Clinical trials: Skin
Healthy
Evaluation of Tetrix Cream in the Healing of Injured Skin in Subjects With Contact Dermatitis
To determine if Tetrix Cream,, when applied to the skin lesions on patients with contact dermatitis, slows or interferes with the healing of the lesions.
- Trial name
- NCT00643214
- Testing
- Tetrix
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Coria Laboratories, Ltd.
Breast Neoplasms, Invasive Breast Cancer
(Z)-Endoxifen for the Treatment of Premenopausal Women With ER+/HER2- Breast Cancer
This open-label research study is studying (Z)-endoxifen as a possible treatment for pre-menopausal women with ER+/HER2- breast cancer.
- Conditions
- Breast Neoplasms, Invasive Breast Cancer, Estrogen-receptor-positive Breast Cancer, HER2-negative Breast Cancer
- Trial name
- EVANGELINE (NCT05607004)
- Testing
- (Z)-endoxifen, goserelin
- Where
- 14 sites in United States
- Volunteers
- 87 people
- Sponsor
- Atossa Therapeutics, Inc.
Breast Carcinoma
Prospective Study of UDP-gluconoryltransferase 2B17 Genotype as a Predictive Marker of Exemestane PK and PD
Aromatase inhibitors have led to significant improvements in clinical outcomes for women with postmenopausal hormone receptor-positive advanced breast cancer.
- Trial name
- NCT01655004
- Testing
- Exemestane
- Where
- Singapore
- Volunteers
- 110 people
- Sponsor
- National University Hospital, Singapore
Psoriasis
Efficacy Study of Dietary Intervention and Weight Loss in Improving Psoriasis
This is a multicenter randomized controlled clinical trial evaluating the impact of a structured non pharmacological intervention consisting in intensive weight reduction (qualitative and quantitative changes in diet associated…
- Trial name
- NCT01714284
- Testing
- Informative, Diet and Exercise
- Where
- 11 sites in Italy
- Volunteers
- 303 people
- Sponsor
- Centro Studi Gised
Gut Microbiome
Effects of Mango or Low-Fat Cookie Consumption on Gut Health, and Its Relationship With Mental, Sexual and Skin Health
The objective of the proposed research is to determine the effects of fresh mango consumption on gut microbiome, and its relationship with skin health, sexual and mental health in relatively healthy adults.
- Trial name
- NCT06800833
- Testing
- Low fat cookies, Mango
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- San Diego State University
PREMATURITY
Skin-to-skin Contact to Promote Bacterial Decolonization in Preterm Infants
BACKGROUND Decolonization with topical antibiotics is necessary to prevent and / or control outbreaks of multidrug-resistant bacterial infection in the NICU (Neonatal Intensive Care Unit), but can trigger bacterial resistance.
- Trial name
- NCT01498133
- Testing
- skin-to skin contact
- Where
- Brazil
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Maranhão
Breast Neoplasms, Fever
A Prospective, Randomized, Phase III Trial of FLAC (5-Fluorouracil, Leucovorin, Adriamycin, Cytoxan) Chemotherapy With GM-CSF (Granulocyte-Macrophage Colony-Stimulating Factor) Versus PIXY 321 in Advanced Breast Cancer
This is a prospective, randomized Phase III trial of FLAC chemotherapy with GM-CSF versus PIXY321 in advanced breast cancer. The primary endpoints of this study will be the duration of thrombocytopenia and the time to recovery of…
- Conditions
- Breast Neoplasms, Fever, Hematologic Diseases, Neutropenia
- Trial name
- NCT00001338
- Testing
- FLAC chemotherapy with GM-CSF
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- National Cancer Institute (NCI)
Advanced Breast Cancer
Study of Zoladex Given Every 12 Weeks Versus Given Every Month in Advanced Breast Cancer (ABC) Pre-menopausal Women
The primary objective is to evaluate whether Zoladex 10.8 mg (12-weekly) is non-inferior to Zoladex 3.6 mg (4-weekly) in pre-menopausal women with oestrogen receptor positive advanced breast cancer by assessment of…
- Trial name
- NCT00322348
- Testing
- Goserelin acetate
- Where
- 14 sites in Czechia, Russia and 1 more
- Volunteers
- 98 people
- Sponsor
- AstraZeneca
Pain
Association With Spinal Needle-puncture Pain and Menstrual Phase
This prospective observational study aimed to evaluate the relationship between menstrual phase cycles and spinal needle-puncture pain during spinal anesthesia in female patients of reproductive age.
- Trial name
- NCT05481255
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Konya Meram State Hospital
Breast Cancer
Primary Paclitaxel Plus Gemcitabine in Patients With Stage II and III Breast Cancer
This is an open labeled phase II single arm trial. The patients with clinical stage II and III will undergo core-needle biopsy of breast tumor for histologic diagnosis, immunohistochemical studies for estrogen receptor (ER)…
- Trial name
- NCT00532285
- Testing
- Paclitaxel/Gemcitabine
- Volunteers
- 44 people
- Sponsor
- National Cancer Center, Korea
Atopic Dermatitis, Psoriasis
Disease Trajectories and Anti-cytokine Response Signatures in Atopic Dermatitis and Psoriasis
The clinical study investigates the long-term course of disease in patients with chronic inflammatory skin diseases (atopic eczema and psoriasis) and the impact of tarheted therapies on the clinical and molecular level.
- Conditions
- Atopic Dermatitis, Psoriasis, Healthy
- Trial name
- DiTrAP (NCT03361215)
- Testing
- Biosampling for molecular analysis
- Where
- Germany
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Hospital Schleswig-Holstein
Psoriasis, Moderate to Severe Plaque Psoriasis
A Study to Compare SB17 (Proposed Ustekinumab Biosimilar) to Stelara® in Subject With Moderate to Severe Plaque Psoriasis
This is a randomised, double-blind, multicentre clinical study to evaluate the efficacy, safety, tolerability, PK, and immunogenicity of SB17 compared to Stelara® in subjects with moderate to severe plaque psoriasis.
- Trial name
- NCT04967508
- Testing
- Stelara® (Ustekinumab), SB17 (Proposed Ustekinumab Biosimilar)
- Where
- 32 sites in Czechia, Estonia and 6 more
- Volunteers
- 503 people
- Sponsor
- Samsung Bioepis Co., Ltd.
Spondyloarthritis, Ankylosing Spondylitis
Monitoring Spondyloarthritis With SpA-Net
Randomized controlled trial to assess the effectiveness and cost-effectiveness of an intervention combining patient initiated care and telemonitoring through the online eHealth platform SpA-Net versus standard care for patients…
- Conditions
- Spondyloarthritis, Ankylosing Spondylitis, Psoriatic Arthritis, Spondyloarthropathy
- Trial name
- TeleSpA (NCT04673825)
- Testing
- Patient initiated care + telemonitoring
- Where
- 2 sites in Netherlands
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Arthritis, Psoriatic
A Study to Test Different Doses of BI 730357 and Find Out Whether They Reduce Symptoms in People With Active Psoriatic Arthritis
This study is open to adults with active psoriatic arthritis who have tender and swollen joints. The purpose of this study is to find out whether a medicine called BI 730357 helps to reduce symptoms and to prevent damage to…
- Trial name
- NCT04680676
- Testing
- BI 730357
- Sponsor
- Boehringer Ingelheim
Systemic Sclerosis (SSc), Magnetic Resonance Imaging (MRI)
7.0 Tesla Resonance Magnetic Imaging of the Hand in Systemic Sclerosis
Systemic sclerosis (SSc) is a rare systemic autoimmune disease with specific osteoarticular pattern of unknown mechanism. Ischemic phenomenon have been suggested to participate to the osteoarticular involvement in SSc.
- Trial name
- PREM'S (NCT04223817)
- Testing
- 7.0 T RMI
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Poitiers University Hospital
Methohexitone Pulmonary Adverse Reaction
Methotrexate Therapy and High-Resolution CT Chest and Spirometry Test Findings in Patients With Rheumatoid Arthritis.
ABSTRACT Background: Rheumatoid arthritis (RA) is characterized by symmetrical erosive synovitis and progressive disability, often complicated by extra-articular manifestations especially in seropositive patients, among them…
- Trial name
- NCT07360340
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Psoriasis
A Long Term Study To Evaluate The Safety, Tolerability And Efficacy Of CP-690,550 In Patients With Moderate To Severe Plaque Psoriasis And/Or Psoriatic Arthritis
The main objective of this study is to evaluate the long term safety of CP-690,550 in patients being treated for moderate to severe plaque psoriasis and/or psoriatic arthritis.
- Trial name
- NCT01519089
- Testing
- CP-690,550, CP-690, 550
- Where
- 16 sites in Japan
- Volunteers
- 95 people
- Sponsor
- Pfizer
Breast Neoplasms, Radiotherapy
Hypofractionated LocoRegional Radiotherapy in Breast Cancer
The primary objective of this study is to determine if hypofractionated RT delivered over 1 week to the breast or chest wall and regional nodes (26Gy in 5 daily fractions) following BCS or mastectomy, is non-inferior to…
- Conditions
- Breast Neoplasms, Radiotherapy, Lymphedema
- Trial name
- RHEAL (NCT04228991)
- Testing
- Locoregional radiation treatment - Conventional fractionation, Locoregional radiation treatment - Hypofractionation
- Where
- 20 sites in Canada
- Volunteers
- 588 people
- Sponsor
- Ontario Clinical Oncology Group (OCOG)
Breast Cancer, Triple Negative Breast Cancer
Abraxane With or Without Tigatuzumab in Patients With Metastatic, Triple Negative Breast Cancer
Breast cancer is the most commonly diagnosed cancer and the second leading cause of cancer deaths in American women. Metastatic disease including metastatic breast cancer unfortunately remains incurable.
- Conditions
- Breast Cancer, Triple Negative Breast Cancer, Stage IV Breast Cancer, Metastatic Breast Cancer
- Trial name
- NCT01307891
- Testing
- Abraxane alone, Abraxane + Tigatuzumab
- Where
- 10 sites in United States
- Volunteers
- 64 people
- Sponsor
- University of Alabama at Birmingham
Breast Cancer
Telephone-Based Decision Support for Rural Patients
The investigators community based resource center has implemented visit preparation by prompting patients to write down their questions.
- Trial name
- NCT01217333
- Testing
- In-person CP, Tele-CP
- Where
- 2 sites in United States
- Volunteers
- 74 people
- Sponsor
- University of California, San Francisco