Clinical trials: Sigmoid Cancer
Quality of Life, Stoma Ileostomy
QoL of Colorectal Cancer Patients and Spouses
The aim of the present prospective, comparative study was to compare the quality of life (QoL) of patients after colorectal surgery to the QoL of their spouses.
- Conditions
- Quality of Life, Stoma Ileostomy, Stoma Colostomy, Rectum Cancer
- Trial name
- NCT04744792
- Testing
- Short Form - 36, WHODAS-II
- Volunteers
- 200 people
- Sponsor
- Cihangir Akyol
Left-Sided Ulcerative Colitis, Proctosigmoiditis
Safety, Tolerability, Efficacy Study of PUR 0110 Rectal Enema in Mild-to-Moderate Distal Ulcerative Colitis
PUR 0110 is a 100% natural novel investigational medicinal product that has been demonstrated in several in vitro and in vivo pharmacology studies to have potent anti-inflammatory, anti-oxidative and immunomodulatory effects.
- Trial name
- NCT01149707
- Testing
- PUR 0110 Rectal Enema 250 mg, PUR 0110 Rectal Enema 500 mg, PUR 0110 Rectal Enema 1000 mg
- Where
- 6 sites in Germany
- Volunteers
- 34 people
- Sponsor
- PurGenesis Technologies Inc.
Rectal Cancer, Sigmoid Cancer
A Study of Perfusion of Colorectal Anastomosis Using FLuorescence AnGiography (FLAG-trial)
This is a randomized, controlled, parallel study to determine the difference in post-operative anastomotic leak rate of colorectal anastomosis where colon and rectal tissue perfusion is evaluated using fluorescence angiography…
- Trial name
- FLAG (NCT03390517)
- Testing
- Fluorescence angiography with indocianyne green
- Where
- Russia
- Volunteers
- 377 people, healthy volunteers welcome
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Bladder Cancer
Comparison Capsule Sparing Cystectomy and Radical Cystoprostatectomy in Men With Bladder Cancer
Bladder cancer is a common malignant tumor of the urinary system, radical resection plus urinary diversion is the first choice of treatment for muscle invasive bladder cancer.
- Trial name
- NCT05067101
- Testing
- Capsule Sparing Cystectomy (CSC), Conventional Radical Cystoprostatectomy (CRC)
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Zhujiang Hospital
Disposable Intestinal Isolation and Protection Device
Disposable Intestinal Isolation and Protection Device for Patients With Rectal and Lower Sigmoid Colon Tumors Undergoing Laparoscopic AR/LAR Surgery
The small intestine is the main organ in the abdominal cavity, approximately 4 to 5 meters in length, occupying most of the middle and lower abdomen.
- Trial name
- NCT07825129
- Testing
- According to the different structures, it is divided into TPYRIB type and TPYRIS type. According to the different outer dimensions of the pocket and the outer sleeve, it is divided into two specificat, sterile gauze
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Beijing Friendship Hospital
Colo-rectal Cancer
Single-stapled Double Purse-string Technique for Colorectal Anastomosis
A single-arm, single-center prospective study of a novel double purse-string technique for constructing the colorectal anastomosis in robot-assisted laparoscopic resection of the sigmoid colon for cancer.
- Trial name
- NCT04223141
- Testing
- SIA
- Where
- Denmark
- Volunteers
- 39 people
- Sponsor
- Vejle Hospital
Cancer, Colorectal Neoplasms
Improving Radical Treatment Through MRI Evaluation of Pelvic Sigmoid Cancers
Patients with suspected or proven sigmoid colon adenocarcinoma, eligible for curative treatment whose MRI can be reviewed prior to surgery and has no decision regarding radical treatment are eligible.
- Conditions
- Cancer, Colorectal Neoplasms, Colon, Sigmoid, Magnetic Resonance Imaging
- Trial name
- IMPRESS (NCT02222844)
- Testing
- Preoperative MRI scan
- Where
- 16 sites in United Kingdom
- Volunteers
- 244 people
- Sponsor
- Imperial College London
Rectal Cancer, Sigmoid Cancer
Adaptive Anastomosis for Anterior Resection in Sigmoid and Proximal Rectal Cancer or Premalignant Lesions
Background: Anastomotic leakage (AL) after colorectal surgery remains a significant challenge, associated with increased morbidity, mortality, poor oncological outcomes, and reduced quality of life.
- Conditions
- Rectal Cancer, Sigmoid Cancer, Premalignant Lesion, Colorectal Cancer
- Trial name
- ADAPT (NCT07056374)
- Testing
- C-REX RectoAid Cath
- Where
- Netherlands
- Volunteers
- 165 people
- Sponsor
- Amsterdam UMC, location VUmc
Natural Orifice Specimen Extraction Surgery, Robotic Surgery
A Prospective Single-center Randomized Controlled Trial of Robotic Surgery With Transrectal Resection Specimens (NOSES-IV) and Traditional Assisted Robotic Surgery for the Treatment of High Rectal and Sigmoid Colon Cancer
This study aimed to compare the short-term efficacy of robotic radical resection of high rectal cancer and sigmoid colon cancer (NOSES-IV) with transrectal resection specimens and traditional robotic surgery in the treatment of…
- Conditions
- Natural Orifice Specimen Extraction Surgery, Robotic Surgery, Short-term Outcomes
- Trial name
- NCT06906952
- Testing
- robotic natural orifice specimen extraction surgery, robotic transabdominal specimen extraction surgery
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Nanchang University
Rectal Cancer
Sigmoid Take-off, New Rectum Definition
The diversity of definitions for the rectosigmoid junction is becoming a major obstacle to the standardization of optimal treatment of rectal cancers.
- Trial name
- NCT04293835
- Testing
- Whether to have intestinal-related disease
- Where
- China
- Volunteers
- 835 people
- Sponsor
- Peking University Third Hospital
Colorectal Cancer, Anastomotic Leak
Indocyanine Green Fluorescent Imaging in Robotic Assisted Rectosigmoidal Resection; a Multicenter Assessment of Interobserver Variation and Comparison With Computer-based Pixel Analysis
A serious complication to colorectal surgery is anastomotic leakage (AL). AL increases post-operative mortality, decreases long-term survival, reduces the functional result and reduces qual-ity of life.
- Trial name
- NCT04766060
- Testing
- Fluorescent Imaging
- Where
- Denmark
- Volunteers
- 55 people
- Sponsor
- Odense University Hospital
Colorectal (Colon or Rectal) Cancer
Endoscopic Submucosal Dissection of Large Recto-sigmoid Lesions Under Spinal Anesthesia
The investigators collected data on all consecutive patients who underwent ESD for recto-sigmoid laterally spreading tumors (LSTs) >35 mm under SA between January 2021 and March 2024.
- Trial name
- NCT06316401
- Testing
- ESD of large LSTs under SA
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Azienda USL Modena
Colorectal Cancer (CRC), Rectal Cancer Surgery
Indocyanine Green Fluorescence Angiography in Laparoscopic Sigmoid and Rectal Cancer Surgery
Anastomotic leakage remains a major complication after colorectal cancer surgery. Indocyanine green fluorescence angiography (ICG-FA) allows real-time intraoperative assessment of bowel perfusion; however, its clinical impact…
- Conditions
- Colorectal Cancer (CRC), Rectal Cancer Surgery, Sigmoid Colon Cancer
- Trial name
- NCT07423130
- Where
- Poland
- Volunteers
- 115 people
- Sponsor
- Jagiellonian University
Sigmoid Diverticulosis, Sigmoid Diverticulitis
Perfusion Evaluation by Real-time Fluorescence-based Enhanced Reality of Anastomosis
The aim of this study is to evaluate the ability of a ICG-fluorescence guidance complemented with enhanced reality to correctly document intestinal pre-anastomotic perfusion and to validate the accuracy of this technique with…
- Conditions
- Sigmoid Diverticulosis, Sigmoid Diverticulitis, Colorectal Malignancy
- Trial name
- PERFECT (NCT02626091)
- Testing
- Left-sided colonic resection
- Where
- France
- Volunteers
- 27 people
- Sponsor
- IHU Strasbourg
Epithelial Ovarian Cancer
Surgical Trial Comparing LIGASURE Assisted Recto-Sigmoid Resection and Omentectomy Compared to Stand
The objective of this prospective randomized surgical trial is to evaluate whether the use of the LIGASURE surgical device during omentectomy and/or recto-sigmoid resection for women with ovarian cancer will reduce the surgical…
- Trial name
- NCT01549925
- Testing
- Standard Surgical resection, LIGASURE
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Utah
Orthotopic Neobladder
The Supraspinal Control of Lower Urinary Tract Function in Patients With Orthotopic Sigmoid Neobladder.
Orthotopic sigmoid neobladder surgery is one of the ideal urinary diversion methods after radical cystectomy.In recent years, functional imaging studies have revealed brain regions related to urinary system function, but brain…
- Trial name
- NCT05558111
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Colorectal Anastomosis, Left-sided Colon Resection
Post-Market Study of the Signia Circular Stapler With Tri-Staple Technology in Left-sided Colon, Sigmoid, and Rectal Resections
The purpose of this study is to evaluate the safety and performance of the Signia™ power handle, Signia™ circular adapter, and Signia™ Tri-Staple™ 2.0 circular reloads (hereafter referred to as Signia™ circular stapler) in…
- Conditions
- Colorectal Anastomosis, Left-sided Colon Resection, Anastomotic Leak, Anastomotic Complication
- Trial name
- SECURE (NCT07351071)
- Testing
- Signia™ circular stapler with Tri-Staple™ Technology (Signia™ Circular Stapling system)
- Where
- 10 sites in United States
- Volunteers
- 137 people
- Sponsor
- Medtronic - MITG
Colorectal Cancer, Diverticulitis of Sigmoid
Intraoperative Use of Oxygen Saturation Imaging to Assess Intestinal Perfusion
This will be a prospective, observational study of patients undergoing laparoscopic colorectal resection with anastomosis. After anastomosis creation and at the time of routine intraoperative flexible sigmoidoscopy, 4 mucosal…
- Trial name
- NCT07587619
- Testing
- Fujifilm monitoring
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Southern California
Bladder Cancer, Urinary Diversion
Comparison of Safety and Efficacy of Detaenial Sigmoid Neobladder and Ileal Neobladder
Bladder cancer is a common malignant tumor of the urinary system, radical resection plus urinary diversion is the first choice of treatment for muscle invasive bladder cancer.
- Trial name
- NCT03108196
- Testing
- sigmoid, ileal
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Zhujiang Hospital
Rectal Diseases, Sigmoid Colon Disease, Rectal Cancer, Sigmoid Colon Cancer
Extra-Peritoneal Tunneling Versus Conventional Drain Fixation After Anterior or Low Anterior Resection
The goal of this clinical trial is to learn whether the extra-peritoneal tunneling (EPT) drain fixation method works better and more safely than the conventional drain insertion method after rectal cancer surgery.
- Trial name
- ExPeTuD (NCT07241143)
- Testing
- EPT drain fixation, Conventional drain insertion
- Where
- South Korea
- Volunteers
- 596 people
- Sponsor
- Yeungnam University Hospital