Clinical trials: Sepsis
Drug Resistance, Bacterial
Epidemiology of Antimicrobial-use and Antimicrobial-resistant Infections in Four Hospitals in Thailand
The main goal of this retrospective observational study is to understand how stepping down antibiotic treatment (called antibiotic de-escalation) affects patients who receive it compared to those who don't after received a…
- Conditions
- Drug Resistance, Bacterial, Bacteremia
- Trial name
- NCT07082465
- Where
- 4 sites in Thailand
- Volunteers
- 108,000 people
- Sponsor
- University of Oxford
Invasive Candidiasis, Esophageal Candidiasis
Study of Mycamine® in Infants and Toddlers With Fungal Infections to Evaluate Safety and Blood Levels of the Drug
Infants and toddlers with fungal infections will receive 10 to 14 days of treatment with an antifungal drug. Safety and drug blood levels will be assessed
- Conditions
- Invasive Candidiasis, Esophageal Candidiasis, Oropharyngeal Candidiasis, Candidemia
- Trial name
- NCT00607763
- Testing
- Micafungin (Mycamine)
- Where
- 6 sites in United States
- Volunteers
- 9 people
- Sponsor
- Astellas Pharma Inc
Euthyroid Sick Syndromes, Septic Shock
Thyroid Hormone Supplementation in Patients With Septic Shock
The primary aim of the study would be to determine whether there is a difference in survival in the Intensive Care Unit between the group of patients with septic shock diagnosed with euthyroid sick syndrome who were treated with…
- Trial name
- NCT05270798
- Testing
- triiodothyronine
- Where
- Bosnia and Herzegovina
- Volunteers
- 108 people
- Sponsor
- Cantonal Hospital Zenica
Maternal Health Care, Hypertensive Disorder of Pregnancy
Implementation Models for Blood Pressure Monitoring in Pregnancy and Postpartum: Connected MOM Plus
Quality improvement (QI) initiative to improve uptake and utilization of Connected MOM, particularly among those with limited access to health care
- Trial name
- NCT07691541
- Testing
- Connected MOM +
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Tulane University
Shock, Septic, Shock, Hemorrhagic
Usefulness of Capillary Refill Time and Skin Mottling Score to Predict Intensive Care Unit Admission
In the emergency department (ED), the severity assessment of shock is a fundamental step prior to the admission in intensive care unit (ICU).
- Trial name
- TRCMARBSAU (NCT03831022)
- Testing
- Capillary refill time and skin mottling score measurement at the admission to the emergency department
- Where
- France
- Volunteers
- 1,500 people
- Sponsor
- Hôpital Necker-Enfants Malades
Newborn; Infection, Newborn Sepsis
New Protocol for Febrile Neonate Management
The objective of present study was to evaluate clinical and laboratory characteristics of febrile neonate and describe the incidence of SBI in febrile neonates.
- Trial name
- NCT03183531
- Testing
- C reactive protein
- Where
- Turkey (Türkiye)
- Volunteers
- 328 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Sepsis, Sepsis and Coagulopathy
Sepsis-associated Thrombocytopenia and Platelet Transfusion （STAPT）
Currently, there are no multicenter studies on platelet transfusion for SAT patients, and the benefits and risks of platelet transfusion still require further validation based on large-sample data.
- Trial name
- NCT07230067
- Testing
- SAT patients
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Macrophage Activation Syndrome
Characterization of the Inflammatory Profile of Patients With Macrophage Activation Syndrome Secondary to Bacterial Sepsis
The pathophysiology of macrophage activation syndrome has been mainly studied in pediatric genetic primary forms. There is little data in secondary forms related to bacterial sepsis.
- Trial name
- SAMOKINE (NCT03721809)
- Testing
- Blood samples
- Where
- France
- Volunteers
- 27 people
- Sponsor
- University Hospital, Rouen
Bloodstream Infection (BSI)
Prolonged Cardiopulmonary Bypass Time as Predictive Factor for in Hospital Infection
This study is to analyse the demographics and microbiological factors concerning patients undergoing cardio surgical intervention using CPB complicated with bloodstream infection (BSI) postoperatively.
- Trial name
- NCT04548167
- Where
- Switzerland
- Volunteers
- 7,064 people
- Sponsor
- University Hospital, Basel, Switzerland
Acute Renal Failure
Open-Label Study To Evaluate the Safety and Efficacy of the Renal Assist Device In Patients With Acute Renal Failure
Although conventional hemodialysis removes waste products and corrects fluid imbalance, it does not replace critical absorptive, metabolic, endocrine, and immunologic functions performed by healthy renal tubule cells.
- Trial name
- NCT00511407
- Testing
- Renal tubule assist device
- Where
- 13 sites in United States
- Volunteers
- 58 people
- Sponsor
- RenaMed Biologics
ARDS, Human
The Mechanism of Extracellular Vesicles Containing Mitochondrial DNA in ARDS Lung Injury Caused by Extrapulmonary Sepsis
The acute respiratory distress syndrome (ARDS) remains a common and morbid complication of critical illness. Sepsis contribute to a lot of ARDS cases, but mechanisms by which non-pulmonary insults such as extrapulmonary sepsis…
- Trial name
- NCT05061212
- Volunteers
- 50 people
- Sponsor
- Southeast University, China
Sepsis-Associated Encephalopathy
Role of MSCT Volumetry in Assessment of Brain Atrophy in Septic Patients
assessment of brain atrophy associated with septic ICU patients by using MSCT Volumetry
- Trial name
- NCT06112119
- Testing
- MSCT
- Volunteers
- 55 people
- Sponsor
- Assiut University
Complication of Prematurity, Immunologic Deficiency Syndromes
Novel Mechanisms and Approaches to Treat Neonatal Sepsis
Mortality related to neonatal sepsis exceeds 1 million deaths worldwide; the highest risk of mortality is in preterm neonates, especially low birth weight (LBW), and very low birth weight (VLBW) neonates.
- Trial name
- NCT02554630
- Testing
- Adjuvant, Blood Collection
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Florida
Staphylococcus Aureus, Bacteremia
Comparison of Nephrotoxicity and Hospital Costs in Patients With Methicillin-Resistant Staphylococcus Aureus Bacteremia Who Received Vancomycin Versus Teicoplanin Therapy
Staphylococcus aureus, the most virulent of the many staphylococcal species, has been recognized as one of the most important and lethal human bacterial pathogens.
- Trial name
- NCT01352936
- Where
- Taiwan
- Volunteers
- 190 people
- Sponsor
- Taipei Medical University WanFang Hospital
Peritonitis, Sepsis
The Value of PSP in Predicting Outcome in ICU Surgical Peritonitis Patients
The purpose of this study is to determine the diagnostic accuracy of Pancreatic Stone Protein (PSP) in predicting patient outcomes with suspected peritonitis in the Intensive Care Unit after abdominal surgery and compare PPS with…
- Conditions
- Peritonitis, Sepsis, Multiple Organ Failure, Death
- Trial name
- NCT01465711
- Testing
- All abdominal surgical procedures, Intubation, Imaging
- Where
- Germany
- Volunteers
- 137 people
- Sponsor
- University of Magdeburg
Severe Sepsis
De-escalation of Empirical Antimicrobial Therapy Study in Severe Sepsis
Rational: Severe sepsis is one of the leading cause of mortality in intensive care unit patients. Early initiation of an appropriate empirical antimicrobial therapy is associated with improved outcomes.
- Trial name
- NCT01626612
- Testing
- continuation of the empirical antimicrobial therapy, streamlining of the empirical antimicrobial therapy
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Obesity, Sepsis
Transluminal or Percutaneous Endoscopic Drainage and Debridement of Abcesses After Bariatric Surgery
Patients presenting intra-abdominal abcesses following bariatric surgery complicated by fistulae are classically treated by external drainage and endoprosthesis or surgical redo.
- Trial name
- NCT02266901
- Testing
- endoscopic drainage
- Volunteers
- 9 people
- Sponsor
- Erasme University Hospital
Sepsis, Perfusion Index
Observational Study About the Use of Perfusion Index to Use Vasopressor in Sepsis
In this thesis we will use the current state of knowledge that PI can provide a reliable information about the state of peripheral microcirculation during the state of sepsis and septic shock in ICU patients and that can…
- Conditions
- Sepsis, Perfusion Index, Vasopressor
- Trial name
- NCT06860438
- Testing
- Vasoconstrictor Agents
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Sepsis, Septic Shock
Fluid Resuscitation in Septic Shock Patients With BMI Elevation
To explore the safety and feasibility of alternative fluid resuscitation strategies in obese patients with septic shock.
- Conditions
- Sepsis, Septic Shock, Obesity
- Trial name
- FRISSBE (NCT04759989)
- Testing
- Actual Body Weight Dosing, Adjusted Body Weight Dosing, Ideal Body Weight Dosing
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Wake Forest University Health Sciences
Beta Lactam Resistant Bacterial Infection, Enterobacteriaceae Infections
PipEracillin/Tazobactam Versus mERoPENem for Treatment of AmpC Producing Blood Stream Infections
Data regarding optimal treatment for extended-spectrum beta-lactamase (ESBL) producing Enterobacterales bloodstream infection are lacking.
- Conditions
- Beta Lactam Resistant Bacterial Infection, Enterobacteriaceae Infections, Bacteremia
- Trial name
- SPICE-M (NCT05355350)
- Testing
- Piperacillin / Tazobactam Injection, Meropenem
- Where
- 4 sites in Israel
- Sponsor
- Rambam Health Care Campus