Clinical trials: Sedative
Hypnotics and Sedatives, Addiction
Monitoring and Risk Prediction of Iatrogenic Sedative Hypnotics Addiction in a Shanghai Psychiatric Hospital
This study will establish a sedative and hypnotics iatrogenic addiction risk monitoring network composed of 4 psychiatric hospitals in Shanghai through standardized data construction of outpatient prescription data and personnel…
- Trial name
- NCT04504162
- Volunteers
- 100,000 people
- Sponsor
- Shanghai Mental Health Center
Withdrawal Syndrome
Protocolized Sedative Weaning VS. Usual Care in Pediatric Critically Ill, RCT
Sedative and analgesic agents are widely used in the ICU. These agents can provide hypnotic effect, pain alleviation, cooperation, and synchronizing ventilatory support.
- Trial name
- NCT03018977
- Testing
- The sedative weaning protocol group, The usual group
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Ramathibodi Hospital
Remimazolam, Orthopedic Procedures
Effective Dose of Remimazolam for Sedation in Patients Undergoing Lower Extremity Surgery Under Spinal Anesthesia
Currently used drugs for monitored general anesthesia include propofol, midazolam, and dexmedetomidine. Each drug has different advantages and disadvantages.
- Conditions
- Remimazolam, Orthopedic Procedures, Sedatives, Anesthesia, Spinal
- Trial name
- NCT05379777
- Testing
- Remimazolam
- Where
- South Korea
- Volunteers
- 51 people
- Sponsor
- Asan Medical Center
Acute Respiratory Failure
Randomized Trial of Sedative Choice for Intubation
Among critically ill adults undergoing emergency tracheal intubation, one in five experience hypotension, cardiac arrest, or death.
- Trial name
- RSI (NCT05277896)
- Testing
- Ketamine, Etomidate
- Where
- 6 sites in United States
- Volunteers
- 2,367 people
- Sponsor
- Vanderbilt University Medical Center
Delirium, Aging
MIND-ICU Study: Delirium and Dementia in Veterans Surviving ICU Care
This will be the first large cohort study to define the epidemiology of and identify modifiable risk factors for long-term CI and functional deficits of ICU survivors.
- Conditions
- Delirium, Aging, Dementia
- Trial name
- NCT00400062
- Where
- 3 sites in United States
- Volunteers
- 800 people
- Sponsor
- VA Office of Research and Development
Patients Undergoing Diagnostic EGD
Meperidine for Patients Expected to Have Poor Tolerance During Diagnostic Esophagogastroduodenoscopy.
Our pilot results showed that meperidine reduce patient discomfort during EGD (esophagogastroduodenoscopy). But many patients can tolerate EGD well without any sedative agents.
- Trial name
- NCT01948921
- Testing
- Meperidine
- Where
- Taiwan
- Volunteers
- 110 people
- Sponsor
- Dalin Tzu Chi General Hospital
Sleep Disorders
Providing "Good Sleep" for ICU Sedation
Cognitive dysfunction, either alone or as an element in the syndrome of delirium, is a common occurrence with an incidence as high as 75% in intensive care unit (ICU) patients and can independently result in serious consequences…
- Trial name
- ASRV (NCT01342328)
- Testing
- Normal saline infusion, Dexmedetomidine, Propofol
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Anxiety
Pre-procedural Anxiety and Sedation.
Colonoscopy is an outpatient procedure performed frequently as a screening test for diagnosis and treatment of a wide range of gastrointestinal problems.
- Trial name
- NCT01958151
- Testing
- State-Trait Anxiety Inventory Scores
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Basak Ceyda MECO
Sedative Adverse Reaction
Target Controlled Infusion Using Propofol and Remifentanil for Moderate Sedation in Dentistry
The purpose of this university study is to evaluate the use of an advanced dental sedation technique involving two syringe-type pumps called Target Controlled Infusion (TCI) pumps.
- Trial name
- NCT03995134
- Testing
- Propofol and Remifentanil administered by TCI pump
- Where
- 2 sites in Canada, New Zealand
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Noise Exposure, Sedative Withdrawal Delirium
Sound Levels in the Pediatric Cardiac Critical Care Unit and Their Correlation With Sedation Administration, Delirium Scores and Patient Heart Rate
There is limited data regarding sound levels and burden in the pediatric cardiac critical care unit and how this compares with WHO standards.
- Conditions
- Noise Exposure, Sedative Withdrawal Delirium, Sedative Toxicity
- Trial name
- NCT04777695
- Testing
- Decibel Monitor
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Children's National Research Institute
Flexible Bronchoscopy
Effect of the Topical Application of Anaesthetics With EnkFiberoptic Atomizer During the Bronchoscopy
The aim of this prospective study is to examine the benefits and risks of administration of local anaesthetics with a special atomizing set (Enk Fiberoptic Atomizer, Cook Medical) during flexible bronchoscopy.
- Trial name
- EnkAtomizerII (NCT02262442)
- Testing
- Enk Fiberoptic Atomizer, bronchoscope
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- RWTH Aachen University
Aging, Balance
Sleepiness and the Risk of Falling
The purpose of this project is to examine the impact of sleeping pills and waking up in the middle of the night on walking balance and cognitive function, to identify risk factors for falls in older adults.
- Conditions
- Aging, Balance, Sleep
- Trial name
- NCT00383357
- Testing
- zolpidem
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Perioperative Anxiety, Perioperative Pain Management
Evaluation of the Effectiveness of Virtual Reality as an Adjunct to Standard Care in Managing Perioperative Anxiety and Pain in Patients Undergoing Lower Limb Orthopedic Surgery Under Spinal Anesthesia
The goal of this clinical trial is to evaluate whether virtual reality (VR) can effectively reduce perioperative anxiety and pain in patients undergoing lower limb orthopedic surgery under spinal anesthesia.
- Conditions
- Perioperative Anxiety, Perioperative Pain Management, Hemodynamic Stability, Satisfaction
- Trial name
- NCT07134764
- Testing
- Virtual reality session
- Where
- Tunisia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Sfax
Delirium, Postoperative Complications
Acceptable Hemodynamic Changes in Dexmedetomidine for Single Intravenous Bolus Injection
Dexmedetomidine（DEX）is a potent and highly selective α 2 adrenergic receptor agonist. It has the pharmacological effects of sedation, hypnosis, analgesia, anti-sympathetic and neuroprotective.
- Conditions
- Delirium, Postoperative Complications, Pathologic Processes, Neurocognitive Disorders
- Trial name
- NCT03655847
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
ECMO Treatment, ARDS (Acute Respiratory Distress Syndrome)
Ciprofol's Impact on Oxygenator Function in Extracorporeal Membrane Oxygenation (ECMO) Patients
This study evaluates the safety and effectiveness of Ciprofol, a new sedative, in critically ill patients receiving Extracorporeal Membrane Oxygenation (ECMO), a life-support system for heart or lung failure.
- Conditions
- ECMO Treatment, ARDS (Acute Respiratory Distress Syndrome), ECMO and Acute MI, Respiratory Failure Patients Treated With ECMO
- Trial name
- CIP-OXY (NCT06934811)
- Testing
- Ciprofol, Midazolam
- Volunteers
- 30 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Cannabis Use Disorder, Stimulant Use Disorder
Emotional Brain Training for Addiction Medicine Treatment - A Pilot Study
The goal of this clinical trial is to determine whether Emotional Brain Training (EBT), a behavioral modification method, can help manage stress and health problems related to addiction.
- Conditions
- Cannabis Use Disorder, Stimulant Use Disorder, Opioid Use Disorder, Tobacco Use Disorder
- Trial name
- NCT07001371
- Testing
- Emotional Brain Training, Standard addiction counseling and medical therapy
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Loma Linda University
Anesthesia
Effect of Sedative and Anxiolytic Premedication on Children Experience After General Anesthesia
Children undergoing general anesthesia for surgery commonly need sedative and anxiolytic premedication but little clinical evidence supports is benefit for children older than 7 years old.
- Trial name
- pediaPREM (NCT05681572)
- Testing
- Midazolam, Dexmedetomidine
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Montpellier
Frailty, Deprescription
Understanding Benzodiazepine and Non-benzodiazepine Sedative Use
Inappropriate medication use among the elderly ranges from 11% to 62% and is a major concern for patient safety. Benzodiazepines account for approximately 20 to 25% of inappropriate medications prescribed to the elderly, thus…
- Conditions
- Frailty, Deprescription, Aged
- Trial name
- NCT02833272
- Testing
- EMPOWER Educational Brochure
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Pregnancy Complications
Use of Propofol as a Sedative Agent Versus Spinal Analgesia With Bupivacaine in External Cephalic Version
External Cephalic Version (ECV) is a maneuver to modify fetal position in pregnant women with a non-cephalic presentation. Its objective is to achieve a cephalic presentation that allows for vaginal delivery with less risk than a…
- Trial name
- PropoSpinECV (NCT06449430)
- Testing
- Sedation with propofol, Spinal analgesia with bupivacaine
- Where
- Spain
- Volunteers
- 270 people
- Sponsor
- Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia
Cirrhosis, Liver
Propofol Versus Midazolam for Lower Gastrointestinal Endoscopy
propofol versus use of midazolam as sedative agent in patients with liver cirrhosis presented for lower gastrointestinal endoscopy
- Trial name
- NCT03388151
- Testing
- Midazolam, Propofol
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sherief Abd-Elsalam