Clinical trials: Sexually Transmitted Infections
Human Immunodeficiency Virus
Jamii Bora: A Home-Based Couples Intervention
The purpose of the study is to develop and pilot-test a home-based intervention to facilitate sate HIV testing and disclosure within pregnant couples in order to increase use of prevention-of-mother-to-child-transmission (PMTCT)…
- Trial name
- NCT02403583
- Testing
- Intervention- Home Visits
- Where
- 5 sites in Kenya
- Volunteers
- 233 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
HIV Infections
A Network Intervention for Prevention of HIV Infection in Chennai, India - 1
The purpose of this study is to evaluate a peer-based HIV prevention intervention that targets active injection drug users and their drug and sex partners in Chennai India.
- Trial name
- NCT00218686
- Testing
- psychoeducational, control
- Where
- India
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
HIV Infections
Promoting Adherence to Anti-HIV Drug Regimens
One of the main causes of treatment failure in HIV infected individuals is lack of adherence to complicated drug regimens. The purpose of this study is to evaluate the effectiveness of a behavioral intervention program designed…
- Trial name
- NCT00051805
- Testing
- Promotion of adherence to ARV medications
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infection, AIDS
Accuracy of the Pima™ CD4 Test for Enumeration of CD4+ T-Cell Counts
This is a multi-center study designed to assess the accuracy of Pima™ CD4 Test to enumerate CD4+ T-cells in whole blood over the measurement range expected for the intended population.
- Conditions
- HIV Infection, AIDS, HIV Infections
- Trial name
- NCT00951795
- Where
- 3 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Abbott RDx Cardiometabolic
HIV Infections, Hepatitis C Virus
Pilot Study to Assess Gut Mucosal B Cells in Individuals With HCV and HIV
This pilot study aims to study gut B cells in HCV+HIV+, HCV+HIV-, HCV-HIV+, and HCV-HIV- volunteers. Volunteers will undergo a screening blood draw and flexible sigmoidoscopy with biopsy.
- Trial name
- NCT01040039
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
HIV I Infection, HIV Associated Lipodystrophy
Neuroinflammation and Neurodegeneration in HIV-positive Subjects Switched and Initially Treated With INSTI
Since the HIV changed its course to the chronic disease, high incidence of metabolic syndrome both in HIV positive and negative subjects has become an issue.
- Conditions
- HIV I Infection, HIV Associated Lipodystrophy, Metabolic Syndrome, Aging
- Trial name
- NCT04887675
- Testing
- MRI
- Where
- Serbia
- Volunteers
- 120 people
- Sponsor
- University of Novi Sad
Opiate Dependence, HIV Infections
Reducing Sex-Related HIV Risk Behaviors in Patients Receiving Treatment for Opioid Dependence
The major goal is to determine in patients entering buprenorphine treatment, the prevalence of specific sex-related HIV risk behaviors, their physician's screening of these behaviors and to evaluate the impact of risk reduction…
- Trial name
- Project RED (NCT00548275)
- Testing
- Enhanced Sexual Risk Management, Standard Sexual Risk Management
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Yale University
Human Immunodeficiency Virus (HIV)
An Observational Study to Evaluate Tolerability of PREZISTA or INTELENCE in HIV-1 Infected Patients
The purpose of this study is to evaluate tolerability of darunavir (PREZISTA) or etravirine (INTELENCE) in patients infected with human immunodeficiency virus type 1 (HIV-1) who are naïve to these medications and in patients who…
- Trial name
- POISE (NCT01615601)
- Testing
- darunavir (PREZISTA), etravirine (INTELENCE), ritonavir
- Where
- Canada
- Volunteers
- 77 people
- Sponsor
- Janssen Inc.
HIV Infections
Non-virologic Methods to Diagnose Treatment Eligibility in HIV-exposed Infants
This study is designed to develop and evaluate a set of non-virologic diagnostic algorithms to monitor HIV-exposed children of unknown infection status for treatment eligibility during the first year of life.
- Trial name
- IDX (NCT01222130)
- Where
- 3 sites in Zambia
- Volunteers
- 1,126 people
- Sponsor
- University of North Carolina, Chapel Hill
HIV - Human Immunodeficiency Virus, Hepatitis B Virus (HBV)
Combating Related Epidemics in HCV
This is a two-arm cluster randomized control trial to evaluate the effectiveness of a single-visit point-of-care (POC) test and treat bundle (intervention arm) compared to the current standard-of-care (SOC, control arm).
- Conditions
- HIV - Human Immunodeficiency Virus, Hepatitis B Virus (HBV), HEPATITIS C (HCV)
- Trial name
- CREST (NCT07560046)
- Testing
- Cepheid GeneXpert HCV Test, Abbott Determine HIV - 1/2 Ag/Ab, Abbott Determine HbsAg 2
- Volunteers
- 1,280 people
- Sponsor
- Duke University
HIV Infections
A Phase I Safety and Immunogenicity Trial of the Facilitated HIV-1 Gag-Pol DNA Vaccine (APL-400-047, Apollon, Inc.) Given Intramuscularly by Needle and Syringe or Biojector 2000 Needle-Free Jet Injection System in HIV-1 Uninfected Adult Volunteers
To evaluate the safety, tolerability and immunogenicity in humans of the APL-400-047 vaccine when administered intramuscularly by needle and syringe at 1 of 3 doses or by Biojector at the intermediate dose.
- Trial name
- NCT00001088
- Testing
- APL 400-047, Bupivacaine hydrochloride
- Where
- 4 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections, Cervix, Dysplasia
Safety and Effectiveness of Giving Isotretinoin to HIV-Infected Women to Treat Cervical Tumors
The purpose of this study is to see if it is safe and effective to give isotretinoin to HIV-infected women with cervical tumors to prevent these tumors from becoming cancerous.
- Trial name
- NCT00001073
- Testing
- Isotretinoin
- Where
- 40 sites in United States, Puerto Rico and 1 more
- Volunteers
- 150 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Risk Behavior, Sexually Transmitted Diseases
Utilization of the Community Popular Opinion Leader (C-POL) Model in Alabama
Community members within the treatment city will report: 1)engaging in fewer sexual risk practices; 2)significantly higher condom use; 3) significantly higher rates of STD care seeking (including STD screening behaviors); 4)…
- Trial name
- NCT00260754
- Testing
- Community-Popular Opinion Leader Model, Diffusion of Innovations
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
HIV Infections, Opioid Use
Optimizing CAB-LA as PrEP for Women Who Inject Drugs
The goal of this study is to elicit information crucial for designing strategies to support engagement in cabotegravir, a long-acting injectable form of pre-exposure prophylaxis (PrEP) to reduce HIV risk among women who inject…
- Conditions
- HIV Infections, Opioid Use, Trauma, Psychological
- Trial name
- NCT05799339
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Alexis Roth
HIV Infections
Improving Treatment and Retention Adherence in Nontraditional Settings
This is a hybrid implementation-effectiveness study using both qualitative and quantitative methods. The research aims to examine whether providing a new, but approved, HIV once a month injection treatment…
- Trial name
- I-TRAINS (NCT04973254)
- Testing
- CAB-RPV LA, Standard treatment within an HIV clinic
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Boston Medical Center
Gonorrhea
Antimicrobial Susceptibility Patterns of N. Gonorrhea Isolates in an Era of Quinolone Resistance
To perform a laboratory sensitivity testing survey of antibiotic agents against Neisseria gonorrhea isolates from men with symptomatic urethritis seen at an STD clinic.
- Trial name
- NCT00692822
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Florida
HIV Infections, Acquired Immunodeficiency Syndrome
TMC125-TiDP2-C238: An Exploratory Pharmacokinetics, Safety and Anti-HIV Activity Study of Etravirine (ETR) When Given With Boosted Atazanavir (ATV/Rtv) at Two Different Doses and 1 Nucleoside Reverse Transcriptase Inhibitor (NRTI) in Treatment Experienced HIV Patients
The purpose of this study is to determine the pharmacokinetics (how the body absorbs, distributes, metabolizes and eliminates a drug) (PK) of ETR when given with ATV/rtv and 1 NRTI in treatment experienced HIV-1 infected…
- Trial name
- NCT00896051
- Testing
- Atazanavir (ATV) 300 mg, Atazanavir (ATV) 400 mg, Ritonavir (rtv) 100 mg
- Where
- 18 sites in United States, Argentina and 3 more
- Volunteers
- 50 people
- Sponsor
- Janssen R&D Ireland
HIV Infections
Directly Observed Therapy in HIV Infected Adolescent Focus Groups
The purpose of this study is to help researchers use information from HIV infected adolescents to design a directly observed therapy (DOT) program that will help adolescents take their anti-HIV medications correctly.
- Trial name
- NCT00079729
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Liver Cirrhosis, Hepatitis C Virus
Retreatment With High Doses of pegIFN Alfa-2a and Ribavirin of Previous Nonresponders HIV-coinfected Patients With Cirrhosis Due to HCV 1-4
Objective: To evaluate the efficacy and safety of high doses of both peginterferon-alfa 2a (360 ug per week) plus ribavirin (800 mg b.i.d.) in HIV-infected patients with compensated liver cirrhosis by HCV genotype 1 or 4 without…
- Conditions
- Liver Cirrhosis, Hepatitis C Virus, HIV Infection
- Trial name
- NCT01006031
- Testing
- Pegylated interferon alfa-2a and Ribavirin
- Where
- 4 sites in Spain
- Volunteers
- 25 people
- Sponsor
- Sociedad Andaluza de Enfermedades Infecciosas
HIV, Hepatitis C
Brain Deficits in HIV/HCV Coinfected People Before and After Anti-HCV Therapy
This study will evaluate the impact of standard hepatitis C virus treatment on brain deficits in people who are infected with both HIV and the hepatitis C virus.
- Conditions
- HIV, Hepatitis C, Infections
- Trial name
- NCT00747539
- Testing
- Pegylated interferon alfa and ribavirin (PEG-IFN/RBV)
- Where
- 4 sites in United States
- Volunteers
- 330 people
- Sponsor
- University of California, Los Angeles