Clinical trials: Sepsis, pill or tablet or capsule or oral, open to volunteers
Sepsis, Trauma Injury
Microbiome Dysfunction in Surgical Intensive Care Unit Survivors
Oral and gastrointestinal microbiome dysfunction has been demonstrated to be a culprit of various systemic dysfunctions in peripheries such as cardiovascular, nervous, endocrine and musculoskeletal systems.
- Trial name
- NCT05357170
- Testing
- Human feces collection
- Where
- United States
- Volunteers
- 468 people, healthy volunteers welcome
- Sponsor
- University of Florida
Staphylococcus Aureus Endocarditis, Staphylococcus Aureus Septicemia
Dabigatran vs. Oral Anti-Xa Inhibitors in S. Aureus Bacteremia
This is an open-label randomized controlled trial which will enroll patients with S. aureus bacteremia who are already taking oral anticoagulant medications (apixaban, edoxaban, or rivaroxaban) for an approved indication (stroke…
- Conditions
- Staphylococcus Aureus Endocarditis, Staphylococcus Aureus Septicemia, Staphylococcus Aureus Bacteremia, Staphylococcus Aureus Bloodstream Infection
- Trial name
- DABI-SNAP (NCT06650501)
- Testing
- Dabigatran, Apixaban, edoxaban
- Where
- 3 sites in Canada
- Volunteers
- 300 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Sepsis
Adaptive Platform Trial for Personnalisation of Sepsis Treatment in Children and Adults: a Multi-national, Treatable Traits-guided, Adaptive, Exploratory, Bayesian Basket Trial
PALETTE is a perpetual adaptive platform to efficiently study sepsis interventions within 'treatable traits' in all-ages patients enabling prompt evaluation of pandemic treatments.
- Trial name
- PALETTE (NCT06381661)
- Testing
- Tocilizumab, Baricitinib, Anakinra
- Where
- 19 sites in France
- Volunteers
- 2,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sepsis
Rapid Recognition of Corticosteroid Resistant or Sensitive Sepsis
Main objective and primary endpoint: To compare the effect hydrocortisone plus fludrocortisone vs. placebo on a composite of death or persistent organ dysfunction - defined as continued dependency on mechanical ventilation, new…
- Trial name
- RECORDS (NCT04280497)
- Testing
- Administration procedures
- Where
- France
- Volunteers
- 1,800 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Preeclampsia Severe, Toxemia Of Pregnancy
LDA and LMWH vs LDA Alone in High-risk Patients for Preeclampsia Prevention
Preeclampsia is a major cause of maternal and perinatal morbidity and mortality worldwide. Low-dose aspirin started in the first trimester reduces the risk of preeclampsia in high-risk women.
- Conditions
- Preeclampsia Severe, Toxemia Of Pregnancy, Preeclampsia, Pregnancy Complications
- Trial name
- preGO (NCT07361679)
- Testing
- Aspirin, Tinzaparin
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Alexandra Hospital, Athens, Greece
Infections
Antimicrobial Stewardship for Enterobacterales Bacteremia Management
We hypothesize that a multifaceted antibiotic stewardship intervention incorporating physician education, prospective chart review with antibiotic recommendation, and provision of follow-up by a multidisciplinary antibiotic…
- Trial name
- NCT06257147
- Testing
- multifaceted antibiotic stewardship intervention
- Where
- Hong Kong
- Volunteers
- 420 people
- Sponsor
- Chinese University of Hong Kong
Early-onset Sepsis
Promoting Optimal Treatment Choices in Neonates With Suspected Early-Onset Sepsis
In this study, three neonatal evidence-based antibiotic stewardship strategies will be implemented in Dutch hospitals. These include the early-onset sepsis (EOS) calculator, procalcitonin (PCT)-guided therapy, and IV-to-oral…
- Trial name
- PrOTeCt-NEO (NCT06845332)
- Where
- 11 sites in Netherlands
- Volunteers
- 55,000 people
- Sponsor
- Franciscus Gasthuis
Periodontitis
Evaluation of the Systemic Burden of Non-surgical Periodontal Therapy: A Randomized Clinical Trial on Five Different Treatment Protocols
Periodontitis is a chronic inflammatory disease of the periodontal tissues leading to the destruction of the tooth supporting structures.
- Trial name
- NCT07077122
- Testing
- Scaling and Root Planing, antibiotic prophylaxis, 810nm Diode Laser
- Where
- Greece
- Volunteers
- 75 people
- Sponsor
- National and Kapodistrian University of Athens
Heart Rhythm Disorder
Role of Ivabradine for Heart Rate Control in Management of Patients With Sepsis and Septic Shock
Tachycardia is associated with excess mortality during septic shock. This may be related to the increase in cardiac metabolic demand, impaired cardiac diastolic function and less effect of administered exogenous catecholamines.
- Trial name
- NCT06742164
- Testing
- Ivabradine 5mg Tab, control
- Volunteers
- 76 people
- Sponsor
- Ain Shams University
Sepsis Induced Myocardial Dysfunction
The Treatment of Sepsis Induced Myocardial Dysfunction With Yiqilishui Formula
The goal of this clinical trial is to learn if Chinese medicine - Yiqilishui formula works to treat sepsis-induced myocardial dysfunction (SIMD). It will also learn about the safety of Yiqilishui formula.
- Trial name
- YQSIMD (NCT06686355)
- Testing
- Yiqilishui formula
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Dongzhimen Hospital, Beijing
Gram-negative Bacteremia
Gram-Negative Bloodstream Infection Oral Antibiotic Therapy Trial
The Gram-negative bloodstream infection Oral Antibiotic Therapy trial (The GOAT Trial) is a multi-center, randomized clinical trial that hypothesizes that early transition to oral antibiotic therapy for the treatment of…
- Trial name
- GOAT (NCT06080698)
- Testing
- Intravenous Antibiotics, Oral Antibiotics
- Where
- 11 sites in United States
- Volunteers
- 1,030 people
- Sponsor
- Johns Hopkins University
Dengue, Sepsis
Immune Responses to Dengue and Sepsis
The goal of this research study is to help the investigators better understand serious dengue disease. The investigators will collect clinical information and up to four blood samples from participants with dengue, influenza…
- Conditions
- Dengue, Sepsis, Influenza
- Trial name
- DEN-SEP (NCT07040202)
- Where
- 4 sites in Cambodia
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur du Cambodge
Hypertensive Disorder of Pregnancy, Preeclampsia
Blood Pressure Goal in Preterm Preeclampsia
The purpose of this study is to compare latency (prolongation of pregnancy from diagnosis till delivery) in patients with hypertensive disorders of pregnancy (HDP) with severe features < 34 weeks gestational age (GA), undergoing…
- Trial name
- NCT07894705
- Testing
- Treating BP acutely with intravenous or rapid acting oral medications
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Ohio State University
Sepsis
Effect of Rutin and Vitamin C on Outcomes in Adults With Sepsis Admitted to the Intensive Care Unit
The goal of this prospective, randomized, open-label, controlled clinical trial is to evaluate the efficacy and safety of rutin combined with vitamin C (Ruta C) and vitamin C alone as adjunctive therapies in adult patients aged…
- Trial name
- NCT07922213
- Testing
- Rutin plus Vitamin C, Vitamin C
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Ain Shams University
Candidemia, Candidiasis, Invasive
A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Participants With Candidemia and/or Invasive Candidiasis.
The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called Fosmanogepix) for the potential treatment of candidemia and/or invasive candidiasis, a life-threatening fungal infection…
- Trial name
- NCT05421858
- Testing
- Fosmanogepix, Caspofungin, Fluconazole
- Where
- 146 sites in United States, Argentina and 18 more
- Volunteers
- 450 people
- Sponsor
- Basilea Pharmaceutica
Gram-negative Bacteremia
A Platform Trial for Gram Negative Bloodstream Infections
BALANCE+ is a perpetual multiple domain randomized controlled platform trial to evaluate various treatment strategies for Gram-negative bloodstream infections (GN BSIs).
- Trial name
- BALANCE+ (NCT06537609)
- Testing
- De-escalation VS No De-escalation, Oral beta-lactams VS non beta-lactams, Central vascular catheter retention VS Central vascular catheter replacement
- Where
- 39 sites in Australia, Canada and 3 more
- Volunteers
- 2,500 people
- Sponsor
- Sunnybrook Health Sciences Centre
Staphylococcus Aureus Bloodstream Infections (BSI; Bacteremia)
Linezolid Plus Standard of Care
The aim of the study is to assess whether targeting virulence factors by administering linezolid in addition to standard antibiotic treatment improves outcomes in patients with Staphylococcus aureus bacteraemia.
- Trial name
- LIPS (NCT06958835)
- Testing
- Linezolid 600 mg
- Where
- 12 sites in Switzerland
- Volunteers
- 606 people
- Sponsor
- University Hospital, Basel, Switzerland
Supraventricular Arrhythmia, Septic Shock
Rate, Rhythm or Risk Control for New-onset Supraventricular Arrhythmia During Septic Shock: a Randomized Controlled Trial
New-onset supraventricular arrhythmia (NOSVA) is reported in 40 % of patients with septic shock and is associated with hemodynamic alterations and mortality.
- Trial name
- CAFS (NCT04844801)
- Testing
- Risk control strategy, Heart-Rate control strategy:, Rhythm control strategy:
- Where
- France
- Volunteers
- 240 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sepsis, Infection
Plasma Neprilysin for Predicting Sepsis Within 48 Hours in ICU Patients With Infection or Suspected Infection
The goal of this multicenter prospective observational cohort study is to determine whether plasma neprilysin can predict the development of sepsis within 48 hours in adults admitted to an intensive care unit with confirmed or…
- Trial name
- NEPSIS (NCT07796386)
- Testing
- Plasma Neprilysin Measurement, Conventional Sepsis Biomarker Measurement, Sublingual Microcirculation Assessment
- Where
- 2 sites in China
- Volunteers
- 488 people
- Sponsor
- Zhujiang Hospital
Infective Endocarditis (IE)
From Commensalism to Pathogenicity: Exploring the Pathophysiology of Bacteremia to Better Understand Enterococcus Faecalis Infective Endocarditis
Enterococci are pathobionts of the human intestinal microbiota: they colonize the gastrointestinal tract as well as the skin, urine, wounds, bile, the oral cavity and endodontic canal, and medical devices (urinary catheters…
- Trial name
- BAC-ENDO (NCT07313865)
- Testing
- Microbiological sampling (swab collection)
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Clermont-Ferrand