Clinical trials: Sibling Relations
ART
A Sibling Oocyte Study- Comparison of ZyMotTM Microfluidics Device to Density Gradient for Sperm Selection During ICSI
The primary objective of this study is to evaluate whether the percentage of good quality embryo formation following Intracytoplasmic Sperm Injection (ICSI) is improved with the use of ZyMot method of microfluidic sperm…
- Trial name
- NCT04818593
- Testing
- ZyMot Multi Sperm Separation Device (850 ul), Density Gradient Centrifugation
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
aGVHD
Efficacy and Safety Study of ATG for Prophylaxis of aGVHD in Matched Sibling Donor PBSCT
The purpose of this study is to determine the efficacy and safety of combined ATG （antithymocyte globulin ） regimen for aGVHD(acute graft-versus-host disease ) prophylaxis in matched sibling donor peripheral blood stem cell…
- Trial name
- NCT02677181
- Testing
- ATG, CsA, mycophenolate mofetil
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chinese PLA General Hospital
Infertility, Reproductive Sterility
Does in Vivo Culture of Pre-cleavage Stage Embryo Reduce the Incidence of Aneuploidy?
This Clinical Study has been designed to assess and compare the impact of in vitro or in vivo culture conditions on the euploidy of sibling blastocysts.
- Trial name
- NCT02652143
- Testing
- AneVivo (Medical device for in vivo culture of embryos), comparator for embryo culture in vitro
- Where
- Spain
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Anecova SA
Acute Lymphoblastic Leukemia, Pediatric
A Prospective, Open-label, Randomized Controlled, Multicenter Clinical Study of MSD-HSCT Using a TBI or TMLI Conditioning Regimen for Pediatric ALL
This study aims to compare the effects of two different conditioning regimens on patients with acute lymphoblastic leukemia (ALL) undergoing matched sibling donor hematopoietic stem cell transplantation (MSD-HSCT): Total Body…
- Trial name
- NCT06564493
- Testing
- TBI, TMLI, Cyclophosphamide
- Where
- China
- Volunteers
- 170 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Bronchiolitis
Dexamethasone in the Treatment of Bronchiolitis in Patients With Either Eczema and or Family History of Asthma
The investigators hypothesized that oral Dexamethasone in addition to nebulized Salbutamol will improve the Bronchiolitis Clinical Severity Score,duration of treatment in the short stay unit,need for hospitalization and…
- Trial name
- #9105 (NCT01065272)
- Testing
- Dexamethasone
- Where
- Qatar
- Volunteers
- 200 people
- Sponsor
- Hamad Medical Corporation
Suicide
Tool for Sibling and Children of Someone With Suicidal Thoughts
This study aims to investigate to what extent a website developed for siblings and children (16-25 years old) of someone with suicidal thoughts and/or behaviors is effective in improving perceived pressure, knowledge, attitudes…
- Trial name
- NCT06100575
- Testing
- Website (www.mee-leven.be)
- Where
- Belgium
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University Ghent
Fertility
Effect of Oocyte Vitrification on Fertilization Rate, Embryo Quality and Development
Indications for oocyte (egg) vitrification (fast freezing) include the preservation of reproductive competence of young cancer patients who need chemotherapy, pelvic radiation, or surgical removal of ovaries for treatment.
- Trial name
- NCT01422395
- Testing
- Freezing
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Main Line Fertility Center
Rheumatoid Arthritis
Genetics of Rheumatoid Arthritis
This study attempts to identify the genes responsible for rheumatoid arthritis (RA), or inflammation of the joints. It is known that genes play an important role in RA, but their number and significance have not been determined.
- Trial name
- NCT00001678
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Intensive Care Pediatric
Experiences Reported by Siblings of Children Hospitalized in the PICU
The care for a child in pediatric intensive care is recognized as a traumatic experience for the patient and their entourage. The needs and feelings of parents are relatively well supported in the literature.
- Trial name
- SIBCARE (NCT06664333)
- Testing
- Semi-structured interviews
- Where
- 2 sites in France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Lymphoid Leukemia
Donor-specific Allogeneic Hematopoietic Cell Transplantation for Acute Lymphoblastic Leukemia (ALL)
[Study Objectives] To evaluate the efficacy of allogeneic hematopoietic cell transplantation (HCT) in patients with acute lymphoblastic leukemia (ALL) in the first or second complete remission (CR).
- Trial name
- AHCTALL (NCT01037764)
- Testing
- alloHCT
- Where
- 2 sites in South Korea
- Volunteers
- 100 people
- Sponsor
- Asan Medical Center
Anorexia Nervosa
Speech Groups for Children Living With a Sibling Who Suffers From Anorexia Nervosa
Anorexia nervosa (AN) is a complex mental disease with a huge impact on the patient's siblings life and well-being. Based on literature, group interventions for siblings of children suffering from a chronic disease could provide…
- Trial name
- EMA-FRaM (NCT06528158)
- Testing
- sibling group
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Toulouse
Renal Transplant Rejection, Tolerance
Study of Combined Kidney and Blood Stem Cell Transplant From a Brother or Sister Donor
The purpose of this study is to find out if an investigational treatment will allow kidney transplant recipients to better accept their new kidney and stop immunosuppressive medicines.
- Conditions
- Renal Transplant Rejection, Tolerance, Kidney Transplant
- Trial name
- NCT03707262
- Testing
- Donor CD34+ and CD3+ cells
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Jeffrey Veale, MD
Acute Myeloid Leukemia, Myelodysplastic Syndrome
Study With Intravenous Busulfan And Fludarabine Myeloablative Conditioning Regimen For HLA Identical Sibling Donor HSCT
Analyze the results of conditioning with once-daily dose intravenous busulfan and fludarabine in patients undergoing HLA identical sibling Allogeneic HSCT for myeloid malignancies.
- Conditions
- Acute Myeloid Leukemia, Myelodysplastic Syndrome, Myeloproliferative Disorders, Chronic Myeloid Leukemia
- Trial name
- BUFLU (NCT01683123)
- Volunteers
- 143 people
- Sponsor
- Grupo Espanol de trasplantes hematopoyeticos y terapia celular
Defibrillators, Implantable, Myocardial Infarction
Risk of Life-threatening Heart Rhythm Disturbances in Siblings
The purpose of this study is to determine if heredity influences the risk of life-threatening heart rhythms (ventricular tachycardia and ventricular fibrillation) after heart attack (myocardial infarction).
- Conditions
- Defibrillators, Implantable, Myocardial Infarction, Tachycardias, Ventricular
- Trial name
- SIBFIB (NCT00498524)
- Testing
- ICD
- Where
- United States
- Volunteers
- 2,047 people
- Sponsor
- Duke University
Leukemia, Lymphoma
Mycophenolate Mofetil, Tacrolimus, Daclizumab, and Donor Peripheral Stem Cell Transplantation in Treating Patients With Hematologic Cancer
RATIONALE: Monoclonal antibodies such as daclizumab can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells.
- Conditions
- Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes
- Trial name
- NCT00006350
- Testing
- daclizumab, therapeutic allogeneic lymphocytes, mycophenolate mofetil
- Where
- United States
- Sponsor
- University of Maryland, Baltimore
Schizophrenia, Bipolar Disorder
Impact of Genetic Counseling for Female First Degree Relatives of Individuals With Mental Illness
Women with a close relative who has experienced mental illnesses like schizophrenia, bipolar disorder or schizoaffective disorder often have a poor understanding of the causes of the illness, and are often very worried about the…
- Conditions
- Schizophrenia, Bipolar Disorder, Schizoaffective Disorder
- Trial name
- NCT00714818
- Testing
- Genetic Counseling
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- University of British Columbia
IVM, PCOS (Polycystic Ovary Syndrome)
Low vs. Air Oxygen Concentration CAPA-IVM Culture of Cumulus-oocyte Complexes
IVM with a pre-maturation step, known as capacitation IVM (CAPA-IVM), has demonstrated enhanced maturation of human oocytes in vitro and successful live births.
- Trial name
- NCT06087354
- Testing
- The way of Cumulus-oocyte complexes (COC) CAPA-IVM culture condition
- Where
- Vietnam
- Volunteers
- 20 people
- Sponsor
- Mỹ Đức Hospital
Acute Lymphoid Leukemia, Acute Myeloid Leukemia
Prophylactic DLI-X for Leukemia Relapse After HCT
The primary objective of this proposal is to conduct the first-in-human randomized clinical trial evaluating prophylactic DLI-X (pro-DLI-X) for relapse prevention following matched sibling donor (MSD) or haploidentical (haplo)…
- Conditions
- Acute Lymphoid Leukemia, Acute Myeloid Leukemia, Acute Undifferentiated Leukemia (AUL), Myelodysplastic Syndrome
- Trial name
- NCT07254793
- Testing
- Exercise Mobilized Prophylactic DLI, Standard Prophylactic DLI
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Arizona
Caesarean Section, Obesity
Obesity Among Young Adult Males Born With Cesarean Section.
Previous research has suggested that cesarean section may be associated with an increased risk of developing obesity in childhood, adolescence and adulthood.
- Conditions
- Caesarean Section, Obesity, Cesarean Section Complications
- Trial name
- NCT03918044
- Where
- Sweden
- Volunteers
- 97,291 people
- Sponsor
- Karolinska Institutet
Hematologic Diseases, Hematologic Malignancies
Granulocyte Colony Stimulating Factor (G-CSF) for Bone Marrow Transplant (BMT)
The major purpose of this study is to evaluate the curative potential of white cell growth hormone (G-CSF)-stimulated bone marrow cells in allogeneic bone marrow transplants.
- Trial name
- NCT00231309
- Testing
- Granulocyte Colony Stimulating Factor
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Emory University