Clinical trials: Short Bowel
Short Bowel Syndrome
Liraglutide on Decreasing Parenteral Support in Short Bowel Patients (SLIPS)
Pilot study looking at the effect on Liraglutide in the reduction of parenteral support in patients with short bowel.
- Trial name
- SLIPS (NCT03371862)
- Testing
- Liraglutide Pen Injector [Victoza]
- Where
- United Kingdom
- Sponsor
- Imperial College London
Short Bowel Syndrome
Metabolic Balance Study of Apraglutide in Patients With Short Bowel Syndrome, Intestinal Failure (SBS-IF) and Colon-in-Continuity (CIC)
The primary objective of the trial is to evaluate the safety of apraglutide in adult subjects with SBS-IF and CIC.
- Trial name
- STARSnutrition (NCT04964986)
- Testing
- Apraglutide
- Where
- 2 sites in Belgium, France
- Volunteers
- 10 people
- Sponsor
- VectivBio AG
Neoadjuvant Treatment, Rectal Cancer
Neoadjuvant Cetuximab + Chemotherapy Combined With Short-course Radiotherapy
Prospectively Investigate the effectiveness and safety of neoadjuvant cetuximab + chemotherapy (mFOLFOX6) combined with short-course radiotherapy (25Gy/5Fx) for RAS wild-type locally advanced rectal cancer
- Conditions
- Neoadjuvant Treatment, Rectal Cancer, Cetuximab, Radiotherapy
- Trial name
- NCT04923620
- Testing
- cetuximab+mFOLFOX6, short-course radiotherapy
- Where
- China
- Volunteers
- 51 people
- Sponsor
- Shanghai Minimally Invasive Surgery Center
IBS
Fecal Metabolome and the Intestinal Microbiota in Irritable Bowel Syndrome
The purpose of this study is to find out the relationship between the bile acids, fatty acids (fatty acids are part of the diet) and bacteria that are present in the intestines.
- Trial name
- IBS (NCT02981888)
- Testing
- X-Ray
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Indiana University
Rectal Cancer
Comparing Preoperative Short-course Radiotherapy With or Without Local Boost for Rectal Cancer
A randomized trial comparing weather preoperative short-course radiotherapy with local boost is better than conventional preoperative short-course radiotherapy for local advanced rectal cancer.
- Trial name
- NCT02498353
- Testing
- preoperative short-course radiotherapy with local boost, preoperative short-course radiotherapy without local boost, TME surgery
- Volunteers
- 100 people
- Sponsor
- Zhongnan Hospital
Short Bowel Syndrome, Intestinal Failure
Quality of Life in Patients With Short Bowel Syndrome Treated Without and With Teduglutide - a Prospective Nested Matched Pair Analysis
The aim of this prospective longitudinal study is to compare the quality of life of short bowel patients prior to and on teduglutide treatment with a non-treated patient group in a matched-pair design.
- Trial name
- MatchedQoL (NCT04733066)
- Testing
- Teduglutide
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Charite University, Berlin, Germany
Ulcerative Colitis, Ileal Pouch
Short Versus Long Interval to Ileostomy Reversal After Ileal Pouch Surgery
In patients with ulcerative or indeterminate colitis who undergo ileal pouch anal anastomosis and diverting loop ileostomy (IPAA) surgery* a short interval to loop ileostomy reversal will result in differences in complications…
- Conditions
- Ulcerative Colitis, Ileal Pouch, Ileostomy - Stoma
- Trial name
- SLIRPS (NCT03587519)
- Testing
- Early, Late
- Where
- 8 sites in United States
- Volunteers
- 36 people
- Sponsor
- University of Colorado, Denver
Obesity & Overweight, Gut -Microbiota
Effects of Monday-Thursday Sunnah Fasting on Short-Chain Fatty Acids, GLP-1, Satiety, and Nutritional Status in Obese Males
This quasi-experimental study investigated the effects of 8 weeks of Monday-Thursday Sunnah fasting on fecal short-chain fatty acids (SCFA), fasting total GLP-1, appetite regulation (hunger and satiety area under the curve)…
- Trial name
- NCT07703865
- Testing
- Monday-Thursday Sunnah Dry Fasting
- Where
- Indonesia
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Muhammadiyah Jakarta
Rectal Cancer
Comparison of Short-term Outcomes of Robotic and Laparoscopic Surgery in Patients With Different Body Mass Index for Mid and Low Rectal Cancer
Numerous comparison studies on the outcomes of robotic and laparoscopic surgery in the treatment of rectal cancer have been undertaken and reported.
- Trial name
- NCT06396975
- Testing
- robotic surgery
- Where
- China
- Volunteers
- 1,413 people
- Sponsor
- Daorong Wang
Short Bowel Syndrome
Effect of a Short Message Service Intervention on Patients With Short Bowel Syndrome
The investigators will be using a text messaging intervention to identify potentially dangerous and re- admission causing symptoms in patients with Short Bowel Syndrome (SBS) on Total Parenteral Nutrition (TPN).
- Trial name
- NCT03419156
- Testing
- Text Message Arm Intervention
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- St. Louis University
Healthy
Effects of Teduglutide on Cardiac Repolarisation and Conduction in Healthy Male and Female Volunteers
The primary objective of this trial is to investigate if teduglutide has an effect on cardiac repolarisation (QT, QTc interval).
- Trial name
- NCT01028924
- Testing
- Teduglutide
- Where
- Germany
- Volunteers
- 72 people
- Sponsor
- Nycomed
Short Bowel Syndrome
Efficacy, Safety and Tolerability of Enteric-Coated Cholestyramine Capsules for Adult Short Bowel Syndrome
A new Enteric-Coated Cholestyramine (ECC) capsule has been developed to manage diarrhea associated with Short Bowel Syndrome (SBS) in adults.
- Trial name
- NCT04046328
- Testing
- Enteric-Coated Cholestyramine (ECC) Capsule
- Where
- 3 sites in Poland
- Volunteers
- 13 people
- Sponsor
- Pharmascience Inc.
Emotions, Stress
The Role of Short Chain Fatty Acids in Microbiota-gut-brain Axis
The role of short chain fatty acids (SCFA) in the microbiota-gut-brain axis is examined in a sample of healthy volunteers. SCFA are the major products of bacterial fermentation of dietary fiber in the colon, and are hypothesised…
- Conditions
- Emotions, Stress, Fear
- Trial name
- SCFA-AP (NCT03688854)
- Testing
- SCFA mixture
- Where
- Belgium
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Colon Cancer, Malnutrition
The Patient in Laparoscopic Colon Surgery:Impact of Comorbidities,Frailty,Malnutrition and Sarcopenia on Short-term Mortality
There are many factors involved in outlining the patient's profile and in defining which factors can be configured as risks related to the surgical act; for the modern surgeon it is no longer possible to identify the patient at…
- Conditions
- Colon Cancer, Malnutrition, Sarcopenia, Comorbidities and Coexisting Conditions
- Trial name
- NCT04729738
- Where
- Italy
- Volunteers
- 420 people
- Sponsor
- University Hospital of Ferrara
Short Bowel Syndrome
Trial to Evaluate Efficacy and Safety of Apraglutide in SBS-IF
The primary objective of the trial is the confirmation of the efficacy of apraglutide to evaluate the efficacy of weekly subcutaneous apraglutide in reducing parenteral support dependency.
- Trial name
- STARS (NCT04627025)
- Testing
- apraglutide
- Where
- 68 sites in United States, Argentina and 16 more
- Volunteers
- 164 people
- Sponsor
- VectivBio AG
Ulcerative Colitis, Anti TNF Therapy
The Influence of Biologcal Treatment on the Short-Term Complications of Surgery in Patients With Inflematory Bowel Disease.
BACKGROUND: Previous studies of short-term surgical outcomes after preoperative exposure to anti-TNF therapy in ulcerative colitis (UC) patients who have undergone IPAA have been conflicting.
- Conditions
- Ulcerative Colitis, Anti TNF Therapy, Ileal Pouch Anal Anastomosis (IPAA)
- Trial name
- NCT03747068
- Testing
- Anti-TNF Drug
- Volunteers
- 130 people
- Sponsor
- HaEmek Medical Center, Israel
Short Gut Syndrome
Fiber Food Introduction in Pediatric Short Bowel Syndrome
Short bowel syndrome (SBS) is a rare but challenging condition in which patients have insufficient bowel length to meet fluid, electrolyte, and nutrient requirements without parenteral support.
- Trial name
- NCT05432648
- Testing
- Green bean puree
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Cow's Milk Protein Allergy, Eosinophilic Gastrointestinal Disorders
A Study to Monitor the Use of an Amino Acid-Based Infant Formula
To assess the frequency and nature of adverse events in infants fed a free amino acid based infant formula.
- Conditions
- Cow's Milk Protein Allergy, Eosinophilic Gastrointestinal Disorders, Malabsorption/Maldigestion, Short Bowel Syndrome
- Trial name
- EAGLE (NCT02953223)
- Testing
- Free amino acid infant formula
- Where
- 29 sites in United States
- Volunteers
- 144 people
- Sponsor
- Société des Produits Nestlé (SPN)
Hypoxic-Ischemic Encephalopathy, Bronchopulmonary Dysplasia
Efficacy Evaluation of UCB-MNCs in the Treatment of Refractory Neonatal Diseases
Hypoxic-ischemic encephalopathy (HIE), bronchopulmonary dysplasia (BPD), short bowel syndrome (SBS) are refractory in clinical treatment.
- Conditions
- Hypoxic-Ischemic Encephalopathy, Bronchopulmonary Dysplasia, Short Bowel Syndrome
- Trial name
- NCT06427642
- Testing
- Mononuclear cells, Mild hypothermia therapy, Breathing support technique
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shandong Qilu Stem Cells Engineering Co., Ltd.
Essential Fatty Acid Deficiency (EFAD)
Pediatric Study to Evaluate Risk of Developing Essential Fatty Acid Deficiency When Receiving Clinolipid or Standard-of-Care Lipid Emulsion
This will be a descriptive study designed to evaluate the propensity for hospitalized pediatric patients treated adequately with Clinolipid or standard of care for up to 90 days to develop Essential Fatty Acid Deficiency (EFAD).
- Trial name
- NCT02476994
- Testing
- Clinolipid, Intralipid
- Where
- 4 sites in United States
- Volunteers
- 1 people
- Sponsor
- Baxter Healthcare Corporation