Clinical trials: Seizure Disorder, Partial
Focal Epilepsy, Intraoperative Monitoring
Evaluation of New Flexible High-density Intra-operative ECoG Electrodes for Epilepsy Surgery. ( EpiGrid )
The objective of this prospective interventional monocentric clinical investigation is to evaluate the feasibility and performance of the flexible high-density SOFT ECoG electrode grids, manufactured by Neurosoft Bioelectronics…
- Trial name
- EpiGrid (NCT06205160)
- Testing
- SOFT ECoG subdural grid electrode
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- Neurosoft Bioelectronics SA
Refractory Partial Seizures
Safety Study of Rufinamide Given as an add-on Therapy to Treat Patients With Seizures
This study will evaluate the efficacy and safety of Rufinamide in reducing seizure frequency in subjects with partial seizures not fully controlled despite treatment with 1 to 3 concomitant antiepileptic drugs.
- Trial name
- NCT04558580
- Testing
- Rufinamide
- Where
- United States
- Sponsor
- University of South Alabama
Epilepsy, Focal Epilepsy
Modified Atkins Diet Treatment for Adults With Drug-resistant Epilepsy
In Oslo University Hospital, department of complex epilepsy, offer ketogenic diet to treat children with medically intractable epilepsy. From 2009 we added modified Atkins diet as a treatment option for children up to 18 years.
- Conditions
- Epilepsy, Focal Epilepsy, Generalized Epilepsy
- Trial name
- NCT01311440
- Testing
- Modified Atkins diet treatment
- Where
- Norway
- Volunteers
- 75 people
- Sponsor
- Oslo University Hospital
Epilepsy
Pilot Study to Evaluate MR-guided Laser Ablation of Focal Lesions in Patients With Medically Refractory Partial Epilepsy
To investigate whether MR-guided laser induced thermal therapy in patients diagnosed with focal lesional epilepsy using the Visualase Thermal Therapy System is both a feasible and safe minimally invasive technique for control of…
- Trial name
- NCT01703143
- Testing
- Laser ablation
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Mayo Clinic
Epilepsy
Noninvasive Pre-surgical Evaluation of Patients With Focal Epilepsy and Establishment of a Normative Imaging Database
Objectives: The overall study objective is to compare the sensitivities and specificities of morphometric analysis techniques using structural MRI images based on pre- and postsurgical localization of epileptic foci in patients…
- Trial name
- NCT02107989
- Testing
- MRI, MEG
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Focal Epilepsy
A Study of Lu AG06466 in Participants With Treatment Resistant Focal Epilepsy
The main purpose of this study is to investigate effects of Lu AG06466 on seizure activity after increasing daily doses during 4 weeks in participants with an implanted responsive neurostimulation system.
- Trial name
- NCT05081518
- Testing
- Lu AG06466
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- H. Lundbeck A/S
Focal Epilepsy With and Without Secondary Generalization
Real-world Clinical Response to Cenobamate Early add-on in France, Germany and Spain
Aim of the study is to better characterize the clinical profile of adjunctive cenobamate by collecting data from the current standard clinical practice in France, Germany, and Spain, to describe the real-world clinical response…
- Trial name
- NCT06716801
- Testing
- Cenobamate
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Aziende Chimiche Riunite Angelini Francesco S.p.A
Epilepsies, Partial
Treatment of Difficult to Control Focal Epilepsy With Repetitive Transcranial Magnetic Stimulation (rTMS)
The investigators will treat patients with fully characterized refractory unifocal neocortical epilepsy with a technique that delivers magnetic waves (transcranial magnetic stimulation, TMS) to the region that causes the…
- Trial name
- NCT01745952
- Testing
- figure-of-eight active rTMS coil, round active rTMS coil
- Where
- Belgium
- Volunteers
- 11 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Focal Epilepsy
Optimized Volumetry in Radiology: Interest in Pediatric Brain MRI in the Exploration of Focal Epilepsy
Multicentre cross-sectional study with prospective recruitment comparing the detection rate of lesions on brain MRI without and with quantitative volumetry and T1 relaxometry information during the management of children with…
- Trial name
- ORACLE (NCT05100771)
- Testing
- Pediatric brain MRI
- Where
- 5 sites in France
- Volunteers
- 240 people
- Sponsor
- University Hospital, Tours
Epilepsy
Study in Pediatric Subjects With Epilepsy
This is an open-label study to evaluate the pharmacokinetics, safety and tolerability of ezogabine/retigabine in subjects aged 12 years to less than 18 years with uncontrolled partial onset seizures or Lennos-Gastaut syndrome.
- Trial name
- NCT01494584
- Testing
- ezogabine/retigabine
- Where
- 4 sites in United States
- Volunteers
- 5 people
- Sponsor
- GlaxoSmithKline
Epilepsy, Partial, Motor, Epilepsy, Complex Partial
An Open-Label Extension Study of the Safety and Tolerability of Carisbamate as Add-On Therapy in Patients With Partial Onset Seizures
The purpose of this study is to obtain long-term safety and tolerability information on carisbamate as add-on therapy for the treatment of partial onset seizures in patients with epilepsy.
- Conditions
- Epilepsy, Partial, Motor, Epilepsy, Complex Partial, Epilepsy, Simple Partial, Focal Motor Epilepsy
- Trial name
- NCT00744731
- Testing
- carisbamate
- Volunteers
- 403 people
- Sponsor
- SK Life Science, Inc.
Epilepsy Syndrome
Cognitive Impairments in Children With Epilepsy
Since the proportion of language and attentional difficulties in patients with epilepsy is recognized, both in the literature and in the clinical experience of practitioners, it is appropriate to propose a complete…
- Trial name
- NCT05097742
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Epilepsy
Safety & Efficacy of Eslicarbazepine Monotherapy in Sub.w/Partial Epilepsy Not Well Controlled by Current Antiepileptic
This is an 18-week, double-blind, multicenter study with gradual conversion from previous antiepileptic therapy to eslicarbazepine acetate monotherapy in subjects with partial epilepsy.
- Trial name
- NCT01091662
- Testing
- Eslicarbazepine acetate 1600 mg, Eslicarbazepine acetate 1200 mg
- Where
- 62 sites in United States, Bulgaria and 3 more
- Volunteers
- 172 people
- Sponsor
- Sumitomo Pharma America, Inc.
Seizures
Effectiveness and Safety Study for RWJ-333369 as Adjunctive Therapy in Korean and Japanese Patients With Partial Onset Seizures
The purpose of the study is to evaluate the effectiveness and safety of adjunctive RWJ-333369 at a dose of 200 or 400 mg/day in comparison with placebo in Korean and Japanese partial epilepsy patients who have poor seizure…
- Trial name
- NCT00697762
- Testing
- RWJ-333369
- Volunteers
- 56 people
- Sponsor
- SK Life Science, Inc.
BECTS, Epilepsy, Rolandic
Emotion Recognition in Benign Epilepsy of Childhood With Centro-Temporal Spikes (BECTS)
The social processes depend on complex cognitive mechanisms, which involve mainly the frontal and temporal lobe regions. Patients with early onset frontal and temporal lobe lesions might later develop important deficits in social…
- Trial name
- BECTS (NCT03465566)
- Testing
- IDS;MMSPE;CDI 2;CBCL;tests of facial expression evaluation
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Refractory Epilepsy, Focal Epilepsy
Study of Predictive Biomarkers for Rational Management of Drug-resistant Epilepsy Associated With Focal Cortical Dysplasia
Focal Cortical Dysplasias (FCDs) are neurodevelopmental disorders that represent a major cause of early onset drug-resistant epilepsies with cognitive and behavioral impairments, carrying a lifelong perspective of disability and…
- Conditions
- Refractory Epilepsy, Focal Epilepsy, Focal Cortical Dysplasia
- Trial name
- SPREAD (NCT03321240)
- Testing
- visual and quantitative SEEG signal analysis, Resective epilepsy surgery procedure
- Where
- 11 sites in France
- Volunteers
- 240 people
- Sponsor
- University Hospital, Strasbourg, France
Epilepsies, Partial
MRI in Autosomal Dominant Partial Epilepsy With Auditory Features
This study will examine the possible structural and functional abnormalities in patients with an inherited form of epilepsy. It will use magnetic resonance imaging (MRI).
- Trial name
- NCT00072813
- Where
- 2 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Epilepsy
Open Label, Zonegran (Zonisamide) In Partial Onset Seizures
To determine the efficacy and safety of adjunctive open label Zonegran treatment in patients with refractory partial seizures.
- Trial name
- NCT00215592
- Testing
- Zonegran
- Where
- 33 sites in Austria, Denmark and 5 more
- Volunteers
- 1,000 people
- Sponsor
- Eisai Limited
Seizures, Epilepsy
Investigating Epilepsy: Screening and Evaluation
Background: Epilepsy affects about 1 percent of the U.S. population. Most people with epilepsy respond well to medicine, but some do not.
- Conditions
- Seizures, Epilepsy, Epilepsy, Temporal Lobe, Partial Epilepsy
- Trial name
- NCT03478852
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Epilepsy
Role of Hormones in Susceptibility to Seizures in Women With Epilepsy
This study will measure and compare hormone levels in women with catamenial epilepsy (epilepsy in which seizures are more frequent during menstrual periods), women with seizures not related to their menstrual cycle, and normal…
- Trial name
- NCT00044252
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)