Clinical trials: Shock
Glucose, Metabolism
Tracing Of Real-time glu13Cose Metabolism in Human Immune Cells - Intensive Care Unit
The purpose of this study is to understand how cells of the immune system use the common sugar glucose during critical illness. Investigators will intravenously infuse a non-radioactive carbon-13 glucose tracer into adult…
- Conditions
- Glucose, Metabolism, Isotope Labeling, Immune System and Related Disorders
- Trial name
- TORCH-ICU (NCT07811180)
- Testing
- 13C6-Glucose
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Vanderbilt University Medical Center
Septic Shock
Association Between Muscle L3 CT Scan Muscle Derived Parameters of Muscle Function Upon Intensive Care Unit Admission and 3 Months Mortality After ICU Discharge for Patients Admitted for Septic Shock. The SIMS Study
Muscle dysfunction in intensive care units is associated with significant morbidity and mortality. During septic shock, there is an increased catabolism and systemic inflammation resulting in quantitative and qualitative muscle…
- Trial name
- SIMS (NCT07483710)
- Testing
- Evaluation of muscle dysfunction in intensive care units for septic schock patients
- Where
- 4 sites in France
- Volunteers
- 196 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Patient Satisfaction, Extracorporeal Shock Wave Lithotripsy
COMPARİSON OF THE EFFECTS OF ULTRASOUND-GUİDED ERECTOR SPİNAE PLANE BLOCK AND INTRAMUSCULAR NONSTEROİDAL ANTİ-INFLAMMATORY DRUG ADMİNİSTRATİON ON INTRAOPERATİVE ANALGESİA AND PATİENT SATİSFACTİON DURİNG EXTRACORPOREAL SHOCK WAVE LİTHOTRİPSY
The aim of this study is to compare two ways of reducing pain during extracorporeal shock wave lithotripsy (ESWL), a non-invasive treatment that breaks up kidney and urinary stones with shock waves.
- Conditions
- Patient Satisfaction, Extracorporeal Shock Wave Lithotripsy, Erector Spinae Plane Block
- Trial name
- NCT07880535
- Testing
- Ultrasound-guided erector spinae plane block, Diclofenac Sodium (DCS)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Sanliurfa Mehmet Akif Inan Education and Research Hospital
Bacteremia, Bacteremia Sepsis
Monocyte Distribution Width (MDW) in the General Population of Emergency Department Patients With and Without Bacteremia
This project will evaluate the usefulness of Monocyte Distribution Width (MDW) for the diagnosis of blood culture positivity (BSI) in patients in the Emergency Department (ED) and reevaluate the usefulness of MDW in patients with…
- Conditions
- Bacteremia, Bacteremia Sepsis, Sepsis, Septic Shock
- Trial name
- NCT05296590
- Testing
- Monocyte Distribution Width (MDW) , observation
- Where
- United States
- Volunteers
- 50,000 people
- Sponsor
- Henry Ford Health System
Essential (Primary) Hypertension, Hypertensive Heart Disease With (Congestive) Heart Failure
Positive Care Effect of the Digital Health Assistant ADELE Blood Pressure for Hypertension Patients
High blood pressure (hypertension) can cause damage to vital organs such as the heart, kidneys, eyes, brain and blood vessels. The risk of developing high blood pressure increases with age.
- Conditions
- Essential (Primary) Hypertension, Hypertensive Heart Disease With (Congestive) Heart Failure, Hypertensive Heart Disease Without (Congestive) Heart Failure, Other Secondary Hypertension
- Trial name
- A0007 (NCT06663280)
- Testing
- Digital health assistant ADELE
- Where
- 2 sites in Germany
- Volunteers
- 108 people
- Sponsor
- Alma Phil Gmbh
Acute Kidney Injury, Septic Shock
Targeting Abdominal Perfusion Pressure in Septic Shock
A randomized control trial among patients with septic shock, studying the incidence, progression and recovery of AKI.
- Conditions
- Acute Kidney Injury, Septic Shock, Resuscitations
- Trial name
- MAP-APP (NCT03582046)
- Testing
- Abdominal Perfusion Pressure (APP), Mean Arterial Pressure (MAP)
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- Potrero Medical
Cardiogenic Shock, Cardiac Arrest
Outcome of Patients Treated With ECLS
Extracorporeal life support (ECLS), also called extracorporeal membrane oxygenation (ECMO), is an extracorporeal technique of providing effective circulatory and (or) respiratory failure, with a growing number of critically ill…
- Conditions
- Cardiogenic Shock, Cardiac Arrest, Heart Failure, Acute Respiratory Failure
- Trial name
- NCT04405817
- Testing
- ECMO
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Nanjing Medical University
Sepsis, Septic Shock
Impact of the Introduction of a Performance Improvement Program on the Initial Management of Sepsis and Septic Shock in Adults in the Emergency Department: a Before-and-after Study (IPA-SOS)
The goal of this observational study is to evaluate if a performance improvement program can improve the initial management of sepsis and septic shock in adults at Brest University Hospital.
- Conditions
- Sepsis, Septic Shock, Critical Illness, Emergency Medicine
- Trial name
- IPA-SOS (NCT06657625)
- Testing
- Sepsis Performance Improvement Program
- Where
- France
- Volunteers
- 600 people
- Sponsor
- University Hospital, Brest
Shock
The CCUS Based Characteristic of Hemodynamic and Lung Pathology in Early Stage of Shock in ICU: The Epidemic and Prognostic Value
Shock is a common condition in critical care unit (ICU). It is extremely important that the patient accepts early goal-directed therapy (EGDT) treatment in the early stage of shock.
- Trial name
- NCT03082326
- Where
- China
- Volunteers
- 181 people
- Sponsor
- West China Hospital
Infection, Sepsis
Short-course Antimicrobial Therapy in Sepsis
The purpose of this study is to compare the effect of a short course antimicrobial therapy (5-days) versus a 10-days therapy on sepsis-related organ dysfunction.
- Conditions
- Infection, Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT02899143
- Testing
- Antibiotic
- Where
- 4 sites in Italy
- Volunteers
- 320 people
- Sponsor
- Ospedale Santa Maria delle Croci
Overactive Bladder, Urinary Incontinence, Urge
Efficacy of Li-SWT on Persistent Storage Symptoms After Transurethral Surgery for BPO
comparing the outcome of low-intensity shock wave therapy (Li-SWT) versus solifenacin on persistent storage symptoms after transurethral surgery for benign prostatic obstruction (BPO)
- Conditions
- Overactive Bladder, Urinary Incontinence, Urge, Urgency-frequency Syndrome, Post Prostatectomy
- Trial name
- NCT04437108
- Testing
- Li-SWT (suprapubic approach), Li-SWT (perineal approach), Li-SWT (combined approach)
- Where
- Egypt
- Volunteers
- 132 people
- Sponsor
- Mansoura University
Severe Sepsis and Septic Shock
Statistical Analysis Plan for an Individual Patient Data Meta-analysis of Three, International Trials Comparing Protocolised With Usual Resuscitation in Patients Presenting to the Emergency Department With Severe Sepsis and Septic Shock
This is the statistical analysis plan for an individual patient data meta-analysis (IPDMA) of three EGDT clinical trials.
- Trial name
- NCT02030158
- Volunteers
- 4,210 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Dengue Shock Syndrome, Dengue Hemorrhagic Fever
Safety of and Immune Response to DEN4 Vaccine Component Candidate for Dengue Virus
Infection with dengue viruses is one of the leading causes of hospitalization and death in children in several tropical Asian counties.
- Trial name
- NCT00919178
- Testing
- DEN4 Vaccine Candidate
- Where
- 2 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Low Back Pain
Radial Extracorporeal Shock Wave Therapy on Chronic Low Back Pain: a Prospective Controlled Study
The aim of this prospective study is to explore the pain-alleviating effect of low-energy extracorporeal shock wave therapy(ESWT) in patients with chronic low back pain.
- Trial name
- NCT01928784
- Testing
- Radial Extracorporeal Shock Wave Therapy 2000 impulses, Radial Extracorporeal Shock Wave Therapy 4000 impulses
- Where
- China
- Volunteers
- 26 people
- Sponsor
- Beijing Jishuitan Hospital
Septic Shock, Arterial Pressure
Assessment of Two Levels of Arterial Pressure on Survival in Patients With Septic Shock
The ideal mean arterial pressure in patients with septic shock is unknown. The expert's recommandations have stated a target between 65 and 70 mm Hg. However the scientific basis are weak.
- Conditions
- Septic Shock, Arterial Pressure, Hemodynamics, Mortality
- Trial name
- SEPSISPAM (NCT01149278)
- Testing
- maintain mean arterial pressure between 80-85 mm Hg, maintain mean arterial pressure between 65-70 mm Hg
- Where
- France
- Volunteers
- 800 people
- Sponsor
- University Hospital, Angers
Hyperdynamic, Left Ventricular Ejection Fraction
Hyperdynamic Left Ventricular Ejection Fraction as a Predictor of Mortality in Intensive Care Unit Patients With Septic Shock
The study aimed to evaluate the cause and prognosis of hyperdynamic left ventricular ejection fraction in critically ill patients with sepsis.
- Conditions
- Hyperdynamic, Left Ventricular Ejection Fraction, Mortality, Intensive Care Unit
- Trial name
- NCT06993948
- Testing
- Transthoracic echocardiography
- Where
- Egypt
- Volunteers
- 235 people
- Sponsor
- Ain Shams University
Sepsis, Septic Shock
Towards Novel BIOmarkers to Diagnose SEPsis on the Emergency Room
Objectives: 1. To compare the immune response of patients with or without sepsis presenting to the ED with a(n) (suspected) infection. 2.
- Conditions
- Sepsis, Septic Shock, Sepsis, Severe, Infections
- Trial name
- BIOSEP (NCT06178822)
- Testing
- No intervention
- Where
- 3 sites in Netherlands
- Volunteers
- 3,300 people
- Sponsor
- Amsterdam University Medical Centers (UMC), Location Academic Medical Center (AMC)
Sepsis, Severe, Sepsis
Microcirculation Properties of Albumin for Fluid Resuscitation in Septic Shock
The sublingual microcirculation is impaired in sepsis and septic shock. Sidestream dark field imaging technology has been developed into a clinical tool to help the clinician assess the microcirculation at the bedside.
- Conditions
- Sepsis, Severe, Sepsis, Septic Shock
- Trial name
- NCT05357339
- Testing
- 20% Albumin, Crystalloid
- Where
- Ireland
- Volunteers
- 100 people
- Sponsor
- Rachael Cusack
Coronary Artery Disease, Coronary Calcification
Intravascular Lithotripsy With or Without Rotational Atherectomy for Coronary Calcified Nodule Treatment
The NODULE-SHOCK trial is a prospective, investigator-initiated, single-center, randomized controlled trial designed to compare the efficacy of intravascular lithotripsy (IVL) with or without rotational atherectomy (RA) in…
- Trial name
- NODULE-SHOCK (NCT07000045)
- Testing
- Intravascular lithotripsy, Rotational atherectomy
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Annapoorna Kini
Sepsis, Septic Shock
Intravenously Administered M6229 in Critically Ill Sepsis Patients
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Mortality is high and survivors frequently suffer from long-term sequelae.
- Conditions
- Sepsis, Septic Shock, Critical Illness
- Trial name
- HistoSeps (NCT05208112)
- Testing
- M6229
- Where
- 2 sites in Netherlands
- Volunteers
- 10 people
- Sponsor
- A.P.J. Vlaar