele.
- Conditions
- Shift Work Type Circadian Rhythm Sleep Disorder, Diabetes Mellitus, Type 2, Circadian Rhythm Sleep Disorder, Shift Work Type, Insulin Resistance
- Trial name
- SHIFT (NCT02997319)
- Where
- United States
- Volunteers
- 365 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Stress Disorders, Stress
Measuring the Effectiveness of Forest Therapy to Alleviate Stress Among International Students
International students often face high levels of stress, leading to mental health conditions, from factors including cultural and social change, educational system, financial insecurity and family responsibilities.
- Conditions
- Stress Disorders, Stress, Anxiety, Anxiety Depression (Mild or Not Persistent)
- Trial name
- FTIS-2024 (NCT06792656)
- Testing
- standardized Forest Therapy session (120 min)
- Where
- Australia
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- International Nature and Forest Therapy Alliance
Glaucoma, Sleep Disturbance
Effects of Melatonin Supplementation on Sleep Quality in Patients With Advanced Glaucoma
A prospective, randomized, parallel, crossover, double-blind therapeutic clinical trial was conducted in accordance with the principles of the Resolution nº 466/12 of the National Health Council and was approved by the Ethics and…
- Conditions
- Glaucoma, Sleep Disturbance, Circadian Rhythm, Melatonin
- Trial name
- NCT06868745
- Testing
- Experimental: melatonin treatment group
- Where
- Brazil
- Volunteers
- 64 people
- Sponsor
- University of Sao Paulo
Narcolepsy, Sleep Apnea, Obstructive
Armodafinil (CEP-10953) for Treatment of Narcolepsy, Obstructive Sleep Apnea/Hypopnea Syndrome, or Chronic Shift Work Sleep Disorder
The primary objective of this study is to evaluate the safety and tolerability of Armodafinil (CEP-10953) administered on a flexible-dosage regimen of 100 to 250 mg/day for up to 12 months to patients with excessive sleepiness…
- Conditions
- Narcolepsy, Sleep Apnea, Obstructive, Sleep Apnea Syndromes, Shift-Work Sleep Disorder
- Trial name
- NCT00078312
- Testing
- CEP-10953 (Armodafinil)
- Where
- 50 sites in United States, Russia
- Volunteers
- 328 people
- Sponsor
- Cephalon
Mild Cognitive Impairment
Rhythmic Light Therapy for Alzheimer's Disease Patients
The investigator will investigate how light delivering 40 hertz (Hz) affects subjective sleep and cognition in a controlled laboratory study.
- Trial name
- NCT05015478
- Testing
- Tailored Rhythmic Lighting Intervention
- Where
- 2 sites in United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Seasonal Affective Disorder
Ramelteon in the Treatment of Sleep and Mood in Patients With Seasonal Affective Disorder
The purpose of this study is to determine whether treating sleep difficulties in patients with seasonal affective disorder also improves their depressive symptoms.
- Trial name
- SAM-SAD (NCT00502320)
- Testing
- Ramelteon
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Lehigh Valley Hospital
Ischemic Stroke, Acute, Sleep Disorders, Circadian Rhythm
The Role of Circadian Factors in Regulation of Neuroplasticity in Ischemic Stroke (Interventional)
There is a lack of complex studies which could establish the association between genetic circadian factors with the features and short-term outcomes of ischemic stroke, as well as the effects of various auxiliary therapies for…
- Trial name
- NCT05247125
- Testing
- Blue light exposure + Melatonin treatment, Melatonin treatment, Blue light exposure
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Pain, Back, Pain, Acute
Relieving Pain and Improving Sleep: Evaluating Topical Pain Relief and Sleep Patches
This minimal risk, randomized, double-blind, placebo controlled Institutional Review Board (IRB)-approved study with functional measurements, will evaluate pain relief and sleep improvement after use of a drug- free, non-invasive…
- Conditions
- Pain, Back, Pain, Acute, Sleep Disorder, Sleep Disorders, Circadian Rhythm
- Trial name
- RESTORE (NCT06505005)
- Testing
- Drug- free, non-invasive patch (FREEDOM or REM Patch) with haptic vibrotactile trigger technology (VTT) Other Names:
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- SuperPatch Limited LLC
Alzheimer Disease
Wearables-and Blood-based Biomarkers-incorporated Modernisation of Circadian Rhythm Disruption Management in People Living With Alzheimer's Dementia: A Stepwise Study From Digital Inclusivity, Digital Therapy, to Digital Phenotyping and Biomarker Exploration
By 2025, Taiwan will become a super-aged society, with the number of Alzheimer's disease patients continuing to rise. However, the vast majority of dementia patients experience "behavioral and psychological symptoms of dementia"…
- Trial name
- NCT07222449
- Testing
- Photobiomodulation
- Where
- Taiwan
- Volunteers
- 162 people
- Sponsor
- China Medical University Hospital
Obstructive Sleep Apnea
Circadian Intraocular Pressure Patterns in Patients With Sleep Apnea Syndrome and Treatment With Continuous Air Pressure
The purpose of this study is to evaluate the influence of sleep apnea-hypopnea syndrome (SAHS) syndrome and treatment with continuous air pressure (CPAP) on the circadian intraocular pressure (IOP) patterns and its structural…
- Trial name
- NCT06152692
- Testing
- Continuous positive airway pressure
- Where
- Spain
- Volunteers
- 111 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Nocturnal Enuresis
The Effect of Melatonin on Nocturnal Enuresis
Aim: To investigate the effect of melatonin in bedwetting.
- Trial name
- NCT01575678
- Testing
- Melatonin, Lactose
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- University of Aarhus
Shift Work Type Circadian Rhythm Sleep Disorder
The Influence of Nocturnal Food Intake in Eating Behavior of Night Workers
This study aimed to verify the influence of night work and food intake during the night shift on the eating behavior of fixed night workers the next day.
- Trial name
- NCT03800732
- Testing
- With Meal during night work, Without Meal during night work, Sleep night
- Where
- Brazil
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Federal University of Uberlandia
Infant Sleep Problem
The Role of Circadian Rhythm in the Effect of Sleep Intervention on Obesity Prevention in Early Childhood
Over the last 40 years, obesity has increased dramatically among all age groups, especially in infants and young children, and became an important global public health challenge, thus early prevention is the highest priority.
- Trial name
- NCT05159141
- Testing
- Behavioral sleep intervention
- Where
- China
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Cataract, Sleep
The Effect of Cataract Surgery on Sleep Quality
A cataract is a clouding of the crystalline lens inside the eye, which leads to a decrease in vision. It is the most prevalent, treatable cause of visual impairment and blindness in the world.
- Trial name
- NCT02593669
- Testing
- Phacomulsification lens removal cataract surgery with neutral Intraocular lens(IOL) implantation, Phacomulsification lens removal cataract surgery with blue-blocking Intraocular lens(IOL) implantation, Subconjunctival dexamethasone and general anesthesia
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Sun Yat-sen University
Physiological Stress, Cognitive Dysfunction
DEEPTIME: Human Adaptation in Time Underground Isolation
The objectives of this scientific expedition are: a/ Evaluation of temporal cognitive perception and collective synchronization in a temporally anomalous universe (underground environment), b/ Influence of group living on the…
- Conditions
- Physiological Stress, Cognitive Dysfunction, Sleep
- Trial name
- DEEPTIME (NCT05603780)
- Testing
- exploratory protocol
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Fatigue, Shift Work Type Circadian Rhythm Sleep Disorder
Does Fatigue Coaching Improve Functioning and Fatigue in Resident Night Shifts
Emergency Medicine (EM) requires 24/7 staff coverage resulting in healthcare workers' circadian rhythm disruptions that impair clinical and cognitive performance, physical recovery, and contribute to burnout.
- Trial name
- NCT06100809
- Testing
- Personalized coaching, Nutrition handout
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester