Clinical trials: Skeletal Muscle Atrophy
Muscle Atrophy, Muscle Disuse Atrophy
Examining Sex-based Differences in Metabolic and Mechanistic Responses to Disuse Induced Muscle Atrophy
The purpose of the proposed research is to define whether there are differences between females and males (i.e. sex-based differences) in the metabolic and mechanistic regulation of disuse-induced muscle atrophy in vivo in humans.
- Trial name
- NCT05314413
- Testing
- Single Leg Immobilization
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- McGill University
Muscle Atrophy or Weakness, Ventilator-associated Lung Injury
Serial Daily Diaphragm Ultrasounds in Ventilated Patients
When a person is put on a breathing machine the investigators think that the breathing muscles can get weaker. The investigators are not sure how quickly this happens but in some people this leads to problems when they try to…
- Trial name
- NCT02174029
- Testing
- Ventilation- mandatory, Ventilation- voluntary mode only, Voluntary with preceding mandatory
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- Steve Reynolds
Cancer, Muscle Atrophy
Influence of Motor Proteins on Muscle Atrophy in Cancer Patients
The aim of the study is to investigate the effect of exercise in form of whole-body electromyostimulation (WB-EMS) on early tumor-induced muscular dysfunction.
- Trial name
- NCT03551990
- Testing
- whole-body electromyostimulation WB-EMS
- Where
- Germany
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Covid19, Muscle Loss
The Impact of Covid-19 on Skeletal Muscle
With the recent worldwide outbreak of the COVID-19 infection and the huge impact it has had upon lives in the UK, it is key to increase knowledge on the impact of the virus on the body.
- Conditions
- Covid19, Muscle Loss, Mitochondrial Alteration
- Trial name
- NCT04756674
- Testing
- No intervetion will be used
- Where
- United Kingdom
- Sponsor
- University of Nottingham
Metabolic Disease, Amyotrophy
Clinical Safety Evaluation and Preliminary Efficacy Study of Subcutaneous Myografts Transplantation
This study aims to apply autologous differentiated myocyte subcutaneous transplantation in patients with muscle atrophy to explore its safety, feasibility, and efficacy.
- Trial name
- NCT07426068
- Testing
- Autologous differentiated myocyte transplantation
- Where
- 2 sites in China
- Volunteers
- 6 people
- Sponsor
- National Clinical Research Center for Orthopedics, Sports Medicine and Rehabilitation, China
Duchenne Muscular Dystrophy (DMD)
Safety and Dystrophin Expression of SPOT-03 in Duchenne Muscular Dystrophy (DMD) Patients
The primary objective of this study is to evaluate the safety and tolerability of SPOT-03 administered by intravenous (IV) infusion to DMD patients.
- Trial name
- NCT07188012
- Testing
- SPOT-03
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Shanghai Siponuoyin Biotechnology Co Ltd
Fatigue
Sleep and Training Aspects in Dialysis Fatigue - Exercise Intervention
The purpose of the current study is to investigate whether changes in patients' sleep quality and quantity will be followed by improvements in parameters related to physical and mental fatigue in patients receiving hemodialysis…
- Trial name
- StandFirm (NCT01721551)
- Testing
- Exercise, Usual Treatment
- Where
- 3 sites in Greece
- Volunteers
- 50 people
- Sponsor
- University of Thessaly
Stroke
Effects of HIIT on Muscle Strength, Atrophy and Aerobic Capacity in Stroke Patients.
To determine the effects of High-Intensity Interval Training on muscle strength, atrophy, and aerobic capacity in stroke patients.
- Trial name
- NCT06292442
- Testing
- traditional physical therapy, High intensity interval training
- Where
- Pakistan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Exercise, Detraining
Effects of COVID-19 Lockdown in Exercising Early Postmenopausal Women
While "conditioning" by exercise training has been widely evaluated, the available literature on "passive deconditioning" (i.e. forced deconditioning) is predominately limited to studies with or with almost complete mechanical…
- Conditions
- Exercise, Detraining, Muscle Weakness, Muscle Atrophy
- Trial name
- NCT04420806
- Testing
- HIT-exercise
- Where
- Germany
- Volunteers
- 21 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Osteoporosis, Sarcopenia
Skeletal Maturation and Endocrine Health in Young Adults
Diseases which can be the result of poor lifestyle choices in adult life, such as osteoporosis, obesity or poor muscle mass (sarcopenia) can also be driven by heritable genetic factors.
- Conditions
- Osteoporosis, Sarcopenia, Obesity, Cardiovascular Diseases
- Trial name
- EPIPEAK (NCT06509776)
- Where
- 9 sites in Denmark
- Volunteers
- 2,000 people
- Sponsor
- Holbaek Sygehus
Pulmonary Disease, Chronic Obstructive
The Impact of a Home-based Pulmonary Telerehabilitation Program in Acute Exacerbations of COPD
COPD impacts a significant proportion of the Veteran population. Acute exacerbations, or flare-ups, of COPD are associated with impaired muscle function and worse quality of life.
- Trial name
- NCT03997513
- Testing
- Pulmonary Telerehabilitation
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- VA Office of Research and Development
Skeletal Muscle, Bariatric Surgery
Circulating Muscle-specific microRNAs and Renal, Nutritional and Inflammatory Biomarkers of Skeletal Muscle Loss During the First 18 Months After Laparoscopic Sleeve Gastrectomy
Metabolic and bariatric surgery produces substantial and durable weight loss, but a considerable proportion of that loss is not adipose tissue.
- Trial name
- NCT07806513
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- General Committee of Teaching Hospitals and Institutes, Egypt