Clinical trials: Skeletal Muscle Function
Sarcopenia
Dose Range Finding Study of Bimagrumab in Sarcopenia
The purpose of this study was to determine the efficacy of repeat dosing with multiple dose levels of bimagrumab on patient physical function, skeletal muscle mass and strength in older adults with sarcopenia.
- Trial name
- NCT02333331
- Testing
- bimagrumab
- Where
- 58 sites in United States, Australia and 11 more
- Volunteers
- 217 people
- Sponsor
- Novartis Pharmaceuticals
Obesity
Mechanisms Underlying Postoperative Insulin Resistance and Inflammation
Having an operation places an enormous burden on the body, leading to the development of inflammation and so called 'insulin resistance'.
- Trial name
- NCT01470534
- Testing
- carbohydrate drink, Muscle biopsy, Blood sampling
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- University of Nottingham
Genetic Disorder
Skeletal Muscle Biomarkers in People With Fragile Sarcolemmal Muscular Dystrophy
Background: Some kinds of muscular dystrophy affect the skeletal muscle membrane. In these conditions, the muscle membrane is more fragile. This affects how the muscles contract and relax, which causes movement problems.
- Trial name
- NCT01851447
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Sarcopenic Obesity
Nutritional Strategies for Metabolic Health in Aging
Sarcopenic obesity in older individuals presents a clinical conundrum without an effective therapeutic strategy. This study will determine the impact of precision amino acid delivery as part of a meal replacement (EMR) during…
- Trial name
- NSMH (NCT04282603)
- Testing
- Weight Loss and Weight Maintenance
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Alaska Fairbanks
Healthy Volunteers, Exercise Intensity
Combined Effect of Exercise Intensity With Nutritional Supplementation on Skeletal Muscle Function
The main objective of this study is to determine the effectiveness of a nutritional intervention (olive leaf extract) combined with a specific training session (MICT or SIT) on PDH activation (as well as other protein…
- Conditions
- Healthy Volunteers, Exercise Intensity, Neuromuscular Fatigue, Skeletal Muscle Adaptations
- Trial name
- NUTSPORT (NCT05350566)
- Testing
- Olive leaf extract
- Where
- Switzerland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Menopause Related Conditions, Sarcopenia
Effects of Time-restricted Eating and Exercise Training on Skeletal Muscle Mass Quantity, Quality and Function in Postmenopausal Women With Overweight and Obesity
The goal of this randomized controlled trial] is to investigate the effects of a 12-week time restricted eating (TRE) and exercise combined intervention, as compared to (i) TRE alone, and to (ii) Caloric Restriction (CR) plus the…
- Conditions
- Menopause Related Conditions, Sarcopenia, Osteoporosis Postmenopausal, Obesity
- Trial name
- NCT05912309
- Testing
- Time Restricted Eating (TRE), Exercise, Caloric Restriction
- Where
- Spain
- Volunteers
- 78 people
- Sponsor
- Idoia Labayen
Iron-deficiency
Ferric Carboxymaltose to Improve Skeletal Muscle Metabolism in Heart Failure Patients With Functional Iron Deficiency
The purpose of this study is to better understand how body levels of iron affect the ability to exercise in patients with heart failure (HF).
- Trial name
- NCT03218384
- Testing
- Ferric Carboxymaltose, 31P MRS/MRI
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- NYU Langone Health
Muscle Loss
The Effect of Leucine on Carnitine Transport to Skeletal Muscle
The primary aim of the current research project is to explore whether leucine stimulates carnitine transport, and thus affecting muscle carnitine content.
- Trial name
- ROL (NCT05009654)
- Testing
- L-carnitine, L-leucine
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Barth Syndrome
Heart and Muscle Metabolism in Barth Syndrome
Barth syndrome (BTHS) is an X-linked disorder caused by abnormal cardiolipin metabolism and is characterized by skeletal and cardiomyopathy and high mortality rates.
- Trial name
- NCT01625663
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Duke University
Peripheral Arterial Disease, Critical Limb Ischemia
BOLD MRI as a Surrogate of Improved Muscle Oxygenation Following Endovascular Therapy for the Treatment of CLI
The purpose of this study is to determine if an MRI technique called Blood Oxygen Level Dependent, or BOLD, can be used to evaluate blood flow in the leg before and after treatment with standard endovascular therapy in patients…
- Trial name
- NCT02601430
- Testing
- BOLD-MRI
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Zimmer Biomet
Sarcopenia
Effect of Exercise and Protein Supplementation on Muscle Function in Patients With Hemodialysis
Sarcopenia can be easily observed in patients with hemodialysis. However, there were few studies on the precise concept and diagnostic criteria for sarcopenia in patients with hemodialysis.
- Trial name
- NCT04927208
- Testing
- exercise and nutritional support
- Where
- South Korea
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Chungnam National University Hospital
Healthy Volunteers, Skeletal Muscle
Device Evaluating the Muscular Functional Age
The CHRONOS project aims to provide a device to detect earlier the motor decline, by developing a precise quantitative device measuring "Motor Functional Age" (MFA) of young, middle-aged and old people, thus preventing future…
- Trial name
- CHRONOS (NCT03560648)
- Testing
- High definition surface electromyography combined with accelerometer
- Where
- France
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Heart Failure With Preserved Ejection Fraction (HFPEF)
Effects of a Multicomponent Training Program on Cardiac Function, Skeletal Muscle Metabolism, Functional Capacity, and Quality of Life in Patients With HFpEF: SENSORFIT-4HEART Study
Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome with increasing incidence and poor prognosis, accounting for up to 50% of heart failure cases.
- Trial name
- SENSORFIT-4HEA (NCT07251361)
- Testing
- Supervised training
- Where
- Spain
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universidad Pública de Navarra
Muscular Atrophy
Two Weeks of Reduced Activity and Skeletal Muscle Health in Older Men
Muscle size declines at around 0.5-1% per year after 50 years of age, with muscle strength declining up to twice as fast as muscle size.
- Trial name
- NCT02495727
- Testing
- Step-reduction, Pre-training, Exercise snacking
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Bath
Inclusion Body Myositis
IBM Dietary Surveillance Study
The goal of this observational study is to understand how diet may influence the disease characteristics of inclusion body myositis (IBM).
- Trial name
- NCT07535996
- Testing
- Whole-Body Dual-Energy X-ray Absorptiometry, Anthropometry, Capillary Blood Sampling
- Where
- United Kingdom
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Manchester Metropolitan University
Pompe Disease
A Pilot Study of Pyridostigmine in Pompe Disease
Pyridostigmine is an acetylcholinesterase inhibitor, which degrades acetylcholine at the neuromuscular junction. Based on recent studies, pyridostigmine may be an effective adjuvant treatment for people with Pompe disease, as it…
- Trial name
- NCT02357225
- Testing
- Pyridostigmine Bromide
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Florida
Overweight and Obesity
GRK-Biased Activation Via β2-Adrenergic Receptors in Human Skeletal Muscle
This longitudinal mechanistic physiological study examines biased β2-adrenergic receptor (β2-AR) signaling in human skeletal muscle, with emphasis on G protein-coupled receptor kinase (GRK)-mediated pathways.
- Trial name
- GAIN (NCT07421024)
- Testing
- ATR-258
- Where
- Denmark
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Morten Hostrup, PhD
Healthy
Effect of a Nutritional Supplement on Muscle Recovery
The aim is to develop a food supplement drink that supports muscle health by combining specific fatty acids, which can positively affect metabolic and inflammation processes that are important for muscle health.
- Trial name
- RECOVER (NCT07586839)
- Testing
- Control drink, Vegan supplement containing caprylic acid and omega-3 fatty acids
- Where
- Netherlands
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Chronic Kidney Diseases
Skeletal Muscle Oxygenation in Patients With Chronic Kidney Disease Stage 2, 3 and 4
Endothelial dysfunction occurs early in chronic kidney disease (CKD) and is associated with target organ damage, progression of renal injury, cardiovascular events, and mortality.
- Trial name
- NCT05250167
- Where
- Greece
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Heart Failure
Impact of Heart Failure on Calcium Homeostasis and Mitochondrial Function in Human Skeletal Muscle
The aim of this project is to investigate the impact of heart failure (HF) on calcium homeostasis, mitochondrial function and oxidative stress in human skeletal muscle, before and after exercise training.
- Trial name
- Calcicard (NCT01014611)
- Where
- France
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France