Clinical trials: Skeletal Muscle Atrophy
Massage Therapy, Muscular Atrophy
Effect of Percussive Massage on Skeletal Muscle During Limb Immobilization
The primary aims of this study are to determine the effect of percussive massage (30 min/session, 2 sessions/day, daily) during 10 days of unilateral limb immobilization on preserving muscle, vascular, and mitochondrial function.
- Trial name
- NCT06053229
- Testing
- percussive massage, Leg Immobilization
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Brigham Young University
Anterior Cruciate Ligament Injuries, Quadriceps Muscle Atrophy
Neuromuscular Control in Individuals Following ACL-Reconstruction
The purpose of this study is to investigate the neurophysiological contributors to muscle function following ACL Reconstruction and the influence of motor control biofeedback exercise on measures of muscle function.
- Trial name
- NCT04495075
- Testing
- Visuomotor Therapy, Passive Motion
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Virginia
Rotator Cuff Injuries, Rotator Cuff Tear
Ultrasound and Shear Wave Elastography for Assessment of the Quality of Rotator Cuff Muscles
Rotator cuff disorders are among the most frequent musculoskeletal causes of shoulder pain, weakness, and limited movement. In many individuals with rotator cuff disease, the damaged muscles gradually shrink (muscle atrophy) and…
- Conditions
- Rotator Cuff Injuries, Rotator Cuff Tear, Muscular Atrophy, Fatty Infiltration
- Trial name
- NCT07837583
- Volunteers
- 70 people
- Sponsor
- Assiut University
Head and Neck Cancer, Skeletal Muscle
Skeletal Muscle Mass Changes on Images for Prediction of Prognosis After Exercise Training in HNSCC Patients
This project adopts a prospective study design. It is scheduled to enroll 60 participants diagnosed with Head and Neck cancer in this hospital, of which 30 are in the experimental group and 30 are in the control group.
- Trial name
- NCT06666881
- Testing
- HIIT only, HIIT & Record of physical activities at home.
- Where
- Taiwan
- Volunteers
- 280 people
- Sponsor
- Chang Gung Memorial Hospital
Sarcopenia, Stroke, Complication
Reliability of Rehabilitative Ultrasound for the Quadriceps Muscle and Sarcopenia in Poststroke Patients
The purpose of the study is search the interrater and intrarater reliability of the quadriceps muscle using rehabilitative ultrasound imaging and search for an association between sarcopenia and quadriceps muscle in poststroke…
- Conditions
- Sarcopenia, Stroke, Complication, Quadriceps Muscle Atrophy, Hemiplegia
- Trial name
- NCT04042818
- Testing
- Rehabilitative Ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Pulmonary Disease, Chronic Obstructive (COPD)
Inspiratory Flow Rates Achieved by the COPD Patients Through Breezhaler®, Ellipta® and Handihaler® Inhaler Devices
The purpose of this study was to compare dynamic inspiratory flow rates achieved by a population of Chronic Obstructive Pulmonary Disease (COPD) patients through the Breezhaler®, Ellipta® and Handihaler® dry powder inhaler (DPI)…
- Trial name
- NCT02596009
- Testing
- Breezhaler®, Ellipta®, Handihaler®
- Where
- 5 sites in Argentina
- Volunteers
- 97 people
- Sponsor
- Novartis Pharmaceuticals
Achilles Tendon Ruptures
Calf Muscle Atrophy After Achilles Tendon Rupture. A Clinical-Radiological-Biomechanical Multicenter Study.
Multicenter Achilles tendon study Switzerland. Comparing three mainstream treatment types: open, percutaneous and conservative (non-operative) treatments. Comparing force torque measurements, muscle volume and clinical scores.
- Trial name
- NCT01778816
- Volunteers
- 52 people
- Sponsor
- University Hospital, Basel, Switzerland
Age-Related Loss of Skeletal Muscle Mass, Aging
Agility Training for Older Adults to Improve Fall Risk Factors
In this randomized controlled trial the effect of 4 months of multi-component (strength, balance, cognition, endurance) exercise training intervention on measures of neuromuscular performance, cognition, and endurance as well as…
- Conditions
- Age-Related Loss of Skeletal Muscle Mass, Aging, Sarcopenia, Cognitive Decline
- Trial name
- AgilE (NCT05727254)
- Testing
- Agility training, Exercise recommendations, Exercise diary
- Where
- Switzerland
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Oliver Faude
Spinal Muscular Atrophy
Implementation of FEES in Spinal Muscle Atrophy
The major aim of this project is to assess comprehensively frequency and extent of dysphagia and bulbar dysfunction in SMA1, 2, and 3 patients by applying FEES and validated dysphagia scores.
- Trial name
- DYS-SMA (NCT04773470)
- Testing
- Flexible Endoscopic Evaluation of Swallowing
- Where
- Germany
- Volunteers
- 79 people
- Sponsor
- University of Giessen
ACL Reconstruction
Protein Supplementation After ACL Surgery
The purpose of the study is to assess the longitudinal post-operative care effects of protein supplementation on muscle atrophy in the post-operative period following ACL reconstruction.
- Trial name
- NCT06311058
- Testing
- Whey protein isolate, Protein + BAA
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- The Methodist Hospital Research Institute
Muscle Atrophy, Weightlessness
The Effects of Whole Body Unloading on Physiological Function
This study is a collaboration between the Centre of Human \& Aerospace Physiological Sciences (CHAPS) and the Sleep and Brain Plasticity Centre (Department of Neuroimaging) at King's College London and the Sleep Disorders Centre…
- Conditions
- Muscle Atrophy, Weightlessness, Sleep Disturbance, Astronaut-Bone Demineralisation Syndrome
- Trial name
- NCT03195348
- Testing
- HBF Bed Rest
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- King's College London
Cardiac Ageing, Physical Activity
The Cardio-Sarcopenia Study
The use of surrogate markers such as body mass index (BMI) as a target outcome of physical activity may not be appropriate in older adults who are at risk of muscle sarcopenia.
- Conditions
- Cardiac Ageing, Physical Activity, Older Adults, Sarcopenia
- Trial name
- NCT05203406
- Where
- Singapore
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Heart Centre Singapore
Breast Neoplasms, Body Composition
Longitudinal Body Composition Assessment in Breast Cancer Patients
This observational cohort study aims to track longitudinal changes in body composition, including skeletal muscle mass and fat distribution, in patients diagnosed with breast cancer.
- Conditions
- Breast Neoplasms, Body Composition, Sarcopenia, Fat Redistribution
- Trial name
- NCT07472803
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Knee Injuries
The Effect of Blood Flow Restriction Training on Muscle Atrophy Following Knee Surgery
The investigators will compare differences in quadriceps strength, leg girth, and functional outcome scores between two groups of patients after weeks 6 and 12 as well as 6 months following meniscus or articular cartilage…
- Trial name
- NCT03035266
- Testing
- Blood Flow Restriction, Standard rehabilitation
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Keller Army Community Hospital
Elderly, Sarcopenia
Human Muscle Gene Expression Profiles in Young and Old Men
To reach the goals of living longer in better medical conditions, many countries reach the same conclusion: new strategies have to be developed to avoid, or at least limit, the effects of age; this requires a better knowledge of…
- Trial name
- CERA (NCT00725166)
- Testing
- Skeletal muscle aging
- Where
- France
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Severe Sepsis, Respiratory Failure
Muscle Atrophy in Patients With Severe Sepsis
This study is being done to help determine whether patients with severe sepsis (overwhelming inflammation in the body as a result of an infection) lose muscle and become weak more rapidly than patients with other severe…
- Trial name
- NCT01717651
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Ohio State University
Type 2 Spinal Muscular Atrophy
Efficacy and Safety of Intrathecal OAV101 (AVXS-101) in Pediatric Patients With Type 2 Spinal Muscular Atrophy (SMA)
This was a Phase III multi-center, single dose (1.2 x 10^14 vector genomes), randomized, sham controlled, double-blind study that investigates the efficacy, safety and tolerability of OAV101B in treatment naive, sitting and never…
- Trial name
- STEER (NCT05089656)
- Testing
- OAV101
- Where
- 42 sites in United States, Brazil and 11 more
- Volunteers
- 126 people
- Sponsor
- Novartis Pharmaceuticals
Muscle Loss
Carnitine Supplementation and Skeletal Muscle Mass
The primary aim of the current research project is to investigate the effect of carnitine supplementation on muscle strength and body composition.
- Trial name
- ROM (NCT05009641)
- Testing
- L-carnitine
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Community-Based Participatory Research, Aged
Associations Between Self-Reported Sleep Duration and Sarcopenia in Community-Dwelling Older Adults
1. BACKGROUNDS: Currently, elderly people comprise more than 10% of the total Taiwanese population. However, within the context of self-reported sleep duration and health risks, research into the association between sleep…
- Conditions
- Community-Based Participatory Research, Aged, Sleep, Body Composition
- Trial name
- NCT02126410
- Where
- Taiwan
- Volunteers
- 488 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Sarcopenia, Muscle Loss
Counteracting Age-related Loss of Skeletal Muscle Mass (CALM)
Up to 66 healthy elderly individuals (at least 65 years old) are recruited as subjects. They will be recruited as a subgroup to protocol ID: H-4-2013-070.
- Trial name
- CALM (NCT02115698)
- Testing
- Heavy Resistance Training, Light Intensity Training, Protein Whey
- Where
- Denmark
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital