Clinical trials: Side Effect
Solar Lentigines
Side Effects of Q-Switched Ruby Laser for the Treatment of Lentigines in Light and Dark Skin Types
The purpose of this study is a comparison of efficacy and side effects of Q-switched Ruby laser treatment for solar lentigines in two different skin types II and IV.
- Trial name
- NCT00386204
- Testing
- Q-switched Ruby Laser
- Where
- Iran
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Allergy Drug
De-labeling of Patients With False Diagnosis of Penicillin Allergy
The purpose of this study is to estimate the prevalence of penicillin allergy, evaluate the diagnostic value of the allergologic work-up used in the study, and the health effects of penicillin allergy.
- Trial name
- NCT03581604
- Testing
- Allergy work-up, Blood samples
- Where
- Norway
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Gestational Diabetes Mellitus
Comparing the Effects of Water Temperature and Actives in Glucose Solution on Pregnant Women
To assess the effect of water temperature and additives on pregnant women's taste and side effect during the oral glucose tolerance test (OGTT) evaluation.
- Trial name
- NCT05508425
- Testing
- oral glucose tolerance test using water at room temperature, oral glucose tolerance test using hot water, oral glucose tolerance test using cold water
- Where
- Taiwan
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Chiayi Christian Hospital
Systemic Lupus Erythematosus
A Prospective Study of Cyclophosphamide in Systemic Lupus Erythematosus Treatment
The purpose of this study is to compare the genotype-based personal prescription of cyclophosphamide with the traditional prescription.
- Trial name
- SLE (NCT01689350)
- Testing
- Genotype Detection
- Where
- China
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Melanoma
Feasibility of an Enhanced Symptom Monitoring and Expedited Subspecialty Care Referral Intervention to Improve Side Effect Management for Patients With Melanoma Receiving an Immune Checkpoint Inhibitor
This clinical trial tests the feasibility of patient reported outcomes monitoring with early, rapid immunotherapy toxicity subspecialty care to improve side effect management for patients with melanoma receiving an immune…
- Trial name
- NCT07660666
- Testing
- Electronic Health Record Review, Internet-Based Intervention, Patient Navigation
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- OHSU Knight Cancer Institute
Oxygen Deficiency, Desaturation of Blood
THRIVE Use in Pediatric Populations- Multi Site
THRIVE (Transnasal Humidified Rapid-Insufflation Ventilatory Exchange) refers to the use of high-flow nasal cannula to augment the ability to oxygenate and ventilate a patient under general anesthesia.
- Conditions
- Oxygen Deficiency, Desaturation of Blood, Hypoventilation, Anesthesia; Adverse Effect
- Trial name
- NCT04322994
- Testing
- Transnasal Humidified Rapid-Insufflation Ventilatory Echange
- Where
- 5 sites in United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Stanford University
Drug Induced Liver Injury
Acetaminophen Adduct Formation in Non-Drinkers Taking Therapeutic Doses of Acetaminophen for Ten Consecutive Days
Acetaminophen is commonly used to treat fever or pain. Your body clears acetaminophen by processing it in the liver. During the processing, some of the acetaminophen may bind to proteins in the liver.
- Trial name
- Non-Drinker (NCT00616018)
- Testing
- acetaminophen
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Kennon Heard
Hot Weather; Adverse Effect, Kidney Dysfunction
Renal Considerations in the Heat Stress Recommendations
An epidemic of chronic kidney disease is occurring in laborers who undertake physical work outdoors in hot conditions. The reason for this is unknown, but may be related to kidney dysfunction caused by increases in body…
- Conditions
- Hot Weather; Adverse Effect, Kidney Dysfunction, Kidney Injury, Hyperthermia
- Trial name
- Aim1 (NCT04767347)
- Testing
- 23.0°C WBGT - Fixed Work Rate, 25.5°C WBGT - Fixed Work Rate, 27.5°C WBGT - Fixed Work Rate
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Indiana University
Adverse Effects
Pneumococcal Protein Vaccine Safety and Immunogenicity Trial
This is an observer-blind, randomised, vaccine-controlled, vaccine trial to determine the safety and immunogenicity of a pneumococcal protein vaccine.
- Trial name
- PPR02 (NCT01764126)
- Testing
- Pneumococcal protein vaccine
- Where
- Bangladesh
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Side Effects of Creatine Monohydrate Dosing
Gastrointestinal and Fluid Retention Symptoms Associated With Creatine Monohydrate With and Without Loading Dose Over 28 Days of Supplementation
This study aimed to investigate the incidence and severity of GI symptoms associated with daily CM supplementation, with and without a loading phase, in healthy male and female adults.
- Trial name
- NCT07176325
- Testing
- Creatine Monohydrate
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Vireo Systems, Inc.
Chronic Pain, Widespread
Treatment of Chronic Pain With Cannabidiol (CBD) and Delta-9-tetrahydrocannabinol (THC)
This is a study comparing the effects of Delta-9-Tetrahydrocannabinol (THC) versus Cannabidiol (CBD) versus a placebo on chronic non-cancer pain.
- Trial name
- NCT03215940
- Testing
- Delta-9-Tetrahydrocannabinol, Cannabidiol
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Utah
Adverse Effects in the Therapeutic Use of Other and Unspecified Agents Primarily Acting on the Respiratory System
Dexmedetomidine Versus Propofol for Sedation in Stereotactic Brain Biopsy
Pre-operative anxiety leads to higher sympathetic stimulation. Propofol in the main drug used during interventional or imaging techniques that need sedation.
- Trial name
- NCT03375385
- Testing
- dexmedetomidine/ propofol
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Drug-induced Liver Injury
Establishment of Drug-induced Liver Injury Databases and Application of Circulating microRNA(miRNA)
The purpose of the study is to establish drug-induced liver injury databases in China, make criteria for Chinese drug-induced liver injury patients and evaluate the application of certain circulating miRNA in diagnosis or…
- Trial name
- NCT02061826
- Where
- China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Beijing Ditan Hospital
Contraception
Side Effect Profiles of Brand Name Versus Generic Oral Contraceptives
This is a randomized control trial of Ortho tricyclen versus Trinessa (generic equivalent) to determine if they have similar effects.
- Trial name
- NCT00775190
- Testing
- ortho tricyclen, Trinessa
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Corewell Health East
Depression
Prediction of Antidepressant Response Using Pharmacogenetics and Peripheral Lymphocytic Phenotype
The purpose of this study is to determine whether pharmacogenomic study of bioamine transporters and peripheral lymphatic biomarkers(phenotype) predict antidepressant responsiveness in advance before the appearance of the drug…
- Trial name
- NCT01352559
- Testing
- responders, non-responders
- Where
- South Korea
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis
Outcomes in Stevens Johnsons Syndrome and Toxic Epidermal Necrolysis
This is a prospective, multicenter cohort observational; study to compare treatment outcomes in patients admitted to the hospital with Stevens-Johnsons Syndrome/Toxic Epidermolysis, aiming to assess the utility of medical…
- Conditions
- Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis, Drug Reaction
- Trial name
- NCT03585946
- Testing
- Site specific standard of care comparison
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Left Ventricular Dysfunction, Spinal Anesthetics Causing Adverse Effects in Therapeutic Use
Effects of Intrathecal Local Anesthetics on Left Ventricular Global Longitudinal Strain
The objective of this study is to assess the effects of intrathecal local anesthetics on left ventricular global longitudinal strain (LVGLS) using transthoracic echocardiography (TTE).
- Conditions
- Left Ventricular Dysfunction, Spinal Anesthetics Causing Adverse Effects in Therapeutic Use, Global Cardiac Wall Motion Dysfunction
- Trial name
- NCT05650008
- Testing
- Intrathecal local anesthesia
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Drug-Induced Liver Injury
Surveillance for Early Liver Injuries Caused by Xianlin Gubao Granule
This is a prospective registry study to surveil early liver injuries caused by Xianlin Gubao Granule (XLGB Granule) through a non-intervention observational way.
- Trial name
- NCT03091608
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Beijing 302 Hospital
Pain, Postoperative
Comparison of Adverse Drug Reactions Associated for Oxycodone and Morphine in Postoperative Pain After Abdominal Hysterectomy
The objective of this study is compare adverse reactions associated with oxycodone and morphine for the treatment of postoperative pain after abdominal hysterectomy
- Trial name
- NCT02936934
- Testing
- Morphine, Oxycodone
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Hospital Civil de Guadalajara
Drug-Induced Liver Injury
Surveillance for Early Liver Injuries Caused by Xianlin Gubao Capsule.
This is a prospective registry study to surveil early liver injuries caused by Xianlin Gubao Capsule (XLGB Capsule) through a non-intervention observational way.
- Trial name
- NCT03091244
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Beijing 302 Hospital