Clinical trials: Sedative
Remimazolam, Anesthesia, General
Bispectral Index and Patient State Index During General Anesthesia With Remimazolam
The aim of this study is to compare the bispectral index (BIS) and patient state index (PSI) during general anesthesia using remimazolam.
- Conditions
- Remimazolam, Anesthesia, General, Hypnotics and Sedatives, Thyroid Disease
- Trial name
- NCT05432050
- Testing
- Bispectral index and Patient state index monitoring
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Seoul National University Hospital
Sedative, Hypnotic, or Anxiolytic Withdrawal, Airway Control
Sedation Compaired With Anesthesia With THRIVE in Endotracheal Intubation With Difficult Airways
To compare the difference in endotracheal intubation in participants with difficult airway between under general anesthesia by Transnasal Humidified Rapid-Insufflation Ventilatory Exchange and under traditional sedation by mask…
- Trial name
- NCT04924621
- Testing
- Respiratory Humidification Treatment Device, AIRVO 2 PT101AZ, Fisher & Paykel Healthcare, Inc., Mask ventilation, Midazolam(T group)
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Peking University
Sedative Adverse Reaction
The Effect of Real-time Binaural Sound on Sedation Using Dexmedetomidine
The aim of the study is to evaluate whether real-time binaural sound affects the dose of dexmedetomidine in patients undergoing sedation with dexmedetomidine after spinal anesthesia.
- Trial name
- NCT04866433
- Testing
- Real-time binaural sound, Music, Control
- Where
- South Korea
- Volunteers
- 189 people
- Sponsor
- Seoul National University Hospital
Noise Exposure, Sedative Withdrawal Delirium
Sound Levels in the Pediatric Cardiac Critical Care Unit and Their Correlation With Sedation Administration, Delirium Scores and Patient Heart Rate
There is limited data regarding sound levels and burden in the pediatric cardiac critical care unit and how this compares with WHO standards.
- Conditions
- Noise Exposure, Sedative Withdrawal Delirium, Sedative Toxicity
- Trial name
- NCT04777695
- Testing
- Decibel Monitor
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Children's National Research Institute
Sleep Apnea, Obstructive, Sleep Apnea
Comparison Between Natural Sleep Endoscopy and Drug-induced Sleep Endoscopy in Patients With Obstructive Sleep Apnea
Drug-induced sleep endoscopy (DISE) is the most used technique for identifying the obstruction site associated with obstructive sleep apnea (OSA).
- Conditions
- Sleep Apnea, Obstructive, Sleep Apnea, Sleep Apnea Syndromes, Apnea
- Trial name
- NCT04729478
- Testing
- Drug-induced sleep endoscopy, Natural sleep endoscopy
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- ethisch.comite@uza.be
Prone Position, Severe Acute Respiratory Syndrome Coronavirus 2
Evaluation of Sedation in COVID-19 ARDS
This study focuses on the evaluation of various factors repeatedly discussed in relation to the impaired sedation of intubated ventilated COVID-19 patients.
- Conditions
- Prone Position, Severe Acute Respiratory Syndrome Coronavirus 2, Hypnotics and Sedatives, Pulmonary Ventilation
- Trial name
- NCT04667936
- Testing
- Treatment group
- Where
- Germany
- Volunteers
- 114 people
- Sponsor
- Goethe University
Intensive Care Unit Syndrome, Mechanical Ventilation Complication
Ketamine Infusion as Sedative Analgesic in Severe ARDS
To evaluate whether ketamine is a safe sedative-analgesic agent to be used in an intensive care unit (ICU) setting as compared to traditionally used agents such as propofol, opioids, and midazolam
- Conditions
- Intensive Care Unit Syndrome, Mechanical Ventilation Complication, Sedatives and Hypnotics Causing Adverse Effects in Therapeutic Use, Delirium
- Trial name
- KISS (NCT04818827)
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Interfaith Medical Center
Hypnotics and Sedatives, Addiction
Monitoring and Risk Prediction of Iatrogenic Sedative Hypnotics Addiction in a Shanghai Psychiatric Hospital
This study will establish a sedative and hypnotics iatrogenic addiction risk monitoring network composed of 4 psychiatric hospitals in Shanghai through standardized data construction of outpatient prescription data and personnel…
- Trial name
- NCT04504162
- Volunteers
- 100,000 people
- Sponsor
- Shanghai Mental Health Center
Dental Anxiety, Sedative; Anxiety Disorder
Influence of Lavender Oil on Vital Signs in Oral Surgery Patients
The aim of this study is to investigate the impact of lavender oil (Lavandula angustifolia) on anxiety, mood, vital signs (blood pressure, respiratory rate, heart rate and saturation) for oral surgery patients.
- Trial name
- NCT03722771
- Testing
- Inhalation, Anxiety Questionnaires 1, Anxiety Questionnaires 2
- Where
- Turkey (Türkiye)
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Nazife Begüm KARAN
Sedative Adverse Reaction, Sleep
Reducing Sedatives in Hospital Study
Inappropriate prescription of unnecessary and potentially harmful medications continues to be a widespread problem for hospitalized patients.
- Trial name
- NCT03420898
- Testing
- Quality Improvement Intervention, prescription reduction
- Where
- Canada
- Volunteers
- 19,090 people
- Sponsor
- Mount Sinai Hospital, Canada
Effect of Sedatives
Effect of Sedatives on Perioperative Electroencephalogram in Elderly Patients Undergoing Spinal Anesthesia
In the present study, we observe perioperative findings of electroencephalogram in sedated and non-sedated elderly patients undergoing total knee arthroplasty under spinal anesthesia.
- Trial name
- NCT04248075
- Testing
- Electroencephalogram
- Volunteers
- 120 people
- Sponsor
- SMG-SNU Boramae Medical Center
Sedative Adverse Reaction, Analgesic Adverse Reaction
The Use of Midazolam and Remifentanil During Dialysis Access Procedures
BACKGROUND: Sedation and analgesia are related to unexpected adverse events in chronic renal failure patients undergoing arteriovenous fistula placement procedures under monitored anesthesia care (MAC).
- Conditions
- Sedative Adverse Reaction, Analgesic Adverse Reaction, Midazolam Adverse Reaction, Adverse Reaction to Drug
- Trial name
- NCT04226443
- Testing
- Midazolam intravenous injection, Remifentanil intravenous bolus dose
- Volunteers
- 99 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Intensive Care Unit Patient, Mechanical Ventilation
Evaluation of Decision Capacity of ICU Patients Under Sedatives. A Prospective Observational Multicenter Study.
This prospective observational multicenter study is intended to investigate the impact of sedatives on the decision capacity of intensive care units patients.
- Conditions
- Intensive Care Unit Patient, Mechanical Ventilation, Sedatives, Decision-making Capacity
- Trial name
- DexCap (NCT04193540)
- Testing
- ACE questionnaire
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Clermont-Ferrand
Unconsciousness, Apnea, Postanesthetic
Race-Specific Propofol Titration to Effect for Procedural Sedation
Prospectively evaluate newly established guidelines and make clinicians aware of inter-racial difference in propofol sensitivity.
- Conditions
- Unconsciousness, Apnea, Postanesthetic, Sedative Overdose, Hypoxemia
- Trial name
- NCT03290859
- Testing
- Titrate propofol monotherapy infusion to effect
- Where
- United States
- Volunteers
- 2,780 people
- Sponsor
- University of Florida
Delirium, Postoperative Complications
Acceptable Hemodynamic Changes in Dexmedetomidine for Single Intravenous Bolus Injection
Dexmedetomidine（DEX）is a potent and highly selective α 2 adrenergic receptor agonist. It has the pharmacological effects of sedation, hypnosis, analgesia, anti-sympathetic and neuroprotective.
- Conditions
- Delirium, Postoperative Complications, Pathologic Processes, Neurocognitive Disorders
- Trial name
- NCT03655847
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Sedative Adverse Reaction
Evaluating the Effects of Propofol vs. Dexmedetomidine
The primary purpose of this observational study is to compare what drugs work best in sedating children (> 3 months to < 36 months) who need an MRI.
- Trial name
- NCT03552146
- Testing
- Propofol, Dexmedetomidine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Children's Healthcare of Atlanta
Coronary Angiography, Sedative Premedication
Sedative Premedication in Coronary Angiography
Evaluation of the possible positive effect of sedative premedication prior to coronary angiography in regards to pain and anxiety.
- Trial name
- NCT03576456
- Testing
- Alprazolam 0.5 mg
- Where
- Belgium
- Volunteers
- 264 people
- Sponsor
- Universitair Ziekenhuis Brussel
Critical Illness, Hypnotics and Sedatives
Generalized Versus Personalized Music Therapy in the ICU to Reduce Sedation
Admission to an Intensive Care Unit (ICU) is one of the major causes of stress and both physical and emotional difficulties for critically ill patients, both because of the illness that caused the admission and of the ICU…
- Conditions
- Critical Illness, Hypnotics and Sedatives, Music Therapy
- Trial name
- NCT03280329
- Testing
- Generalized Music therapy, Personalized Music therapy
- Where
- Italy
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- University of Milan
Hypercatabolism, Sedative, Hypnotic, or Anxiolytic Use Disorders
Sedation Protocols and Skeletal Muscle Metabolism in Mechanical Ventilated Patients
To investigate the effects of different sedation protocols on skeletal muscle metabolism in mechanical ventilated patients in ICU.
- Trial name
- NCT03402113
- Testing
- Dexmedetomidine, Midazolam
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Chinese Medical Association
Sedative Adverse Reaction
Effect of Sedation on Pulmonary Aeration in Children
Pediatric sedation is an anesthesiological technique with a good safety profile, but various complications might ensure, especially from the respiratory point of view.
- Trial name
- LunSed (NCT03392012)
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- IRCCS San Raffaele