Clinical trials: Sinusitis
Sinusitis
Xolair in Patients With Chronic Sinusitis
The purpose of this study is to determine if treatment with the anti-IgE antibody, Xolair (omalizumab), will improve objective and subjective evidence of chronic sinusitis.
- Trial name
- NCT00117611
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Chicago
Rhino Sinusitis
Analysis of Hemostatic Agents Compared to Physiologic Hemostasis
This study is a prospective comparison between absorbable hemostatic agents as a group and the body's natural hemostatic ability without aid of therapy in patients undergoing bilateral sinus surgery with or without septoplasty.
- Trial name
- NCT03068728
- Testing
- Arista, Nexfoam, Nasopore
- Volunteers
- 62 people
- Sponsor
- St. Louis University
Chronic Sinusitis
Comparison of Topical Vasoconstriction in Endoscopic Sinus Surgery
The purpose of our study is to assess the effect of topical vasoconstriction (cocaine 4% versus adrenaline 1/1000) on the surgical field during endoscopic sinus surgery.
- Trial name
- NCT01706952
- Testing
- Cocaine, Adrenaline
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Marc Tewfik
Chronic Rhinosinusitis (Diagnosis)
Topical Probiotic Sinus Irrigations for Treating Chronic Sinusitis
The purpose of this randomized study will be to determine whether topical probiotic sinus irrigations are more effective compared to saline sinus irrigation controls in the treatment of active CRS in patients who have had prior…
- Trial name
- NCT05427695
- Testing
- Lactobacillus sakei proBio65, Isotonic Saline Solution
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Illinois at Chicago
Chronic Sinusitis
In-office Placement of the Propel Mini Sinus Implant in the Frontal Sinus Ostia
A randomized controlled trial
- Trial name
- FRONTIER (NCT02880514)
- Testing
- PROPEL Mini Sinus Implant, Balloon Sinus Dilation Alone
- Where
- 9 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Intersect ENT
Chronic Sinusitis
A Study Evaluating the Efficacy of Endoscope Ethmoid Infundibulum Expansion Surgery (EEIES) Combined With Stapokibart in the Treatment of Type 2 Chronic Rhinosinusitis
Through a prospective study, the efficacy of Endoscope Ethmoid Infundibulum Expansion Surgery (EEIES) in the surgical treatment of patients with type 2 chronic rhinosinusitis was verified.
- Trial name
- NCT07073664
- Testing
- The surgical side of Endoscope Ethmoid Infundibulum Expansion Surgery (EEIES), The surgical side of Endoscopic Sinus Surgery (ESS)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- China-Japan Union Hospital
Chronic Sinusitis
The Feasibility of Using MRI During ESS
Before performing endoscopic sinus surgery (ESS-Endoscopic Sinus Surgery), every candidate for surgery is referred to perform a sinus CT scan of the sinuses.
- Trial name
- ESS (NCT03903432)
- Testing
- MRI
- Where
- Israel
- Volunteers
- 45 people
- Sponsor
- Roee Landsberg
Rhinosinusitis
Dexmedetomidine Infusion in Either Total Intravenous Anesthesia or Inhalational Anesthesia to Improve Surgical Field Visibility in Endoscopic Sinus Surgery
Dexmedetomidine Infusion in either Total Intravenous Anesthesia or Inhalational Anesthesia to Improve Surgical Field Visibility in Endoscopic Sinus Surgery
- Trial name
- NCT06866145
- Testing
- functional endoscopic sinus surgery, Dexmedetomidine
- Where
- 2 sites in Egypt
- Volunteers
- 50 people
- Sponsor
- Menoufia University
Chronic Sinusitis
The Effect of Tranexamic Acid on Intraoperative and Post-Operative Bleeding in Functional Endoscopic Sinus Surgery
Sinus surgery is a common, day surgery procedure performed by general and subspecialty trained otolaryngologists. In most cases, this is a safe surgery with a low incidence of complications.
- Trial name
- NCT00671281
- Testing
- Tranexamic acid
- Where
- Canada
- Volunteers
- 74 people
- Sponsor
- University of Calgary
Sinusitis
Validation of the Facial and Cephalic Pain Inventory
This study proposes to develop and validate a new instrument designed to measure facial and nasal discomfort related to chronic sinusitis.
- Trial name
- FACE PAIN (NCT01001039)
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Greg Davis
Sinusitis, Acute
Treatment of Acute Sinusitis With High-Dose vs. Standard-Dose Amoxicillin/Clavulanate
Comparative-effectiveness study of the treatment of acute bacterial sinusitis with amoxicillin/clavulanate 875mg/125mg bid for 7 days with or without the addition of immediate-release amoxicillin 875 mg bid x 7 days. .
- Trial name
- NCT03431337
- Testing
- Amoxicillin 875 mg
- Where
- United States
- Volunteers
- 157 people
- Sponsor
- Paul Sorum, MD
Chronic Sinusitis, Nasal Polyposis
Safety Evaluation of Repeat Placement of the S8 Sinus Implant in Chronic Sinusitis Patients With Nasal Polyps (ENCORE)
The ENCORE Study is designed to evaluate the repeat administration of the S8 Sinus Implant in chronic sinusitis (CS) patients with recurrent nasal polyps.
- Trial name
- NCT03358329
- Testing
- S8 Sinus Implant
- Where
- 9 sites in United States
- Volunteers
- 50 people
- Sponsor
- Intersect ENT
Cystic Fibrosis
Impact of Triple Combination CFTR Therapy on Sinus Disease.
The study's main goal is to observe how effective elexacaftor-tezacaftor-ivacaftor is for improving the symptoms and signs of CF-related sinus disease.
- Trial name
- NCT04056702
- Testing
- Elexacaftor-tezacaftor-ivacaftor exposure
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Jennifer Taylor-Cousar
Sinusitis, Chronic, Sinus Disease
Microbiota Transfer for Chronic Rhinosinusitis
Chronic sinusitis (CRS) is a common inflammatory condition of the sinuses that affects up to 2.5% of the Canadian population, and is thought to be caused by bacterial infection, resistant biofilms, chronic inflammation and…
- Conditions
- Sinusitis, Chronic, Sinus Disease, Sinus Infection, Sinus Infection Chronic
- Trial name
- SNMT (NCT05454072)
- Testing
- Sinonasal Microbiota Transfer
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Amin Javer
Sinusitis, Nasal Polyps
A Study to Evaluate 611 in Patients With Chronic Rhinosinusitis With Nasal Polyps
This study will evaluate the effect and safety of 611 in patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)
- Trial name
- NCT06639295
- Testing
- 611
- Where
- China
- Volunteers
- 243 people
- Sponsor
- Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd.
Chronic Sinusitis
Distribution of Topical Nasal Medication Within the Nasal Cavity and Sinuses by Radiographic Comparison
The purpose of this study is to determine the distribution of nasal sprays and nasal drops when used.
- Trial name
- NCT00626366
- Testing
- Sinus CT Scan, Omnipaque 240 Contrast Solution, Omnipaque 240 mg I/mL
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Chronic Rhinosinusitis With Nasal Polyps
A Study of GR1802 in Participants With Chronic Sinusitis With Nasal Polyps
The goal of this clinical trial is to learn if GR1802 works to treat severe chronic rhinosinusitis with nasal polyps (CRSwNP) in adults. It will also learn about the safety of GR1802. The main questions it aims to answer are: 1.
- Trial name
- NCT06516302
- Testing
- GR1802
- Where
- China
- Volunteers
- 228 people
- Sponsor
- Genrix (Shanghai) Biopharmaceutical Co., Ltd.
Chronic Sinusitis
Efficacy of Seprapack Sinus Dressing Versus No Dressing in the Prevention of Intranasal Adhesions Following Sinus Surgery
The purpose of this study is to investigate if the space occupying effect of Seprapack will lead to a reduction in post operative adhesions and more healing of the sinus cavity when compared to the use of no packing material.
- Trial name
- NCT00140608
- Testing
- Seprapack Sinus Dressing
- Where
- 3 sites in United States
- Sponsor
- Genzyme, a Sanofi Company
Anti-Infective Agents
Special Drug Use Investigation - Assessment of Efficacy and Safety in Treating Secondary Infection of Chronic Respiratory Disease
The objective of this study is to assess the efficacy and safety of Avelox Tablet 400 mg (hereinafter as "Avelox") in treating secondary infection of chronic respiratory disease.It is a local prospective and observational study…
- Trial name
- NCT01690533
- Testing
- Avelox (Moxifloxacin, BAY12-8039)
- Where
- Japan
- Volunteers
- 497 people
- Sponsor
- Bayer
Sinusitis
Sinonasal Gas Exchange Dynamics
Sinonasal gas exchange is facilitated by the unique anatomy and topography of the sinonasal interface that represents a collection of airfoils creating an aerodynamic structure.
- Trial name
- NCT01671098
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center Shreveport