Clinical trials: Short-Term Memory Impairment
Mild Cognitive Impairment, Healthy Aging
Novel, Individualized Brain Stimulation, Network-based Approaches to Improve Cognition
Impaired working memory (WM) plays a crucial role in normal aging, in mild cognitive impairment (MCI) and cognitive decline associated with dementia, such as Alzheimer's disease (AD).
- Trial name
- NiBS-iCog (NCT04986787)
- Testing
- tACS, TMS, TIS
- Where
- Czechia
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Cognitive Impairment, Cognitive Decline
A Mechanistic Study to Investigate tDCS and Working Memory in MCI Patients
The current study is a mechanistic study to evaluate working memory gains from application of transcranial direct current stimulation (tDCS) in older adults with mild cognitive impairments (MCI) compared to cognitively healthy…
- Trial name
- AIM (NCT05998031)
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Florida
Mild Cognitive Impairment
Neurofeedback to Improve Working Memory in Mild Cognitive Impairment
Mild cognitive impairment (MCI) has been identified as an early phase of Alzheimer's disease (AD), a neurodegenerative disorder expected to affect 13.9 million Americans by 2060.
- Trial name
- NCT04566900
- Testing
- Neurofeedback
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- University of California, San Diego
Aphasia, Acquired, Short-Term Memory Impairment
Short-term Memory Assessment in Patients With Poststroke Aphasia
Background and aim There is a growing awareness that people with aphasia (language problems) after a stroke often have difficulties with their short-term memory (STM).
- Trial name
- NCT06068296
- Testing
- short term memory assessment, Oxford cognitive screen, Token Test
- Where
- 2 sites in Belgium
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Mild Cognitive Impairment (MCI)
TACS to Engage Theta-Gamma Coupling and Enhance Working Memory in Patients With MCI (tACS-MCI)
This study is looking at a new non-invasive brain stimulation methods called transcranial alternating current stimulation (tACS) to see if it can improve working memory and thinking processes in people with Mild Cognitive…
- Trial name
- tACS-MCI (NCT06783283)
- Testing
- Transcranial Alternating Current Stimulation
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Centre for Addiction and Mental Health
Postoperative Cognitive Dysfunction, Cognitive Impairment
Cognitive Changes After Major Joint Replacement - Full Trial (Cognigram 2)
Patients assume that cognitive performance rapidly returns to baseline after anesthesia and surgery. Several studies have shown that one week after major non-cardiac surgery about 27% of patients have postoperative cognitive…
- Conditions
- Postoperative Cognitive Dysfunction, Cognitive Impairment, Mild Cognitive Impairment, Delirium
- Trial name
- NCT03147937
- Testing
- Cognitive Testing
- Where
- Canada
- Volunteers
- 505 people
- Sponsor
- Dr. Stephen Choi
Cognitive Rehabilitation, Brain Injuries
Hypnosis in Working Memory Rehabilitation
Establishment of effective, efficient, and evidence-based interventions in rehabilitation of working memory (WM) deficits after acquired brain injury (ABI) is sorely needed.
- Conditions
- Cognitive Rehabilitation, Brain Injuries, Cognitive Impairment, Working Memory
- Trial name
- NCT05287542
- Testing
- Hypnotic suggestion, Mindfulness
- Where
- Norway
- Volunteers
- 90 people
- Sponsor
- Sunnaas Rehabilitation Hospital
Working Memory, Post-covid-19
Influence of Fampridine on Working Memory in Individuals With Post COVID-19 Condition With Subjective Cognitive Impairment
In genome-wide association studies we identified potassium channels to be genetically linked to performance and neural activity of working memory in healthy humans.
- Trial name
- FamC (NCT05274477)
- Testing
- Fampridine SR
- Where
- Switzerland
- Volunteers
- 8 people
- Sponsor
- Prof. Dominique de Quervain, MD
Mild Cognitive Impairment
Cognitive Ability Training in Seniors
This study investigates the beneficial effects of prefrontal brain stimulation (with transcranial direct current stimulation [tDCS]) during working memory training in seniors with subjective memory impairments.The…
- Trial name
- CATS (NCT02587338)
- Testing
- Verum tDCS
- Where
- Germany
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Wuerzburg University Hospital
Brain Neoplasms, Malignant, Brain Neoplasms, Benign
Pioglitazone Hydrochloride in Preventing Radiation-Induced Cognitive Dysfunction in Treating Patients With Brain Tumors
RATIONALE: Pioglitazone hydrochloride may be effective treatment for cognitive dysfunction caused by radiation therapy. PURPOSE: This phase I trial is studying the side effects and best dose of pioglitazone hydrochloride in…
- Conditions
- Brain Neoplasms, Malignant, Brain Neoplasms, Benign, Malignant Meningioma, Glioblastoma Multiforme
- Trial name
- NCT01151670
- Testing
- pioglitazone
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Wake Forest University Health Sciences
Traumatic Brain Injury, Severe Traumatic Brain Injury
Efficacy of Pharmacological Treatment of Working Memory Impairment After Traumatic Brain Injury: Evaluation With fMRI
This study is designed to examine the effects of a wake-promoting agent (Modafinil) on working memory (WM) in persons with moderate to severe TBI utilizing a double blinded placebo controlled methodology.
- Trial name
- NCT00489892
- Testing
- Modafinil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Kessler Foundation
Postoperative Cognitive Dysfunction, Mild Cognitive Impairment
Cognitive Changes After Major Joint Replacement
Patients assume that cognitive performance rapidly returns to baseline after anesthesia and surgery. Several studies have shown that one week after major non-cardiac surgery about 27% of patients have postoperative cognitive…
- Conditions
- Postoperative Cognitive Dysfunction, Mild Cognitive Impairment, Delirium, Cognitive Deficit
- Trial name
- Cognigram (NCT02964221)
- Testing
- Cognitive Testing
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Dr. Stephen Choi
Mild Cognitive Impairment (MCI)
Working Memory Training in Patients with Mild Cognitive Impairment
The purpose of this study is to test whether a special memory training program, called CogMed, can help people with early memory problems.
- Trial name
- NCT06734286
- Testing
- CogMed
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Memory Deficits Schizophrenia Neurostimulator; Complications
Investigating the Cognitive Source of Visual Working Memory Impairment in Schizophrenia
The investigators plan to investigate the effect of enhancement on visual working memory (VWM) in patients of chronic schizophrenia and determine the predictive factors of effective treatment.
- Trial name
- NCT05496413
- Testing
- STARSTIM
- Where
- Taiwan
- Volunteers
- 31 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Mild Cognitive Impairment, Memory Disorders
Behavioral Interventions to Prevent or Delay Dementia
This study will compare the effectiveness of different combinations of 5 types of behavioral interventions across patient-centered outcomes. It will also evaluate which outcomes (e.g.
- Conditions
- Mild Cognitive Impairment, Memory Disorders, Mild Dementia, Impaired Cognition
- Trial name
- NCT02265757
- Testing
- Cognitive Rehabilitation, Computer Brain Fitness Training, Support Group (patient and partner)
- Where
- 3 sites in United States
- Volunteers
- 272 people
- Sponsor
- Mayo Clinic
Stroke, Stroke Sequelae
Therapeutic Effect of Transcranial Magnetic Stimulation on Memory Impairment in Patients After Stroke
The goal of this clinical trial is to test the therapeutic effect of theta burst stimulation (TBS), which is one of stimulus pattern of repetitive transcranial magnetic stimulation, in patients with post stroke cognition…
- Conditions
- Stroke, Stroke Sequelae, Cognitive Impairment
- Trial name
- NCT05578183
- Testing
- theta burst stimulation
- Where
- China
- Sponsor
- China Rehabilitation Research Center
Mild Cognitive Impairment
Neurofeedback to Aid Vets' Memory
Military deployment is associated with increased risk of mild cognitive impairment (MCI). Combat stress related memory deficits has been well documented.
- Trial name
- TUNe (NCT04446481)
- Testing
- Neurofeedback
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Cognitive Impairments, Schizotypal Personality Disorder
Clinical Testing of a D1 Agonist for Cognitive Enhancement in Schizotypal Personality Disorder
Currently, no study to date has directly tested a selective D1R agonist in relation to the cognitive impairment of Schizophrenia without the confound of neuroleptics.
- Trial name
- SPD (NCT01466205)
- Testing
- DAR-0100A
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Larry J. Siever
Multiple Sclerosis, Electric Stimulation
Effectiveness of Personalized Alternating Current Stimulation for Treating Cognitive Impairment in CNS Demyelination Patients
Background: Central nervous system inflammatory demyelinating diseases often lead to significant cognitive impairment, presenting a critical challenge in patient management.
- Trial name
- NCT06968039
- Testing
- Neuroelectrics StarStim 32
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Xuanwu Hospital, Beijing
Mild Cognitive Impairment
Memory Training and Neural Plasticity
This study will evaluate the efficacy of working memory training in older adults with amnestic mild cognitive impairment (MCI).
- Trial name
- WMTrain (NCT05380739)
- Testing
- Working Memory Training
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Michigan