Clinical trials: Shock
Kidney Stones
Evaluation of Different Treatment Modalities for Lower Pole and Renal Pelvis Stones
It is aimed to evaluate the treatment results, rates of success and complications, and injury given to the kidney by measuring preoperative and postoperative blood urea, creatinine, Cystatin C and Netrin-1 levels and urine…
- Trial name
- NCT02522676
- Testing
- Endoscopic kidney stone surgery, Non-invasive kidney stone treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Selcuk University
Severe Sepsis, Septic Shock
Neutrophil Gelatinase Associated Lipocalin (NGAL) in Urine: Can This Prove to be a Biomarker for Acute Kidney Injury in Patients With Sepsis?
Patients with severe infection and sepsis are in high risk of hypo perfusion and therefore organ affection. Temporary or permanent kidney failure is a common complication in these patients.
- Conditions
- Severe Sepsis, Septic Shock, Acute Kidney Injury
- Trial name
- NCT02034240
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Sygehus Lillebaelt
Gram-Negative Bacterial Infections, Sepsis
Early Use of Polymyxin B Hemoperfusion in Abdominal Sepsis
This clinical study designed as a prospective, open labelled, multi-centre, RCT will be carried out to evaluate if direct hemoperfusion with polymyxin B immobilized fiber column (PMX) is superior to conventional medical therapy…
- Conditions
- Gram-Negative Bacterial Infections, Sepsis, Septic Shock
- Trial name
- EUPHAS (NCT00629382)
- Testing
- Polymyxin B immobilized fiber column, Conventional medical therapy in the ICU
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- St. Bortolo Hospital
Coccydynia
The Effects of Extracorporeal Shock Wave Therapy in Patients With Coccydynia: A Randomized Controlled Trial
The purpose of this study is to evaluate the effects of extracorporeal shock wave therapy (ESWT) on the outcomes of coccydynia.
- Trial name
- ESWT (NCT02313324)
- Testing
- Extracorporeal shock wave therapy (ESWT), SWD combined IFC
- Volunteers
- 42 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Cardiogenic Shock, Myocardial Infarction
Clinical Outcome and Cost-effectiveness of Reduced Noradrenaline by Using a Lower Blood Pressure Target in Patients With Cardiogenic Shock From Acute Myocardial Infarction
Rationale: Pump failure due to acute myocardial infarction (AMI) can lead to cardiogenic shock (CS): a state of low blood flow to end-organs with subsequent multi-organ failure that is associated with high mortality rated.
- Trial name
- NORSHOCK (NCT05168462)
- Testing
- Reduced noradrenaline use
- Where
- Netherlands
- Volunteers
- 776 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Stroke, Ischemic, Stroke Hemorrhagic
Extracorporeal Shock Wave Therapy and Assessment Strategy Through a Novel Gait Analysis Tool for Post-stroke Spasticity
The aim of this study is to objectively evaluate the effectiveness of radial extracorporeal shock wave therapy (rESWT) and conventional physical therapy program on the gait pattern through a new gait analysis system which…
- Conditions
- Stroke, Ischemic, Stroke Hemorrhagic, Spasticity, Muscle, Spastic Gait
- Trial name
- NCT05206240
- Testing
- Radial extracorporeal shock wave therapy and conventional physical therapy
- Where
- Romania
- Volunteers
- 15 people
- Sponsor
- Carol Davila University of Medicine and Pharmacy
Obstructive Sleep Apnea
DISE-HNS Effect Study
The purpose of this study is to assess the site, pattern and degree of upper airway collapse before and during hypoglossal nerve stimulation (HNS) treatment using clinical standard drug-induced sleep endoscopy (DISE) and using a…
- Trial name
- DISE-HNS (NCT06372847)
- Testing
- Hypoglossal nerve stimulation implant, Polysomnography, Drug-induced sleep endoscopy (DISE)
- Where
- Belgium
- Volunteers
- 58 people
- Sponsor
- University Hospital, Antwerp
Acute Kidney Injury in Critically Ill Children
Utility of NGAL to Diagnose AKI in Critically Ill Children
Acute Kidney Injury is common in critically ill children and is associated with high morbidity and mortality in pediatric intensive care unit.
- Trial name
- NCT03034876
- Volunteers
- 140 people
- Sponsor
- Aga Khan University
Shock
Cardiovascular Metabolic Remodeling in Shock
The aim of the study is to increase our knowledge of energy dysfunction in the cardiovascular dysfunction observed during shock states by analysing the omics molecules involved.
- Trial name
- METASHOCK (NCT06285513)
- Testing
- Cardiac ultrasound
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Rouen
Lateral Epicondylitis, Tennis Elbow
The NOrwegian Tennis Elbow (NOTE) Study
Trial Design: The Norwegian Tennis Elbow (NOTE) study is a single-centre; three-armed, feasibility randomised controlled trial. Aim: The primary aim of this study is to pilot the methods proposed to conduct a definite RCT study.
- Conditions
- Lateral Epicondylitis, Tennis Elbow, Tendinopathy, Elbow
- Trial name
- NCT04803825
- Testing
- Heavy Slow Exercises, Extracorporeal Shock wave therapy, Information and advice
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Oslo University Hospital
Pediatric Urinary Lithiasis
Stepwise Shock Wave Lithotripsy in Pediatric Urolithiasis
To evaluate and compare the results of conventional and stepwise shock wave lithotripsy treatment modalities in pediatric urinary lithiasis.
- Trial name
- NCT01807260
- Testing
- Shock wave lithotripsy
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people
- Sponsor
- TC Erciyes University
Shock, Septic
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of 3 Doses of MOTREM (Nangibotide) in Patients With Septic Shock
This is a randomised, double-blind, two-stage, placebo controlled study. It is designed to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of 3 doses of nangibotide versus placebo in adult patients…
- Trial name
- NCT03158948
- Testing
- Nangibotide 0.3 mg/kg, Nangibotide 1 mg/kg, Nangibotide 3 mg/kg
- Where
- 4 sites in Belgium, France and 2 more
- Volunteers
- 50 people
- Sponsor
- Inotrem
Shock, Hypotension
Point of Care Ultrasonography In The Management of Shock: A Pilot Study
This project aims to determine the feasibility of conducting a randomized controlled trial investigating point of care ultrasound guided resuscitation compared with usual care in the management of shock at the Critical Care…
- Trial name
- NCT03296891
- Testing
- PoCUS Guided Resuscitation of Shock
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Western University, Canada
Cardiogenic Shock
Early Left Ventricular unLoading by Impella vs Intra-aortic Balloon Pump
Over the past decade, VA-ECMO has become the main mechanical support for cardiogenic shock (CS) unresponsive to medical therapy.
- Trial name
- ELLIPSE1 (NCT06645990)
- Testing
- Impella, IABP
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Montpellier
Sepsis, Septic Shock
Improvement of Organ Function by Apigenin in Elderly Patients With Sepsis
In this single-center, randomized, single-blind, placebo-controlled pilot clinical trial. The effect of apigenin on the improvement of organ function will be investigated in elderly patients with sepsis.
- Trial name
- NCT05999682
- Testing
- apigenin, sterilized water
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Zhujiang Hospital
Hemorrhage, Trauma
Empiric Calcium in Massive Transfusion
Calcium helps blood to clot and thereby stop bleeding. Trauma patients who experience large volume blood loss often require blood transfusions and bleeding is the most common cause of death.
- Conditions
- Hemorrhage, Trauma, Hypocalcemia, Shock, Hemorrhagic
- Trial name
- NCT05953376
- Testing
- Calcium Gluconate
- Sponsor
- University of California, Irvine
Medical Knowledge, Clinical Performance
Utility of High-Fidelity Simulation In the Education and Assessment of Residents in the Recognition and Management of the Sepsis Syndrome
The primary objective of the proposed study will be to determine if a multi-modality teaching curriculum utilizing high-fidelity simulation and didactic lecture will result in sustained improvement by internal medicine residents…
- Trial name
- NCT01992120
- Testing
- Debriefing of high-fidelity sepsis simulation scenarios
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Severe Sepsis
Plasma Exchange in Children With Severe Sepsis and Septic Shock
The aim of the study will be to to evaluate whether therapeutic plasma exchange (TPE) reduces mortality in critically ill children with severe sepsis or septic shock compared to the standard care of sepsis alone.
- Trial name
- PE/Sepsis (NCT07706413)
- Testing
- Plasma exchange (PE)
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- Menoufia University
Atrial Fibrillation
AV-node Stimulation Clinical Download Study to Reduce Ventricular Rate During AF
The aim of this multi-center research study is to evaluate the performance (primary purpose) and safety of a new algorithm aimed at controlling ventricular rate (VR) during rapidly conducted atrial fibrillation (AF) by delivering…
- Trial name
- AVNS (NCT01095952)
- Testing
- AVNS ON
- Where
- 4 sites in Germany, Italy and 1 more
- Volunteers
- 45 people
- Sponsor
- Medtronic BRC
COVID-19
A Prospective, Phase II Study to Evaluate Safety of 101-PGC-005 ('005) for Moderate to Severe COVID-19 Disease Along With Standard of Care
In December 2019, a novel pneumonia caused by a previously unknown pathogen emerged in Wuhan, China. The pathogen was soon identified as a novel coronavirus (SARS-CoV-2), which is closely related to severe acute respiratory…
- Trial name
- NCT05195749
- Testing
- 101-PGC-005 ('005) + SOC
- Where
- Israel
- Volunteers
- 3 people
- Sponsor
- 101 Therapeutics