Clinical trials: Sensitisation
Allergic Contact Dermatitis
A Prospective Study to Investigate Contact Sensitization Using Classic and Machine Learning Techniques
The goal of this study is to look into the patterns of sensitization to figure out how allergic contact dermatitis (ACD), individual susceptibility, and patient characteristics are connected.
- Trial name
- NCT05991674
- Testing
- patch test for diagnosing allergic contact dermatitis
- Where
- Greece
- Volunteers
- 80 people
- Sponsor
- Andreas Syggros Hospital of Venereal and Dermatological Diseases
Fibromyalgia
The Relationship Between Serum S100B and Brain-Derived Neurotrophic Factor
Fibromyalgia is a chronic pain syndrome characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and cognitive symptoms.
- Trial name
- S100B-BDNF (NCT07358754)
- Testing
- No Intervention (Observational Study)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Chronic Shoulder Pain
Influence of Biopsychosocial Factors and Central Sensitization in Predicting the Recovery of Chronic Shoulder Pain
Background: Shoulder pain is the third most common musculoskeletal condition presenting to physicians or physiotherapists ) in primary healthcare after low back and neck pain being a significant cause of morbidity and functional…
- Trial name
- NCT02738372
- Testing
- Diagnosis/Prognosis
- Volunteers
- 90 people
- Sponsor
- University of Malaga
Skin Irritability, Skin Sensitisation
Safety Dermatological Assessment of Topical Use Product Through Dressings Predictive Studies for Evaluation of Photoirritation and Dermal Photosensitivity
The purpose of this study is to prove the product tested does not cause photoirritation or photosensitization reactions when exposed to sun light.
- Trial name
- SAF DER ASSESS (NCT03015103)
- Testing
- Intimate Lubrificant Gel
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Kley Hertz S/A
Temporomandibular Disorder
Assessment of Nociceptive Processing Among Patients With Temporo-mandibular Disorders
This case control study will investigate the physiological effect of nociceptive input in individuals with temporomandibular disorders.
- Trial name
- NCT04086732
- Testing
- High-frequency electrical stimulation
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Acute Myeloid Leukemia, Myelodysplastic Syndromes
AML/MDS Drug Sensitization by in Vivo Chemotherapy Administration
In this study, the investigators will explore the feasibility of ex vivo drug screening to predict sensitivity to chemotherapy resistance and to identify novel synergy between chemotherapies.
- Trial name
- NCT04263181
- Testing
- Peripheral blood draw, Bone marrow aspirate, Buccal swab
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Washington University School of Medicine
Kidney Transplant Rejection
Immune Response in Desensitized Patients
Kidney transplantation is the best treatment for chronic renal failure in terms of morbidity and mortality, quality of life for patients and health economics.
- Trial name
- DELIGHT (NCT05785936)
- Testing
- Desensitization
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Chronic Pain
The Effect of Pain Education Group Therapy and Its Impact on Chronic Pain, Kinesiophobia, and Physical Activity
The goal of this clinical trial is to learn if pain knowledge group intervention among chronic pain patients would influence their level of physical activity, pain intensity, depression, kinesiophobia and central sensitization.
- Trial name
- NCT07491549
- Testing
- pain education
- Where
- Estonia
- Volunteers
- 50 people
- Sponsor
- University of Tartu
Skin Sensitisation
Skin Sensitization Test (Modified Draize-95 Test)
Skin Sensitization Test (Modified Draize-95 Test) to Support a Low Dermatitis Potential Claim for a Blue Non Sterile Powder Free Nitrile Examination Gloves.
- Trial name
- NCT03886987
- Testing
- Blue Non Sterile Powder Free Nitrile Examination Gloves
- Where
- United States
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- Central Medicare Sdn. Bhd.
Atrial Fibrillation
Atrial Fibrillation Symptoms and Pain Sensitization
Atrial fibrillation (AF) is the most common sustained arrhythmia and the number of patients with AF is expected to increase substantially in the coming decades.
- Trial name
- NCT04649437
- Testing
- Quantitative sensory testing
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Region Örebro County
Complex Regional Pain Syndrome (CRPS)
Effectiveness of Transcranial Direct Current Stimulation (tDCS) in the Management of Complex Regional Pain Syndrome
Transcranial direct current stimulation (tDCS) is a non-invasive therapy increasingly used in facilities treating patients with chronic pain.
- Trial name
- ALGOSTIM (NCT07361692)
- Testing
- transcranial direct current stimulation
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Polyclinique de l'Europe
Kidney Transplantation, Graft Failure
Evaluation of the Safety of Use of Anti-IL6 Receptor Antibodies to Reduce Allo-sensitization Post Allograft Nephrectomy
Graft nephrectomy is associated with massive allo-sensitization following this event. The occurrence of anti-HLA antibodies is a major barrier to perform a second kidney transplantation.
- Trial name
- RAIPONS (NCT04779957)
- Testing
- Tocilizumab
- Where
- France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Toulouse
Skin Care
Evaluation of Skin Irritancy and Sensitization of a Liquid Bandage
The investigational product constitutes a medical device that is freely accessible to consumers and, as such, must be safe under real or reasonably foreseeable conditions of use and its safety must be tested before being placed…
- Trial name
- NCT05876546
- Testing
- Liquid bandage, Saline Solution
- Where
- 2 sites in Brazil
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Eurofarma Laboratorios S.A.
Pain
Tramadol and Pain Sensitization
Tramadol is a largely used analgesic drug. Its role however on sensitization as occurs for example in neuropathic pain is not very well known.
- Trial name
- TRAMADOL (NCT00487175)
- Testing
- Tramadol
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Chronic Pain, Central Sensitisation
The Effect of Griffonia Simplicifolia on Pain Intensity, Central and Peripheral Sensitization, Painmodulation in Healthy Volunteers
This planned study is based on a randomized, placebo-controlled cross-over design. Griffonia simplicifolia contains the serotonin-precursor 5-hydroxytryptophan (5-HTP), an endogenous amino acid.
- Conditions
- Chronic Pain, Central Sensitisation, Peripheral Sensitization, Neuroinflammatory Response
- Trial name
- NCT06893822
- Testing
- Griffonia simplicifolia
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Cervical Spondylopathy
Observation on the Curative Effect of Acupuncture At Sensitized Points on Gallbladder Meridian in the Treatment of Neck Type Cervical Spondylopathy
To investigate the changes of acupoint sensitization characteristics of patients with Neck Type Cervical Spondylopathy through Gallbladder meridian observe the curative effect of acupuncture intervention and optimize the clinical…
- Trial name
- NCT06847945
- Testing
- Acupuncture
- Where
- China
- Volunteers
- 80 people
- Sponsor
- LiChaoran
Pain, Chronic Postsurgical, Knee Osteoarthritis
Central Sensitization in Total Knee Arthroplasty Patients with Persistent Pain
Persistent post-surgical pain is a significant adverse effect after total knee arthroplasty, present in around 20% of the patients. Central sensitization may contribute to developing and maintaining pain.
- Conditions
- Pain, Chronic Postsurgical, Knee Osteoarthritis, Sensitization, Central
- Trial name
- NCT05575310
- Testing
- Total Knee Arthroplasty
- Where
- Spain
- Volunteers
- 117 people
- Sponsor
- University of Barcelona
Rheumatoid Arthritis
Evaluation of Pain Sensitization in Rheumatoid Arthritis: Analysis on a Cohort of Tofacitinib Treated Patients
Persistent pain and chronic fatigue are very common complaints in rheumatoid arthritis (RA) patients, whatever the anti-inflammatory treatment response.
- Trial name
- TOPRA (NCT03815578)
- Testing
- Clinical examination, Pain assessment, blood sample
- Where
- 2 sites in France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Bordeaux
Breast Cancer Surgery, Reconstruction Breast Surgery
Improvement in Breast Skin Sensibility After Breast Reconstruction: a Comparison of 3 Surgical Techniques
The goal of this clinical trial is to learn if nerve sutures in free flap breast reconstruction can optimize sensibility in the reconstructed breast in patients opting for DIEP flap breast reconstruction due to breast cancer or…
- Conditions
- Breast Cancer Surgery, Reconstruction Breast Surgery, Sensitization, DIEP Flap Breast Reconstruction
- Trial name
- S-DIEP (NCT06930378)
- Testing
- Nerve Suture
- Where
- Switzerland
- Volunteers
- 63 people
- Sponsor
- Patricia Esther Engels
Kidney Transplantation, Immunosuppressive Agents
Anti-HLA Immunization And Immunosuppressive Therapy Management In Kidney Transplant Patients Returning to Dialysis
This study is an analytical observational retrospective cohort study. It is a single-center study conducted in the Nancy University Hospital. End stage renal disease is the ultimate stage of the chronic kidney disease.
- Conditions
- Kidney Transplantation, Immunosuppressive Agents, HLA Sensitization, Dialysis
- Trial name
- NCT05282875
- Testing
- management of immunosuppressive therapy
- Where
- France
- Volunteers
- 430 people
- Sponsor
- Central Hospital, Nancy, France