Clinical trials: Skin Pigment
Hyperpigmentation
Randomized and Open Label Study for Safety and Efficacy of DBI-102 vs. Vehicle vs. Hydroquinone on Skin Pigmentation and Lentigos
This is a randomized, observer-blinded, vehicle-controlled multi-dose trial that examines the effect of twice daily application of 0.8% DBI-102 Gel, 4% Hydroquinone cream, and Vehicle Gel for 12 weeks in adults with Fitzpatrick…
- Trial name
- NCT05511948
- Testing
- DBI-102, Vehicle gel, Hydroquinone Cream
- Where
- El Salvador
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- DermBiont, Inc.
Mastocytosis
Mast Cell Connect: A Registry for Patients With Mastocytosis
The Mast Cell Connect Registry is a voluntary, observational database that will capture demographic, socioeconomic, and disease information directly from patients with mastocytosis via a secure web-based tool.
- Trial name
- NCT02620254
- Where
- United States
- Volunteers
- 743 people
- Sponsor
- Blueprint Medicines Corporation
Facial Hyperpigmentation
Open-label, Single-arm, Proof of Concept Study in Subjects with Mild-to-moderate Facial Hyperpigmentation
This research study will test how well hyperpigmentation treatment works for subjects with mild-to-moderate facial hyperpigmentation. The study will also test if the hyperpigmentation treatment causes any irritation.
- Trial name
- K-BRIGHT (NCT06473974)
- Testing
- Test cosmetic product
- Where
- 2 sites in United States
- Sponsor
- Kayuraeffect, LLP
Vitiligo
Feasibility Study to Evaluate RECELL and Melanocyte Keratinocyte Transplantation Procedure for Repigmentation of Stable Vitiligo Lesions
Prospective randomized within-subject controlled feasibility study to evaluate the clinical performance of RECELL for repigmentation of stable, depigmented lesions.
- Trial name
- NCT04271501
- Testing
- Melanocyte-Keratinocyte Transplantation and Ultraviolet Lamp (UVB), RECELL 1:5 and Ultraviolet Lamp (UVB), RECELL 1:10 and Ultraviolet Lamp (UVB)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Avita Medical
Acne
A Clinical Trial to Evaluate the Effectiveness of an Acne Serum in Improving Facial Acne and Post-Acne Pigmentation
This study will evaluate the efficacy of the Rael Miracle Clear Complete Acne Serum product in improving facial acne and post-acne pigmentation. This study will last for 56 days.
- Trial name
- NCT06120452
- Testing
- Rael Miracle Clear Complete Acne Serum
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rael
Alopecia Areata, Vitiligo
A Pilot Cohort Study of Risk Factors and Novel Methods of Skin Lesion Assessments in Adults With Atopic Dermatitis, Alopecia Areata, Psoriasis or Vitiligo
The objective of the study is to explore various clinical and biochemical parameters and their potential associations with disease severity, activity, and prognosis in atopic dermatitis, psoriasis, alopecia areata, and vitiligo.
- Conditions
- Alopecia Areata, Vitiligo, Atopic Dermatitis, Psoriasis
- Trial name
- Derma-001 (NCT06319781)
- Testing
- Observational
- Where
- 3 sites in Denmark
- Volunteers
- 370 people
- Sponsor
- Blueskin AS
Alopecia Areata, Vitiligo
A Study of DR-01 in Subjects With Alopecia Areata and Vitiligo
This is a multi-center, parallel-group, open-label, randomized, Phase 1b study to explore the safety, clinical activity, pharmacokinetics and pharmacodynamics of DR-01 in adults with Alopecia Areata or Vitiligo.
- Trial name
- NCT06602232
- Testing
- DR-01
- Where
- 20 sites in United States, Australia and 1 more
- Volunteers
- 81 people
- Sponsor
- Dren Bio
Vitiligo
A Clinical Trial of Multiple Doses of GR2301 Injection Combined With Phototherapy in Trial Participants With Vitiligo
This is a randomized, double-blind, placebo-controlled Phase Ib/II clinical trial of multiple subcutaneous injections of GR2301 in combination with phototherapy to evaluate the tolerability, safety, pharmacokinetics, and…
- Trial name
- GREVIT (NCT07647237)
- Testing
- GR2301 injection
- Volunteers
- 116 people
- Sponsor
- Genrix (Shanghai) Biopharmaceutical Co., Ltd.
Actinic Keratosis
Study to Determine the Safety of Two Applications of PEP005 Topical Gel to Actinic Keratoses
The purpose of this study is to determine whether topical application of PEP005 is safe for the treatment of actinic keratoses.
- Trial name
- NCT00107965
- Testing
- PEP005
- Where
- 6 sites in Australia
- Volunteers
- 60 people
- Sponsor
- Peplin
Vital Signs, Oxygen Saturation
Validation of Vital Signs Recording With VT-Patch Connected Devices in Children
: Patient readmission to PICU is a major point of concern for physicians because, although being a rare event, it has been strongly associated with more morbidity and death.
- Conditions
- Vital Signs, Oxygen Saturation, Children, Intensive Care Unit
- Trial name
- VT (NCT05451875)
- Testing
- Non-invasive monitoring
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- VitalTracer Ltd.
Pigment; Lesion, Lesion; Vascular
Image Data Collection of Tanned Skin During Phototherapy Treatment Using a Multi-spectral Camera
This is a prospective, observational, single-center, image collection study. Any patient who arrived at the phototherapy clinic for the first time, regardless of this study, and is prescribed a total of 30 treatments can be…
- Trial name
- NCT05692544
- Testing
- Phototherapy treatment
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Lumenis Be Ltd.
Fine Lines, Contour
Evaluation of the Efficacy of a Cosmetic Light Mask
The present study evaluated facial skin health over a 12-week period using an at-home device that provides 12 minutes of LED light and vibration once daily, six days a week.
- Conditions
- Fine Lines, Contour, Sagging Skin, Dark Spots
- Trial name
- NCT07054710
- Testing
- LED Light Treatment, Vibration Only
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- Therabody, Inc.
Vitiligo
Afamelanotide and Narrow-Band Ultraviolet B (NB-UVB) Light in the Treatment of Nonsegmental Vitiligo (NSV)
The purpose of this study is to look at the efficacy of afamelanotide, when combined with narrow-band ultraviolet B (NB-UVB) light, in patients with nonsegmental vitiligo.
- Trial name
- CUV102 (NCT01430195)
- Testing
- Afamelanotide, Narrow-Band UVB Light Treatment
- Where
- 2 sites in United States
- Volunteers
- 56 people
- Sponsor
- Clinuvel Pharmaceuticals Limited
Melanoma
Post-Approval Study of MelaFind
The purpose of this study is to collect data to describe the real-world use and safety and effectiveness of MelaFind® in a post-approval clinical setting.
- Trial name
- NCT01700114
- Testing
- MelaFind
- Where
- 6 sites in United States
- Volunteers
- 487 people, healthy volunteers welcome
- Sponsor
- MELA Sciences, Inc.
Benign Pigmented Lesions
Picosecond Laser for Ttreatment of Benign Pigmented Lesions
The purpose of this study is to determine whether Pico laser is effective and safe in the treatment of benign pigmented lesions.
- Trial name
- NCT02146820
- Testing
- GentleMax system
- Where
- 2 sites in United States, China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Syneron Medical
Acne, Postinflammatory Hyperpigmentation
A Combination Treatment Reduces Acne Severity and PIHP
Acne is a chronic, inflammatory skin condition. It may cause scars and post-inflammatory hyperpigmentation (PIHP). PIHP frequently affects individuals with a phototype of IV or above.[1] PIHP is worsened by UV radiation, lasts…
- Trial name
- NCT05601960
- Testing
- anti-acne dermocosmetic
- Where
- United Arab Emirates
- Volunteers
- 1,785 people
- Sponsor
- Cosmetique Active International
Vitiligo
A Study to Assess the Changes in Pigmentation and Safety of Afamelanotide in Patients With Vitiligo on the Face
The CUV104 study will assess the efficacy and safety of afamelanotide in patients with vitiligo on the face and body as a monotherapy in repigmentation.
- Trial name
- NCT05210582
- Testing
- Afamelanotide
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Clinuvel, Inc.
Melasma
Anti-pigmenting Effect of a Routine of Facial Products in Subjects With Melasma
This 6 month, comparative study assesses the benefit of a dermocosmetic regimen (Serum B3 + B3 retinol night cream) for 6 months compared to hydroquinone 4% (the gold standard in hyperpigmentation) followed by the dermocosmetic…
- Trial name
- NCT06516224
- Testing
- Liftactiv® B3 Serum, Liftactiv® B3 retinol night cream, Sunscreen UVAage® Inter SPF 50+
- Where
- Brazil
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Vitiligo, Non-Segmental Vitiligo (NSV)
Study of D-2570 in Subjects With Non-Segmental Vitiligo
This study tests D-2570, an investigational drug, in people with non-segmental vitiligo to check its safety and effect on skin discoloration.
- Trial name
- D2570-206 (NCT07625891)
- Testing
- D-2570 Dose 1, D-2570 Dose 2, D-2570 Dose 3
- Where
- China
- Volunteers
- 160 people
- Sponsor
- InventisBio Co., Ltd
Melasma
Randomized Study Using SM-030 Gel for Adults With Melasma
Brief Summary This is a phase 2b, observer-blinded, randomized study that will evaluate the safety and efficacy of topically applied SM-030 gel 0.64% and SM-030 gel 0.08% compared against placebo gel in healthy adult male and…
- Trial name
- NCT06454747
- Testing
- SM-030 gel 0.64%, SM-030 gel 0.08%
- Where
- 2 sites in El Salvador
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- DermBiont, Inc.