Clinical trials: Serious Mental Illness
COVID-19, Cardiorespiratory Failure
Lift Mobile Mindfulness for COVID-19 Distress Symptoms
This is a randomized clinical trial (RCT) nested within the NIH PETAL Network's COVID cohort study (BLUE CORAL [Biology and Longitudinal Epidemiology: COVID Observational Study]) of patients hospitalized for COVID-19-related…
- Trial name
- LIFTCOVID (NCT04581200)
- Testing
- Lift
- Where
- 4 sites in United States
- Volunteers
- 56 people
- Sponsor
- Duke University
Opioid Overdose
Serious Game to Teach Opioid Overdose Response
This study evaluates the efficacy of a serious game to teach students how to recognize and respond to opioid overdose
- Trial name
- NCT06727786
- Testing
- Serious game training
- Volunteers
- 850 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Reno
Nicotine Addiction, Serious Mental Illness
Feasibility Trial of a Tailored Smoking Cessation App for People With Serious Mental Illness
Quitting smoking has important health benefits for people with serious mental illness, more than half of whom are smokers. Smoking reductions in this population, in turn, could contribute to saving billions of dollars in…
- Trial name
- NCT03069482
- Testing
- Learn to Quit App, Nicotine patch, Nicotine lozenge
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Duke University
Standard Treatment Versus Engagement Focused Treatment
Improving Transitional Care Experiences in Mental Health
The cost of serious mental illness (SMI) in the U.S. is $317 billion annually. This translates to more than $1000 for every man, women, and child in the U.S. Hospitalization and Emergency Room (ER) visits have the highest costs.
- Trial name
- NCT02213198
- Testing
- Engagement focused care, Standard Care
- Where
- United States
- Volunteers
- 465 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Vocational Rehabilitation, Schizophrenia
Cognitive Remediation in Supported Employment at Human Service Center (HSC)
This project seeks to evaluate the feasibility and effectiveness of combining cognitive remediation and Supported Employment Program (SEP) services to improve work outcomes in people with a serious mental illness who have been…
- Conditions
- Vocational Rehabilitation, Schizophrenia, Mental Disorders, Cognitive Symptoms
- Trial name
- CT+SE (NCT00138021)
- Testing
- Computerized cognitive training program
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Human Service Center, Illinois
Alzheimer Disease
AZ@GAME-Eco: Economic Assessment of Serious Games for the Management of Alzheimer's Disease and Related Disorders
The main objective of AZ@GAME ECO is to evaluate the cost-utility of the management of patients suffering from Alzheimer's disease using a serious game providing cognitive and physical straining compared to a usual management.
- Trial name
- AZ@GAME-Eco (NCT03208491)
- Testing
- serious games use, usual care
- Where
- France
- Volunteers
- 136 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Schizophrenia, Schizoaffective Disorder
Optimizing CBSST With Executive Function Training for Schizophrenia (R33)
This randomized controlled clinical trial will test a blended intervention that combines Executive Function Training with Cognitive-Behavioral Skills Training (E-CBSST).
- Trial name
- ECBSST R33 (NCT07658391)
- Testing
- E-CBSST, E-SC
- Where
- 2 sites in United States
- Volunteers
- 106 people
- Sponsor
- University of California, San Diego
Loneliness, Social Isolation
Community Navigators
The Temple University Collaborative on Community Inclusion (TU Collaborative) is testing a community navigation intervention study based upon effective health navigation models by conducting a randomized controlled trial of the…
- Conditions
- Loneliness, Social Isolation, Mental Health Issue
- Trial name
- Navigators (NCT06594029)
- Testing
- Community Navigator Intervention, Control Group
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Temple University
Tobacco Dependence, Schizophrenia
The Appeal and Impact of E-cigarettes in Smokers With SMI
This study will evaluate behavioral and psychological appeal, toxicity, and effect of e-cigarettes on smoking behavior and nicotine addiction in chronic smokers with serious mental illness (SMI) who have failed to quit smoking.
- Conditions
- Tobacco Dependence, Schizophrenia, Bipolar Disorder, Schizoaffective Disorder
- Trial name
- NCT03050853
- Testing
- E-cigarette
- Where
- 2 sites in United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Dementia
VR&R: Providing Caregiver Respite by Managing BPSDs and Improving QoL in People with Dementia Using Immersive VR-Therapy
The goal of this interventional trial is to learn about how immersive Virtual Reality (VR) therapy can be used at home by individuals with dementia, with assistance from their informal (e.g., friend/family) caregivers.
- Trial name
- VR&R (NCT05867641)
- Testing
- Immersive VR Therapy in Head-Mounted Display (HMD) (Solo), Immersive VR Therapy in a Head-Mounted Display (HMD) (Social)
- Where
- 7 sites in Canada
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto
Bipolar Disorder (BD), Schizophrenia Disorders
Creating a Global Research Database That Connects Genetic Information and Long-term Health Data to Improve Personalized Treatment for People With Serious Mental Illness
This observational study aims to provide new insights into the nature and classification of severe mental illness and dementias that in time should help improve diagnostic practise, and enable the development of new and improved…
- Conditions
- Bipolar Disorder (BD), Schizophrenia Disorders, Major Depressive Diorder, Dementia
- Trial name
- GlobalMinds (NCT06641726)
- Testing
- Not applicable- observational study
- Where
- United Kingdom
- Volunteers
- 50,000 people
- Sponsor
- Akrivia Health
Schizophrenia, Schizoaffective Disorder
Evaluation of mHealth for Serious Mental Illness
This study is a waitlist control trial evaluating the acceptability and preliminary efficacy of a smartphone application with people with mental illness.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Major Depressive Disorder, Bipolar Disorder
- Trial name
- NCT04068467
- Testing
- Smartphone App, Waitlist Control
- Where
- United States
- Volunteers
- 315 people
- Sponsor
- University of Washington
Adolescents
SAEM: A Serious Game for Emotional Regulation Problems in Adolescents
This study aims to assess the effects of an intervention to improve emotional regulation skills in adolescents with affective (anxiety and/or depression) and behavioral problems.
- Trial name
- SAEMGame (NCT05154292)
- Testing
- Serious Game: Emotional Health Island (SAEM)
- Where
- 3 sites in Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universidad de Almeria
Bipolar Disorder, Schizophrenia
Life Goals Behavioral Change to Improve Outcomes for Veterans With Serious Mental Illness
Persons with serious mental illness are at increased risk of cardiovascular disease. The goals of this study are to test a treatment, Life Goals Collaborative Care to help promote health behavior change and to get feedback from…
- Conditions
- Bipolar Disorder, Schizophrenia, Major Depressive Disorder, Chronic Affective Disorders
- Trial name
- NCT01244854
- Testing
- Life Goals Collaborative Care
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- VA Office of Research and Development
Dementia, Primary Palliative Care
Supportive Care for Cognitively Impaired Patients and Families
Currently almost 5 million Americans suffer from the distressing symptoms related to dementia and this number that will triple by 2050.
- Conditions
- Dementia, Primary Palliative Care, Mild Cognitive Impairment
- Trial name
- NCT03881579
- Testing
- nurse-led supportive care assessment
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Stanford University
Learning Disorder, Specific, Learning Disabilities
Rhythm Training of a Serious Game on the Reading Skills of Children w/ a Specific Learning Disorder Impacting Reading
Mila-Learn-01 is a double-blind clinical study (meaning that neither the patient nor the doctor or his/her team will know which game the child has), which enables us to see the effect of a serious game on the child's reading…
- Conditions
- Learning Disorder, Specific, Learning Disabilities, Dyslexia, Specific Learning Disorder, With Impairment in Reading
- Trial name
- NCT05154721
- Testing
- experimental Group - Mila-Learn
- Where
- 3 sites in France
- Volunteers
- 151 people
- Sponsor
- Poppins
Autism Spectrum Disorder
Mobile-based Games for Cognitive Training in Children With Neurodevelopmental Disorders
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with characteristic deficits in social functioning and presence of stereotypic behavior.
- Trial name
- NCT04308915
- Testing
- Game-based cognitive training
- Where
- India
- Volunteers
- 14 people
- Sponsor
- Indian Institute of Technology Kanpur