Clinical trials: Shift-work Disorder
Obesity & Overweight, Circadian Rhythm Disorders
Effects of Akkermansia Muciniphila and Berberine Supplementation on Insulin Sensitivity in Night-shift Workers
Night shift work is associated with an increased risk of obesity, insulin resistance, and cardiometabolic disorders, largely due to circadian misalignment, disrupted sleep, and altered eating patterns.
- Conditions
- Obesity & Overweight, Circadian Rhythm Disorders, Gut Microbiota Modulation, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
- Trial name
- Shift2Health (NCT07440147)
- Testing
- Verum (A)
- Where
- Austria
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- FH Joanneum Gesellschaft mbH
Shift Work Schedule, Sleep Deprivation
Quick Returns - Sleep, Cognitive Functions and Individual Differences
The project will contribute with new knowledge concerning how short rest periods between two consecutive shifts (<11h, often defined as a Quick Return (QR)) affects sleep and cognitive performance.
- Trial name
- NCT05162105
- Testing
- Short rest (8 hour) between two consecutive shifts., 16 hour rest opportunity between to consecutive shifts.
- Where
- Norway
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Sleep, Fatigue
Sleep, Mindfulness, and Shift-Level Safety Performance in Perianesthesia Nurses
Perianesthesia (preoperative and postanesthesia care unit, PACU) nurses work rotating, often extended shifts that can disrupt sleep and increase fatigue, both of which are recognized threats to patient safety in high-acuity…
- Conditions
- Sleep, Fatigue, Patient Safety
- Trial name
- NCT07832721
- Testing
- Sleep, Mindfulness, and Shift-Level Safety Observation Toolkit
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Volkan Gokmen
Antenatal Care, Maternal Health
AI Blind-Sweep Ultrasound for Antenatal Screening by Non-Specialist Health Workers in Rural DR Congo
FS2 evaluates the diagnostic accuracy and implementation feasibility of an AI-assisted blind-sweep obstetric ultrasound (SPAQ E-con AI), operated by trained non-specialist health workers, for antenatal screening in rural…
- Conditions
- Antenatal Care, Maternal Health, Gestational Age, Placenta Praevia
- Trial name
- FS2 (NCT07677670)
- Testing
- SPAQ E-con AI blind-sweep ultrasound
- Where
- Democratic Republic of the Congo
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- SOIK Corporation Sarl
Shift-work Disorder
Use of Consumer Sleep Technology to Treat Shift Work Disorder
The purpose of this study is to examine the effectiveness of a personalized light exposure schedule for Shift Work Disorder (SWD) in night shift workers compared to a non-personalized light exposure schedule.
- Trial name
- SHIFT (NCT05186233)
- Testing
- Phototherapy
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Henry Ford Health System
Shift Work, Sleep Perception
Impact of Workload and Fatigue on Sleep in OR Nurses
This study aims to explore the impact of individual workload and fatigue levels on the sleep quality of operating room (OR) nurses, highlighting a critical aspect of healthcare professionals' well-being that directly affects…
- Trial name
- NCT06285344
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- Kilis 7 Aralik University
Circadian Dysregulation
Development of Countermeasures Against Adverse Metabolic Effects of Shift Work
The goal of this application is to determine whether changing the timing of food intake prevents the adverse metabolic effects of circadian misalignment.
- Trial name
- NCT02291952
- Testing
- Meal schedule
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Fatigue, Shift Work Type Circadian Rhythm Sleep Disorder
Does Fatigue Coaching Improve Functioning and Fatigue in Resident Night Shifts
Emergency Medicine (EM) requires 24/7 staff coverage resulting in healthcare workers' circadian rhythm disruptions that impair clinical and cognitive performance, physical recovery, and contribute to burnout.
- Trial name
- NCT06100809
- Testing
- Personalized coaching, Nutrition handout
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Shift-Work Sleep Disorder
Biological Rhythms Impact of 12 Hours Shift Work
Nonstandard time-schedules work are widespread in the world of work. Shift and night work have been shown to be responsible for a desynchronization of biological rhythms, associated with melatonin secretion impairment and sleep…
- Trial name
- MELACTI-12 (NCT03153917)
- Testing
- melatonin and cortisol sampling
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Shift-work Disorder, Insomnia
SHIFTPLAN: an RCT Investigating the Effect of a Shift Work Intervention on Fatigue, Sleep and Health.
Shift work is associated with disturbed life rhythms resulting from chronic exposure to circadian misalignment and sleep restriction, with long-term participation in most shift schedules causing serious health problems.
- Conditions
- Shift-work Disorder, Insomnia, Fatigue, Mental Health Issue
- Trial name
- SHIFTPLAN (NCT05452096)
- Testing
- Education program and ergonomic schedulling
- Volunteers
- 176 people
- Sponsor
- University Hospital, Antwerp
Shift-Work Sleep Disorder
Light Treatment to Shift-working Nurses
This project examines 1) the effects of appropriately timed bright light on adaptation (in terms of sleep and sleepiness) to three consecutive night shifts; and 2) the effects of such bright light on re-adaptation (in terms of…
- Trial name
- NCT02978053
- Testing
- Bright light, Red light
- Where
- Norway
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Gambling, Shift Work
Interaction Between Atypical Work Schedules and/or Idel Time at Work on At-risk Gambling Practices
At-risk gambling causes individual and social harm, influenced by environmental, psychological, and socioeconomic factors. In France, 5% of adult gamblers show at-risk gambling practices.
- Conditions
- Gambling, Shift Work, Addictive Behavior, Boredom
- Trial name
- PRAT-JEU (NCT07421765)
- Testing
- semi-structured interview
- Where
- 2 sites in France
- Volunteers
- 25 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Caffeine, Sleep Deprivation
Real-Time Caffeine Optimization During Total Sleep Deprivation
Sleep deprivation (SD) has a powerful degrading effect on cognitive performance, particularly psychomotor vigilance (PV) and reaction time. Caffeine is well known to be an effective countermeasure to the effects of SD.
- Conditions
- Caffeine, Sleep Deprivation, Shift-Work Related Sleep Disturbance
- Trial name
- NCT04399083
- Testing
- Caffeine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Musculoskeletal Pain, Cognitive Change
Health, Wellbeing and Performance in Law Enforcement Workers
This study aims to assess current health and fitness of law enforcement workers in various roles, and to evaluate the impact of an exercise intervention on markers on physical and mental wellbeing in this population.
- Conditions
- Musculoskeletal Pain, Cognitive Change, Occupational Stress, Inflammation
- Trial name
- NCT04204486
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University College, London
Circadian Rhythm; Inversion, Metabolic Disease
Impact of Night Shift Work on 24-hour Blood Glucose Levels
This study will determine whether nurses regularly working night shifts have elevated 24-hour glucose levels compared to nurses regularly working day shifts, using continuous glucose monitoring (CGM).
- Trial name
- NCT05559762
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Lincoln Memorial University
Sleep Quality
Filtered Eyewear to Prevent Light-induced Melatonin Suppression - Aim 1
The aim of this study is to determine the relative effectiveness of monocular and binocular light exposures, with and without selective blue-blocking filtering, on nocturnal melatonin suppression, subjective sleepiness, and…
- Trial name
- NCT06310135
- Testing
- Filtered Eyewear, Unfiltered Eyewear, No Filters
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cardiovascular Diseases, Circadian Rhythm Sleep Disorder, Shift Work Type
Effect of a Grape Seed Proanthocyanidin Extract (GSPE) on LDL Cholesterol Levels in Rotating Night Shift Workers
The physiological processes of the body present daily oscillations called circadian rhythm. The circadian rhythm is essential for maintaining the vital functions of organisms, intervening directly and indirectly in a multitude of…
- Conditions
- Cardiovascular Diseases, Circadian Rhythm Sleep Disorder, Shift Work Type, Cholesterol Level, High
- Trial name
- CIRCAFENOL (NCT06422741)
- Testing
- grape seed proanthocyanidin extract
- Where
- 2 sites in Spain
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Fundació Eurecat
Burnout, Sleep Disturbance
Non-Invasive Sleep Monitoring for Burnout and Retention Risk in Postgraduate Nurses
Newly graduated nurses often experience high levels of psychological stress, sleep disturbance, fatigue, and burnout during the early transition into clinical practice.
- Conditions
- Burnout, Sleep Disturbance, Occupational Stress, Mental Health
- Trial name
- NCT07666633
- Testing
- Non-Invasive Sleep Monitoring
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Armed Forces General Hospital
Chronic Insomnia, Sleep Deprivation
Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia
This clinical trial aims to evaluate the safety and efficacy of PROSOMNIA Sleep Therapy (PSTx) for individuals suffering from chronic insomnia, sleep deprivation, and REM sleep disorders.
- Conditions
- Chronic Insomnia, Sleep Deprivation, REM Behavior Disorder, REM Sleep Behavior Disorder
- Trial name
- PSHW (NCT06644573)
- Testing
- PROSOMNIA Sleep Therapy™ (PSTx), Anesthesia-Induced Sleep Therapy, Diprivan (propofol), Astra-Zeneca
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nyree Penn
Shift-work Disorder
EMS Providers' Health Initiative Study
This study aims to explore dietary factors that influence glycemic control in night shift EMS providers and to test the feasibility of a dietary intervention among these providers.
- Trial name
- NCT05153759
- Testing
- Meal service
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo