Clinical trials: Sleep Deprivation, open to volunteers
Sleep Deprivation
Study on the Mechanism of Central Obesity Induced by Sleep Restriction and the Therapeutic Effect of n-3 Polyunsaturated Fatty Acid: a Randomized, Double-blind, Placebo-controlled Trial (COSPA Study)
This randomized, double-blind, placebo-controlled trial aims to investigate whether n-3 polyunsaturated fatty acid (PUFA) supplementation attenuates abdominal visceral fat accumulation induced by experimental sleep restriction.
- Trial name
- NCT07897097
- Testing
- n-3 PUFA Supplementation, Experimental Sleep Restriction
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Beijing Anzhen Hospital
Physical Activity, Energy Intake
Effects of Acute Sleep Deprivation on Human Behaviours
This study will investigate whether acute sleep deprivation affects appetite, eating behavior, and physical activity in both regular exercisers and physically inactive individuals.
- Conditions
- Physical Activity, Energy Intake, Appetite, Food Choice
- Trial name
- NCT07393607
- Testing
- Normal sleep, Partial sleep deprivation
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National Taiwan Normal University
Lifestyle Factors, Overweight and Obesity
Effect of Sleep Extension on Ceramides in People With Overweight and Obesity
The overall goal is to determine how a sleep extension intervention (increasing time in bed) in individuals who maintain less than 6.5 hours sleep per night affects their plasma ceramides and insulin sensitivity.
- Conditions
- Lifestyle Factors, Overweight and Obesity, Insulin Sensitivity, Eating Habit
- Trial name
- NCT06180837
- Testing
- Sleep Extension Intervention
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Utah
ICU Hospitalization, Circadian Rhythm
Sleep and Circadian Rhythm Intervention in ICU
Intensive care unit (ICU) patients are frequently exposed to various stressors that contribute to severe sleep disruption and circadian rhythm disturbances.
- Conditions
- ICU Hospitalization, Circadian Rhythm, Sleep Deprivation
- Trial name
- NCT07869901
- Testing
- Sound and Light Optimization, Night-time Patient Care Activities, Enhanced Daytime Mobility
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Shanghai Zhongshan Hospital
Sleep Deprivation, Circadian Rhythm
Circadian Rhythms and Time Perception in Healthy Adults During Constant Wakefulness
This study examines how the internal body clock (circadian rhythms) influences the way healthy adults experience time, think, and feel when they stay awake for an extended period.
- Conditions
- Sleep Deprivation, Circadian Rhythm, Healthy Volunteers, Time Perception
- Trial name
- CircaTime (NCT07294781)
- Testing
- Constant Routine Wakefulness
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Sleep Apnea, Insomnia
Adult Sleep Health in the Rural Appalachia and Mississippi Delta Region and Its Relationships With Cardiometabolic Health Disparities.
Rural communities in the southern U.S. suffer a disproportionate burden of morbidity and mortality from cardiometabolic disease, with traditional risk factors explaining only a modest proportion of the excess burden of disease.
- Conditions
- Sleep Apnea, Insomnia, Sleep Deprivation, Sleep Disorders, Circadian Rhythm
- Trial name
- NCT06336525
- Where
- United States
- Volunteers
- 3,680 people
- Sponsor
- Brigham and Women's Hospital
Sleep Deprivation, Cold Exposure
Modafinil to Optimize the Performance of Cold-Stressed Sleep-Deprived Personnel
Environmental and workplace stressors are common and often unavoidable in military operations. Two critical stressors are cold stress and sleep loss. They both can substantially degrade operational effectiveness.
- Trial name
- NCT07830056
- Testing
- Modafinil (M), 200 mg Microcrystalline Cellulose
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Sleep, Insomnia
The Effect of Sleep Loss on Emotion Regulation
The study is designed to investigate the impact of three nights of sleep restricted to 4 hours per night, on the processing and regulation of emotional information compared to Insomnia Disorder and control.
- Conditions
- Sleep, Insomnia, Sleep Deprivation
- Trial name
- NCT05393830
- Testing
- Sleep Restriction
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
ICU, Sleep Deprivation
Evolution of Sleep in Intensive Care Unit Patients
Sleep plays a key role in immune, metabolic, and neurological regulation, particularly in critically ill patients. However, the intensive care environment significantly disrupts sleep due to noise, light exposure, and frequent…
- Trial name
- SOMNOREA (NCT07867912)
- Testing
- Sleep monitoring using Sleepscan®, Actigraphy
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Chronic Insomnia
Restorative Effects of Sleep on Everyday Health and Wellbeing: A Treatment Study
The purpose of this study is to evaluate the mechanisms through which Cognitive Behavioral Therapy for Insomnia (CBT-I) leads to improvements in sleep and sleep-related daytime outcomes, specifically as it relates to cortisol and…
- Trial name
- RESET (NCT07156383)
- Testing
- Cognitive Behavioral Therapy for Insomnia
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- University of Notre Dame
Histamine, Cowhage
Investigation of the Effects of Sleep Fragmentation on Itch and Pain Sensitivity
In This experiment, the investigators would like to test following hypotheses regarding the influence of sleep fragmentation on itch: To investigate similarity and differences between itch and pain by comparing the effect of…
- Conditions
- Histamine, Cowhage, Sleep Fragmentation
- Trial name
- NCT06081946
- Testing
- Histamine, Cowhage
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Chronic Insomnia, Sleep Deprivation
Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia
This clinical trial aims to evaluate the safety and efficacy of PROSOMNIA Sleep Therapy (PSTx) for individuals suffering from chronic insomnia, sleep deprivation, and REM sleep disorders.
- Conditions
- Chronic Insomnia, Sleep Deprivation, REM Behavior Disorder, REM Sleep Behavior Disorder
- Trial name
- PSHW (NCT06644573)
- Testing
- PROSOMNIA Sleep Therapy™ (PSTx), Anesthesia-Induced Sleep Therapy, Diprivan (propofol), Astra-Zeneca
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nyree Penn
Stroke, Sleep-disordered Breathing
Apnea, Stroke and Incident Cardiovascular Events
This prospective cohort study aims to compare the proportion of cardiac or cerebrovascular events after a first stroke, a first transient ischemic attack (TIA) or recurrent TIA, between sleep-disordered breathing (SDB) and…
- Conditions
- Stroke, Sleep-disordered Breathing, Sleep Apnea Syndromes, Sleep Apnea, Obstructive
- Trial name
- ASCENT (NCT04399200)
- Testing
- Treatment according to standard care recommandation
- Where
- France
- Volunteers
- 1,620 people
- Sponsor
- University Hospital, Grenoble
Sleep Deprivation
Cardiovascular Risk and Circadian Misalignment in Short Sleepers - Role of Extended Eating Period
Short sleep duration confers high cardiovascular and metabolic risk, but lifestyle factors and molecular mechanisms that contribute to increased blood pressure and poor glucose control during short sleep are not completely…
- Trial name
- CRISP (NCT06070194)
- Testing
- Time restricted eating (TRE)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Suicidal Ideation, Circadian Rhythm Disorders
Mind After Midnight
This study examines whether wakefulness during the biological night (2:00-4:00 AM) is associated with increased negative mood, impaired decision-making, and suicidal thoughts.
- Conditions
- Suicidal Ideation, Circadian Rhythm Disorders, Sleep Deprivation, Sleep Wake Disorders
- Trial name
- MaM (NCT07438912)
- Testing
- Sleep Pressure Manipulation
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Arizona