Clinical trials: Skeletal Muscle
Diabetes Mellitus, Type 2, Pre-diabetes
Skeletal Muscle Diacylglycerol and Sphingolipids - Impact of Localization and Species on Insulin Resistance in Humans
The rationale for the proposed research is that elucidating changes in localized diacylglycerol (DAG) and sphingolipid species that predict insulin sensitivity will reveal specific localized lipids to target in therapeutics for…
- Conditions
- Diabetes Mellitus, Type 2, Pre-diabetes, Obesity
- Trial name
- NCT03077360
- Testing
- Lifestyle
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Anterior Cruciate Ligament Reconstruction
Prevention of Skeletal Muscle Adaptations to Traumatic Knee Injury and Surgery
Traumatic knee injury is common and highly debilitating. Surgical reconstruction/repair improves knee biomechanics and function, but neuromuscular dysfunction persist for years despite rehabilitation, hindering resumption of…
- Trial name
- NCT02945553
- Testing
- Neuromuscular electrical stimulation, Microstimulation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Vermont
Knee Osteoarthristis
Skeletal Muscle Atrophy and Dysfunction Following Total Knee Arthroplasty
Total knee replacement, or arthroplasty, is the final clinical intervention available to relieve pain and functional limitations related to advanced stage knee osteoarthritis.
- Trial name
- NCT03051984
- Testing
- Neuromuscular electrical stimulation
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Aging, Sedentary Lifestyle
Nitrites, Skeletal Muscle Mitochondrial Bioenergetics, and Physical Activity in Old Age
This 2-site randomized double blinded controlled trial is to confirm and more definitively clarify the impact of a 12-week course of nitrite versus placebo on mitochondrial bioenergetics in older sedentary adults.
- Conditions
- Aging, Sedentary Lifestyle, Frailty
- Trial name
- Nitrite (NCT04405180)
- Testing
- 20mg sodium nitrite tid
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Gladwin, Mark, MD
Weight Loss, Starvation
Effect of Caloric Restriction and Protein Intake on Metabolism and Anabolic Sensitivity
The purpose of this study is to determine if an increased protein intake can attenuate the suppression of metabolic and anabolic hormones during caloric restriction
- Trial name
- NCT02945410
- Testing
- Caloric Restriction, Protein, Exercise
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nebraska Lincoln
Sarcopenia
Blood Flow, Muscle Regeneration and Sarcopenia
Due to the rapid aging of the population, sarcopenia is among the greatest challenges facing the health care system over the next quarter century.
- Trial name
- NCT01035060
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Florida
Stroke
Power Training Post-stroke
Hemiparesis, strictly defined as (muscular) weakness affecting one side of the body, is seen in three-quarters of individuals following stroke.
- Trial name
- NCT01970592
- Testing
- POWER training
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Protein Restriction, Diet
Inflammation and Protein Restriction
There is strong scientific data that supports that short-term protein restrictive diets reduce surgical stress responses. The investigators are hoping to use the information collected from the blood serum and muscle tissue of…
- Conditions
- Protein Restriction, Diet, Inflammation
- Trial name
- NCT03995979
- Testing
- 4 Day Protein Restricted Diet
- Where
- 2 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Florida
Type 2 Diabetes
Effect of Pioglitazone on TIMP-3 and TACE in Type 2 Diabetes
Background: Pioglitazone has been shown to have potent anti-inflammatory as well anti-atherosclerotic effects. However, the mechanisms by which pioglitazone exerts these effects are not clear.
- Trial name
- PIO-TACE (NCT01223196)
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Skeletal Muscle Mitochondrial Dysfunction in the Elderly
A Phase 2 Study to Evaluate the Impact of MTP-131 (Bendavia™) on Skeletal Muscle Function in Elderly
This was a Phase 2, randomized, double-blind, placebo-controlled study, enrolling 41 elderly subjects with previous evidence of mitochondrial dysfunction to evaluate whether the administration of MTP-131 (elamipretide) will…
- Trial name
- MOTION (NCT02245620)
- Testing
- Elamipretide
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Stealth BioTherapeutics Inc.
Aging, Sarcopenia
Resistance Exercise and Low-Intensity Physical Activity Breaks in Sedentary Time to Improve Muscle and Cardiometabolic Health
What are the effects of resistance exercise (RE) alone or RE plus low intensity physical activity (LPA) breaks in sedentary time (ST) on skeletal muscle health in older adults? What are the effects of resistance exercise (RE)…
- Conditions
- Aging, Sarcopenia, Disability Physical, Cardiovascular Diseases
- Trial name
- REALPA (NCT03771417)
- Testing
- Exercise Intervention
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Louisiana State University and A&M College
Stroke
Strength Training for Skeletal Muscle Adaptation After Stroke
Chronically disabled stroke survivors experience accelerated skeletal muscle atrophy and other detrimental changes to muscle and surrounding tissues on the paretic side.
- Trial name
- NCT00827827
- Testing
- Exercise- Strength Training, Exercise- Stretching Control
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- VA Office of Research and Development
Aging, Vascular Endothelium
Vascular Dysfunction During Physical Inactivity
Prolonged periods of reduced activity are associated with decreased vascular function and muscle atrophy. Physical inactivity due to a sedentary lifestyle or acute hospitalization is also associated with impaired recovery…
- Conditions
- Aging, Vascular Endothelium, Skeletal Muscle
- Trial name
- NCT04872998
- Testing
- Step Count Reduction
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Utah
Healthy Volunteers
Training Effects on Skeletal Muscle Fatty Acid Metabolism
We are interested in how skeletal muscle processes fat and how this may affect insulin resistance. This is an important question since insulin resistance predates and predicts type 2 diabetes.
- Trial name
- NCT00786487
- Testing
- 20% lipid infusion, glycerol
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Glycogen Depletion
Carbohydrate Availability and microRNA Expression
This investigation will examine the impact of skeletal muscle glycogen stores on skeletal muscle and circulating microRNA expression and exogenous carbohydrate oxidation.
- Trial name
- NCT03250234
- Testing
- Adequate Carbohydrate, Low Carbohydrate
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Strength, Range of Motion
Low-Load Blood Flow Restriction Training vs Traditional Resistance Training Exercises Following ACLR Surgery
The main objective/s of the study is to compare the effectiveness of low load blood flow restriction training (LL-BFR) with traditional resistance training exercises (T-RT) at improving skeletal muscle hypertrophy, strength…
- Conditions
- Strength, Range of Motion, Pain-Knee, Skeletal Muscle Hypertrophy
- Trial name
- NCT06480032
- Testing
- Blood Flow Restriction band
- Where
- Pakistan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Abasyn University Peshawar
Diabetes Mellitus, Type 2, Skeletal Muscle Insulin Sensitivity
Effects of 5 Weeks Treatment With Dapagliflozin in Type 2 Diabetes Patients on How the Hormone Insulin Acts on Sugar Uptake in Muscles.
The purpose of this study is to investigate the effects of 5 weeks treatment with dapagliflozin in type 2 diabetes patients on how the hormone insulin acts on sugar uptake in muscles.
- Trial name
- DAPAMAAST (NCT03338855)
- Testing
- Dapagliflozin
- Where
- Netherlands
- Volunteers
- 26 people
- Sponsor
- AstraZeneca
Inflammation, Insulin Resistance
Mechanisms of Insulin Resistance in Humans
The Objectives of the study are to: (1)compare the inflammatory response and insulin resistance in skeletal muscles during a systemic infusion of lipid with that during a local infusion of lipid into the femoral artery.
- Trial name
- NCT00330967
- Testing
- 20% Intralipid
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Insulin Resistance
Acute Cardiovascular and Metabolic Effects of Exercise Training in Individuals With Insulin Resistance
The overall aim of the project is to determine whether or not exercise influences cardiovascular or nervous responses to meal ingestion in individuals with insulin resistance or type 2 diabetes.
- Trial name
- NCT00954109
- Testing
- Exercise
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- US Department of Veterans Affairs
Chronic Kidney Disease Requiring Chronic Dialysis
Immuno-nutrition Supplementation in Haemodialysis
The purpose of this pilot study is to test if an "immuno-nutrition" supplement can decrease inflammation in people on haemodialysis.
- Trial name
- NCT05700851
- Testing
- Immuno-nutrition supplement
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- University of Nottingham