Clinical trials: Skeletal Muscle Physiology, open to volunteers
Inclusion Body Myositis
IBM Dietary Surveillance Study
The goal of this observational study is to understand how diet may influence the disease characteristics of inclusion body myositis (IBM).
- Trial name
- NCT07535996
- Testing
- Whole-Body Dual-Energy X-ray Absorptiometry, Anthropometry, Capillary Blood Sampling
- Where
- United Kingdom
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Manchester Metropolitan University
To Determine Whether Estrogen Influences the Effects of Training on Glycemic Control and Insulin Sensitivity
Does Estrogen Blunt the Effects of Exercise Training on Glycemic Control
Previous research has found that males and females respond differently to exercise training, particularly with respect to improvements in blood sugar control and immune system health.
- Trial name
- NCT07791394
- Testing
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Heart Failure With Preserved Ejection Fraction (HFPEF)
The Effect of Adiposity on Muscle and Microvascular Function in HFpEF
This project is an observational study in patients with heart failure with preserved ejection fraction (HFpEF) who are candidates for treatment with weight loss medication to manage obesity or diabetes as part of their standard…
- Trial name
- NCT06930495
- Testing
- Weight loss SOC Treatment with second generation anti-diabetic medications
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
ICU Acquired Weakness, Sepsis
ICU Combined Assessment of Cardio-Respiratory Exercise
This study aims to investigate how sepsis and critical illness can impair the cardiovascular system and microcirculation in intensive care unit (ICU) patients, which can lead to long-lasting muscle weakness/dysfunction or…
- Conditions
- ICU Acquired Weakness, Sepsis, Shock, Critical Illness
- Trial name
- ICU-CARE (NCT06193980)
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- University of Manitoba
Breast Cancer, Gynecologic Cancers
Near Infrared Spectroscopy (NIRS) as a Method for Measuring Oxidative Capacity of Skeletal Muscle Mitochondria in Breast Cancer and All Gynecological Cancer Patients
Participants recruited for this study will be breast cancer or gynecological cancer patients who agree to participate in an exercise study examining the effects of chemotherapy on muscle mitochondrial oxidative capacity, a…
- Conditions
- Breast Cancer, Gynecologic Cancers, Mitochondrial Function
- Trial name
- NCT06672497
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of South Carolina
Unilateral Lower Limb Suspension (Simulated Microgravity)
Unloaded Minds - How Prolonged Unloading Shapes Human Performance in Lunar Gravity
During spaceflight and lunar missions, reduced gravitational loading causes the muscles and nervous system to decondition rapidly.
- Trial name
- UnloadedMinds (NCT07607340)
- Testing
- Unilateral lower limb suspension
- Where
- Sweden
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Obesity, Sarcopenia
Effectiveness of Combined GLP-1/GIP Dual Agonist Therapy and Structured Exercise on Skeletal Muscle Morphology, Quality, and Physical Function in Overweight and Obese Individuals
This randomized controlled trial aims to investigate the effects of a 24-week home-based progressive resistance exercise program combined with tirzepatide treatment on skeletal muscle mass, muscle quality, and functional capacity…
- Conditions
- Obesity, Sarcopenia, Overweight (Without Type 2 Diabetes) With Weight-related Comorbidities
- Trial name
- NCT07609160
- Testing
- Resistance exercise, Lifestyle recommendations
- Volunteers
- 108 people
- Sponsor
- Acibadem University
Post COVID-19 Syndrome, Functional Inspiratory Muscle Training
Effectiveness of Functional Respiratory Muscle Training in Post-COVID-19 Syndrome
This study aims to investigate the effects of core stabilization exercises and functional inspiratory muscle training (IMT) on various physiological and psychological parameters in individuals with post-COVID-19 syndrome.
- Conditions
- Post COVID-19 Syndrome, Functional Inspiratory Muscle Training, Core Stabilization
- Trial name
- NCT07051954
- Testing
- Core Stabilization, Functional Inspiratory Muscle Training (IMT)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Hacettepe University
Obesity (Disorder)
Tirzepatide and Muscle Outcomes in Obesity
This study is evaluating whether a dual glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist, tirzepatide, can affect the function, structure and metabolism of skeletal muscles…
- Trial name
- TIRMO (NCT07373834)
- Testing
- Tirzepatide
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Copd, Athletes
Effects of CreaSafe® on Kidney, Muscle, and Cardiopulmonary Function in Athletes and COPD Patients
Creatine supplementation (CS) offers numerous health benefits, with no proven side effects reported to date. CS positively impacts all organs and systems of the body.
- Trial name
- NCT06991426
- Testing
- CreaSafe® creatine
- Where
- Brazil
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
ICU Acquired Weakness, Post Intensive Care Unit Syndrome
Muscle Recovery After Critical Illness
The overarching goal of the proposed study is to determine the trajectories of physical recovery and cellular markers involved with the underlying failure to recover muscle after critical illness, while exploring which…
- Conditions
- ICU Acquired Weakness, Post Intensive Care Unit Syndrome, Muscle Weakness, Critical Illness
- Trial name
- TRACER (NCT05537298)
- Where
- 3 sites in United States
- Volunteers
- 209 people
- Sponsor
- Esther Dupont-Versteegden
Chronic Obstructive Pulmonary Disease, Pulmonary Artery Hypertension
: Vascular Function in Health and Disease
Many control mechanisms exist which successfully match the supply of blood with the metabolic demand of various tissues under wide-ranging conditions.
- Conditions
- Chronic Obstructive Pulmonary Disease, Pulmonary Artery Hypertension, Heart Failure, Hypertension
- Trial name
- NCT02966665
- Testing
- Maximum Exercise Tests, BH4, L-NMMA, Vitamin C, Vitamin E, α-Lipoic Acid and L-Ascorbate, BQ-123
- Where
- United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- D. Walter Wray
Intestinal Failure, Low Muscle Mass
Effects of Whey Protein and Resistance Training on Muscle Mass in Patients With Intestinal Failure
This single-center, prospective, four-arm randomized controlled trial will enroll 72 adults with chronic intestinal failure and low muscle mass.
- Trial name
- NCT07759271
- Testing
- Whey Protein Supplementation Group, Resistance Training Group
- Volunteers
- 72 people
- Sponsor
- Wang Xinying
Heart Failure With Preserved Ejection Fraction (HFPEF)
Effects of a Multicomponent Training Program on Cardiac Function, Skeletal Muscle Metabolism, Functional Capacity, and Quality of Life in Patients With HFpEF: SENSORFIT-4HEART Study
Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome with increasing incidence and poor prognosis, accounting for up to 50% of heart failure cases.
- Trial name
- SENSORFIT-4HEA (NCT07251361)
- Testing
- Supervised training
- Where
- Spain
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universidad Pública de Navarra
Obesity, Skeletal Muscle
Glucagon-like Peptide 1 (GLP-1) Receptor Agonist Therapy and Exercise Training in People With Obesity
The use of glucagon-like peptide receptor agonists (GLP-1 RAs) may have clinically important effects on skeletal muscle mass (SMM), and physical function.
- Conditions
- Obesity, Skeletal Muscle, Brain Connectivity
- Trial name
- NCT07091500
- Testing
- Exercise training, Semaglutide, Therapy Cessation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Washington University School of Medicine
Chronic Obstructive Pulmonary Disease
Long-term Effects of Endobronchial Valve Implantation on Cardiac Function and Skeletal Muscle Function
The goal of this type of study: clinical trial is to evaluate the effect of bronchial valve implantation on cardiac function and skeletal muscle function in Chronic Obstructive Pulmonary Disease.
- Trial name
- NCT05775588
- Testing
- Lung volume reduction surgery with endobronchial valve implantation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- China-Japan Friendship Hospital
Healthy Volunteers, Muscle Hypertrophy
Glycolytic Phenotype (vLapeak) and Magnitude of Skeletal Muscle Hypertrophy After Resistance Training
The HyperLa study investigates whether a person's "glycolyticness"-the efficiency with which their body uses glycolysis for energy-can predict how much their muscles will grow (hypertrophy) in response to resistance training.
- Conditions
- Healthy Volunteers, Muscle Hypertrophy, Glycolysis, Moderately Trainend
- Trial name
- HyperLa (NCT07721766)
- Testing
- Hypertrophy-focused Resistance Training
- Where
- 8 sites in Finland, Germany and 2 more
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Aging, Muscle Atrophy or Weakness
C-Protein in Fatigue and Aging
This study is investigating changes to the proteins in skeletal muscle that contribute to reduced muscle size and muscle function that occurs with aging.
- Conditions
- Aging, Muscle Atrophy or Weakness, Sarcopenia in Elderly, Sarcopenia
- Trial name
- NCT05926219
- Testing
- Fatiguing Exercise
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Obesity (BMI > 35)
Preserving Muscle Mass During Incretin-Induced Weight Loss
Treatment with incretin-based obesity medications leads to clinically meaningful weight loss and reduced cardiometabolic risk. However, the weight lost includes not only adipose tissue but also skeletal muscle, which may impair…
- Trial name
- INCRETraIN (NCT07761923)
- Testing
- Unilateral Resistance Training
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Karolinska Institutet
Critically Ill Patients
Disease Severity, Mortality Risk, and Muscle Function in Intensive Care Unit Patients
Intensive Care Units are specialized, technologically advanced hospital units that provide continuous monitoring and care from multiple healthcare disciplines for patients who are critically ill and face a high risk of death or…
- Trial name
- NCT07124442
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Istinye University