Clinical trials: Serious Mental Illness
Alzheimer Disease
Socially Assistive Robots for Interaction With Older Adults With Dementia
A 12-month pilot study will be comprised of two groups of people diagnosed with mild Alzheimer's disease and related dementia for a total of 80 senior subjects.
- Trial name
- NCT04384978
- Testing
- Play Serious Games with a Social Robot (Ryan), Play Solitary Games Without a Social Robot
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- DreamFace Technologies, LLC
Mild Cognitive Impairment, Mild Dementia
Combined Cognitive and Physical Exercises Through Computer Games in Elderly: The LLM Project
The study involved Information and Communication Technologies (ICT) and more specifically computer exercises blended with game activities.
- Conditions
- Mild Cognitive Impairment, Mild Dementia, Healthy
- Trial name
- LLM (NCT02267499)
- Testing
- LLM training
- Volunteers
- 322 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Serious Mental Illness, Older Adults
A Pilot Randomized Controlled Trial of the Hopeful and Healthy Living Program
The goal of this clinical trial is to learn if a novel psychosocial intervention is effective in helping adults over 50 with serious mental illness (SMI) increase their social connections and participate in more healthy lifestyle…
- Trial name
- (HHL) (NCT06940843)
- Testing
- Hopeful and Healthy Living (HHL)
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Boston University Charles River Campus
Schizophrenia, Bipolar Disorder
Skills Training to Enhance Vocational Outcomes in Veterans With Serious Mental Illness
Maintenance of employment is dependent upon being able to successfully integrate into one's work setting. This can present a significant challenge to individuals with serious mental illness, as they typically exhibit impairment…
- Conditions
- Schizophrenia, Bipolar Disorder, Psychotic Disorders
- Trial name
- NCT02663349
- Testing
- Social Cognition and Intervention Training
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Obesity, Mentally Ill Persons
Interactive Obesity Treatment Approach (iOTA) for Obesity Prevention in Serious Mental Illness
The proposed project aims to pilot and adapt a scalable and sustainable interactive obesity treatment approach (iOTA) program for adults with serious mental illness (SMI).
- Trial name
- iOTA-SMI (NCT03695289)
- Testing
- iOTA SMI, Health Education Control
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Washington University School of Medicine
Weight Loss, Diabetes Mellitus, Type 2
Reducing Weight and Diabetes Risk in an Underserved Population (STRIDE)
The purpose of this study is to examine the effectiveness of a lifestyle intervention designed to reduce weight and diabetes risk in a population of individuals with mental illness who are also taking antipsychotic medications.
- Conditions
- Weight Loss, Diabetes Mellitus, Type 2, Psychotic Disorders
- Trial name
- STRIDE (NCT00790517)
- Testing
- Premier Lifestyle Intervention with DASH Diet
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Kaiser Permanente
Diabetes Mellitus, Type 2, Schizophrenia
Metformin in Co-morbid Diabetes or Prediabetes and Serious Mental Illness
Schizophrenia is associated with a lifespan shortened by 20 years, due to cardiovascular disease (CVD), with antipsychotic (AP) medications understood to contribute to this risk through associated metabolic side-effects.
- Trial name
- NCT02167620
- Testing
- Metformin
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- Centre for Addiction and Mental Health
Alcoholism, Diagnosis, Dual (Psychiatry)
12-step Facilitation for the Dually Diagnosed
This is a randomized trial testing the efficacy of a modified 12-step facilitation therapy for individuals with serious mental illness and alcohol use disorders, compared to usual treatment.
- Trial name
- TSFDD (NCT00583440)
- Testing
- 12-step facilitation, Treatment as usual
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- University of New Mexico
Mild Cognitive Impairment
Serious Game-based Interventions in Patients With Mild Cognitive Impairment Outside the Clinic
This study will evaluate the therapeutic efficacy of Neuro-World cognitive training games (Woorisoft, S. Korea) in patients with mild cognitive impairment.
- Trial name
- NCT04920123
- Testing
- Neuro-World
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- University of Massachusetts, Amherst
General Surgery
The GUARDIAN Pilot Trial
The treatments will be: 1) norepinephrine or phenylephrine infusion to maintain intraoperative MAP ≥85 mmHg, delayed resumption of chronic antihypertensive medications, and a target ward MAP ≥80 mmHg (tight pressure management)…
- Trial name
- GUARDIAN (NCT04789733)
- Testing
- Tight pressure management, Routine pressure management
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The Cleveland Clinic
Tobacco Use, Tobacco Smoking
Persistence Targeted Smoking Cessation in Serious Mental Illness (SMI)
Due to the pandemic, this study was modified from a randomized clinical trial to test the feasibility, initial efficacy, and mechanisms of action of our PTSC-S intervention to a feasibility and acceptability test of our…
- Conditions
- Tobacco Use, Tobacco Smoking, Tobacco Use Cessation, Tobacco Use Disorder
- Trial name
- PTSC-S (NCT03873337)
- Testing
- Persistence Targeted Smoking Cessation in SMI (PTSC-S), Nicotine patch
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Rutgers, The State University of New Jersey
Other
Creating Welcoming Faith Communities for People With Serious Mental Illnesses
The goal of this intervention study is to test a behavioral intervention to increase inclusionary practices toward individuals with serious mental illness in faith communities. The main questions it aims to answer are: 1.
- Trial name
- NCT06336980
- Testing
- Increasing Inclusionary Practices in Faith Communities
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Temple University
Cognitive Decline, Alzheimer Disease
Effects of Real vs. Soundless Acoustic Stimulation During Deep Sleep on Brain Activity, Memory, and Blood Biomarkers in Older Adults (60-85) With Mild Memory Impairment
This study aims to explore a non-invasive way to improve memory and slow cognitive decline in older adults by enhancing sleep quality.
- Conditions
- Cognitive Decline, Alzheimer Disease, Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI)
- Trial name
- NCT06669546
- Testing
- Phase-locked auditory stimulation (PLAS)
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University of Bern
Serious Emotional Disturbance
Family Health and Development Project
The Family Health and Development Project (FHDP) is a randomized controlled trial to evaluate the effectiveness of the Intensive In-home Child and Adolescent Psychiatric Service (IICAPS) intervention, targeting emotionally…
- Trial name
- FHDP (NCT01567969)
- Testing
- Intensive In-home Child and Adolescent Psychiatric Service, Home-based Child Treatment Coordination
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Yale University
Mental Illness, Shared Decision Making
Goal Elicitation, Treatment Prioritization, & Electronically-Practiced Discussion for Psychiatry
GET PrEPD-Psychiatry is a mixed-methods, developmental study to adapt a shared decision making (SDM) intervention to be specific for psychiatry decisions (Aim 1, previously completed), evaluate its feasibility and acceptability…
- Trial name
- GET-PrEPD (NCT04601194)
- Testing
- Coaching and Virtual Provider Program Practice
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Indiana University
Post-Traumatic Stress Disorder
Cognitive Behavioral Treatment for Post-Traumatic Stress Disorder in People With Additional Serious Mental Illnesses
This study will evaluate the effectiveness of tailored cognitive behavioral therapy in treating post-traumatic stress disorder in people with additional mental illnesses.
- Trial name
- NCT00494650
- Testing
- Cognitive behavioral therapy (CBT), Brief PTSD treatment
- Where
- 5 sites in United States
- Volunteers
- 200 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Serious Mental Illness, Tobacco Use Disorder
Facilitation to Increase Tobacco Treatment
Smoking disproportionally impacts Veterans, and VA spends $2.7 billion annually on smoking-related health conditions. Veterans with serious mental illness (SMI) smoke tobacco products at triple the rate of Veterans without any…
- Trial name
- FITT (NCT07455526)
- Testing
- Multi-component facilitation
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- VA Office of Research and Development
Serious Mental Illness
Evaluating the Use of Peer Specialists to Deliver Cognitive Behavioral Social Skills Training
The Veterans Health Administration (VHA) is advocating that Veterans with serious mental illness (SMI) receive recovery-oriented, rehabilitation approaches that target real-world functioning.
- Trial name
- CBSST-PEER (NCT03467243)
- Testing
- Cognitive Behavioral Social Skills Training, Social Skills Training, Treatment as usual
- Where
- United States
- Volunteers
- 191 people
- Sponsor
- VA Office of Research and Development
Mental Disorder, Physical Illness
Peer Navigators for the Health and Wellness of People With Psychiatric Disabilities
Adults with psychiatric disabilities get sick and die 20 to 30 years younger than same-age peers, with even greater disparities occurring when the person is from a low SES or of color.
- Trial name
- DRRRP-PHN (NCT05018351)
- Testing
- Integrated Care, Peer Navigation
- Where
- 2 sites in United States
- Volunteers
- 354 people
- Sponsor
- Illinois Institute of Technology
Specific Phobia, Anxiety Disorder
Online Psychological Treatment for Rat Phobia Guided by a Virtual Assistant
The research work proposes an exposure treatment through a virtual therapeutic assistant called Thera, that interacts verbally with the patient, to guide and control exposure therapies for phobias to small animals delivered…
- Trial name
- NCT05081323
- Testing
- Self-applied treatment for phobias
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Baja California