Clinical trials: Sinusitis, Acute
Acute Rhinosinusitis, Recurrent Acute Rhinosinusitis
NAC Inhalation in the Treatment Of Symptomatic acuTe rhinosinUSitis
N-acetylcysteine (NAC), known to have mucolytic and antioxidant effects, is widely used to treat respiratory diseases and manage post-surgery pulmonary complications.
- Conditions
- Acute Rhinosinusitis, Recurrent Acute Rhinosinusitis, Chronic Rhinosinusitis
- Trial name
- NOTUS (NCT04131686)
- Where
- South Korea
- Volunteers
- 294 people
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Acute Bronchitis, ACUTE SINUSITIS
Improving Patient-centered Communication and Antibiotic Use With Information Sheets for Acute Respiratory Tract Infections: A Study Protocol
The goal of this trial is to investigate if the use of information sheets regarding acute respiratory tract infections will lead to more rational antibiotic prescribing and increase patient-centered communication i Danish general…
- Conditions
- Acute Bronchitis, ACUTE SINUSITIS, Sore Throat
- Trial name
- NCT07383350
- Testing
- ARTI Info-sheets
- Where
- Denmark
- Volunteers
- 1,144 people
- Sponsor
- Research Unit for General Practice in Aalborg
Maxillary Sinusitis
Study to Measure the Impact of Antibiotics on Bacterial Flora in Adults With Acute Sinusitis
The purpose of this study is to measure the speed of microbial eradication due to azithromycin or telithromycin in acute maxillary sinusitis (AMS).
- Trial name
- NCT00245440
- Testing
- Azithromycin, Telithromycin
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- CPL Associates
Covid19
COVID-19 and Acute Invasive Fungal Rhinosinusitis
Data for acute invasive rhinosinusitis was obtained from the Otorhinolaryngology departments at our tertiary hospital at the period from January 2017 to December 2020.
- Trial name
- NCT04809480
- Testing
- Fungal rhinosinusitis
- Volunteers
- 56 people
- Sponsor
- Al-Azhar University
Maxillary Sinusitis
A Multicenter, Randomized, Double-Blind, Double-Dummy Trial of Azithromycin SR Compared With Levofloxacin for the Treatment of Sinus Infections in Adults
The objectives of the study were to confirm that a single, 2.0-g dose of azithromycin sustained release (SR) was at least as effective to 10 days of oral levofloxacin 500 mg once a day, when used to treat adults with…
- Trial name
- NCT00643409
- Testing
- azithromycin SR (Zithromax; compound: CP-62,993), levofloxacin
- Where
- 89 sites in United States, Argentina and 11 more
- Volunteers
- 541 people
- Sponsor
- Pfizer
Acute Respiratory Infection, Sinusitis
Middle Meatal Bacteriology During Acute Respiratory Infection in Children
The purpose of this study is to find out whether the children with respiratory infection and the presence of pathogenic bacteria (S. pneumoniae, H. influenzae or M.
- Trial name
- NCT00545961
- Testing
- amoxicillin clavulanate acid
- Where
- 3 sites in Finland
- Volunteers
- 120 people
- Sponsor
- Oulu University Hospital
Acute Sinusitis, Streptococcal Pharyngitis
Antimicrobial Stewardship for Primary Care Pediatricians
The purpose of the study is to determine if physician education coupled with audit and feedback of antibiotic prescribing can improve antibiotic prescribing by primary care clinicians.
- Conditions
- Acute Sinusitis, Streptococcal Pharyngitis, Pneumonia, Viral Infection
- Trial name
- PARTI (NCT01806103)
- Testing
- Antimicrobial Stewardship Bundle
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Children's Hospital of Philadelphia
Sinusitis, Acute
Treatment of Acute Sinusitis With High-Dose vs. Standard-Dose Amoxicillin/Clavulanate
Comparative-effectiveness study of the treatment of acute bacterial sinusitis with amoxicillin/clavulanate 875mg/125mg bid for 7 days with or without the addition of immediate-release amoxicillin 875 mg bid x 7 days. .
- Trial name
- NCT03431337
- Testing
- Amoxicillin 875 mg
- Where
- United States
- Volunteers
- 157 people
- Sponsor
- Paul Sorum, MD
Sinusitis
Zmax Compared to Augmentin in Sinusitis
This study will enroll patients with Bacterial Sinusitis who will be treated with either Zmax (Azithromycin Extended Release) or Augmentin (Amoxicillin/Clavulanate).
- Trial name
- NCT00367120
- Testing
- Azithromycin Extended Release, Amoxicillin/Clavulanate
- Volunteers
- 762 people
- Sponsor
- Pfizer
Rhinosinusitis, Acute Bronchitis
Clinical Trial for the Assessment of Delayed Antibiotic Treatment in Pediatric (DAP-Pediatrics)
The general hypothesis is that delayed antibiotic treatment strategy present similar effectiveness, when compared with non-prescription of antibiotics or the prescription of antibiotics, in the non-complicated acute respiratory…
- Conditions
- Rhinosinusitis, Acute Bronchitis, Acute Otitis Media, Pharyngotonsillitis
- Trial name
- DAP (NCT01800747)
- Testing
- Antibiotic prescription strategies
- Where
- Spain
- Volunteers
- 450 people
- Sponsor
- Asociacion Colaboracion Cochrane Iberoamericana
Sinusitis
The Study of Nasonex® Compared With Placebo for the Relief of Symptoms Associated With Acute Bacterial Sinusitis When Used With Antibiotics (Study P04824AM3)
The purpose of this study is to evaluate the efficacy and safety of Nasonex® (mometasone furoate nasal spray), when used together with an antibiotic, for the relief of symptoms associated with acute bacterial sinusitis.
- Trial name
- NCT00423176
- Testing
- MFNS and antibiotic
- Volunteers
- 237 people
- Sponsor
- Organon and Co
Acute Bacterial Sinusitis
Single Use Device Endoscopy for the Diagnosis of Acute Bacterial Rhinosinusitis in Primary Care
This is a pilot study to assess the first time use of the JGG endoscope® in humans and in primary care. The JGG endoscope® is attached to a Heine® otoscope and allows to inspect and to collect samples from the middle meatus of…
- Trial name
- Sinus-Endo (NCT03766568)
- Testing
- JGG endoscope(R)
- Where
- 6 sites in Switzerland
- Volunteers
- 60 people
- Sponsor
- Dominik Glinz
Rhinosinusitis, Rhinitis
Safety and Efficacy of DSM 32444 Postbiotic in the Treatment of Acute Rhinosinusitis
Rhinitis is a type of upper respiratory infection with a common nasal pathology especially in Southeast Asia, which is characterized by the presence of one or more of the following symptoms: itchy nose, sneezing, runny nose, and…
- Trial name
- NCT05999955
- Testing
- Neomycin/ Dexameythasone/Xylometazoline, Bacillus subtilis DSM32444
- Where
- Vietnam
- Volunteers
- 60 people
- Sponsor
- Huro Biotech Joint Stock Company
Maxillary Sinusitis, Sinusitis, Acute
Endoscopic Sinus Surgery in Recurrent Acute Rhinosinusitis
The aim of this study is to find out if endoscopic sinus surgery improves the quality of life in patients suffering from recurrent acute rhinosinusitis.
- Conditions
- Maxillary Sinusitis, Sinusitis, Acute, Sinusitis
- Trial name
- NCT04241016
- Testing
- Endoscopic sinus surgery (ESS)
- Where
- 2 sites in Finland
- Volunteers
- 80 people
- Sponsor
- Oulu University Hospital
Sinusitis
Guidelines for Acute Sinusitis
Viral upper respiratory infections occur frequently during childhood (6-8 per year) and are, for the most part, self-limited episodes that resolve spontaneously and do not require antibiotic therapy.
- Trial name
- NCT00132275
- Testing
- Amoxicillin potassium clavulanate
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- University of Pittsburgh
Chronic Sinusitis, Acute Sinusitis
Efficacy of Bee Venom Phonophoresis in Treating Chronic Sinusitis:
This double-blind, randomized controlled trial (BEE-SONIC) aims to evaluate the efficacy of bee venom phonophoresis in the treatment of chronic sinusitis.
- Conditions
- Chronic Sinusitis, Acute Sinusitis, Rhinosinusitis
- Trial name
- BEE-SONIC (NCT07151313)
- Testing
- Bee Venom Phonophoresis, Standard Care (oral decongestants + saline nasal irrigation)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Sinai University
Sinusitis, Acute
Dose Finding Study of Fluticasone Furoate Nasal Spray for Uncomplicated Acute Rhinosinusitis
The purpose of this study is to assess the safety and efficacy of fluticasone furoate nasal spray (FFNS), without the use of an antibiotic, in the treatment of adult and adolescent subjects who are 12 years of age and older with…
- Trial name
- NCT01018030
- Testing
- FFNS 110 mcg QD, FFNS 110 mcg BID
- Where
- 87 sites in Bulgaria, Canada and 10 more
- Volunteers
- 741 people
- Sponsor
- GlaxoSmithKline
Rhino Sinusitis
Herbal Tea Extract for Management of Rhinosinusitis
The objective of this phase I controlled clinical trial is to determine the safety and efficacy of Berry leaves \& Mango leaves mixture in symptomatic treatments on disease-related quality of life in adults with clinically…
- Trial name
- NCT07534280
- Testing
- mango leaves extract, local steroids, nasal saline
- Where
- 2 sites in Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Deraya University
Sinusitis, Cystic Fibrosis
Pulmozyme in Cystic Fibrosis With Sinusitis
The hypothesis is that the intranasal use of Pulmozyme will decrease the severity of sinusitis in Cystic Fibrosis and lead to an improved quality of life.
- Trial name
- NCT01155752
- Testing
- Pulmozyme single use ampule
- Where
- United States
- Sponsor
- Milton S. Hershey Medical Center
Sinusitis
CHOOSE : Telithromycin, Acute Bacterial Sinusitis
Primary objective: To demonstrate that the clinical efficacy of telithromycin (800 mg od for 5 days) is non-inferior to amoxicillin-clavulanic acid (875/125 mg bid for 10 days) at the test-of-cure (TOC) visit (Day 17-21) in…
- Trial name
- NCT00174694
- Testing
- Telithromycin
- Volunteers
- 298 people
- Sponsor
- Sanofi