Clinical trials: Skin Pigmentation
Vitiligo Vulgaris
Ginkgo Biloba for the Treatment of Vitiligo Vulgaris in Adolescents
Vitiligo is a common hypopigmentation disorder with significant psychological impact if occurring before adulthood. One study investigating the use of Ginkgo biloba for the treatment of vitiligo in adults reports effectiveness…
- Trial name
- NCT00907062
- Testing
- Ginkgo biloba
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Pulmonary Fibrosis, Healthy Volunteers
Analysis of Specimens From Individuals With Pulmonary Fibrosis
The etiology of pulmonary fibrosis is unknown. Analyses of blood, genomic DNA, and specimens procured by bronchoscopy, lung biopsy, lung transplantation, clinically-indicated extra-pulmonary biopsies, or post-mortem examination…
- Conditions
- Pulmonary Fibrosis, Healthy Volunteers, Hermansky-Pudlak Syndrome (HPS)
- Trial name
- NCT00084305
- Where
- United States
- Volunteers
- 315 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Vitiligo
Human Beta-defensin 1 in Vitiligo
There is a need to know the role of human beta defensin-1 in vitiligo pathogenesis and the probability of finding newer and effective therapy for vitiligo in the future.
- Trial name
- NCT03832751
- Testing
- skin biopsy before and after NB-UVB phototherapy
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Cairo University
Skin Wrinkling
A Study to Validate Cosmetic Outcome Scales Used to Rate Uneven Skin Color and Wrinkling
Skin chronically exposed to the sun may become damaged and then develop wrinkles and/or uneven skin color. The purpose of this research study is to evaluate a newly developed scale (grading tool) that rates wrinkles and uneven…
- Trial name
- NCT00114673
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Graceway Pharmaceuticals, LLC
Vitiligo
Comparative Efficacy of hUCMSC-Secretome Delivered Via Microneedling and Intradermal Microinjection as Adjuvant Therapy to NB-UVB in Nonsegmental Vitiligo: A Quasi-Experimental Study
The goal of this clinical trial is to analyze the effectiveness of SM-hUCMSC secretome administered via microneedling and intradermal microinjection as adjuvant therapy to NB-UVB, compared with NB-UVB alone, in terms of…
- Trial name
- Vitiligo (NCT07509242)
- Testing
- NB-UVB combined with microneedling and topical 10% secretome, receives NB-UVB combined with intradermal secretome injection, NB-UVB alone
- Where
- Indonesia
- Volunteers
- 150 people
- Sponsor
- Yohanes Firmansyah, dr, MH, MM
Photodamage, Irregular Pigmentation
Comparison of the RevLite Electro-optic Q-Switched Neodymium-doped Yttrium Aluminium Garnet (EO QS Nd:YAG) Laser to a Fractionated Laser System
The purpose of this study is to compare the results of treatment between the side of the face treated with the RevLite Laser and the side of the face treated with a fractionated laser system.
- Conditions
- Photodamage, Irregular Pigmentation, Acne Scars
- Trial name
- NCT00955461
- Testing
- RevLite laser treatment, Fractionated Laser treatment
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- ConBio, a Cynosure Company
Skin Whitening
Role of Oral Glutathione in Skin Whitening
Oral and intravenous glutathione have been used widely to whiten the skin. The investigators tested this hypothesis by giving oral glutathione for 4 weeks to medical students.
- Trial name
- NCT01016080
- Testing
- glutathione
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Chulalongkorn University
Hyperpigmentation
Fractionated 1927nm Laser for Hyperpigmentation in Fitzpatrick Skin Phototypes V and VI
The primary objective of this study is to assess the efficacy of 1927nm non-ablative fractionated laser therapy to treat hyperpigmentation in patients ages 18-75 with Fitzpatrick Skin Phototypes V and VI and explore an effective…
- Trial name
- NCT05493280
- Testing
- MOXI
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Vitiligo
Clinical Study to Investigate the Safety and Effectiveness of RECELL for Repigmentation of Stable Vitiligo Lesions
This is a prospective blinded within-subject randomized study to evaluate the application of Spray-On Skin™ Cells, prepared using the RECELL® Device for safe and effective repigmentation of ablated stable vitiligo lesions.
- Trial name
- NCT04547998
- Testing
- Control Intervention (UVB), Investigational Interventions (Ablative Laser Resurfacing + RECELL + UVB)
- Where
- 12 sites in United States
- Volunteers
- 25 people
- Sponsor
- Avita Medical
Ocular Albinism (OA), Oculocutaneous Albinism (OCA)
The Effects of Lutein and Zeaxanthin Supplementation on Vision in Patients With Albinism
The LUVIA study is a randomized placebo-controlled trial designed to investigate the effects of lutein and zeaxanthin supplementation on macular pigment and visual function in ocular or oculocutaneous albinism.
- Trial name
- LUVIA (NCT02200263)
- Testing
- Lutein plus Zeaxanthin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Johns Hopkins University
Gingival Hyperpigmentation, Oral Pigmentation
Comparison of Er-YAG Laser, Air Polishing, and Surgical Excision for Gingival Hyperpigmentation
This randomized controlled clinical trial aimed to compare the effectiveness of different treatment approaches for physiologic gingival hyperpigmentation.
- Trial name
- APGH (NCT07672587)
- Testing
- Er:YAG Laser Therapy, Air Polishing with Erythritol Powder, Air Polishing with Sodium Bicarbonate Powder
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Vitiligo
Comparison of Surgical Methods on Resistant Sites in Stable Vitiligo Patients
Comparing the Efficacy of Three Different Surgical Methods on Resistant Sites in Stable Vitiligo.
- Trial name
- NCT03717025
- Testing
- SUCTION BLISTER EPIDERMAL GRAFTING, MINI PUNCH GRAFTING, NON CULTURED EPIDERMAL CELL SUSPENSION
- Where
- India
- Volunteers
- 20 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Hyperpigmentation, Dark Spots
A Clinical Study to Assess the Effects of a Dark Spot Corrector on Dark Spots and Overall Complexion
This is a single-group, open-label, 90-day clinical study to assess the effectiveness of the Dark Spot Corrector by DIME Beauty on reducing the visibility of dark spots and improving overall complexion in females aged 50-65.
- Conditions
- Hyperpigmentation, Dark Spots, Skin Complexion
- Trial name
- NCT07900217
- Testing
- Dark Spot Corrector Group
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Dime Beauty Co.
Vitiligo
Vitiligo and the Koebner Phenomenon (Model of Vitiligo Induction and Therapy: a Clinical and Immunological Analysis)
We will investigate the process of vitiligo induction and the influence of different commonly used cream treatments on this process.
- Trial name
- Koebner (NCT01082393)
- Testing
- topical tacrolimus treatment, topical pimecrolimus treatment, local mometasone furoate treatment
- Where
- Belgium
- Volunteers
- 14 people
- Sponsor
- University Hospital, Ghent
Melasma
Comparison of Topical Silymarin With Hydroquinone in the Treatment of Melasma
A randomized clinical trial will be done on 92 patients , randomly divided into two groups by lottery method to compare the efficacy and safety of topical silymarin cream 0.7% with topical 4% hydroquinone cream.
- Trial name
- NCT03982849
- Testing
- Hydroquinone 4% Cream, silymarin 0.7% cream
- Where
- Pakistan
- Volunteers
- 92 people
- Sponsor
- Islamabad Medical and Dental College
Melasma
Oral Tranexamic Acid and Topical Hydroquinone in the Treatment of Melasma
This study assess the effectiveness of oral tranexamic acid in combination with hydroquinone cream in the treatment of melasma.
- Trial name
- NCT03751163
- Testing
- Tranexamic Acid Oral Product, Hydroquinone 4% Cream, Sunscreen
- Volunteers
- 50 people
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Postinflammatory Hyperpigmentation
Straberi Epistamp Device for Postinflammatory Hyperpigmentation
This pilot study will expand knowledge and application needling using the Straberi device for the improvement of Postinflammatory Hyperpigmentation (PIH) caused by acne.
- Trial name
- EPH (NCT04740255)
- Testing
- Straberi Epistamp
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universal Skincare Institute
Acanthosis Nigricans
Study of the Effect of Fractional co2 Laser Versus Q Switched:NdYAG Laser in the Treatment of Acanthosis Nigricans
This prospective randomized comparative split study will be conducted at the outpatient clinic, Dermatology department, Faculty of Medicine, Cairo University and will include 20 patients with acanthosis nigricans in otherwise…
- Trial name
- NCT04893304
- Testing
- co2 laser
- Volunteers
- 20 people
- Sponsor
- Cairo University
Hyperpigmentation
Randomized and Open Label Study for Safety and Efficacy of DBI-102 vs. Vehicle vs. Hydroquinone on Skin Pigmentation and Lentigos
This is a randomized, observer-blinded, vehicle-controlled multi-dose trial that examines the effect of twice daily application of 0.8% DBI-102 Gel, 4% Hydroquinone cream, and Vehicle Gel for 12 weeks in adults with Fitzpatrick…
- Trial name
- NCT05511948
- Testing
- DBI-102, Vehicle gel, Hydroquinone Cream
- Where
- El Salvador
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- DermBiont, Inc.
Aging
The Effectiveness of Epidermal Growth Factor Serum in Improve Facial Skin Hydration, Elasticity, Pigmentation, and Wrinkles.
EGF is a polypeptide that promotes cell differentiation and collagen production while decreasing melanin production. This study is designed to study its effectiveness in improving the texture and appearance of facial skin after…
- Trial name
- NCT05724589
- Testing
- Epidermal Growth Factor
- Where
- Thailand
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Institute of Dermatology, Thailand