Clinical trials: Septic Shock, injection or injectable or infusion or IV or syringe or subcutaneous, open to volunteers
- Condition Septic Shock
- Drug or intervention injection OR injectable OR infusion OR IV OR syringe OR subcutaneous
- Status Open to volunteers
Septic Shock
Metabolic Cluster Analysis in Septic Shock Patients
Observational study including septic shock patients within 24 hours of ICU admission, monitored with a cardiac output estimation system, with ongoing resuscitation.
- Trial name
- ACMEcat (NCT06500156)
- Testing
- Fluid challenge
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Corporacion Parc Tauli
Septic Shock, Sepsis
Umbilical Mesenchymal Stromal Cells as Cellular Immunotherapy for Septic Shock
Septic shock is associated with substantial burden in terms of both mortality and morbidity for survivors of this illness. Pre-clinical sepsis studies suggest that mesenchymal stem (stromal) cells (MSCs) modulate inflammation…
- Conditions
- Septic Shock, Sepsis, Pathologic Processes, Shock
- Trial name
- UC-CISSII (NCT05969275)
- Testing
- Allogeneic umbilical cord-derived human mesenchymal stromal cells
- Where
- 2 sites in Canada
- Volunteers
- 296 people
- Sponsor
- Ottawa Hospital Research Institute
Septic Shock
POCUS-Guided Esmolol in Septic Shock: A Pilot RCT
The goal of this pilot clinical trial is to determine if conducting a larger study using point-of-care ultrasound (POCUS) to guide beta-blocker therapy in patients with septic shock is feasible.
- Trial name
- Epic-Beta (NCT07313605)
- Testing
- Esmolol
- Volunteers
- 100 people
- Sponsor
- John Basmaji
Septic Shock, Sepsis
Effect of Targeting Upper Normal Serum Magnesium Levels on Norepinephrine Requirements in Septic Shock Patients
The goal of this clinical trial is to assess the effect of targeting upper normal serum magnesium levels on norepinephrine requirements in adult patients with septic shock. The main questions it aims to answer are: 1.
- Trial name
- NCT07716956
- Testing
- magnesium sulfate, standard care treatment
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Sepsis, Septic Shock
Ventriculo-arterial Coupling and Myocardial Work in Sepsis and Septic Shock
Sepsis is a term which describes an excessive response of the body to an infection and, if not promptly treated, can turn into septic shock a condition in which the organs don't receive enough oxygen to satisfy their needs.
- Trial name
- NCT06853574
- Testing
- Fluid therapy, Noradrenaline infusion
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- General and Teaching Hospital Celje
Sepsis
Extracorporeal cfDNA Removal in Septic Shock Patients With Elevated DNA Levels
Sepsis continues to be a major global health concern, characterized by high morbidity and mortality rates. As a clinical syndrome characterized by a dysregulated systemic response to infection, its progression toward…
- Trial name
- NCT07657767
- Testing
- Extracorporeal therapy, Extracorporeal elimination of cfDNA using "Nucleocore"
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Sergey Savko
Septic Cardiomyopathy, Septic Shock
The Preventive Effect of Shenfu Injection on Myocardial Dysfunction in Sepsis
This study focuses on improving heart function in patients with life-threatening blood infections (septic shock). When the body fights severe infections, the heart sometimes struggles to pump blood effectively, which can lead to…
- Trial name
- SHIELD Trail (NCT06898723)
- Testing
- Shenfu Injection
- Where
- China
- Volunteers
- 440 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Sepsis, Severe
Early Administration of Norepinephrine in Sepsis
The management of septic states includes, in addition to the specific treatment (antimicrobials and eradication of the source), a restoration of the hemodynamic disorders and assistance of the failing organs.
- Trial name
- EA-NE-TUN (NCT05836272)
- Testing
- Norepinephrine Bitartrate
- Where
- Tunisia
- Volunteers
- 200 people
- Sponsor
- Tunis University
Septic Shock, Acute Kidney Injury
The Effect of Vasopressor Therapy on Renal Perfusion in Septic Shock
Acute kidney injury (AKI) is a common complication of septic shock and together these conditions carry a high mortality risk. In septic patients who develop severe AKI renal cortical perfusion is deficient despite normal…
- Trial name
- REPERFUSE (NCT06234592)
- Testing
- Angiotensin II, Vasopressin, Norepinephrine
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- King's College Hospital NHS Trust
Critical Illness, Septic Shock
Human Albumin for Resuscitation in Surgical Septic Shock: A Randomized Controlled Trial (ALBUS Study)
This study will test whether giving human albumin to keep the blood albumin level above 3.5 g/dL, in addition to standard care, improves survival in patients with surgical septic shock.
- Trial name
- ALBUS (NCT07212582)
- Testing
- Human Albumin 20% Solution, Standard Care (in control arm)
- Where
- Thailand
- Volunteers
- 304 people
- Sponsor
- Mahidol University
Septic Shock, Methylene Blue
Efficacy and Safety of Methylene Blue in the Treatment of Severe Septic Shock
The goal of this clinical trial is to investigate whether methylene blue injection can safely and effectively improve the survival rate of patients with severe septic shock, shorten the duration of norepinephrine use, reduce the…
- Conditions
- Septic Shock, Methylene Blue, Sepsis
- Trial name
- NCT06481410
- Testing
- Methylene Blue Intervention Group, Normal Saline Control Group
- Where
- China
- Volunteers
- 488 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Septic Shock
Protocolized Reduction of Non-resuscitation Fluids Versus Usual Care in Septic Shock Patients
The objective of this trial is to assess the beneficial and harmful effects of a restrictive strategy for administration of non-resuscitation fluids in adult patients with septic shock.
- Trial name
- REDUSE (NCT06140147)
- Testing
- Protocolised reduction of non-resuscitation fluids, Usual care
- Where
- 22 sites in Finland, Sweden and 1 more
- Volunteers
- 1,850 people
- Sponsor
- Region Skane
Septic Shock, Sepsis
Effects of Esmolol on Sublingual Microcirculation and Vascular Waterfall Phenomenon in Patients With Septic Shock
This prospective, multicenter, single-arm interventional pilot study aims to evaluate the short-term physiological effects of intravenous esmolol on sublingual microcirculation and vascular-waterfall parameters in adult patients…
- Conditions
- Septic Shock, Sepsis, Critical Illness Sepsis, Severe
- Trial name
- NCT07657754
- Testing
- Esmolol intravenous infusion
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Sepsis, Septic Shock
NAI for Sepsis With Persistent Lymphopenia
This is a Phase 2, randomized, open-label study evaluating the safety and efficacy of nogapendekin alfa inbakicept (NAI, ANKTIVA®) in combination with standard of care versus standard of care alone in critically ill adults with…
- Conditions
- Sepsis, Septic Shock, Lymphopenia, Immunosuppression
- Trial name
- NCT07578558
- Testing
- Nogapendekin alfa inbakicept (NAI), Standard of Care (SOC)
- Volunteers
- 50 people
- Sponsor
- ImmunityBio, Inc.
Septic Shock, Acute Kidney Injury
Early Co-Administration of Crystalloid Fluid and Norepinephrine for Preventing Acute Kidney Injury in Septic Shock
Septic shock is a life-threatening condition that can cause severe circulatory failure and damage to vital organs, including the kidneys.
- Trial name
- NCT07418541
- Testing
- Norepinephrine, Crystalloid Fluid Resuscitation
- Volunteers
- 100 people
- Sponsor
- Universitas Sumatera Utara
Septic Shock
Effect of Shenfu Injection on the Vascular Waterfall Phenomenon in Patients With Septic Shock
This prospective single-center clinical trial aims to evaluate the circulatory and microcirculatory effects of Shenfu Injection in patients with septic shock.
- Trial name
- NCT07603024
- Testing
- Shenfu Injection
- Where
- China
- Volunteers
- 20 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Septic Shock, Vasopressor Resistance
Efficacy of the Alpha 2 Agonist Dexmedetomidine for Sympathetic Deactivation in REfractory Septic Shock
Septic shock is one of the most frequent reasons for admission to intensive care units and remains associated with a high mortality rate of approximatively 40% at 28 days.
- Trial name
- ADRESS (NCT07569536)
- Testing
- Dexmedetomidine 100 µg/mL, intravenous solution, Stardard care
- Where
- 18 sites in France
- Volunteers
- 360 people
- Sponsor
- Hospices Civils de Lyon
Gram Negative Infections, Sepsis and Septic Shock
A Combination Therapy With Ceftazidime and Fosfomycin Will be Compared to Ceftazidime Alone in Hospitalized Adult Patients With Suspected Severe Gram-negative Bacterial Infections
The goal of this clinical trial is to : 1. Test whether the combination of CAZ±AVI and FOS leads to superior clinical outcomes in patients with severe suspected Gram-negative bacterial infection, as demonstrated by a shorter time…
- Trial name
- CAVIFOS (NCT07063095)
- Testing
- Ceftazidime± avibactam with fosfomycin
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Angela HUTTNER
Septic Shock
Weaning Approaches for Vasopressin in Sepsis
In this study, we aim to evaluate the incidence of hypotension during vasopressin weaning by comparing two methods - titrated reduction versus abrupt withdrawal - through the conduct of a randomized clinical trial.
- Trial name
- WAVES (NCT07067866)
- Testing
- Titrated weaning of vasopressin., Abrupt weaning of vasopressin.
- Where
- Brazil
- Volunteers
- 82 people
- Sponsor
- Hospital Nossa Senhora da Conceicao
Neonatal Sepsis, Shock, Septic
Intravenous Methylene Blue for Treating Refractory Neonatal Septic Shock
Preterm infants (born at less than 37 weeks of pregnancy) sometimes develop a serious blood infection leading to low blood pressure, which does not respond to saline or to the standard medicines for increasing blood pressure…
- Trial name
- NCT06306001
- Testing
- Methylene Blue
- Where
- India
- Volunteers
- 130 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh