Clinical trials: Severe Malaria
Malaria
Computerized Cognitive Rehabilitation in Children After Severe Malaria
Brain training exercises will be provided to children who survived an episode of severe malaria. These children will be given assessments for cognition, behaviour and executive functions before and after the brain training…
- Trial name
- CM_CCRT (NCT01743417)
- Testing
- Computerised cognitive rehabilitation training
- Where
- Uganda
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Makerere University
Malaria
Bio-availability of Rectal Artesunate in Children With Severe Falciparum Malaria
The study aims at describing the pharmacokinetic properties of rectal artesunate in well characterized severely ill patients using intravenous artesunate as a comparator.
- Trial name
- REACH (NCT02492178)
- Testing
- Intrarectal artesunate, Intravenous artesunate, Intravenous quinine
- Where
- Democratic Republic of the Congo
- Volunteers
- 82 people
- Sponsor
- University of Oxford
Severe Malaria
Severe and Cerebral Malaria Investigated Through Host Metabolomics
The aim is to describe disease mechanisms of severe and cerebral malaria and identify new targets for adjunctive therapies. Despite treatment between 10-30% of patients with severe malaria die.
- Trial name
- NCT02451904
- Testing
- Observation
- Where
- Bangladesh
- Volunteers
- 840 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Severe Malaria
Malaria Treatment With Injectable ArteSunate
The MATIAS study aims to demonstrate through limited scope implementation studies how injectable artesunate may be progressively rolled out nationwide in the Democratic Republic of the Congo as the preferred treatment for severe…
- Trial name
- MATIAS (NCT01828333)
- Testing
- No intervention
- Where
- 9 sites in Democratic Republic of the Congo
- Volunteers
- 350 people
- Sponsor
- Swiss Tropical & Public Health Institute
Severe Malaria
Lung Ultrasound in Children With Severe Malaria
A prospective cohort study, with 171 children admitted for severe malaria that will be included in the cohort. The study will take place in Kinshasa, Democratic Republic of Congo.
- Trial name
- LUSiSM (NCT04176029)
- Testing
- lung ultrasound
- Where
- Democratic Republic of the Congo
- Volunteers
- 124 people
- Sponsor
- University of Oxford
Severe Malaria, Malaria
Severe Malaria and Anti-malarial Drug Resistance in Cambodia
This study, conducted by the National Center for Malaria Control of Cambodia's Ministry of Health, the Guangzhou University of Traditional Chinese Medicine in the People's Republic of China, and the U.S.
- Conditions
- Severe Malaria, Malaria, Antimalarial Drug Resistance
- Trial name
- NCT00341003
- Where
- Cambodia
- Volunteers
- 2,090 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Severe Malaria, Uncomplicated Malaria
Host Immune and Metabolic Determinants of Sexual Conversion in Plasmodium Parasites IMMETASEX
Understanding the sexual conversion of the malaria parasite is essential to interrupt malaria transmission. A new tool is developed that, based on expression analysis of sexual stage biomarkers, will estimate sexual conversion…
- Conditions
- Severe Malaria, Uncomplicated Malaria, Asyptomatic Plasmodium Infection
- Trial name
- IMMETASEX (NCT06064591)
- Where
- 3 sites in Belgium, Burkina Faso and 1 more
- Volunteers
- 458 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Severe Malaria, Malaria,Falciparum
Effect of Paracetamol on Kidney Function in Severe Malaria
A randomised open labeled, parallel-group, controlled trial to assess the efficacy of paracetamol to reduce kidney dysfunction caused by cell-free haemoglobin-mediated oxidative damage in paediatric patients with falciparum…
- Conditions
- Severe Malaria, Malaria,Falciparum, Acute Kidney Injury, Paracetamol
- Trial name
- PROTECtS (NCT04251351)
- Testing
- Paracetamol, Mechanical antipyresis
- Where
- Democratic Republic of the Congo
- Volunteers
- 460 people
- Sponsor
- University of British Columbia
Diabetes, Hypercholesterolemia
Baromètre Santé Adulte 2021-2022
In 2021-2022, Agence Sanitaire et Sociale Nouvelle Calédonie (ASSNC) is undertaking the "Baromètre Santé Adulte" for the third time.
- Conditions
- Diabetes, Hypercholesterolemia, Renal Failure, Dengue Fever
- Trial name
- NCT05218304
- Testing
- Blood sample
- Where
- New Caledonia
- Volunteers
- 5,471 people, healthy volunteers welcome
- Sponsor
- Agence Sanitaire et Sociale de Nouvelle Calédonie
Falciparum Malaria
Azithromycin Combination Therapy for the Treatment of Severe Malaria
A randomized controlled trial to assess the safety and efficacy of azithromycin combination therapy for use in severe malaria. This pilot trial will be conducted in uncomplicated malaria patients in southeastern Bangladesh.
- Trial name
- NCT01374126
- Testing
- Artesunate, Azithromycin + Artesunate
- Where
- Bangladesh
- Volunteers
- 75 people
- Sponsor
- Medical University of Vienna
Malaria
Evaluation of Artesunate in Infants Being Treated for Severe Malaria
This is essentially a laboratory study that is an addendum to an ongoing prospective Phase 4 multicenter observational study titled: "Safety and Efficacy of Artesunate in Pregnant Women and Infants (ARTEMUM)" being conducted in…
- Trial name
- NCT06555809
- Testing
- Artesunate Injection
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Amivas Inc.
Malaria
Efficacy and Safety of Dihydroartemisinin/Piperaquine (Artekin®) for the Treatment of Uncomplicated Malaria in Peru
In Peru, Mefloquine plus Artesunate (MAS3), is the current first line treatment for P. falciparum malaria in the Amazonian Region, and has proved its efficacy against multi-resistant P.
- Trial name
- NCT00373607
- Testing
- Dihydroartemisin-piperaquine, Mefloquine + Artesunate
- Volunteers
- 522 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Severe Falciparum Malaria
Evaluation of Volume Status, Haemodynamics and Microcirculatory Flow in Adult Patients With Severe Falciparum Malaria
acidosis, acute renal failure and acute pulmonary oedema are common, and frequently fatal, manifestations of severe P. falciparum malaria.
- Trial name
- PRiSM (NCT00692627)
- Where
- Bangladesh
- Volunteers
- 80 people
- Sponsor
- University of Oxford
Malaria, Severe Malaria
Evaluation of Oral Activated Charcoal on Antimalarial Drug's Ability to Kill Parasites in Malian Children With Malaria
Background: Malaria is caused by small parasites carried by some mosquitoes. People can get malaria if an infected mosquito bites them. Malaria destroys red blood cells.
- Trial name
- NCT01955382
- Testing
- Actidose Aqua, Artesunate, Amodiaquine
- Where
- Mali
- Volunteers
- 70 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Bloodstream Infection, Salmonella Bacteremia
Clinical Decision Support in Non-typhoidal Salmonella Bloodstream Infections in Children
In sub-Saharan Africa, non-typhoidal Salmonella (NTS) are a frequent cause of bloodstream infection, display high levels of antibiotic resistance and have a high case fatality rate (15%).
- Conditions
- Bloodstream Infection, Salmonella Bacteremia, Malaria,Falciparum, Severe Malaria
- Trial name
- DeNTS (NCT04473768)
- Where
- Belgium
- Volunteers
- 1,880 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Malaria
Paracetamol Effect on Oxidative Stress and Renal Function in Severe Malaria
Blackwater fever, characterized by intravascular haemolysis and hemoglobinuria, is an important cause of renal impairment and mortality in severe malaria caused by Plasmodium falciparum.
- Trial name
- NCT01641289
- Testing
- Paracetamol, No Paracetamol
- Where
- 2 sites in Bangladesh
- Volunteers
- 62 people
- Sponsor
- University of Oxford
Severe Malaria
Inhaled Nitric Oxide for the Adjunctive Therapy of Severe Malaria: a Randomized Controlled Trial
Despite the use of highly effective anti-malarial medications, 10-30% of African children with severe malaria will die, underscoring the need for adjunctive therapies that can be applied in endemic areas.
- Trial name
- NCT01255215
- Testing
- Inhaled Nitric Oxide
- Where
- Uganda
- Volunteers
- 180 people
- Sponsor
- University Health Network, Toronto
Iron Deficiency, Malaria
Acute vs. Delayed Iron: Effect on Red Cell Iron Incorporation in Severe Malaria
The purpose of this study is to determine whether iron therapy given to iron-deficient Ugandan children with moderate-to-severe anemia and clinical malaria is better absorbed and incorporated into red blood cells if it is given…
- Conditions
- Iron Deficiency, Malaria, Nutrition, Global Health
- Trial name
- NCT01754701
- Testing
- Immediate iron, Delayed iron
- Where
- Uganda
- Volunteers
- 100 people
- Sponsor
- University of Minnesota
Cerebral Malaria
Randomized Trial of Erythropoietin During Cerebral Malaria
Malaria remains one of the most common life-threatening illnesses in the tropics with a dramatic toll of more than one million deaths each year.
- Trial name
- EPOMAL (NCT00697164)
- Testing
- Erythropoietin
- Where
- Mali
- Volunteers
- 120 people
- Sponsor
- Claude Bernard University
Newborn Resuscitation, Severe Malnutrition
Enhancing Pediatric Acute Care Through Adaptive E-Learning and In-Person Skills Practice in Tanzania
The goal of this clinical trial is to evaluate whether the integration of in-person skills practice (ISP) with an adaptive e-learning platform can improve refresher learning progress (RLP) among healthcare providers in pediatric…
- Conditions
- Newborn Resuscitation, Severe Malnutrition, Severe Malaria, Severe Pneumonia
- Trial name
- PACE (NCT06635733)
- Testing
- Rhapsode Capable™ Platform (Intervention Group), Paper-based ISP (Control Group)
- Where
- Tanzania
- Volunteers
- 100 people
- Sponsor
- Stanford University