Clinical trials: Severe Mental Disorders
Depression
Mindfulness Training During Accelerated TMS for Depression
This NIH-funded single-arm pilot tests the feasibility, acceptability, and preliminary effects of embedding brief guided mindfulness practice (via the Waking Up smartphone app) into the inter-session intervals of clinically…
- Trial name
- NCT07369557
- Testing
- Guided Mindfulness Practice using a study created web app that links to the commercially available Waking Up app
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Medical University of South Carolina
Covid19, Neurocognitive Dysfunction
Long-term Neurocognitive and Psychiatric Consequences in Severe COVID-19 Survivors.
Long-term neurocognitive and psychiatric consequences of COVID-19 remain mostly unknown to date. It has been reported that coronaviruses cause direct central nervous system infection (Needham et al. 2020).
- Trial name
- NPQCOVID (NCT05019300)
- Testing
- Exposure: COVID-19 severity
- Where
- Chile
- Volunteers
- 80 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Major Depressive Disorder
Treatment of Patients With Major Depressive Disorder With MK0869 (0869-062)(COMPLETED)
A clinical study to determine the efficacy and safety of MK0869 in the treatment of depression
- Trial name
- NCT00048607
- Testing
- aprepitant, Comparator: paroxetine HCL
- Volunteers
- 600 people
- Sponsor
- Merck Sharp & Dohme LLC
Major Depressive Disorder
Effect of Psilocybin Only and Psilocybin Assisted Cognitive Behavioral Therapy in the Management of Major Depressive Disorder and Associated Metabolic, Immune, Inflammatory, Neuroplasticity and Electrical Activity Markers
This randomized controlled clinical trial evaluates the effectiveness of psilocybin and psilocybin-assisted cognitive behavioral therapy (CBT) in the management of Major Depressive Disorder (MDD).
- Trial name
- NCT06746441
- Testing
- Psilocybin, Cognitive Behavioral Therapy (CBT)
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Khyber Medical University Peshawar
Alzheimer Disease, Late Onset, Stroke
Explore the Sharing Model Intervene to Improve the Knowledge, Attitudes, Service Intentions and Service Start-up Effects of the Eight Major Non-cancer Disease End-stage Caregivers on Well-being and Palliative Care
Since September 1st, 2009, Taiwan has begun to pay attention to the care of patients with organ failure, dementia and the elderly, and brought eight of non-cancer terminal patients into health insurance subsidies to implement the…
- Conditions
- Alzheimer Disease, Late Onset, Stroke, Heart Failure, Pulmonary Disease, Chronic Obstructive
- Trial name
- NCT05407272
- Testing
- Health Education Manual, manual
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wen-Shiou Pan
Major Depressive Disorder (MDD)
Preventing Relapse After Successful Electroconvulsive Therapy for Depression
The present project is designed to study two promising relapse prevention strategies in an RCT. This will be the first project worldwide to study the effects of a personalized ECT treatment algorithm in the continuation phase of…
- Trial name
- PRASED (NCT06751875)
- Testing
- Lithium
- Where
- Belgium
- Volunteers
- 96 people
- Sponsor
- Universiteit Antwerpen
Alcohol Use Disorder (AUD), Major Depressive Disorder (MDD)
Pregnenolone Treatment for Alcohol Use Disorder and Major Depressive Disorder
This study will evaluate whether pregnenolone is an effective treatment for adults with Alcohol Use Disorder (AUD) and Major Depressive Disorder (MDD).
- Trial name
- PREG-AUD-RO1 (NCT07734701)
- Testing
- Pregnenolone
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Sherwood Brown, MD, PhD
Depressive Disorder, Major
Neurobehavioral Mechanisms of Emotion Regulation in Depression Across the Adult Lifespan
The aim of this study is to test a model of demographic (age, sex), clinical, cognitive, and neurocircuitry predictors of emotion regulation ability and long-term depressive symptoms.
- Trial name
- Lifespan (NCT03207503)
- Testing
- fMRI
- Where
- 2 sites in United States
- Volunteers
- 296 people, healthy volunteers welcome
- Sponsor
- Duke University
Major Depressive Disorder
Effects of Intravenous (IV) Citalopram Hydrochloride During Transcranial Magnetic Stimulation in Major Depressive Disorder (MDD)
This study will recruit 30 subjects diagnosed with Major Depressive Disorder (MDD). Subjects will be recieve one infusion treatment of citalopram or placebo and 10 treatments of a form of transcranial magnetic stimulation, theta…
- Trial name
- NCT04846829
- Testing
- intermittent theta burst stimulation, intravenous citalopram hydrochloride (CIT), continuous theta burst stimulation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, Los Angeles
Depressive Disorder, Major
Personalized Sertraline Dosing in Patients With Depression
The aims of this study are to: 1. Determine the proportion of participants who are underdosed or overdosed under recommended dosing regimen of sertraline for the depression treatment (100 mg/day) 2.
- Trial name
- PsyCise-S (NCT05210153)
- Testing
- Sertraline
- Where
- 3 sites in Serbia
- Sponsor
- University of Belgrade
Major Depressive Disorder
EMA-Guided Maintenance TMS for Depression
The goal of this study is to evaluate the use of ecological-momentary-assessment (EMA) as a method for scheduling maintenance treatments for patients with Major Depressive Disorder (MDD) who responded to an initial acute course…
- Trial name
- NCT06145594
- Testing
- EMA Monitoring, Scheduling Maintenance TMS sessions
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Butler Hospital
Schizophrenia, Bipolar Disorder
Task Sharing for the Care of Severe Mental Disorders in a Low-income Country
Task sharing mental health care through integration of mental health into primary health care (PHC) is advocated as a means of narrowing the treatment gap for mental disorders in low-income countries.
- Conditions
- Schizophrenia, Bipolar Disorder, Major Depressive Disorder, Schizoaffective Disorder
- Trial name
- TaSCS (NCT02308956)
- Testing
- Integrated mental health in primary care, Psychiatric nurse-led specialist care
- Where
- Ethiopia
- Volunteers
- 324 people
- Sponsor
- University of Cape Town
Major Depressive Disorder
Iloperidone Augmentation of SSRIs for Patients With Major Depressive Disorder With Residual Anger and Irritability
Iloperidone is an atypical antipsychotic drug, FDA-approved for the acute treatment of schizophrenia in adults in 2009 (Marino et al., 2010); moreover, some of its pharmacological features seem to be very promising in treating…
- Trial name
- NCT01464229
- Testing
- Iloperidone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Maurizio Fava, MD
Obsessive-compulsive Disorder
Evaluating the Feasibility, Safety and Efficacy of Psychotherapy Assisted Psilocybin for Treatment of Severe OCD
Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder characterized by recurrent distressing thoughts and substantial anxiety, accompanied by repetitive behaviors or mental rituals.
- Trial name
- NCT04882839
- Testing
- psychotherapy assisted psilocybin
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Beersheva Mental Health Center
Major Depressive Disorder (MDD), Depressive Episodes
Effectiveness of Clustered Versus Tapered Repetitive Transcranial Magnetic Stimulation (rTMS) as Maintenance Therapy Following Successful Acute rTMS Treatment in Patients With Depressive Syndrome
The goal of this clinical trial is to compare two maintenance transcranial magnetic stimulation (rTMS) strategies following successful acute theta burst stimulation (TBS) treatment in adults with depressive syndrome.
- Conditions
- Major Depressive Disorder (MDD), Depressive Episodes, Depressive Syndrome
- Trial name
- ERTE (NCT07727005)
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS), Theta Burst Stimulation
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Technical University of Munich
Major Depressive Disorder
AV-101 as Adjunct Antidepressant Therapy in Patients With Major Depression
The study will evaluate the safety and efficacy of AV-101.
- Trial name
- ELEVATE (NCT03078322)
- Testing
- AV-101
- Where
- 22 sites in United States
- Volunteers
- 180 people
- Sponsor
- VistaGen Therapeutics, Inc.
Depressive Disorder
An Eight-Week Study Evaluating the Efficacy and Tolerability of Two Doses of SSR149415 in Outpatients With Major Depressive Disorder
The objective is to evaluate the efficacy and safety of two doses of SSR149415 (250 mg and 100 mg twice daily) compared to placebo and escitalopram 10 mg once daily in outpatients with major depressive disorder.
- Trial name
- NCT00358631
- Testing
- SSR149415
- Where
- United States
- Volunteers
- 319 people
- Sponsor
- Sanofi
Major Depressive Disorder
Concurrent fMRI-guided rTMS and Cognitive Therapy for the Treatment of Major Depressive Episodes
Background: Repetitive transcranial magnetic stimulation (rTMS) is a treatment for depression. It stimulates the brain. Researchers want to see if using magnetic resonance imaging (MRI) scans helps locate the best area for rTMS…
- Trial name
- NCT03289923
- Testing
- Active TMS + Cognitive therapy
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- National Institute of Mental Health (NIMH)
Major Depressive Disorder (MDD)
Neurofeedback to Treat Depression - 2
This study tests the efficacy of a new psychotherapeutic strategy for reducing negative attention bias (and therefore depression severity) in participants with MDD.
- Trial name
- NCT07159061
- Testing
- Active Closed Loop Real Time fMRI Neurofeedback
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Pennsylvania
Alzheimer Disease
Bryostatin Treatment of Moderately Severe Alzheimer's Disease
To evaluate the safety, tolerability, and long-term efficacy of bryostatin 1 (hereafter referred to as bryostatin) for the treatment of moderately severe Alzheimer's disease (AD).
- Trial name
- NCT04538066
- Testing
- Bryostatin 1
- Where
- 19 sites in United States
- Volunteers
- 122 people
- Sponsor
- Neurotrope Bioscience, Inc.
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