Clinical trials: Sinusitis
Sinusitis
Guidelines for Acute Sinusitis
Viral upper respiratory infections occur frequently during childhood (6-8 per year) and are, for the most part, self-limited episodes that resolve spontaneously and do not require antibiotic therapy.
- Trial name
- NCT00132275
- Testing
- Amoxicillin potassium clavulanate
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- University of Pittsburgh
Chronic Rhinosinusitis
Long-term Safety and Efficacy of TQH2722 Injection in the Treatment of Chronic Sinusitis With or Without Nasal Polyps
This is a multicenter, randomized, continuing, Phase II expansion trial to evaluate the safety, efficacy, and immunogenicity of two doses of TQH2722 in the long-term treatment of severe chronic sinusitis with or without nasal…
- Trial name
- NCT06439381
- Testing
- 300mg/600mg of TQH2722 injection
- Where
- 27 sites in China
- Volunteers
- 119 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Sinusitis
Clinical Trial of the Treatment of Acute Sinusitis With Standard-dose Versus High-dose Amoxicillin/Clavulanate
The aim is to determine if high-dose amoxicillin/clavulanate is more effective than standard-dose amoxicillin/clavulanate in treating acute bacterial sinusitis in adults seen at a primary care office.
- Trial name
- NCT02340000
- Testing
- standard dose amoxicillin/clavulanate, high dose amoxicillin/clavulanate
- Where
- United States
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- Albany Medical College
Chronic Sinusitis
480 Biomedical Sinus Drug Depot
This is a Phase I, exploratory safety study of the 480 Biomedical Mometasone Furoate Sinus Drug Depot in adult subjects with chronic sinusitis.
- Trial name
- NCT02967731
- Testing
- 480 Mometasone Furoate Sinus Drug Depot
- Where
- 4 sites in Australia, New Zealand
- Volunteers
- 20 people
- Sponsor
- Lyra Therapeutics
Chronic Rhinosinusitis
Rhinosinusitis Italian Network: the Italian Registry for Severe, Uncontrolled Chronic Rhinosinusitis
This observatory aims to collect, as widely as possible, the Italian cases of patients with uncontrolled CRS. Patient will be enrolled by the centers of the Italian Network of Rhinosinusitis (Rhinosinusitis Italian Network…
- Trial name
- RINET (NCT05935683)
- Testing
- Severe Uncontrolled Chronic Rhinosinusitis patients (CRS)
- Where
- Italy
- Volunteers
- 5,000 people
- Sponsor
- Italian Academy of Rhinology
Chronic Rhinosinusitis With Nasal Polyposis (CRSwNP)
Chronic Otitis Media With Effusion in Chronic Sinusitis With Polyps
The relationship between otitis media with effusion (OME) and chronic rhinosinusitis with nasal polyposis (CRSwNP) remains unclear.
- Trial name
- NCT03975842
- Testing
- Sinonasal and otologic evaluation
- Volunteers
- 80 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Sinusitis
Comparison of Nasal Saline Irrigation Bottle Contamination Between Two Solutions
Rhinosinusitis is one of the most prevalent diseases within the United States and leads to decreased quality of life for patients suffering from this condition.
- Trial name
- NCT02413125
- Testing
- ChitoRhino irrigation solution, Normal saline
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Seasonal Allergic Rhinitis, Sinusitis
A Study To Investigate If MRI Scanning Is Effective At Seeing What Hayfever Drugs Do In Nasal Passage.
The purpose of this study is to establish whether MRI scanning is a sensitive measure of the effects of existing drug treatments on nasal dimensions following challenge with intranasal allergen in subjects with hayfever.
- Trial name
- NCT00517946
- Testing
- pseudoephedrine hydrochloride, cetirizine hydrochloride
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- GlaxoSmithKline
Covid19
Fugal Infection in COVID-19 Patients
Screening early detection of invasive fungal sinusitis in COVID-19 positive patients
- Trial name
- NCT04914013
- Testing
- no intervention
- Volunteers
- 50 people
- Sponsor
- Assiut University
Maxillary Sinusitis
Trial to Evaluate Time to Symptom Relief and Elimination of Infecting Bacteria in Treating Sinusitis With Avelox
This study evaluated the time to bacteriological eradication of common pathogens during moxifloxacin therapy for acute bacterial maxillary sinusitis.
- Trial name
- SPEED (NCT00668304)
- Testing
- Avelox (Moxifloxacin, BAY12-8039)
- Where
- 35 sites in United States, Argentina
- Volunteers
- 192 people
- Sponsor
- Bayer
Chronic Sinusitis
Effects of Anti-IgE Antibody Omalizumab on Patients With Chronic Sinusitis
We propose to study the effects of Xolair on patients with chronic sinusitis with or without nasal polyps. Because of the similarities between the inflammatory processes found in asthmas and rhinitis to those found in chronic…
- Trial name
- NCT00603785
- Testing
- Xolair
- Sponsor
- University of California, San Francisco
Chronic Sinusitis, Frontal Sinusitis
Improvement of Outcomes in Draf III/Endoscopic Modified Lothrop Procedure
We propose a randomized, single-blinded, prospective trial in order to evaluate the efficacy of the Cook Biodesign ENT Repair graft in improving outcomes after the Draf III or Endoscopic Modified Lothrop procedure.
- Trial name
- NCT02981017
- Testing
- Porcine Intestinal submucosal xenograft
- Where
- United States
- Sponsor
- University of California, Los Angeles
Sinusitis
Medical Therapy Versus Balloon Sinus Dilation for Patients With Chronic Rhinosinusitis
This post-market study aims to compare health outcomes for Chronic Rhinosinusitis (CRS) patients treated with balloon sinus dilation (BSD) versus continued medical management.
- Trial name
- MERLOT (NCT01685229)
- Testing
- Balloon sinus dilation, Medical Management
- Where
- 20 sites in United States
- Volunteers
- 198 people
- Sponsor
- Integra LifeSciences Corporation
Rhinosinusitis
Levofloxacin in Bacterial Rhinosinussitis
Inflammatory paranasal diseases are among the most common diseases in ENT In Russia, puncture method has been conventional approach to treatment of maxillary sinusitis.
- Trial name
- Levolet (NCT02712502)
- Testing
- Levofloxacin, Amoxicillin-Potassium Clavulanate Combination
- Volunteers
- 100 people
- Sponsor
- Dr. Reddy's Laboratories Limited
Sinusitis, Chronic Sinusitis
Pilot Study To Evaluate A Pharmacologically Active Nasal Sponge Following Endoscopic Sinus Surgery
This study will compare the incidence of post-op infection after sinus surgery using conventional post-op oral antibiotics to the incidence of infection after sinus surgery when a bio-resorbable antibiotic soaked nasal sponge is…
- Trial name
- NCT00705354
- Testing
- Bacitracin, Nasopore sponge soaked with saline
- Where
- United States
- Sponsor
- Lahey Clinic
Sinusitis, Acute
Study to Assess the Efficacy and Safety of Potassium Clavulanate/Amoxicillin in Children With Acute Bacterial Rhinosinusitis
Acute Bacterial Rhinosinusitis (ABRS) is a respiratory inflammation commonly seen in clinical practice, which has with respiratory symptoms including nasal congestion, rhinorrhoea, postnasal discharge and cough and is associated…
- Trial name
- NCT01934231
- Testing
- Amoxicillin-Potassium Clavulanate Combination
- Where
- 3 sites in Japan
- Volunteers
- 27 people
- Sponsor
- GlaxoSmithKline
Sinusitis Chronic
GLS-1200 Topical Nasal Spray to Prevent Sinusitis After Endoscopic Sinus Surgery
This clinical trial will evaluate the safety, tolerability and effectiveness of GLS-1200 nasal spray in addition to the standard of care after endoscopic sinus surgery in people with chronic sinusitis.
- Trial name
- NCT04060316
- Testing
- GLS-1200
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- GeneOne Life Science, Inc.
Sinusitis, Nasal Polyps
Pilot Study of The EPIC Trial
Chronic sinusitis is one of the most common chronic diseases in North America, with over 5% of the Canadian population affected by the disease. Until now, treatment with surgery has been performed only in the operating room.
- Trial name
- NCT02533206
- Testing
- Endoscopic Polypectomy Performed in Clinic, Functional Endoscopic Sinus Surgery (FESS)
- Where
- 5 sites in Canada
- Volunteers
- 20 people
- Sponsor
- Ottawa Hospital Research Institute
Rhinosinusitis Chronic
Effects of Osteopathic Manipulative Treatment in Chronic Non-allergic Rhinosinusitis
Chronic Rhinosinusitis (CRS) is a chronic condition with limited therapeutic options. Moreover, the pathophysiology is poorly understood.
- Trial name
- NCT04420052
- Testing
- Osteopathic manipulative treatment
- Where
- France
- Sponsor
- Institut des Hautes Etudes Osteopathiques de Nantes
Chronic Sinusitis
Clinical Study to Improve Diagnosis and Treatment of Sinusitis
Chronic rhinosinusitis (CRS) is the most common chronic medical condition that affects Americans between 18-44 years of age. While significant advances have been made in the understanding of the molecular pathogenesis underlying…
- Trial name
- NCT00962689
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Ohio State University