Clinical trials: Skin Condition
Leishmaniasis, Cutaneous Leishmaniasis
Intralesional Antimony for Bolivian Cutaneous Leishmaniasis
Intralesional injection of antimony has been used for L major from Iran with a modest cure rate [56%: Asilian 2004]. However, this therapeutic approach has been used for L braziliensis from Brazil, with an attractive cure rate…
- Trial name
- NCT01300975
- Testing
- pentavalent antimony, cryotherapy
- Where
- 2 sites in Bolivia
- Volunteers
- 90 people
- Sponsor
- Fundacion Nacional de Dermatologia
Chemo-refractory Melanoma
Trial of Single Agent Sunitinib for Patients With Chemo-refractory Metastatic Melanoma
Sunitinib is a novel small molecule receptor tyrosine kinase inhibitor with direct antitumor effects as well as antiangiogenetic activity.
- Trial name
- NCT01216657
- Testing
- Sunitinib
- Where
- Germany
- Volunteers
- 7 people
- Sponsor
- Krankenhaus Nordwest
Melanoma
A Study of YM155 Plus Docetaxel in Subjects With Stage III (Unresectable) or Stage IV Melanoma
The purpose of the study is to evaluate survival, response rate, safety and tolerability of YM155 given in combination with docetaxel in subjects with Stage III (unresectable) and Stage IV melanoma.
- Trial name
- NCT01009775
- Testing
- YM155, Docetaxel
- Where
- 13 sites in United States, Canada
- Volunteers
- 64 people
- Sponsor
- Astellas Pharma Inc
Myositis, Dermatomyositis
Study of Deucravacitinib for Refractory Adults With Dermatomyositis/Juvenile Dermatomyositis
Background: Dermatomyositis (DM) and juvenile dermatomyositis (JDM) are diseases that weaken the immune system. DM and JDM can affect the muscles, skin, joints, and lungs and cause skin rashes and muscle inflammation.
- Trial name
- NCT07012057
- Testing
- Deucravacitinb
- Where
- United States
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Breast Cancer, Cardiovascular Diseases
Cardiac Rehabilitation for Breast Cancer Survivors
Women with breast cancer treated using anthracyclines and/or trastuzumab are at an increased risk of cardiovascular disease (CVD) following treatment completion.
- Trial name
- NCT06251401
- Testing
- In-person supervised cardiac rehabilitation, Virtual cardiac rehabilitation
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Women's College Hospital
Systemic Lupus Erythematosus (SLE), Sjogren's Syndrome
Anti-CD19-CD3E-CAR-T Cells in Relapsed/Refractory Autoimmune Disease
This is an investigator-initiated trial to evaluate the safety and efficacy of anti-CD19-CD3E-CAR-T cells in the relapse or refractory autoimmune diseases.
- Conditions
- Systemic Lupus Erythematosus (SLE), Sjogren's Syndrome, Systemic Sclerosis, Inflammatory Myopathy
- Trial name
- NCT06373081
- Testing
- Anti-CD19-CD3E-CAR-T cells
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Shanghai Changzheng Hospital
Advanced Solid Tumors, HER2 Mutation
A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)
Researchers are looking for a better way to treat people who have solid tumors with HER2-activating mutations. Before a treatment can be approved for people to take, researchers do clinical trials to better understand its safety…
- Trial name
- panSOHO (NCT06760819)
- Testing
- BAY2927088
- Where
- 54 sites in United States, Australia and 9 more
- Volunteers
- 111 people
- Sponsor
- Bayer
Diabetic Foot
Role of Adiponectine in Pathophysiology Ogf Diabetic Foot
Diabetic patients with a history of diabetic foot are considered to be a high-risk population for increased cardiovascular and all-cause mortality (1,2,3,).
- Trial name
- NCT03150901
- Testing
- no drug
- Volunteers
- 70 people
- Sponsor
- Wolfson Medical Center
Rheumatoid Arthritis, Periodontal Disease
Periodontal Inflammation and Immunity in Preclinical Rheumatoid Arthritis
The purpose of this study is to evaluate the association of Rheumatoid Arthritis (RA)-related antibodies and periodontal inflammation in subjects at-risk for Rheumatoid Arthritis.
- Trial name
- NCT02794012
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Purpura, Thrombocytopenic, Idiopathic, Immune Thrombocytopenic Purpura
An Epidemiological Study of Subjects With Immune Thrombocytopenic Purpura to Evaluate the Relationship Between Platelet Counts, Endogenous Thrombopoietin Levels, Endogenous Anti-Thrombopoietin Antibodies, and Selected Autoimmune Markers
This study involves the collection of blood samples from patients with immune thrombocytopenic purpura (ITP) to evaluate the relationship between platelet counts, blood levels of a hormone called thrombopoietin that controls…
- Trial name
- NCT00005570
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Acute Steroid Responsive Dermatoses, Chronic Steroid Responsive Dermatoses
An Investigator-Initiated Study to Assess the Cooling Effect of Triamcinolone Acetonide Aerosol When Used for Steroid-Responsive Dermatoses
Triamcinolone acetonide is a mid-potency, class 4/5 topical corticosteroid that is available in a spray formulation (Triamcinolone Acetonide Spray, T Spray).
- Trial name
- NCT01736670
- Testing
- Triamcinolone Acetonide spray, Triamcinolone acetonide cream, Alcohol spray
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Patel, Rita Vikram, M.D.
Cutaneous Mastocytosis, Systemic Mastocytosis
Mastocytosis From Pediatric Age to Adulthood: Local Registry of Cutaneous and Systemic Mastocytosis
Given the renewed focus on mastocytosis (recognized in Italy as a rare disease since 2018) and emerging clinical and immunogenetic knowledge, and considering the rarity of the disease and limited understanding of its progression…
- Trial name
- MaRe (NCT07142473)
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Breast Cancer
EvoLution of Neoadjuvant TreatMent in 'Triple-negative' or 'HER-2-positive' Breast Cancer Diagnosed in the EaRly Phase
The primary objective of this study is to describe the percentage of patients with HER2-positive and Triple Negative tumour underwent neoadjuvant treatment in clinical practice during the past 5 years out of total number of…
- Trial name
- GIM28-ELMER (NCT06894173)
- Where
- 29 sites in Italy
- Volunteers
- 1,000 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Pruritus
Does Indoxyl Sulfate Have a Role in Uremic Pruritus?
Itching is a widespread and disturbing complain from patients with chronic kidney disease (CKD); epidemiologic data have suggested that approximately 40% of patients with end-stage renal disease experience moderate to severe…
- Trial name
- NCT05634083
- Testing
- Uremic pateints with itching
- Where
- 2 sites in Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Benha University
Melanoma, Non-small Sell Lung Cancer (NSCLC)
Phase I/II Study of PDR001 in Patients With Advanced Malignancies
The purpose of this "first-in-human" study of PDR001 was to characterize the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and antitumor activity of PDR001 administered i.v.
- Conditions
- Melanoma, Non-small Sell Lung Cancer (NSCLC), Triple Negative Breast Cancer, Anaplastic Thyroid Cancer
- Trial name
- NCT02404441
- Testing
- PDR001
- Where
- 41 sites in United States, Canada and 12 more
- Volunteers
- 319 people
- Sponsor
- Novartis Pharmaceuticals
Cancer, Breast, Neuropathy
Tango for Neuropathy Among Breast Cancer Survivors
Group dance classes have been found to improve markers of quality of life and physical health (i.e., balance) among some populations engaged in rehabilitation, such as the elderly and individuals with Parkinson Disease.
- Trial name
- NCT05114005
- Testing
- Rhythmic Auditory Stimulation, Evidence-Based Exercise
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Melanoma, Pancreas Cancer
Integration of Whole-Genome Sequencing PrOfiles and ImmuNe StATus in Cancer
The goal of this investigator-initiated tumour profiling study is to analyse the relation between genomic alterations and the tumour immune contexture in patients with advanced melanoma and pancreatic cancer with resistance to…
- Trial name
- SONATA (NCT07796594)
- Testing
- Biopsy
- Where
- Netherlands
- Volunteers
- 180 people
- Sponsor
- Amsterdam UMC, location VUmc
Hirsutism
Facial Hair Reduction Using Intense Pulsed Light (IPL) & Alexandrite Laser
The purpose of this study is to compare the efficacy of the IPL system 650advance handpiece with the alexandrite laser for the purposes of female facial hair reduction
- Trial name
- NCT01461694
- Testing
- Intense Pulsed Light (IPL), Alexandrite Laser
- Where
- United Kingdom
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- NHS Greater Glasgow and Clyde
Melanoma
NG2 and DLL3 CAR-T Cells Targeting Melanoma
The purpose of this study is to assess the feasibility, safety and efficacy of multiple CAR-T cell therapy which targets NG2 and DLL3 surface antigens in patients with relapsed and refractory melanoma.
- Trial name
- NCT07193966
- Testing
- NG2 and DLL3 CAR-T cells
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Thin Hair, Hair Loss
Study to Evaluate Xtresse Serum in Individuals With Thinning Hair
The goal of this study is to determine how safe and effective it is to improve hair growth by applying a serum daily on the scalp of men and women with thinning hair. The main aims of this trial are: 1.
- Conditions
- Thin Hair, Hair Loss, Alopecia, Thinning Hair
- Trial name
- NCT07228156
- Testing
- Xtresse Serum
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Restore Biologics Holdings, Inc. dba Xtressé