Clinical trials: Sinus Endoscopic Surgery
Chronic Rhinosinusitis (CRS)
Effectiveness of Penthrox vs Placebo in Sinus Procedures, a Clinical Trial
The goal of this randomized controlled trial is to evaluate the effectiveness of inhaled methoxyflurane (Penthrox) as an analgesic for patients undergoing minor rhinology and sinus procedures, specifically comparing it to a…
- Trial name
- NCT06750302
- Testing
- Methoxyflurane - Penthrox
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- St. Paul's Hospital, Canada
FESS Operation
Intratracheal Dexmedetomidine Versus Lidocaine for Smooth Tracheal Extubation
compare the efficacy of intratracheal dexmedetomidine versus intratracheal lidocaine in achieving smooth tracheal extubation in patients undergoing Functional Endoscopic Sinus surgery and reconstructive nasal surgeries under…
- Trial name
- NCT07504497
- Testing
- dexmedetomidine Lidocaine Saline
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Younes Ahmed Younes
Esophageal Atresia With Tracheo-esophageal Fistula, Esophageal Atresia
Balloon Inflation Time for Esophageal Strictures (BITES): A Randomized Multi-Center Study
Esophageal atresia (EA) is one of the most common gastrointestinal congenital anomalies that affects 1 in 2500 to 1 in 4000 live births.
- Conditions
- Esophageal Atresia With Tracheo-esophageal Fistula, Esophageal Atresia, Esophageal Strictures
- Trial name
- BITES (NCT07100379)
- Testing
- Endoscopic Balloon Dilation
- Where
- 2 sites in United States
- Volunteers
- 128 people
- Sponsor
- Boston Children's Hospital
Dexmedetomidine, Functional Endoscopic Sinus
Intranasal Dexmedetomidine Versus Intravenous Dexmedetomidine for Improving Quality of Endoscopic Sinus Surgery
compare intranasal dexmedetomidine versus intravenous dexmedetomidine for improving quality of the operative field in Functional endoscopic sinus surgery
- Trial name
- NCT06081933
- Testing
- intranasal dexmedetomidine, intravenous dexmedetomidine
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Kafrelsheikh University
Lidocaine, Dexmedetomidine
Lidocaine and Dexmedetomidine Infusions for Intraoperative Bleeding in Functional Endoscopic Sinus Surgery
This work aims to compare lidocaine and dexmedetomidine infusions for intraoperative bleeding in patients undergoing functional endoscopic sinus surgery.
- Conditions
- Lidocaine, Dexmedetomidine, Infusion, Intraoperative Bleeding
- Trial name
- NCT06848764
- Testing
- Lidocaine, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Chronic Rhinosinusitis (Diagnosis)
Comparison of Topical Therapies in Post op Endoscopic Sinus Surgery Patients
The goal of the study is to compare postoperative symptom scores and endoscopy findings between in patients who receive either nasal saline rinses, saline + budesonide, and saline + topical antibiotics and budesonide following…
- Trial name
- NCT03303677
- Testing
- Saline Nasal, Budesonide Nasal, Topical Antibacterial (Product)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Chronic Rhinosinusitis
A Randomized Controlled Trial Evaluating Postoperative Debridement Following Endoscopic Sinus Surgery
Chronic rhinosinusitis (CRS) is a common sinus and nasal condition affecting more than 33 million Americans. The treatment of CRS typically begins with maximal medical therapy however, when this fails to improve patient symptoms…
- Trial name
- NCT02154555
- Testing
- debridement
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Aminophylline, Dexmedetomidine
Aminophylline on Recovery in Functional Endoscopic Sinus Surgery Under Dexmedetomidine Hypotensive Anesthesia
This study will be conducted to evaluate the effect of intravenous aminophylline on hemodynamics and recovery of patients receiving dexmedetomidine infusion during functional endoscopic sinus surgery.
- Conditions
- Aminophylline, Dexmedetomidine, Functional Endoscopic Sinus Surgery
- Trial name
- NCT05738135
- Testing
- Aminophylline group, normal saline
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Tanta University
Sore Throat
Dexmedetpmidine Versus Ketamine for Postoperative Sore Throat in Sinus Surgery
The aim of this randomized clinical trial is to evaluate the impact of dexmedetomidine versus ketamine soaked pharyngeal packing on postoperative sore throat in functional endoscopic sinus surgery (FESS).
- Trial name
- NCT04955158
- Testing
- Dexmedetomidine, Ketamine, saline 0.9%
- Where
- Egypt
- Volunteers
- 143 people
- Sponsor
- Assiut University
Agitated; State, Acute Reaction to Stress
Preemptive Chlorepheniramine Maleate Reducing Postoperative Agitation
The aim of the study is to identify the role of preoperative chlorepheniramine maleate on alleviating or reducing the severity of postoperative agitation following FESS procedures.
- Trial name
- NCT04293081
- Testing
- Preemptive chlorepheniramine maleate intravenous injection, normal saline
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Hypertension, Hypotension
Intranasal Injection Versus Topical Administration of Epinephrin During Endoscopic Sinus Surgery
Intranasal injection of epinephrine is used routinely during endoscopic sinus surgery (ESS) to reduce bleeding in the nasal mucosa and thereby improve visualization of the surgical field.
- Conditions
- Hypertension, Hypotension, Tachycardia, Bradycardia
- Trial name
- NCT01075581
- Testing
- Epinephrin (Intranasal injection), Epinephrin (Topical administration)
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Chronic Sinusitis
Comparison of Topical Vasoconstriction in Endoscopic Sinus Surgery
The purpose of our study is to assess the effect of topical vasoconstriction (cocaine 4% versus adrenaline 1/1000) on the surgical field during endoscopic sinus surgery.
- Trial name
- NCT01706952
- Testing
- Cocaine, Adrenaline
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Marc Tewfik
Pilonidal Sinus
Pilonidal Excision Versus Endoscopic Surgery
Compare clinical outcomes of endoscopic pilonidal sinus treatment (EPSiT) with excision treatment with a randomised clinical trial.
- Trial name
- PEVES (NCT03923621)
- Testing
- EPSiT, Excision
- Where
- United Kingdom
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- St Helens & Knowsley Teaching Hospitals NHS Trust
Chronic Sinusitis
The Feasibility of Using MRI During ESS
Before performing endoscopic sinus surgery (ESS-Endoscopic Sinus Surgery), every candidate for surgery is referred to perform a sinus CT scan of the sinuses.
- Trial name
- ESS (NCT03903432)
- Testing
- MRI
- Where
- Israel
- Volunteers
- 45 people
- Sponsor
- Roee Landsberg
Magnesium Sulfate, Remifentanil
Anesthesia Techniques, Neuroprotection and Surgical Field in FESS Under Controlled Hypotension
This prospective, randomized controlled trial investigates the effect of four different anesthetic maintenance techniques on surgical field conditions, hemodynamic stability, and neuroprotection during functional endoscopic sinus…
- Conditions
- Magnesium Sulfate, Remifentanil, S 100beta, S100 Beta Protein, Human
- Trial name
- NCT07181564
- Testing
- Propofol / Remifentanil, Ketamine + Magnesium sulfate (drug combination), Sevoflurane and Remifentanil
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- University General Hospital of Patras
Rhinosinusitis
Dexmedetomidine Infusion in Either Total Intravenous Anesthesia or Inhalational Anesthesia to Improve Surgical Field Visibility in Endoscopic Sinus Surgery
Dexmedetomidine Infusion in either Total Intravenous Anesthesia or Inhalational Anesthesia to Improve Surgical Field Visibility in Endoscopic Sinus Surgery
- Trial name
- NCT06866145
- Testing
- functional endoscopic sinus surgery, Dexmedetomidine
- Where
- 2 sites in Egypt
- Volunteers
- 50 people
- Sponsor
- Menoufia University
Chronic Sinusitis
The Effect of Tranexamic Acid on Intraoperative and Post-Operative Bleeding in Functional Endoscopic Sinus Surgery
Sinus surgery is a common, day surgery procedure performed by general and subspecialty trained otolaryngologists. In most cases, this is a safe surgery with a low incidence of complications.
- Trial name
- NCT00671281
- Testing
- Tranexamic acid
- Where
- Canada
- Volunteers
- 74 people
- Sponsor
- University of Calgary
Cough Suppression
Magnesium Sulfate Versus Lidocaine as Additives to Dexmedetomidine for Cough Suppression After Functional Endoscopic Sinus Surgery
Functional Endoscopic Sinus Surgery (FESS) is a widely performed procedure for the management of chronic rhinosinusitis and nasal polyposis.
- Trial name
- NCT07213037
- Testing
- Dexmedetomidine, Magnesium sulfate, lidocaine
- Volunteers
- 102 people
- Sponsor
- Assiut University
Aspirin-exacerbated Respiratory Disease, Sleep
Sleep Quality After Nasosinusal Surgery in AERD Patients
Aspirin exacerbated respiratory disease presents as a triad composed by asthma, eosinophilic rinosinusitis and intolerance to aspirin and NSAIDS.
- Trial name
- NCT03627481
- Testing
- Endoscopic sinus surgery
- Where
- Mexico
- Volunteers
- 32 people
- Sponsor
- Instituto Nacional de Enfermedades Respiratorias
Sinus Endoscopic Surgery, Turbinate
Safety and Effectiveness of TurbAlign™ for Middle Turbinate Medialization After Functional Endoscopic Sinus Surgery
A study of a bioabsorbable implant to separate the middle turbinate from the lateral nasal wall associated with nasal/sinus surgery
- Trial name
- Gaia (NCT07027267)
- Testing
- Implantation of Spirair device into the middle turbinates, TurbAlign
- Where
- 5 sites in United States
- Volunteers
- 50 people
- Sponsor
- Spirair, Inc