Clinical trials: Sedation Complication
Disorder; Mental, Sedative, Pain, Postoperative
Comparison of Hemodynamics Between Dexmedetomidine and Propofol for Sedation in Patients With Abdominal Surgery
This is a single-blind randomized clinical trial. Patients undergoing abdominal tumor surgery were recruited to participate in the study.
- Conditions
- Disorder; Mental, Sedative, Pain, Postoperative, Surgery
- Trial name
- NCT02393066
- Testing
- Propofol, Dexmedetomidine
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Respiration Disorders
Randomized Study of Propofol Versus Fentanyl and Midazolam in Pediatric Patients Requiring Mechanical Ventilation and Sedation Therapy
OBJECTIVES: I. Assess the degree of amnesia afforded by study sedatives relative to the patient's intensive care unit experiences. II.
- Trial name
- NCT00004424
- Testing
- fentanyl, Midazolam, propofol
- Volunteers
- 120 people
- Sponsor
- FDA Office of Orphan Products Development
Critical Illness, Mechanical Ventilation Complication
Enteral Versus Intravenous Sedation in Critically Ill High-risk ICU Patients
Recent studies suggest the employment of 'conscious' sedation (1) for critically high - risk patients (2), showing more efficacy then deep sedation (3).
- Trial name
- NCT01360346
- Testing
- Enteral Sedation (EN), Control group: Intravenous Sedation (IV)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- University of Milan
Mechanical Ventilation Complication
Sequential Use of Propofol/Midazolam and Dexmedetomidine for Sedation in Mechenical Ventialtion Patients in ICU.
For the patient who passed the screen of weaning from ventilation, the traditional sedation drug such as propofol and midazolam should be decreased or stopped, then it would induce the stress response and agitation, such as…
- Trial name
- NCT02122055
- Testing
- Fentanyl, Sedation assessment, Screen of weaning
- Volunteers
- 100 people
- Sponsor
- Tianjin Third Central Hospital
Acute Kidney Injury
Pharmacokinetic Study of 48-hour Sevoflurane Inhalation Using a Disposable Delivery System (AnaConDa©) in ICU Patients With Acute Kidney Injury
Describing a pharmacokinetic model of 48-h sevoflurane sedation in ICU patients with acute kidney failure
- Trial name
- SEVOKID (NCT02042599)
- Testing
- Sedation with sevoflurane during 48-hr in ICU
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Clermont-Ferrand
Sedation Complication
Application of Dexmedetomidine Hydrochloride Injection in Anesthesia for Patients Without Tracheal Intubation
With 0.9% sodium chloride injection as a placebo control, to evaluate the effectiveness and safety of dexmedetomidine hydrochloride injection for sedation in patients with non-tracheal intubation
- Trial name
- NCT04652427
- Testing
- Dexmedetomidine Hydrochloride 0.1 MG/ML, 0.9% Sodium Chloride Injection
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Peking University People's Hospital
Arthroplasty Complications, Knee Osteoarthritis
Virtual Reality Hypnosis in Total Knee Arthroplasty Under Spinal Anesthesia
For many years, total knee arthroplasty (TKA) has been a common and effective procedure to treat chronic refractory joint pain. Although efforts must be pursued, as general anesthesia remains the main tendency for TKA.
- Conditions
- Arthroplasty Complications, Knee Osteoarthritis, Anesthesia Complication, Hypnotic; Anxiety Disorder
- Trial name
- NCT05707234
- Testing
- VRH, Midazolam sedation
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- University of Liege
Postoperative Cognitive Dysfunction, Postoperative Pain, Acute
Propofol and Dexmedetomidin vs Midazolam Intraoperative Sedation and POCD
This study will examine the effect of intraoperative sedation with midazolam, propofol and dexemdetomidine on the occurrence of postoperative cognitive impairment in patients undergoing surgical treatment of pertrochanteric…
- Conditions
- Postoperative Cognitive Dysfunction, Postoperative Pain, Acute, Pertrochanteric Fracture
- Trial name
- ProDex-POCD (NCT05398757)
- Testing
- Mini mental state exame (MMSE), Digit Symbol Substitution Test (DSST), Numeric rating Scale (NRS)
- Where
- Croatia
- Sponsor
- Osijek University Hospital
Dexmedetomidine, Mechanical Ventilation Complication
DOSE Trial of Opioid Sparing Effect
Multicenter, double blind randomized controlled trial of fentanyl vs. fentanyl + dexmedetomidine as the initial regimen for maintenance of sedation in mechanically-ventilated, critically ill children.
- Conditions
- Dexmedetomidine, Mechanical Ventilation Complication, Critically Ill
- Trial name
- DOSE (NCT03938857)
- Testing
- Fentanyl, Dexmedetomidine
- Where
- 19 sites in United States
- Volunteers
- 30 people
- Sponsor
- Duke University
Procedural Sedation, Emergence Delirium
Positive Imagery Therapy and the Incidence of Emergence Reactions With the Use of Ketamine
The purpose of this study is to determine if positive imagery therapy while using ketamine in procedural sedation reduces the number of emergence reactions and impacts pre and post-procedural anxiety.
- Trial name
- NCT04746079
- Testing
- Positive Imagery Therapy
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Mercy Health Ohio
Sedation Complication, Ventilatory Depression
Optimization of Sedation Protocol for Endoscopic Procedures Using Impedance Ventilation Monitor.
The aim of the study is to evaluate the effect of opioids administered during sedation on patients' respiratory activity (ventilation) and comfort of the operator and patient during the endoscopic procedure.
- Trial name
- NCT06060626
- Testing
- Sedation using only Propofol., Sedation using combination of Propofol and Fentanyl.
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- Charles University, Czech Republic
Severe Obesity, Hypoxia
Use of Non-Invasive Positive Pressure Ventilation in Patients With Severe Obesity Undergoing Upper Endoscopy Procedures
The study evaluated the effect of non-invasive positive pressure ventilation (NIPPV) to decrease the incidence of desaturation events in patients with severe obesity undergoing upper endoscopy.
- Trial name
- NCT03529461
- Testing
- Non-invasive positive pressure ventilation through nasal mask, Rescue non-invasive positive pressure ventilation through nasal mask, Secondary rescue maneuvers
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Bristol Hospital
Respiration, Artificial, Postoperative Pain
Sedation Administration Timing: Intermittent Dosing Reduces Time to Extubation
SATIRE is a prospective, randomized control trial assessing two methods of administration of intravenous sedation and narcotics in surgical patients requiring mechanical ventilation.
- Conditions
- Respiration, Artificial, Postoperative Pain, Postoperative Complications
- Trial name
- SATIRE (NCT03181620)
- Testing
- Intermittent Dosing of Medication
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Abington Memorial Hospital
Complication of Anesthesia, Sedation-related Complications
Sedation-related Complications During Gastroenterological Procedures
Applications of non-operating room anesthesia for diagnosis and treatment are required in a variety of disciplines nowadays. Although it is not painful, sedation may be required in the gastrointestinal unit during procedures that…
- Trial name
- NCT05563727
- Where
- Turkey (Türkiye)
- Volunteers
- 693 people, healthy volunteers welcome
- Sponsor
- Gazi University
Airway Complication of Anesthesia
Role of Airway Topicalization in Awake Fiberoptic Intubation
Airway management is an integral part of general anesthesia. Difficult airway management may lead to various adverse events such as airway trauma, up to cardiopulmonary arrest.
- Trial name
- NCT06720220
- Testing
- Dexmedetomidine Hydrochloride, Nebulization, Atomization
- Where
- Egypt
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Hypoxemia, Sedation Complication
Position Intervention to Reduce Hypoxemia in Sedation Patients
Hypoxemia was defined as an SpO2 of < 90% for any duration. Failure to treat promptly can lead to hypoxemia, which may increase the risks of arrhythmia, nausea and vomiting, and cognitive dysfunction.
- Conditions
- Hypoxemia, Sedation Complication, Emergencies, Airway Remodeling
- Trial name
- NCT06459167
- Testing
- The position adopted when patients undergoing procedure or surgery
- Where
- China
- Volunteers
- 1,752 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Prostate Biopsy, Sedation Complication
Effect of Remimazolam on Hypoxemia and/or Hypotension in Prostate Biopsy
This study aims to investigate whether remimazolam, a novel benzodiazepine sedative, can reduce the composite incidence of hypotension and hypoxemia during prostate biopsy in elderly patients compared with propofol.
- Trial name
- NCT07854197
- Testing
- Using remimazolam for sedation during prostate biopsy, Administer 1.5mg/kg of propofol for sedation
- Volunteers
- 1,146 people
- Sponsor
- RenJi Hospital
Sedation Complication, Obesity
Effect of HFNO on Spontaneous Ventilation in Obese Patients During Analgo-sedation for Vitrectomy
Patients suffering from pathology of posterior eye chamber such as diabetic retinopathy, retinal detachment, traumatic eye injury, retained lens fragments, macular hole, pucker, dislocated intraocular lens after cataract surgery…
- Conditions
- Sedation Complication, Obesity, Hypoxic Respiratory Failure, Airway Obstruction, Nasal
- Trial name
- NCT04049240
- Testing
- Device: low-flow nasal oxygenation (LFNO) 18<BMI<30 kg/m2, Device: low-flow nasal oxygenation (LFNO) 30≤BMI<35 kg/m2, Device: low-flow nasal oxygenation (LFNO) BMI≥35 kg/m2
- Where
- Croatia
- Volunteers
- 126 people
- Sponsor
- University of Split, School of Medicine
ARDS, Respiratory Effort
Comparison of Guiding Sedation Level by Respiratory Effort Versus Usual Care in Mechanically Ventilated Patients: A Randomized Controlled Trial (EFFORT-GUIDE Trial 2)
The objective of this research is to utilize respiratory effort parameters as a tool to assist in adjusting sedative drug levels for patients undergoing mechanical ventilation in the intensive care unit, in comparison to the…
- Conditions
- ARDS, Respiratory Effort, Mechanical Ventilation Complication, Sedation
- Trial name
- NCT06242236
- Testing
- The respiratory effort parameters guide sedative dosage.
- Where
- Thailand
- Volunteers
- 156 people
- Sponsor
- Ramathibodi Hospital
Sleep Apnea, Obstructive, Obesity
Propofol vs Propofol + Benzo/Opiates in High Risk Group
This will be a randomized controlled trial that compares the rates of sedation related complications in high risk patients (ASA greater or equal to 3, BMI greater or equal to 30, those at risk for OSA) undergoing advanced…
- Trial name
- NCT01315158
- Testing
- Propofol Alone, Propofol+Benzo/Opioids
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Washington University School of Medicine