Clinical trials: Sedative Use
Burns
Pilot Trial of Statin Use in Burn Patients
This is a 90 day study, with patients receiving either oral Rosuvastatin or placebo for up to 28 days. The study will assess the affect of statins administered soon after burn injury on C-reactive protein (CRP) levels, patient…
- Trial name
- BURNSTAT (NCT00978419)
- Testing
- Rosuvastatin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center
COVID-19, Respiratory Failure
Comparative Study of Anaconda System Use Versus Conventional Sedation in COVID-19 Patients.
At the beginning of 2020, a global alert emerged which saturated intensive care units due to COVID-19 worldwide. This caused a need for mechanical ventilation due to atypical pneumonias that had a rapid evolution and respiratory…
- Trial name
- NCT06208592
- Testing
- Sevoflurane with AnaConDa
- Where
- Mexico
- Volunteers
- 43 people
- Sponsor
- Hospital Español de Mexico
Sleep Disorder (Disorder)
The Correlation Between Sleep Quality and Sleep Aid Use and Dietary Patterns
In this study, medical staff in emergency and critical care departments were investigated. It was assumed that the use of sleep aids and dietary patterns affected their sleep quality.
- Trial name
- NCT07019948
- Volunteers
- 378 people, healthy volunteers welcome
- Sponsor
- Wei XIA, PhD
Colonic Diseases
Propofol Versus the Use of Dexmedetomidine as a Sedative Agent for Colonosopy
Dexmedetomidine as a Sedative Agent for Patients Presented for Lower Gastrointestinal Endoscopy
- Trial name
- NCT03466632
- Testing
- Propofol, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Tanta University
Hypnotic Dependence Among Those With Insomnia
Use of Blinded Tapering for Hypnotic Discontinuation
The study will employ a randomized longitudinal clinical trial design to evaluate the relative efficacy of a blinded hypnotic tapering protocol when used in combination with therapist delivered Cognitive Behavioral Therapy for…
- Trial name
- NCT04050176
- Testing
- Hypnotic Medication Open-Label Taper, Hypnotic Medication Blinded Taper
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- National Jewish Health
Sedative Adverse Reaction
Target Controlled Infusion Using Propofol and Remifentanil for Moderate Sedation in Dentistry
The purpose of this university study is to evaluate the use of an advanced dental sedation technique involving two syringe-type pumps called Target Controlled Infusion (TCI) pumps.
- Trial name
- NCT03995134
- Testing
- Propofol and Remifentanil administered by TCI pump
- Where
- 2 sites in Canada, New Zealand
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Substance Use Disorder
Substance Use in Elderly Individuals: Brain and Cognitive Correlates and the Effect of Psychotherapy
The prevalence of addictive disorders in old age is increasing. Age specific and appropriate therapeutic concepts tailored to in-patients thus represent a promising approach for the future.
- Trial name
- NCT02835144
- Testing
- TIQAAM_therapy, Psychoeducation
- Where
- Switzerland
- Volunteers
- 12 people
- Sponsor
- Prof. Dr. med. Egemen Savaskan
Pediatric Solid Tumor, Pediatric Brain Tumor
Effects of Music and Maternal Voice on Sedation Depth and Sedative Use During Pediatric Magnetic Resonance Imaging.
To evaluate the effects of music and maternal voice in children on sedation depth and sedative use during pediatric magnetic resonance imaging.
- Conditions
- Pediatric Solid Tumor, Pediatric Brain Tumor, Pediatric Cancer
- Trial name
- NCT04944875
- Testing
- Group headphone, Group music, Group maternal voice
- Where
- Turkey (Türkiye)
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Tobacco Smoking
The Effects of Sedatives on Tobacco Use Disorder Version 2
Double-blind, placebo-controlled, randomized mechanistic clinical trial to test an intravenous dose of either ketamine, midazolam, dexmedetomidine, or a placebo (saline) on cigarette smoking behavior, craving, and neural effects.
- Trial name
- SED-TUD2 (NCT05505630)
- Testing
- Ketamine, Midazolam, Dexmedetomidine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Insomnia
Photobiomodulation for Reducing Sedative-Hypnotic Use:Clinical Trial of a Light-Therapy Device
Background: Insomnia is a prevalent and growing public health issue, with one in three adults affected globally and one in five Taiwanese adults reporting significant sleep disturbances.
- Trial name
- NCT07764107
- Testing
- PBM intervention
- Volunteers
- 60 people
- Sponsor
- National Health Research Institutes, Taiwan
Healthy Non-dependent, Recreational Sedative Users
Abuse Potential of Oral Gabapentin in Healthy, Non-Drug-Dependent Individuals With Recreational Sedative Drug Use Experience
The purpose of the present study is to assess prospectively the abuse potential of gabapentin compared to placebo and alprazolam in healthy non-drug-dependent recreational sedative drug users under fasted condition.
- Trial name
- NCT07777965
- Testing
- Alprazolam (Xanax), Gabapentin (Neurontin® (Registered Trademark))
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Viatris Inc.
Frailty, Deprescription
Understanding Benzodiazepine and Non-benzodiazepine Sedative Use
Inappropriate medication use among the elderly ranges from 11% to 62% and is a major concern for patient safety. Benzodiazepines account for approximately 20 to 25% of inappropriate medications prescribed to the elderly, thus…
- Conditions
- Frailty, Deprescription, Aged
- Trial name
- NCT02833272
- Testing
- EMPOWER Educational Brochure
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Sedative Adverse Reaction, Anticholinergic Adverse Reaction
Pharmacist Led Intervention to Improve Medication Use in Older In-patients Living With Frailty: the Drug Burden Index
Older people in Canada commonly take multiple medicines for their health conditions. Certain medicines, especially when taken together can lead to serious harms, such as falls.
- Trial name
- NCT03698487
- Testing
- Intervention
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Emily
Hypercatabolism, Sedative, Hypnotic, or Anxiolytic Use Disorders
Sedation Protocols and Skeletal Muscle Metabolism in Mechanical Ventilated Patients
To investigate the effects of different sedation protocols on skeletal muscle metabolism in mechanical ventilated patients in ICU.
- Trial name
- NCT03402113
- Testing
- Dexmedetomidine, Midazolam
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Chinese Medical Association
Insomnia
Reducing Use of Sleep Medications Assisted by a Digital Insomnia Intervention
Chronic insomnia is one of the most common health problems among Veterans and significantly impacts their health, function, and quality of life.
- Trial name
- SEDATIVE (NCT05027438)
- Testing
- Cognitive Behavioral Therapy for Insomnia, Deprescribing
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development
Post-Traumatic Stress Disorders, Major Depressive Disorder
Repeated Ketamine Infusions for Comorbid PTSD and MDD in Veterans
Co-occurring post-traumatic stress disorder (PTSD) and major depressive disorder (MDD) is the most common response to trauma; it is associated with poor clinical outcomes and substantial human disability.
- Trial name
- NCT04032301
- Testing
- Ketamine, Normal Saline
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Pregnancy Complications
Use of Propofol as a Sedative Agent Versus Spinal Analgesia With Bupivacaine in External Cephalic Version
External Cephalic Version (ECV) is a maneuver to modify fetal position in pregnant women with a non-cephalic presentation. Its objective is to achieve a cephalic presentation that allows for vaginal delivery with less risk than a…
- Trial name
- PropoSpinECV (NCT06449430)
- Testing
- Sedation with propofol, Spinal analgesia with bupivacaine
- Where
- Spain
- Volunteers
- 270 people
- Sponsor
- Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia
Cholangitis, Pancreatic Cancer
Ketamine-midazolam as a Sedative Agent in Endoscopic Retrograde Cholangiopancreatography.
Does Ketamine-Midazolam have a better efficacy and safety profile compared to Midazolam - Pethidine in Endoscopic Retrograde Cholangiopancreatography (ERCP)?
- Conditions
- Cholangitis, Pancreatic Cancer, Choledocholithiasis, Choledochal Cyst
- Trial name
- NCT06111872
- Testing
- Ketamine, Midazolam, Pethidin
- Where
- Malaysia
- Volunteers
- 90 people
- Sponsor
- National University of Malaysia
Substance Use Disorders
ZOlpidem and the stRengthening of pRescription regulatiOn
For several years, the French Addictovigilance Network (FAN) highlights potential problematic consumptions with zolpidem. To prevent abuse and misuse of zolpidem, the French Health Products Agency has changed the regulatory…
- Trial name
- ZORRO (NCT03584542)
- Testing
- No interventional study
- Where
- France
- Volunteers
- 449 people
- Sponsor
- Nantes University Hospital